An analysis of the current status of geriatric oral disease treatment-a dental institutions-based perspective.

Background: This study aimed to investigate and analyze the current status of oral disease treatment among the older adult in Guangxi Zhuang Autonomous Region, while also assessing the continuing medical education (CME) needs of dental institution personnel regarding oral diseases in this population.

Methods: Convenience sampling was used to investigate the oral disease treatment among older adults and to assess CME needs of dental institution personnel regarding oral diseases in this population across various oral medical and health institutions in Guangxi.

Results: A total of 754 valid questionnaires were collected, of which 70.

Exploring the influencing factors of patients sending red packets and the necessity of doctor-patient red packet agreements.

Objective: To investigate the influencing factors of inpatients giving red packets to doctors and explore the necessity of doctor-patient red packet agreements.

Methods: A questionnaire survey was conducted among inpatients and their families who were hospitalized in several hospitals in Chengdu from January to June 2023. The survey asked about the patients' (or their families') attitudes and opinions on whether it was necessary to give red packets to doctors during hospitalization.

Efficacy of Platelet-Rich Plasma in Endoscopic Sinus Surgery for Chronic Sinusitis: A Systematic Review and Meta-Analysis.

Chronic rhinosinusitis (CR) is a persistent inflammation of the nasal mucosa and paranasal sinuses. Endoscopic sinus surgery (ESS) is a procedure that improves sinus drainage and ventilation. Despite advancements in ESS, additional corrective procedures post-ESS are often needed.

Congenital Sublingual Dermoid Cyst Mimicking a Recurrent Ranula in a Pediatric Patient: A Case Report.

In pediatrics, sublingual lesions are not a common disease. Due to the similarity in their clinical and radiological features, they present a diagnostic challenge. Despite the advancement in imaging techniques, the accurate preoperative diagnosis of sublingual lesions may fail.

A Rare Head and Neck Tumor: Making Simple Things Complicated.

Primary cutaneous anaplastic large cell lymphoma (ALCL) is a very uncommon type of CD30-positive T-cell lymphoma, and it very rarely affects the forehead. We report the case of a 68-year-old male presenting with an ulcerative lesion on the right forehead, initially suspected as a benign condition. Fine needle aspiration suggested a lymphoproliferative disorder, with biopsy and immunohistochemistry confirming primary cutaneous ALCL (CD30-positive, anaplastic lymphoma kinase [ALK]-negative).

Targeting accuracy of neuronavigation: a comparative evaluation of an innovative wearable AR platform vs. traditional EM navigation.

Wearable augmented reality in neurosurgery offers significant advantages by enabling the visualization of navigation information directly on the patient, seamlessly integrating virtual data with the real surgical field. This ergonomic approach can facilitate a more intuitive understanding of spatial relationships and guidance cues, potentially reducing cognitive load and enhancing the accuracy of surgical gestures by aligning critical information with the actual anatomy in real-time. This study evaluates the benefits of a novel AR platform, VOSTARS, by comparing its targeting accuracy to that of the gold-standard electromagnetic (EM) navigation system, Medtronic StealthStation S7.

Endurance training and pyruvate dehydrogenase kinase 4 (PDK4) inhibition combination is superior to each one alone in attenuating hyperketonemia/ketoacidosis in diabetic rats.

Objectives: While ketone bodies are not the main heart fuel, exercise may increase their uptake. Objectives: This study aimed to investigate the effect of 6-week endurance training and Pyruvate dehydrogenase kinase 4 )PDK4( inhibition on ketone bodies metabolism in the heart of diabetic rats with emphasis on the role of Peroxisome proliferator-activated receptor-gamma coactivator PGC-1alpha (PGC-1α).

Materials And Methods: Sixty male Wistar rats were divided into eight groups: healthy control group (CONT), endurance training group (TRA), diabetic group (DM), DM + EX group, Dichloroacetate (DCA) group, DM + DCA group, TRA + DCA group, and DM + TRA + DCA group.

Impact of the unconventional extraction on antioxidants and antimicrobial characteristics of hibiscus and olive leaves extracts.

