Assessment of beach litter pollution in Egypt, Tunisia, and Morocco: a study of macro and meso-litter on Mediterranean beaches.

We conducted surveys of Mediterranean beaches in Egypt, Morocco, and Tunisia including 37 macro-litter (> 25 mm) and 41 meso-litter (5-25 mm) assessments. Our study identified key litter items and assessed pollution sources on urban, semi-urban, tourist, and semi-rural beaches. Macro-litter concentration averaged 5032 ± 4919 pieces per 100 m or 1.

Simvastatin is delivered to the brain by high-strength intranasal cationic SMEDDS and nanoemulsions.

The repurposing of statins as neuroprotective agents and/or anti-brain tumor drugs is limited by challenges in brain bioavailability and systemic off-target effects. Therefore, improved and targeted delivery of statins to the brain is necessary. This study aimed to develop a high-strength liquid formulation of the poorly soluble prodrug simvastatin for intranasal administration, as a strategy to achieve high brain concentrations of the prodrug and/or its active form, tenivastatin.

The impact of common and rare genetic variants on bradyarrhythmia development.

To broaden our understanding of bradyarrhythmias and conduction disease, we performed common variant genome-wide association analyses in up to 1.3 million individuals and rare variant burden testing in 460,000 individuals for sinus node dysfunction (SND), distal conduction disease (DCD) and pacemaker (PM) implantation. We identified 13, 31 and 21 common variant loci for SND, DCD and PM, respectively.

Intractable conflicts over end-of-life decisions: A descriptive and ethical analysis of French case-law.

Context: In European and Anglo-Saxon countries, life-sustaining treatment (LST) limitation decisions precede more than 80% of ICU deaths. However, there is now increasing evidence of disagreement and conflict between clinical teams and family members over LST limitation decisions. In some cases, these conflicts are brought to the courts.

Health needs of older people and age-inclusive health care in humanitarian emergencies in low-income and middle-income countries: a systematic review.

Health needs of older people in humanitarian settings are poorly documented, negatively affecting the appropriateness of health services they receive. This Review identified the major health needs of older people across humanitarian contexts, including non-communicable diseases and mental health conditions (eg, psychological distress and depression). Barriers to health care of older people included inaccessibility of health-care services; shortage of appropriate health care; insufficient availability of medications and medical equipment; poor geriatric expertise of health-care staff, health policy makers, and health authorities; and age discrimination by health-care personnel.

International Expert Consensus on Relevant Health and Functioning Concepts to Assess in Users of Tobacco and Nicotine Products: Delphi Study.

Background: A Delphi study was conducted to reach a consensus among international clinical and health care experts on the most important health and functioning self-reported concepts when evaluating a switch from smoking cigarettes to using smoke-free tobacco and/or nicotine products (sf-TNPs).

Objective: The aim of this research was to identify concepts considered important to measure when assessing the health and functioning status of users of tobacco and/or nicotine products.

Methods: Experts (n=105), including health care professionals, researchers, and policy makers, from 26 countries with professional experience and knowledge of sf-TNPs completed a 3-round, adapted Delphi panel.

A Multidisciplinary Approach to Navigating Variants of Uncertain Significance in Sudden Infant Deaths: A Case Report of 2 Siblings With an SCN10A VUS.

The sudden death of a previously healthy infant is a devastating event for a family-the death of 2 even more unimaginable. Prior to the debunking of Meadow's law, a legal concept attributing multiple unexplained infant deaths to Munchausen by proxy, these events could lead to the wrongful prosecution of those who had lost their children to "sudden unexpected infant death (SUID)." Today, these cases, wherein multiple infants within one family pass inexplicably, raise suspicion for a possible genetic cause and point toward a need for postmortem genetic testing.

Unveiling chemical industry secrets: Insights gleaned from scientific literatures that examine internal chemical corporate documents-A scoping review.

Objective: Examine peer-reviewed scientific articles that used internal industry documents in the chemical sector to reveal corporate influence. Summarize sources of internal documents used in prior scientific papers to identify ongoing corporate strategies within the chemical field. Compare the corporate strategies identified in the chemical sector with the ones identified already identified in the pharmaceutical sector.

Environmental impact of an acid-forming alum shale waste rock legacy site in Norway.

Alum shale formations in Scandinavia are generally enriched in uranium (U) and, when exposed to air and water, may produce acidic rock drainage (ARD), releasing potentially harmful elements into the environment. Taraldrud is a legacy site in southeast Norway where approx. 51 000 m of alum shale was deposited in the 1980s-1990s.

Cognitive and preference disparities of Chinese consumers regarding the disclosure of unsafe food recall information.

