Clinicopathological and prognostic significance of stromal p16 and p53 expression in oral squamous cell carcinoma.

The tumor microenvironment is highly heterogeneous and consists of neoplastic cells and diverse stromal components, including fibroblasts, endothelial cells, pericytes, immune cells, local and bone marrow-derived stromal stem and progenitor cells, and the surrounding extracellular matrix. Although the significance of p16 and p53 has been reported in various tumor types, their involvement in the stromal cells of oral squamous cell carcinoma (OSCC) remains unclear. We performed immunohistochemical analyses of p16 and p53 expression in OSCC samples, Of the 116 samples, 74 showed p16-positive stromal cells, and 33 showed p53-positive stromal cells.

Genotypes and clinical phenotypes of pediatric patients with NOG variants: Middle ear surgical outcomes from a Tertiary Center in South Korea.

Objective: Although NOG variants are linked to congenital stapes fixation and conductive hearing loss (CHL), little is known about middle ear surgery outcomes and the characteristics of accompanying inner ear anomalies. We explored auditory phenotypes in patients with NOG variants, with a focus on the outcomes of middle ear surgery.

Methods: This study included 11 patients from five unrelated Korean families harboring NOG variants.

Enhancing equity in academic surgery promotion practices.

Background: Black, Indigenous, People of Color (BIPOC) in medicine and women faculty have lower 10-year promotion rates than their White and male peers, despite controlling for productivity metrics. Promotion standards vary across institutions, but there is likely a common need to improve transparency and consistency while mitigating bias, inequity, and the harm of additional equity work that is commonly expected of Black, Indigenous, People of Color and women faculty (the so-called minority tax).

Methods: A promotion advisory committee consisting of clinical and research faculty at all ranks specified expectations for a faculty member at the associate or full professor ranks, with 10-15 examples given for each "mission" (clinical, research, and education).

Mesenchymal chondrosarcoma of maxilla misdiagnosed as a benign fibrous lesion: A rare case report from Syria.

Introduction: Mesenchymal chondrosarcoma (MC) is a high-grade variant of chondrosarcoma, essentially composed of poorly differentiated spindle cells interspersed with areas of cartilage or chondroid matrix. MC is extremely rare; it only accounts for 0.1 % of head and neck tumors and for only 1 % of all chondrosarcomas (CSs).

Chronic inflammation in a radium dial painter cohort: elevated neutrophil to lymphocyte ratio and radiation-induced hearing loss.

The radium dial painters (RDP) are a well-described group of predominantly young women who incidentally ingested 226Ra and 228Ra as they painted luminescent watch dials in the first part of the twentieth century. In 1974 pathologist Dr. William D.

The Rapid Transport of Excitons in Organic Crystals Can Be Regulated by the Molecular Packing Form.

Long-range exciton transport is crucial for optoelectronic devices based on organic semiconductors, but the method for increasing and regulating the exciton transport rate in organic semiconductors is still underexplored. Here we have achieved rapid-transporting excitons in organic crystals assembled of difluoroboron β-diketonate (BCZ) and found that the exciton transport rate of BCZ crystals can be regulated by the molecular packing form. Using transient absorption microscopy, we find that the BCZ-Y crystal in which BCZ molecules experience uniform head-to-tail antiparallel molecular packing has anisotropic long-range exciton transport.

Natural History and Long Term Follow-Up of Incidental Thyroid Nodules on Computed Tomography Imaging.

Objectives: incidental thyroid nodules (ITNs) are found in up to 25% of CT scans. Increased use of cross-sectional imaging has contributed to the increased incidence of thyroid cancer worldwide. ITNs pose a management dilemma since nodule malignancy rate is 5-15% but most cancers are indolent and prognosis in differentiated thyroid cancer is excellent.

Machine Learning-Based Diagnosis of Chronic Subjective Tinnitus With Altered Cognitive Function: An Event-Related Potential Study.

Objectives: Due to the absence of objective diagnostic criteria, tinnitus diagnosis primarily relies on subjective assessments. However, its neuropathological features can be objectively quantified using electroencephalography (EEG). Despite the existing research, the pathophysiology of tinnitus remains unclear.

Scleredema: An Unusual Cutaneous Manifestation of Coronavirus Infection.

The global pandemic caused by COVID-19 led to numerous novel cases of autoimmune and rheumatologic disorders that developed postinfection. Along these lines, these authors report an unusual case of scleredema following SARS-CoV-2 infection in an individual who lacked any known risk factors. Given the emergence of newer mutant strains of COVID-19 and steadily rising numbers of people receiving COVID-19 vaccinations, physicians should remain alert for as yet unrecognized manifestations of the disease.

Neuromuscular Electrostimulation Increases Microcirculatory Flux in Mixed Etiology Leg Ulcers.

Objective: To determine if intermittent neuromuscular electrostimulation (NMES) of the common peroneal nerve increases microvascular flow and pulsatility in and around the wound bed of patients with combined venous and arterial etiology.

Methods: Seven consenting participants presenting with mixed etiology leg ulcers participated in this study. Microvascular flow and pulsatility was measured in the wound bed and in the skin surrounding the wound using laser speckle contrast imaging.

Interactions between Per- and Polyfluoroalkyl Substances (PFAS) at the Water-Air Interface.

Per- and polyfluoroalkyl substances (PFAS)─so-called "forever chemicals"─contaminate the drinking water of about 100 million people in the U.S. alone and are inefficiently removed by standard treatment techniques.

Impaired axonal transport contributes to neurodegeneration in a Cre-inducible mouse model of myocilin-associated glaucoma.

