Challenges in Diagnosis and Treatment of Mandibular Florid Osseous Dysplasia: A Case Report.

Florid osseous dysplasia (FOD) is a rare, benign fibro-osseous lesion primarily involving the mandible and maxilla, with a higher prevalence in middle-aged women of African or Asian descent. This article presents a case of mandibular FOD complicated by secondary infection, emphasizing clinical presentation, diagnostic challenges, and treatment strategies. The unique radiographic features of FOD necessitate careful differential diagnosis to prevent misdiagnosis with other jaw lesions.

Silent brain infarctions in patients with rheumatic mitral stenosis.

Background: Silent brain infarctions (SBI) are commonly detected in brain imaging. The association of SBI with rheumatic mitral stenosis (MS) is not clearly relevant. Based on magnetic resonance imaging, we aimed to describe the prevalence of SBI in patients with rheumatic MS and the cardiac abnormalities related to their occurrence.

Chronic Kidney Disease of Unknown Etiology: A Global Health Threat in Rural Agricultural Communities-Prevalence, Suspected Causes, Mechanisms, and Prevention Strategies.

Chronic Kidney Disease of Unknown Etiology (CKDu) is a worldwide hidden health threat that is associated with progressive loss of kidney functions without showing any initial symptoms until reaching end-stage renal failure, eventually leading to death. It is a growing health problem in Asia, Central America, Africa, and the Middle East, with identified hotspots. CKDu disease mainly affects young men in rural farming communities, while its etiology is not related to hypertension, kidney stones, diabetes, or other known causes.

Multimodal Machine Learning for Predicting Post-Surgery Quality of Life in Colorectal Cancer Patients.

Colorectal cancer is a major public health issue, causing significant morbidity and mortality worldwide. Treatment for colorectal cancer often has a significant impact on patients' quality of life, which can vary over time and across individuals. The application of artificial intelligence and machine learning techniques has great potential for optimizing patient outcomes by providing valuable insights.

Contribution of Hospital-Based Continuous Positive Airway Pressure (CPAP) Titration to the Treatment of Sleep Apnea Syndrome (SAS) Patients.

Objectives: This retrospective study aims to evaluate the efficacy of continuous positive airway pressure (CPAP) therapy in treating severe obstructive sleep apnea (OSA), based on polysomnographic parameters, and to highlight the importance of hospital-based titration in optimizing treatment and guiding choices of alternative ventilation modes.

Methods: Sixty-nine patients (n=69, 100%), predominantly female (n=49, 71%), were included in the study. Polysomnographic data were collected during hospital-based CPAP titration.

Therapeutic patient education: Impact on lung function in Moroccan adult asthma patients?

Background: Despite the availability of effective asthma medications, the condition remains poorly controlled, making it one of the most common emergency room and physician visits each year. Appropriate asthma education programs are needed to maintain or improve optimal lung function in asthmatics. This study aimed to evaluate changes in lung function parameters in adult asthmatics before and after a structured educational intervention.

Effective and ineffective psychological adjustment in breast cancer patients before receiving neoadjuvant chemotherapy: insights from a cohort study.

Background: The timing of a breast cancer (BC) diagnosis has a significant psychological impact on patients. However, it reported that those eligible for treatment regimens based on neoadjuvant chemotherapy may experience high levels of depression, anxiety and distress. To cope with this situation, patients deploy psychological coping strategies.

Anterior Segment Optical Coherence Tomography-Assisted Surgical Planning for Removal of a Corneal Foreign Body: A Case Report and Literature Review.

Introduction: Corneal foreign bodies account for nearly one-third of all eye injuries and are a common emergency in ophthalmology. While many cases are straightforward, involving clear diagnosis and treatment, some present significant challenges due to the complexity of the foreign body involved.

Observation: A 20-year-old male presented with discomfort in his right eye following an accident while cutting a tree without wearing protective eyewear.

Adenoid cystic carcinoma of maxillary sinus: report of two cases.

Adenoid cystic carcinoma infrequently affects paranasal sinuses. It's a slowly progressing, aggressive cancer with a tendency to invade nerves. The research underscores the significance of prompt diagnosis and effective management of adenoid cystic carcinoma.

Tuberculous otomastoiditis in children complicated by homolateral sigmoid sinus thrombosis: a case report.

Tuberculosis is a major public health problem in Morocco and most of the developing countries but tuberculous otomastoiditis is quite rare. Here we report a case where a seven-year-old patient had chronic right otomastoiditis and retro-auricular fistula, whose specificity is its persistence after prolonged unsuccessful medical and surgical therapy for more than 2 months, and its complication by homolateral sigmoid sinus thrombosis. Computed Tomography (CT) scan of temporal bones showed complete destruction of right mastoid cells and a hypodense complement in the right middle ear.

