HIG-2 promotes glioma stemness and radioresistance mediated by IGFBP2-rich microparticles in hypoxia.

Hypoxia can weaken the efficacy of radiotherapy and decrease tumor immunogenicity leading to immune escape. Thus, a thorough understanding of the key signaling pathways regulated by hypoxia is vitally important to enhance the radiosensitivity and improve immunosuppressive microenvironment of glioma. In this study, we verified the crucial role of hypoxia-inducible gene 2 (HIG-2) in lipid droplet (LD) accumulation and demonstrated that HIG-2 binding to frizzled class receptor 10 (FZD10) activated Wnt/β-catenin signaling pathway and increased its downstream insulin-like growth factor binding protein 2 (IGFBP2) level in microparticles (MPs) derived from glioma stem cells (GSCs), leading to decreased radiosensitivity and immunogenicity of MPs-receiving cells via the cross-talk between GSCs and non-stem glioma cells (GCs).

Anti-Colon Cancer Effects of Lysate from Potential Probiotic Yeast Strains Derived from Human Breast Milk.

Breast milk contains a diverse array of symbiotic microorganisms, including beneficial probiotics. While most research has focused on the bacterial composition of breast milk, the fungal community (mycobiota) has received limited attention. In this study, we isolated and evaluated yeast strains from breast milk, demonstrating the safety and probiotic potential of four strains through hemolysis tests, antimicrobial activity, tolerance to gastrointestinal conditions, aggregation, cell adhesion, and antioxidant activity assays.

Modeling metabolic-associated steatohepatitis with human pluripotent stem cell-derived liver organoids.

Background: Metabolic-associated steatohepatitis (MASH) is one of the most prevalent liver diseases worldwide, with a global prevalence estimated between 3% and 5%, posing a significant health burden. Human liver organoids (HLOs) have previously been generated to model steatohepatitis, offering a potential cellular disease model for studying MASH. However, the current HLO model lacks detailed molecular characterizations and requires further improvement.

The MED13L Foundation strategic research plan: a roadmap to the future.

A strategic research plan (SRP) serves as a compass for the patient advocacy organizations driving the therapeutic options for their rare disorder. The MED13L Foundation commissioned the SRP in 2022 through COMBINEDBrain, a consortium of patient advocacy organizations of rare neurodevelopmental disorders, working toward clinical trial readiness. The MED13L Foundation SRP is an objective evaluation of MED13L literature including clinical and basic science knowledge interwoven with an assessment of preclinical trial readiness tools necessary for achieving therapeutic interventions.

Effects of sex and estrous cycle on extended-access oxycodone self-administration and cue-induced drug seeking behavior.

Introduction: Increasing evidence indicates that sex is a factor that impacts the abuse liability and relapse vulnerability of prescription opioids like oxycodone. However, while women are more likely than men to be prescribed and to use these drugs, the impact of sex and ovarian hormones on prescription opioid use and relapse vulnerability remains unclear. Accurately assessing these measures is complicated by the fact that chronic opioid exposure can lower ovarian hormone levels and cause cycle irregularities.

Effectiveness of nursing interventions based on lung cancer trajectory: A systematic review and meta-analysis.

Aim(s): To evaluate the effectiveness of nursing interventions based on the lung cancer trajectory.

Background: The transition to the chronic state of lung cancer requires a shift in the management paradigm. Nurses are crucial in managing the health of patients with lung cancer through various services.

Labor Pain Management in Ethiopia: A Systematic Review and Meta-Analysis.

Objectives: Labor pain is a subjective phenomenon that varies based on women's expectations. To have a positive childbirth experience, laboring women should have pain relief based on their request. Therefore, this study aimed to determine the utilization of labor pain management and associated factors among obstetric caregivers in Ethiopia DATA SOURCES: Different electronic databases (i.

Medial prefrontal cortex to nucleus reuniens circuit is critical for performance in an operant delayed nonmatch to position task.

Working memory refers to the temporary retention of a small amount of information used in the execution of a cognitive task. The prefrontal cortex and its connections with thalamic subregions are thought to mediate specific aspects of working memory, including engaging with the hippocampus to mediate memory retrieval. We used an operant delayed-non match to position task, which does not require the hippocampus, to determine roles of the rodent medial prefrontal cortex (mPFC), the nucleus reuniens thalamic region (RE), and their connection.

The mediating role of cognitive flexibility in home-school co-education and psychological well-being among Chinese vocational college students.

Objective: This study examines the mediating role of cognitive flexibility in the relationship between home-school co-education (H-SCE) and depressive symptom among vocational college students in urban and rural areas of China.

Methods: Utilizing the Theory of Overlapping Spheres of Influence, this research explores how H-SCE influences depressive symptom, considering cognitive flexibility as a key mediating factor. The study utilized established scales, including the Inventory of Parent and Peer Attachment (IPPA) for parent-child relationships, the Student-Teacher Relationship Scale (STRS), the Cognitive Flexibility Inventory (CFI), and the Center for Epidemiologic Studies Depression Scale (CES-D10).

Tropism of adeno-associated virus serotypes in mouse lungs via intratracheal instillation.

Background: Gene therapy holds great potential for treating various acquired and inherited pulmonary diseases. Adeno-associated viral (AAV) vectors have been thought to be primary candidates for gene delivery in patients with pulmonary diseases. However, the tropism of AAVs in the lungs remains largely unknown.

Health and Economic Impacts of Introducing Vaccae and Enhanced Drug-Resistant Tuberculosis Management Strategies in China.

Background: China faces the highest burden of latent multidrug-resistant or rifampicin-resistant tuberculosis (MDR/RR-TB). We aim to evaluate the health and economic impacts of Vaccae (a novel TB vaccine) and enhanced drug-resistant TB (DR-TB) management strategies.

