Cystic squamous metaplasia in a giant benign phyllodes tumor of the breast: a case report.

Phyllodes tumor is a rare tumor of the breast, which encompasses both stromal and epithelial components. In these components, metaplastic changes can be observed occasionally. We report the case of a 51-year-old woman nulligest menopaused who presented a huge mass, largely ulcerated in her right breast.

Tubal adenocarcinoma: Report of 3 cases and review of the literature.

Introduction: Tumors of the uterine tube are rare pathologies representing less than 1 % of all gynecologic cancers; they are dominated by adenocarcinomas. Secondary metastatic forms are the most frequent, whereas primary tumors are very rare and represent only 10 %, which suggests that the fallopian tube is an organ with low oncogenic potential.

Report Of Two Cases: We report the two cases of a patients followed in the gynecology department C of the CHU IBN ROCHD CASA for a primary tubal adenocarcinoma.

Multi-combined QSAR, molecular docking, molecular dynamics simulation, and ADMET of Flavonoid derivatives as potent cholinesterase inhibitors.

In searching for a new and efficient therapeutic agent against Alzheimer's disease, a Quantitative structure-activity relationship (QSAR) was derived for 45 Flavonoid derivatives recently synthesized and evaluated as cholinesterase inhibitors. The multiple linear regression method (MLR) was adopted to develop an adequate mathematical model that describes the relationship between a variety of molecular descriptors of the studied compounds and their biological activities (cholinesterase inhibitors). Golbraikh and Tropsha criteria were applied to verify the validity of the built model.

Synthesis, biological evaluation and molecular modelling of 3-Formyl-6-isopropylchromone derived thiosemicarbazones as α-glucosidase inhibitors.

Type-2 Diabetes Mellitus (T2DM) is one of the most common metabolic disorders in the world and over the past three decades its incidence has increased drastically. α-Glucosidase inhibitors are used to control the hyperglycemic affect of T2DM. Herein, we report the synthesis, α-glucosidase inhibition, structure activity relationship, pharmacokinetics and docking analysis of various novel chromone based thiosemicarbazones 3(a-r).

Overview of the bioanalytical methods used for the determination of benzodiazepines in biological samples and their suitability for emergency toxicological analysis.

Benzodiazepines are one of the most widely used classes of drugs around the world. They are medically used in different therapeutic areas including insomnia, anxiety, epilepsy, and anesthesia. Unfortunately, these drugs are very widespread in the illicit market for recreational purposes and cause drug dependence, traffic accidents, and criminality.

Characterization and application of natural Moroccan material for methyl violet 2B dye removal from aqueous solution.

In this paper, a natural Moroccan material from the Nador area in the north east of Morocco was studied as an adsorbent to remove methyl violet 2B dye from aqueous solutions. This material has never been studied before in this region, and it will be used in its raw state. It was collected and characterized by X-ray diffraction, FTIR spectroscopy, scanning electron microscopy, X-ray fluorescence, thermal analysis, N gas adsorption-desorption, pH, and Brunauer-Emmett-Teller (BET).

Physicians' perception of health topics covered by traditional media in Morocco: opinion of physicians as consumers of the media.

Introduction: In Morocco, the traditional media allows messages of non-scientific prescriptions for the treatment of diseases and statements criticizing doctors to pass, which are considered by doctors as defamation and attacks on the honor of the medical profession. The aim of this study was to analyze physicians' perception in Morocco regarding health topics in the traditional media (TM).

Methods: This is a descriptive transversal study of physicians practicing in Morocco.

The Impact of Supplementation on Human Asthenozoospermic Sperm Parameter Quality.

Male infertility is a complex multifactorial disease and a real health problem; 50% of infertile men have identifiable causes detectable by fundamental sperm analysis. Numerous research studies have shown the possibility of treating abnormal semen samples with some drugs before artificial insemination, yet evidence of the drug's effectiveness remains minimal. In our previous work, we tested the effectiveness of some essential oils, such as eucalyptus ( Labill.

Kinetics of specific anti-SARS-CoV-2 IgM, IgA, and IgG responses during the first 12 months after SARS-CoV-2 infection: A prospective longitudinal study.