Introduction: Information disclosure is important in promoting unsafe food recalls and reducing potential food safety risks. However, the governance of unsafe food recall information in China is distorted, leading to cognitive dissonance in Chinese consumers' perceptions of unsafe food recall information. Focusing on consumers' search and cognitive costs, this study suggests that market regulators should proactively and fully disclose unsafe food recall information to satisfy consumers' needs and preferences for recall information, thereby optimizing consumer perceptions and facilitating the improvement of the information governance system for unsafe food recalls.

Community case study: Our Wave, an online platform to facilitate survivor disclosure of sexual assault and trauma recovery.

This community case study introduces Our Wave, an online platform that provides a safe, anonymous space for survivors of sexual harm to share their stories, reflect on their healing journeys, and connect with others. Designed to empower survivors, the platform allows users to post anonymous stories or visual media, ask questions, and send messages of hope, all while prioritizing privacy and security. It also aims to create a broader impact by analyzing shared narratives to detect patterns, identify best practices for healing, and inform global approaches to SV recovery.

Advance Directives at Sea: legal and ethical considerations.

This paper delves into the unexplored area of Advance Directives (ADs) in maritime surroundings, diving into the moral and legal quandaries that crop up when these directives are used at sea. ADs, which include durable powers of attorney and living wills, are essential documents that indicate a person's wishes for healthcare in the event of incapacitation. Global variations in legal recognition pose ethical questions, particularly in non-regulated jurisdictions.

Decompression sickness of medical personnel of a hyperbaric centre: A report of cases during 25 years of activity.

Medical hyperbaric sessions for Hyperbaric Oxygen Therapy, conducted at 2.4-2.5 ATA for 80 to 120 minutes, expose staff to increased risk of DCS due to the inhalation of compressed air, which increases gas solubility in body fluids as per Henry's Law.

Historical mining towns: The establishment of 'Soil Planning Areas' for the risk management of contaminated soil.

Historical mining towns face financial challenges with the proposed Soil Monitoring Law of the European Union, which will require the management of soil contamination, since remediating soil in densely populated towns and cities is challenging. We compared the environmental impact of sulfide ore mining in the urban area of Outokumpu in Finland with that of other European sites, focusing on soil contamination. Soil sampling revealed that mine tailings were historically used in road construction.

A Primary Health Care-Anchored Migrant Right to Health: Insights from a Qualitative Study in Colombia.

In recent years there has been a sustained rise in the number of international migrants, and scholarship and practice have increasingly focused on the relationship between health and migration. However, the entitlement to state-subsidized services for migrants with precarious or irregular legal status, often fleeing distressing living conditions, is typically limited to emergency lifesaving health treatment, with nonstate programs attempting to complement this constrained approach. This paper asks whether a primary health care (PHC) approach could serve as a blueprint for institutional priority-setting and for the realization of human rights obligations to help states meet their core international commitments regarding migrant health rights.

Conceptualizing the Social Determinants of Mental Health Within an International Human Rights Framework: A Focus on Housing and Employment.

The social determinants of health and international human rights law share many overlapping concerns and goals in promoting human well-being. However, so far they have been developing largely in silos, resulting in calls for greater interdisciplinary collaboration. The purpose of this paper is to explore how the social determinants of health-specifically mental health-can fit within international human rights law conceptually and practically.

The Spirit of Human Rights: Universal Health Coverage in Makueni County, Kenya.

In view of the United Nations' goal to achieve universal health coverage (UHC) by 2030, this paper investigates MakueniCare, the highly successful UHC program in Makueni County, Kenya, to reveal the spirit of human rights underlying it. Drawing on international, Kenyan, and Makueni County law and policy, as well as 30 interviews with government and civil society leaders in health care policy and programming at the national and county levels, we examine the human rights law and principles that underlie the adoption and implementation of MakueniCare. We first set out key human rights principles grounded in the International Covenant on Economic, Social and Cultural Rights and the 2010 Kenyan Constitution, and then describe the research design and methodology of the project.

From Choice to Justice: Disrupting the Binary Political Logics of Assisted Reproduction.

Reproductive rights and reproductive justice paradigms have long been viewed as incompatible, largely because of their divergent orientations to the notion of choice. According to this oppositional framing, reproductive rights approaches have centered the right of (white, middle-class, heterosexual) women to choose not to have children while reproductive justice organizing has focused on gendered, racialized, and classed obstacles to control over whether and how to have and raise children. Amid increasing examination of assisted reproductive technologies (ARTs) vis-à-vis human rights principles, I see an opportunity to narrow the perceived gap between the politics of rights and justice.

Securing the Right to Health of Asylum Seekers: A Small-Scale Qualitative Case Study in Thessaloniki, Greece.

Deploying legal analysis and a small-scale qualitative dataset, this paper considers the right to health of asylum seekers, as a subgroup of distress migrants, in Greece in the years preceding the COVID-19 pandemic and thereafter. The public health care system in Greece is operating under significant constraints stemming from austerity policies. We analyze the legal entitlements of asylum seekers as found in Greek and international law and confirm a significant gap between the right to health in theory and the right to health in practice.