Gastric cancer and associated pathogens: is there any association in Moroccan region?

Helicobacter pylori, Epstein-Barr virus and human papillomavirus are three pathogens associated with various human cancers. This study aimed to investigate the role of these pathogens in gastric cancer in Moroccan population. For this, a retrospective study has been conducted on participants attending the gastroenterology department of Hassan II University Hospital of Fez.

Diffuse Large B Cell Lymphoma: Immunohistochemical Classification According to Hans Algorithm and Association With Outcome in A Moroccan Institution.

Background: The most prevalent subtype of non-Hodgkin lymphoma is diffuse large B-cell lymphoma (DLBCL). Germinal center B-cell (GCB) and non-germinal center B-cell (non GCB) are the two main biologically different molecular subtypes identified utilizing an immunohistochemistry-based approach.

Aim: Our objective in this study is to analyze the impact of immunohistochemical subtypes of DLBCL (GCB or non GCB) on demographic and clinicopathological parameters, response to chemotherapy and survival outcomes.

Spontaneous spinal epidural hematoma in infants: A case report and review of the literature.

Background: Spontaneous spinal epidural hematomas (SSEHs) are exceedingly uncommon, especially in infants, with only two reported cases. Diagnosis can be delayed due to the nonspecificity of presenting symptoms.

Case Report: We present a case of SSEH in a 10-month-old boy admitted to the pediatric emergency department with a 5-day history of progressive lower extremity motor weakness.

Emergency Endoscopic Endonasal Optic Nerve Decompression for Graves' Orbitopathy.

Graves' orbitopathy (GO) is a rare autoimmune disease that affects patients in their fourth to sixth decade, resulting in retro-orbital inflammation and hypertrophy of extraocular muscles and orbital fat. It is the most common disease affecting the orbit globally, and treatment options vary depending on the severity and activity status of the affection, ranging from local measures such as lubricating eye drops and patching, glucocorticoid eye drops, mydriatics, nonsteroid anti-inflammatory medications to systemic glucocorticoids, and emergency orbital decompression surgery. Immunotherapy and orbital radiation may as well be used as a treatment option even though their efficiency remains controversial.

A systematic review of the impact of therapeutic education programs on the quality of life of people with Multiple Sclerosis.

Background: Faced with a deemed mediocre quality of life (QoL) in people with multiple sclerosis (pwMS), the effectiveness of therapeutic education (TPE) programs is called into question. This systematic review is conducted to examine the impact of the TPE programs on the QoL of pwMS.

Methods: A search was performed in three databases (PubMed, Web of Science and Scopus) to identify relevant studies published between 2007 and 2022.

Hydatid cyst of the gluteal muscle: a case report and literature review.

Introduction: Echinococcosis is a relatively widespread anthropozoonosis in endemic regions, preferentially affecting the liver and lungs. Although rare, it can sometimes be localized in the muscles. The clinical symptoms are insidious and not very indicative, often leading to a delayed diagnosis.

Quality of life and its determinants in patients with chronic respiratory diseases in the Fes-Meknes region, Morocco.

Chronic respiratory diseases (CRDs) pose a serious public health issue, affecting social functioning and psychological well-being and leading to a deterioration in the quality of life. The aim of this study was to assess the quality of life of patients with CRDs and determine the factors associated with their impairment in Morocco. A cross-sectional study was conducted in the Pulmonology Department of the Hassan II University Hospital in Fez in 2021.

Uncommon Etiology of Pancreatic Mass: a Case Report.

IgG4-related autoimmune pancreatitis (AIP) is a chronic inflammatory disease of the pancreas with a distinct histological feature. Its diagnosis remains challenging as some features overlap with pancreatic cancer. We present a case of IgG4-related AIP mimicking pancreatic cancer.

Novel ABL1 mutation in a Moroccan CML patient with Imatinib resistance.

Tyrosine Kinase Inhibitors (TKI), such as Imatinib, are known for their effectiveness in achieving complete remission from Chronic Myeloid Leukemia (CML), a malignancy caused by a reciprocal translocation between the terminal fragments of the long arms of chromosomes 9 and 22 that leads to the famous chimeric BCR::ABL1 gene. Mutations in this fusion gene may induce resistance to TKI treatment, which requires prescribing a second-, or third-generation TKI medication. We report here a case of a Moroccan CML patient with secondary resistance to the frontline TKI treatment (Imatinib), in which, BCR::ABL1 cDNA sequencing reveals the novel mutation p.