1 results match your criteria: "Hasselt Univ.[Affiliation]"
Membrane cholesterol extraction decreases Na+ transport in A6 renal epithelia.
Am J Physiol Cell Physiol
January 2006
Laboratory of Physiology, Hasselt Univ., Agoralaan 1D, B-3590 Diepenbeek, Belgium.
Article Synopsis
- The study investigates how Na+ transport regulation in renal epithelia is influenced by cholesterol levels in both apical and basolateral membranes.
- The researchers found that removing cholesterol from the apical membrane did not significantly impact overall electrical activity, but removing it from the basolateral membrane led to a decrease in Na+/K+ pump activity.
- Additionally, cholesterol extraction from the apical membrane lowered the likelihood of sodium channel openings, thereby affecting the transport response to various stimuli like hypotonicity and hormonal activation.