2 results match your criteria: "Health Research Institute of Santiago de Compostela (IDIS) Universidade de Santiago de Compostela[Affiliation]"
Screening of critical variables in fabricating polycaprolactone nanoparticles using Neuro Fuzzy Logic.
Int J Pharm
May 2021
Department of Pharmaceutical Science and Technology, School of Chemical and Pharmaceutical Sciences, University of Chile, Santos Dumont 964, 4to piso, Of. 09, Independencia, 8380494 Santiago, Chile; Advanced Center for Chronic Diseases (ACCDiS), 8380494 Santiago, Chile; Center of New Drugs for Hypertension (CENDHY), 8380494 Santiago, Chile. Electronic address:
In this work, we used the artificial intelligence tool known as neurofuzzy logic (NFL) for fabricating uniform nanoparticles of polycaprolactone by the nanoprecipitation method with a focus on stabilizer selection. The adaptability of NFL assisted the decision-making on different manufacturing and formulation conditions. The nanoprecipitation method can be summarized as mixing a poorly water-soluble polymer solution with water and its consequent precipitation.
View Article and Find Full Text PDFHeads and Tails of Natriuretic Peptides: Neuroprotective Role of Brain Natriuretic Peptide.
J Am Heart Assoc
December 2017
Clinical Neurosciences Research Laboratory, Department of Neurology, Hospital Clínico Universitario, Health Research Institute of Santiago de Compostela (IDIS) Universidade de Santiago de Compostela, Spain
Background: Besides the relevant role of brain-type natriuretic peptide (BNP) as biomarker of cardioembolic strokes, new experimental evidences suggest that this peptide may mediate neuroprotective effects. In this study, we have evaluated for the first time the clinical association between BNP (by means of proBNP) and good outcome in ischemic stroke patients, and analyzed the effect of blood BNP increase in an ischemic animal model.
Methods And Results: A retrospective study with 2 different cohorts (262 patients in cohort I and 610 in cohort II) from the same prospective stroke registry was performed.