The antioxidant extracts considered a very important food additive which promoting the protection of lipid and prolong the shelf life of food products. The aim of this investigation was decrease the time of extraction of hibiscus leaves extract (HLE) and olive leaves extract (OLE) from 48 h to only 6 h without reducing efficiency of these extracts. HPLC assay, scavenging radical activity by DPPH˙ (IC), inhibition lipid peroxidation by both β-Carotene/Linoleic Acid Bleaching (βCB) and Thiobarbituric Acid Reactive Substances (TBARs) assays, antibacterial and antifungal activities measured for different concentrations of ethanolic extracts by conventional extraction (CE) and difference in pressure extraction (DPE) methods, and the results shown a considerable in mean difference ( < 0.

Nomogram-derived immune-inflammation-nutrition score could act as a novel prognostic indicator for patients with head and neck squamous cell carcinoma.

Aim: This study aims to create and validate a novel systematic immune-inflammation-nutrition (SIIN) score to provide a non-invasive and accurate prognostic tool for head and neck squamous cell carcinoma (HNSCC) patients.

Methods: 259 participants diagnosed with HNSCC from the First Affiliated Hospital of Xi'an Jiaotong University between 2008 and 2017 was included in this retrospective study. Patients were assigned to training (n=181) and validation (n=78) sets.

Disparities in stage at diagnosis of head and neck tumours in Brazil: a comprehensive analysis of hospital-based cancer registries.

Background: The advanced stage of cancer is a determining factor in poor prognosis. Head and neck squamous cell carcinomas (HNSCC) are highly incident in Brazil, but similarly to many Low and Middle-Income Countries, data is limited regarding the proportion of tumours diagnosed at advanced clinical stages and the main factors associated with it. Therefore, this study aimed to identify the factors associated with advanced stage of HNSCC in Brazil.

Position in proton Bragg curve influences DNA damage complexity and survival in head and neck cancer cells.

Background And Purpose: Understanding the cellular and molecular effect of proton radiation, particularly the increased DNA damage complexity at the distal end of the Bragg curve, is current topic of investigation. This work aims to study clonogenic survival and DNA damage foci kinetics of a head and neck squamous cell carcinoma cell line at various positions along a double passively scattered Bragg curve. Complementary studies are conducted to gain insights into the link between cell survival variations, experimentally yielded foci and the number and complexity of double strand breaks (DSBs).

Position-based assessment of head impact frequency, severity, type, and location in high school American football.

Introduction: Research on head impact characteristics, especially position-specific investigations in football, has predominantly focused on collegiate and professional levels, leaving a gap in understanding the risks faced by high school players. Therefore, this study aimed to investigate the effect of three factors-player position, impact location, and impact type-on the frequency, severity, and characteristics of impacts in high school American football. Additionally, we examined whether and how player position influences the distribution of impact locations and types.

Self-healable and pH-responsive spermidine/ferrous ion complexed hydrogel Co-loaded with CA inhibitor and glucose oxidase for combined cancer immunotherapy through triple ferroptosis mechanism.

Tumor microenvironment governs various therapeutic tolerability of cancer such as ferroptosis and immunotherapy through rewiring tumor metabolic reprogramming like Warburg metabolism. Highly expressed carbonic anhydrases (CA) in tumor that maintaining the delicate metabolic homeostasis is thus the most potential target to be modulated to resolve the therapeutic tolerability. Hence, in this article, a self-healable and pH-responsive spermidine/ferrous ion hydrogel loaded with CA inhibitor (acetazolamide, ACZ) and glucose oxidase (ACZ/GOx@SPM-HA Gel) was fabricated through the Schiff-base reaction between spermidine-dextran and oxidized hyaluronic acid, along with ferrous coordination.

Quantitative magnetic resonance imaging responses in head and neck cancer patients treated with magnetic resonance-guided hypofractionated radiation therapy.

Background And Purpose: Quantitative MRI (qMRI) has been explored for detecting tumor changes during radiation therapy (RT) in head and neck squamous cell cancer (HNSCC). Clinical trials show prolonged survival with PD-1 targeted immune checkpoint inhibition. Hypofractionated radiation regimens are being studied to counteract radioresistant clonogen formation.

Diversity, abundance of anopheline species, and malaria transmission dynamics in high-altitude areas of western Cameroon.

: Assessing vector bionomics is crucial to improving vector control strategies. Several entomological studies have been conducted to describe malaria transmission in different eco-epidemiological settings in Cameroon; knowledge gaps persist, particularly in highland areas. This study aimed to characterize malaria vectors in three localities along an altitudinal gradient in the western region: Santchou (700 m), Dschang (1400 m), and Penka Michel (1500 m).

