Antibiotic over-administration in hospitalized infants with Adenovirus infection.

Background: Infection with Adenovirus in children may clinically resemble a bacterial infection in several aspects, including high and prolonged fever, and increased inflammation markers. We aimed to estimate the rate of antibiotics administration among hospitalized infants with Adenovirus infection and to evaluate its justification.

Methods: Included were hospitalized patients aged 2 months - 2 years who found positive for Adenovirus in PCR tests (Ct <36).

Eyebrow bleeding as a rare migraine symptom: a case report.

This case report documents a rare presentation of eyebrow bleeding occurring during migraine episodes in a 10-year-old girl, highlighting atypical signs associated with the disorder. Despite her normal neurological examinations and imaging studies, the patient experienced recurrent, severe headaches accompanied by localized bleeding and red spots on the forehead. This unusual symptomatology suggests potential underlying neurovascular and neuroinflammatory mechanisms, necessitating heightened awareness among healthcare providers.

Effect of alemtuzumab on fatigue, quality of life, and patient/caregiver-reported outcomes in relapsing-remitting multiple sclerosis-A real-world evidence study.

Background: Alemtuzumab is approved in the European Union for treating highly active relapsing-remitting multiple sclerosis (RRMS). Patient-reported outcomes measure the treatment impact on quality of life (QoL), including fatigue, a common symptom in multiple sclerosis (MS). Chronic diseases like MS also affect the patient's caregiver.

Arachnoid Cyst Associated With Traumatic Chronic Subdural Hemorrhage in Children.

Introduction: It was reported that most arachnoid cyst (AC)-associated chronic subdural hematoma (CSDH) was spontaneous. However, AC with CSDH caused by trauma was extremely scarcely reported. In this paper, the authors reported a successful surgical treatment of a case of AC associated with CSDH after trauma.

Quadrigeminal plate lipoma presenting with seizures and hydrocephalus in a child - A case report.

Background: Intracranial lipomas are rare, benign lesions with no neoplastic origin. Most affected patients are asymptomatic and are typically pediatric or young adults. We describe a case of a child with a quadrigeminal plate lipoma presenting with seizures and hydrocephalus.

An infected intracranial dermoid cyst at the region of torcular herophili: A case report.

Background: Dermoid cysts result from embryonic fusion anomalies, with intracranial dermoid cysts being rare (0.1-0.7% of intracranial tumors).

Postacute Sequelae of COVID-19 in Pediatric Patients Within the United States: A Scoping Review.

A subset of children and adolescents experience recurrent or persistent symptoms following SARS-CoV-2 infection, known as postacute sequelae of COVID-19 (PASC), however, the clinical epidemiology within the United States (US) is not yet well understood. This scoping review aims to synthesize the clinical epidemiology of pediatric PASC in the US. A comprehensive literature search was conducted and databases were queried from inception until January 29, 2024.

Micronutrients absorbed via the oral mucosa reduce emotion dysregulation in 5-10-year-old children: A three-phased randomized wait-list-controlled trial.

Objective: Previous evidence has established that micronutrient capsules can improve emotion regulation in children. This three-phased randomized open-label waitlist-controlled study investigated the safety of a micronutrient powder absorbed by the oral mucosa and its effects on emotion dysregulation in 5-to-10-year-old children. The primary outcome measures were the Revised Clinician-rated Temper and Irritability Scale (CL-ARI) and the Clinical Global Impressions-Improvement Scale (CGI-I).

Uncommon primary nasosinusal B-cell lymphoma in children: A case report.

This review presents the case of a 9-year-old patient who reported headaches and unilateral nasal obstruction, without fever, and with a generally preserved condition. An endoscopic examination revealed a polypoid fleshy mass in the left nasal cavity, along with purulent secretions reaching the inferior turbinate. These findings prompted a facial CT scan to assess the nature of the lesion and the extent of infiltration into surrounding structures.

Gender-specific inflammatory burden and headache risk in youth: a NHANES analysis.

Background: Headaches are a common and often debilitating condition among youth. The Inflammatory Burden Index (IBI), a simple surrogate marker of systemic inflammation, has been linked to various diseases. However, evidence for its relationship with headaches, particularly in youth, is lacking.

Outcomes of neuroendoscopy for suprasellar arachnoid cysts: a single center experiences.