Elevation of intraocular pressure (IOP) due to trabecular meshwork (TM) dysfunction, leading to neurodegeneration, is the pathological hallmark of primary open-angle glaucoma (POAG). Impaired axonal transport is an early and critical feature of glaucomatous neurodegeneration. However, a robust mouse model that accurately replicates these human POAG features has been lacking.

Traumatic Anterior Shoulder Dislocation: Epidemiology, Diagnosis, and Treatment.

Background: Traumatic anterior shoulder dislocation is the most common type of joint dislocation, with an incidence of 11 to 29 per 100 000 persons per year. Controversy still surrounds the recommendations for treatment and the available procedures for surgical stabilization.

Methods: This review is based on pertinent publications (2014-2024) that were retrieved by a selective search in the PubMed and Google Scholar databases.

Outcomes of a Population-Based Congenital Cytomegalovirus Screening Program.

Importance: Detection of congenital cytomegalovirus (cCMV) infection has previously relied on targeted screening programs or clinical recognition; however, these approaches miss most cCMV-infected newborns and fail to identify those infants who are asymptomatic at birth but at risk for late-onset sensorineural hearing loss.

Objective: To determine the feasibility of using routinely collected newborn dried blood spots (DBS) in a population-based cCMV screen to identify infants at risk for hearing loss and describe outcomes of infants screened.

Design, Setting, And Participants: This diagnostic study of a population-based screening program in Ontario, Canada, took place from July 29, 2019, to July 31, 2023.

Pyrimidinergic P2Y1-Like Nucleotide Receptors Are Functional in Rat Conjunctival Goblet Cells.

Purpose: To investigate the presence of uridine-5'-triphosphate (UTP)-activated P2Y1-like nucleotide receptors (P2Y2R, P2Y4R, and P2Y6R) in conjunctival goblet cells (CGCs) and determine if they increase intracellular Ca2+ concentration ([Ca2+]i) and induce mucin secretion.

Methods: Adult, male rat conjunctiva was used for culture of CGCs. To investigate the expression of P2YRs, mRNA was extracted from CGCs and used for reverse transcription PCR (RT-PCR) with commercially obtained primers specific to P2Y2R, P2Y4R, and P2Y6R.

Optimising Instrumented Mouthguard Data Analysis: Video Synchronisation Using a Cross-correlation Approach.

Purpose: Head acceleration events (HAEs) are a growing concern in contact sports, prompting two rugby governing bodies to mandate instrumented mouthguards (iMGs). This has resulted in an influx of data imposing financial and time constraints. This study presents two computational methods that leverage a dataset of video-coded match events: cross-correlation synchronisation aligns iMG data to a video recording, by providing playback timestamps for each HAE, enabling analysts to locate them in video footage; and post-synchronisation event matching identifies the coded match event (e.

Rare cancer survivorship research funding at the National Institutes of Health (NIH), 2017 to 2023.

Purpose: Rare cancers are defined as those for which there are less than 15 cases per 100,000 in the population annually. While much progress in detection and treatment has been made over the past decade for many rare cancers, less progress has been made in understanding survivorship needs. The objective of this study was to characterize the National Institutes of Health (NIH) cancer survivorship grant portfolio focused on rare cancers and to identify gaps specific to this area of science.

Challenges and effectiveness of remote neurological follow-up of children with concussion following TBI using telemedicine.

Background: Traumatic brain injury (TBI) in children, including concussion, is one of the major causes of emergency department (ED) registration and a significant burden on the health system.

Objectives: The primary goal of this study was to evaluate the outcomes of a telemedicine strategy for remotely monitoring the children with traumatic brain concussions, focusing on their neurological symptoms and signs. The secondary goal was to explore socioeconomic and educational differences among the participating families.

Polarized vision in the eyes of the most effective predators: dragonflies and damselflies (Odonata).

Polarization is a property of light that describes the oscillation of the electric field vector. Polarized light can be detected by many invertebrate animals, and this visual channel is widely used in nature. Insects rely on light polarization for various purposes, such as water detection, improving contrast, breaking camouflage, navigation, and signaling during mating.

Comparison of background characteristics and neuropathology findings between medico-legal autopsy cases with traumatic axonal injury, vascular axonal injury, or absence of axonal injury in β-amyloid precursor protein stain.

In forensic neuropathology, the β-amyloid precursor protein (β-APP) immunostain is used to diagnose axonal injury (AI). The two most common aetiologies are traumatic (TAI) and ischaemic (vascular; VAI). We aimed to identify background characteristics and neuropathology findings that are suggestive of TAI, VAI, or no AI in neuropathologically examined medico-legal autopsy cases.

Speech therapy for exercise-induced laryngeal obstruction.

Introduction: Exercise- Induced Laryngeal Obstruction (EILO) can lead to disabling exercise related dyspnea and hamper participation in physical activity. In this study, we aimed to investigate the effects of a standardized speech therapy protocol as treatment for EILO.

Methods: Patients diagnosed with EILO at our institution were invited to participate.

Sap Anthropometric Landmark: A Morphometric Orientation Point of the Nasal Tip.

The aim of the present study is to introduce a new anthropometric landmark (sap), parameter (sap-sap) for measuring a width of nasal tip and 7 new proportion indexes. For determinate data mean with standard deviation, 200 healthy individuals (100 men and 100 women) were included in the study. The authors determined and pointed 9 paired cranio-facial anthropometric landmarks: sap, al, ac, mf, en, ex, zy, ch, go.