Methods: Using a compartmental model calibrated with national TB data, we evaluated nine interventions from 2025-2050: enhanced DR-TB management (S1); Vaccae vaccination for those with Mycobacterium tuberculosis infection targeting specific age groups (S2: adolescents, S3: adolescents and young adults, S4: working-age adults, S5: elderly); and combined strategies (S6: S2+S1, S7: S3+S1, S8: S4+S1, S9: S5+S1).

KRT80 in hepatocellular carcinoma plays oncogenic role via epithelial-mesenchymal transition and PI3K/AKT pathway.

Hepatocellular carcinoma (HCC), a globally prevalent form of cancer, is featured by aggressive growth and early metastasis. Elucidating the underlying mechanism and identifying the effective therapy are critical for advanced HCC patients. In the study, we detect that KRT80 was upregulated in HCC samples.

A potent proresolving mediator 17R-resolvin D2 from human macrophages, monocytes, and saliva.

Production of specialized proresolving mediators (SPMs) during the resolution phase in the acute inflammatory response is key to orchestrating complete resolution. Here, we uncovered a trihydroxy resolvin in fresh human saliva. We identified and determined its complete stereochemistry as 7S,16R,17R-trihydroxy-4Z,8E,10Z,12E,14E,19Z-docosahexaenoic acid (17R-RvD2) using total organic synthesis and matching of physical properties.

The CDK8 kinase module: A novel player in the transcription of translation initiation and ribosomal genes.

Survival following stress is dependent upon reprogramming transcription and translation. Communication between these programs following stress is critical for adaptation but is not clearly understood. The Cdk8 kinase module (CKM) of the Mediator complex modulates the transcriptional response to various stresses.

Incorporating iron oxide nanoparticles in polyvinyl alcohol/starch hydrogel membrane with biochar for enhanced slow-release properties of compound fertilizers.

Biochar-based fertilizers show promise in enhancing nutrient utilization and soil health, but their slow-release performance remains a challenge. Herein, hydrogel membranes incorporating iron oxide nanoparticles within a polyvinyl alcohol and starch matrix (Fe/PVA/ST) were synthesized. These membranes were utilized to coat compound fertilizer particles, with biochar powder applied to the outer layer to form what is known as Fe/PVA/ST-BSRFs.

Effect of dynamic high-pressure microfluidization on the structural, emulsifying properties, in vitro digestion and antioxidant activity of whey protein isolate.

The effects of dynamic high-pressure microfluidization (DHPM) on the structural, emulsifying properties, in vitro digestion and antioxidant activity of whey protein isolate (WPI) were investigated. The results demonstrated that WPI treated with 100 MPa DHPM exhibited superior emulsification performance. This can be attributed to the conformational changes induced by 100 MPa DHPM in WPI, leading to a transformation from disordered structures to ordered structures and an increased exposure of fluorophore such as tryptophan residues and hydrophobic groups, reduced aggregation state and particle size of WPI.

Intimate partner violence against women among contraceptive users at a primary health care setting in Southern Ethiopia: a facility-based cross-sectional study.

Background: One in three women experienced intimate partner violence (IPV) worldwide which has remained major public health challenge. Women's reproductive health service utilization has been seriously impacted by IPV. There is a paucity of evidence on the magnitude of IPV among contraceptive users in southern Ethiopia.

Body adiposity index and other indexes of body composition in predicting cardiovascular disease in the Chinese population: A Cohort study.

Objective: The purpose of this study was to compare the ability of four obesity indicators, including waist circumference (WC), body mass index (BMI), body adiposity index (BAI), and waist-to-height ratio (WHtR) on prediction for incident cardiovascular disease (CVD) in Chinese Han population.

Methods: We analyzed data from a prospective population cohort of 3598 participants aged 35 to 74 years from Jiangsu China. The logistic regression model was used to analyze the association between four obesity indicators and CVD risk.

Application of 3D-printed resin guides for the removal of molar fiber posts.

Objective: To evaluate the digital guide technique for removing fiber posts from molars and compare it with the conventional microscope-assisted ultrasound method.

Methods: Two mandibular dentition models, each comprising six extracted molars, were prepared. Two thick and straight canals distributed separately in the distal and mesial roots of each molar were selected for placing the fiber posts.

Modeling the epidemiologic impact of age-targeted vaccination for drug-resistant tuberculosis.

This study used a calibrated mathematical model to evaluate age-specific tuberculosis (TB) vaccination strategies, for drug-resistant (DR)-TB management in China. Prioritizing elderly vaccination significantly reduced multidrug-resistant or rifampicin-resistant TB incidence and mortality, while avoiding the need for second-line treatment, offering a promising approach to mitigate DR-TB burden by 2050.

DNA damage-inducing endogenous and exogenous factors and research progress.

The substances that cause abnormal DNA structures are known as DNA damage-inducing factors, and their resulting DNA damage has been extensively studied and proven to be closely related to cancer, neurodegenerative diseases, and aging. Prolonged exposure to DNA damage-inducing factors can lead to a variety of difficult-to-treat diseases, yet these factors have not been well summarized. It is crucial to use a combination of environmental science and life science to gain a deep understanding of the environmental sources and biological consequences of DNA damage-inducing factors for mechanistic research and prevention of diseases such as cancer.

The relationship between psychological resilience, coping strategies and fear of cancer recurrence in patients with breast cancer undergoing surgery: A descriptive, cross-sectional study.

Purpose: This study aims to determine the relationship between psychological resilience, coping strategies and the fear of cancer recurrence in women who have undergone surgical procedures due to breast cancer.

Methods: The study was conducted using a descriptive, cross-sectional, and correlational research design. The sample of the study consisted of 252 women.