Social, economic, and physical side effects impact PrEP uptake and persistence among transgender women in Peru.

Introduction: Oral pre-exposure prophylaxis (PrEP) for HIV-1 infection is over 99% effective in protecting against HIV acquisition when used consistently and appropriately. However, PrEP uptake and persistent use remains suboptimal, with a substantial gap in utilization among key populations who could most benefit from PrEP. In Latin America specifically, there is poor understanding of barriers to PrEP uptake and persistence among transgender (trans) women.

A conceptual IoT-based early-warning architecture for remote monitoring of COVID-19 patients in wards and at home.

Due to the COVID-19 pandemic, health services around the globe are struggling. An effective system for monitoring patients can improve healthcare delivery by avoiding in-person contacts, enabling early-detection of severe cases, and remotely assessing patients' status. Internet of Things (IoT) technologies have been used for monitoring patients' health with wireless wearable sensors in different scenarios and medical conditions, such as noncommunicable and infectious diseases.

An international comparative study of active living environments and hospitalization for Wales and Canada.

Unlabelled: Previous studies indicate active living environments (ALEs) are associated with higher physical activity levels across different geographic contexts, and could lead to reductions in hospital burden. Both Wales UK and Canada have advanced data infrastructure that allows record linkage between survey data and administrative health information.

Objective: To assess the relationship between ALEs and hospitalization in Wales and Canada.

Does living near hospital obscure the association between active living environments and hospitalization?

Hospitals tend to be among the destinations that make densely populated, well-connected neighbourhoods more conducive to active living. In this study, we determined whether living near a hospital distorts the association between living in favourable ALEs and hospitalization for physical inactivity-related cardiometabolic diseases. We used a record linkage of 442,345 respondents of the Canadian Community Health Survey and their hospitalization records for cardiometabolic disease.

All together now: aggregating multiple records to develop a person-based dataset to integrate and enhance infectious disease surveillance in Ontario, Canada.

Setting: Syndemics occur when two or more health conditions interact to increase morbidity and mortality and are exacerbated by social, economic, environmental, and political factors. Routine provincial surveillance in Ontario assesses and reports on the epidemiology of single infectious diseases separately. Therefore, we aimed to develop a method that allows disease overlaps to be examined routinely as a path to better understanding and addressing syndemics in Ontario.

Sexuality and Sexual Identity Across the First Year of Parenthood Among Male-Partnered Plurisexual Women.

Women who (a) hold plurisexual identities (e.g., bisexual, pansexual) and (b) are male-partnered are understudied.

Annual relative increased in inpatient mortality from antimicrobial resistant nosocomial infections in Thailand.

Antimicrobial resistance is a major health threat worldwide as it brings about poorer treatment outcome and places economic burden to the society. This study aims to estimate the annual relative increased in inpatient mortality from antimicrobial resistant (AMR) nosocomial infections (NI) in Thailand. A retrospective cohort study was conducted at Ramathibodi Hospital, Bangkok, Thailand, over 2008-2012.

Variability in ambient ozone and fine particle concentrations and population susceptibility among Canadian health regions.

Objectives: To estimate the proportion of the Canadian population that is more susceptible to adverse effects of ozone (O) and fine particle (PM) air pollution exposure and how this varies by health region alongside ambient concentrations of O and PM.

Methods: Using data from the census, the Canadian Community Health Survey, vital statistics and published literature, we generated cross-sectional estimates for 2014 of the proportions of the Canadian population considered more susceptible due to age, chronic disease, pregnancy, outdoor work, socio-economic status, and diet. We also estimated 2010-2012 average concentrations of O and PM.

The effect of socio-demographic factors on mental health and addiction high-cost use: a retrospective, population-based study in Saskatchewan.

Objective: A small proportion of the population accounts for the majority of healthcare costs. Mental health and addiction (MHA) patients are consistently high-cost. We aimed to delineate factors amenable to public health action that may reduce high-cost use among a cohort of MHA clients in Saskatoon, Saskatchewan.

Gender differences in felt stigma and barriers to help-seeking for problem gambling.

Background: Men and women differ in their patterns of help-seeking for health and social problems. For people experiencing problem gambling, feelings of stigma may affect if and when they reach out for help. In this study we examine men's and women's perceptions of felt stigma in relation to help-seeking for problematic gambling.

Impact of normalization and filtering on linkage analysis of gene expression data.

Using the Problem 1 data set made available for Genetic Analysis Workshop 15, we assessed sensitivity of linkage results to a correlation-based feature extraction method as well as to different normalization procedures applied to the raw Affymetrix gene expression microarray data. The impact of these procedures on heritability estimates and on expression quantitative trait loci are investigated. The filtering algorithm we propose in this paper ranks genes based on the total absolute correlation of each gene with all other genes on the array and has the potential to extract features that may play role in functional pathways and gene networks.