Fibromuscular Dysplasia Clinical Phenotype Manifesting as a Distal Spontaneous Coronary Artery Dissection in a Middle-Aged Man.

Fibromuscular dysplasia (FMD) is a non-atherosclerotic, non-inflammatory vascular disease of medium-sized arteries that causes abnormal cellular growth in arterial walls and most commonly affects young to middle-aged women (20-50 years of age). While FMD often involves the renal arteries, it can affect any arterial bed. FMD has a characteristic angiographic appearance of a "string of beads.

The Association Between Venous Invasion and Distant Metastasis in Head and Neck Squamous Cell Carcinoma.

Background: In surgically treated cases of head and neck squamous cell carcinoma (HNSCC), even pathological N0 (pN0) cases according to the Tumor, Node, and Metastasis (TNM) Classification, distant metastases can occur relatively early postoperatively. Therefore, we hypothesized that hematogenous distant metastasis may be related to the degree of venous invasion. Lymphatic invasion is considered to be a poor prognostic factor in HNSCC, but knowledge about venous invasion is scarce.

Eosinophilic granulomatosis with polyangiitis; a distinctive presentation with myocarditis and autoimmune haemolytic anaemia: case report.

Background: Eosinophilic granulomatosis with polyangiitis (EGPA) is an extremely rare type of vasculitis characterized by inflammation within small blood vessels or tissues that may cause damage to the lungs, heart, kidneys, and other organs. Here, we present a rare case of EGPA with cardiac involvement that presented with acute heart failure.

Clinical Findings: A 44-year-old woman with a history of bronchial asthma and sinusitis presented with fever, shortness of breath, fatigue, unintentional weight loss, and polyarthritis.

Treatment of distal femur aseptic nonunion after lateral locking plate fixation: Results of medial custom made plating and free fibula flap transfer using CAD-CAM technology.

Background: Aim of the present paper is to report the preliminary results of CAD-CAM (Computer-Aided Design - Computer-Aided Manufacturing) technology application to distal femur nonunion treatment with free fibula flap, custom made medial plating and maintenance of a stable lateral locking plate.

Methods: Two cases of distal femur nonunion that occurred after lateral locking plating were treated and prospectively followed-up. Surgical planning followed the same preoperative protocol adopted for mandibular CAD-CAM reconstruction.

Risk Factors of Delirium Following Reconstructive Surgery for Head and Neck Tumors: A Retrospective Clinical Trial.

Background: Patients after head and neck tumor reconstruction surgery frequently require deep sedation and analgesia in the ICU. However, the risk factors for delirium associated with propofol-based sedation remain unclear.

Objective: The study aimed to explore the risk factors of delirium of propofol singled or combined sedation.

Pediatric Pilomatrixomas: Four Atypical Clinical Presentations.

Pilomatrixoma, also called Malherbe's calcifying epithelioma or pilomatrixoma, is a benign adnexal tumor that originates from keratinocytes (cells of the hair matrix, the internal sheath of the hair root or the cortex) and constitutes the second most prevalent skin neoplasm in children. These lesions are typically slow-growing, firm, nodules located on the head, neck, trunk, and extremities (in decreasing order of frequency). Due to the rarity, combined with their varied clinical presentations, pilomatrixomas are often misdiagnosed.

A Pilot Trial of Tongue Reconstruction Using the Chimeric Innervated Vastus Lateralis Muscle and Antero-Lateral Thigh Free Flap.

Background: Subtotal and total glossectomies for advanced tongue cancer result in significant speech- and swallow-related morbidity, impairing quality of life. This prospective pilot study compares the safety and functional outcomes associated with using a chimeric innervated muscle and fasciocutaneous flap for soft tissue reconstruction.

Materials And Methods: A prospective, non-randomized controlled pilot study evaluated a standardized technique for tongue reconstruction using a chimeric innervated vastus lateralis muscle and anterolateral thigh fasciocutaneous flap.

Iron-associated lipid peroxidation in Alzheimer's disease is increased in lipid rafts with decreased ferroptosis suppressors, tested by chelation in mice.

Introduction: Iron-mediated cell death (ferroptosis) is a proposed mechanism of Alzheimer's disease (AD) pathology. While iron is essential for basic biological functions, its reactivity generates oxidants which contribute to cell damage and death.

Methods: To further resolve mechanisms of iron-mediated toxicity in AD, we analyzed post mortem human brain and ApoEFAD mice.