Background: Arachnoid cysts are extra parenchymal, intra-arachnoid fluid collections of unknown origin, similar in content to cerebrospinal fluid. Suprasellar arachnoid cysts are a rarer localization resulting from abnormalities of the Liliequist membrane or cystic dilatation of the interpeduncular cisterna. We aimed to contribute to the literature by presenting a series of suprasellar arachnoid cyst cases with endoscopic intervention and long-term results.

RSM01, a novel respiratory syncytial virus monoclonal antibody: preclinical characterization and results of a first-in-human, randomised clinical trial.

Background: Respiratory syncytial virus (RSV) is a leading cause of lower respiratory tract disease among infants and young children worldwide, especially in low- and middle-income countries (LMICs). RSM01 is a novel, highly potent, half-life-extended anti-RSV monoclonal antibody (mAb) candidate primarily being developed for LMICs. Here we present the preclinical characterisation and results of a phase 1 trial of RSM01.

Headaches and adolescents: why so many failures in their management.

Unlabelled: The management of headaches in children and adolescents is still a challenge, with patients experiencing pain for years and polypharmacy. We reviewed the medical history of 31 patients referred to our pain clinic for chronic headaches between April 2023 and April 2024. There were more female than male patients (73%).

Papillary Tumor of the Pineal Gland With Discordant FDG and FAPi Uptake.

In recent years, 68Ga-FAP inhibitor has emerged as a possible substitute radiotracer to FDG for imaging of most of the tumors. Here, we report a 7-year-old girl diagnosed with recurrent papillary tumor of the pineal gland, presenting with complaints of headache and vomiting. 18F-FDG PET/CT revealed an FDG-avid enhancing lesion in the posterior part of the third ventricle.

A rare case of intratumoral hemorrhage in a young adult with adamantinomatous craniopharyngioma.

Craniopharyngiomas are rare, slow growing tumors arising along the craniopharyngeal duct. The incidence of craniopharyngioma was 0.13 per 100,000 persons per year.

Cranial vault expansion in treatment of paediatric idiopathic intracranial hypertension.

Introduction: Idiopathic intracranial hypertension (IIH) is a rare clinical entity in the paediatric population. Clinical presentation is mostly similar to adult counterpart and can include headaches, vomiting, papilloedema, deterioration in visual acuity or fields, and 6th cranial nerve palsy, leading to significant morbidity. Therapeutic lumbar puncture and medical treatment with acetazolamide are usually the first-line treatments.

Analysis of prognosis of neurological sequelae in children with carbon monoxide poisoning.

This study retrospectively analyzed children admitted to the Fourth Affiliated Hospital of Guangxi Medical University for CO (carbon monoxide) poisoning from January 2018 to December 2022 and followed up on their neurological sequelae for a long time. The study was approved by the Ethics Committees of the Fourth Affiliated Hospital of Guangxi Medical University (the identification code was KY2023131) and informed consent was obtained from all participants and/or their legal guardians. The study complied with the Declaration of Helsinki.

Enhancing Clinical History Taking Through the Implementation of a Streamlined Electronic Questionnaire System at a Pediatric Headache Clinic: Development and Evaluation Study.

Background: Accurate history taking is essential for diagnosis, treatment, and patient care, yet miscommunications and time constraints often lead to incomplete information. Consequently, there has been a pressing need to establish a system whereby the questionnaire is duly completed before the medical appointment, entered into the electronic health record (EHR), and stored in a structured format within a database.

Objective: This study aimed to develop and evaluate a streamlined electronic questionnaire system, BEST-Survey (Bundang Hospital Electronic System for Total Care-Survey), integrated with the EHR, to enhance history taking and data management for patients with pediatric headaches.

A Case of Pediatric Sjögren's Syndrome Diagnosed With Microcalcifications in Both Parotid Glands.

Sjögren's syndrome (SS), an autoimmune disease primarily affecting the exocrine glands, particularly the lacrimal and salivary glands, typically manifests as sicca symptoms (dry mouth and dry eyes). However, these symptoms are uncommon in pediatric patients. We present a case of a 13-year-old boy diagnosed with SS following the detection of bilateral parotid gland microcalcifications during a computed tomography scan for headache evaluation.