Coronavirus 2019 (COVID-19) is a global health threat. The kinetics of antibodies against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) need to be assessed, as the long-term duration of these immunoglobulins remains largely controversial. The aim of this study was to assess the longitudinal dynamics of anti-SARS-CoV-2 antibodies against the nucleocapsid (N) protein and the receptor-binding domain (RBD) of the spike protein up to one year in a cohort of 190 COVID-19 patients.

Disjunction of the symphysis pubis after vaginal delivery: Case report.

Introduction: Pubic joint enlargement of more than 10 mm is diagnosed and defined as diastasis of the pubic symphysis and is considered a complication of vaginal delivery or pregnancy. As it is a rare pathology.

Case Presentation: We report a patient with severe pelvic pain with impotence of the left IM at day 1 of a dystocic delivery.

Alginate@ZnCOO for efficient peroxymonosulfate activation towards effective rhodamine B degradation: optimization using response surface methodology.

A facile chemical procedure was utilized to produce an effective peroxy-monosulfate (PMS) activator, namely ZnCoO/alginate. To enhance the degradation efficiency of Rhodamine B (RhB), a novel response surface methodology (RSM) based on the Box-Behnken Design (BBD) method was employed. Physical and chemical properties of each catalyst (ZnCoO and ZnCoO/alginate) were characterized using several techniques, such as FTIR, TGA, XRD, SEM, and TEM.

Desynchronized daily activity rhythms and gender related psychological well-being of Moroccan university students during the quarantine-isolation.

Background: The disturbance of students' biological and academic rhythms induced by the Coronavirus generated considerable challenges that had an influence on their psychological well-being. This study aims to highlight the daily rhythm desynchronization and examine the mental health of Moroccan students who were impacted, notably females, in the context of the COVID-19 pandemic.

Methods And Material: A cross-sectional online survey was conducted in May 2020 at ten Moroccan faculties including 312 students with an average age of 22 ± 1.

identification of 20S proteasome-β5 subunit inhibitors using structure-based virtual screening.

Proteasome inhibitors have effective anti-tumor activity in cell culture and can induce apoptosis by interfering with the degradation of cell cycle proteins. 20S Proteasome is acknowledged to be a satisfactory target that has persistent properties against the human immune defense and is obligatory for the degradation of some vital proteins. This study aimed to identify potential inhibitors against 20S proteasome, specifically the β5 subunit, using structure-based virtual screening and molecular docking to reduce the number of ligands that should be eligible for experimental assays.

Immobilization of diphenylcarbazide on paper-based analytical devices for the pre-concentration and detection of chromium VI in water samples.

A novel approach using a smartphone for the detection of Cr (VI) has been developed. In this context, two different platforms were designed for the detection of Cr (VI). The first one was synthesized via a crosslinking reaction of chitosan with 1,5-Diphenylcarbazide (DPC-CS).

Genetic Diversity and Population Structure of in Morocco as Revealed by Multilocus Sequence Typing (MLST) Approach.

is endemic in Morocco, and it causes both visceral (VL) and cutaneous leishmaniasis (CL). In this study, the multilocus sequence typing (MLST) approach was used to investigate the phylogeny and population structure of strains isolated from CL and VL patients and the canine reservoir in different leishmaniasis endemic foci in Morocco. For this purpose, eight loci (, , , , , , and ) were amplified in 40 samples, out of which 31 were successfully sequenced.

Modelling disease spread with spatio-temporal fractional derivative equations and saturated incidence rate.

The global analysis of a spatio-temporal fractional order SIR infection model with saturated incidence function is suggested and studied in this paper. The dynamics of the infection is described by three partial differential equations including a time-fractional derivative order for each one of them. The equations of our model describe the evolution of the susceptible, the infected and the recovered individuals with taking into account the spatial diffusion for each compartment.

Morphology does not allow differentiating the species of the Phlebotomus perniciosus complex: Molecular characterization and investigation of their natural infection by Leishmania infantum in Morocco.

Morphological and DNA-based complemented approaches were applied for characterization of sympatric populations of Phlebotomus longicuspis and Phlebotomus perniciosus in Morocco. Both sand fly species are generally recorded in sympatry in North Africa but on few occasions have been molecularly characterized. The diagnostic confusion of these species has led to errors in their geographical distribution and probably, in the assignment of their role in the transmission of L.

The anti-SARS-CoV-2 activity of novel 9, 10-dihydrophenanthrene derivatives: an insight into molecular docking, ADMET analysis, and molecular dynamics simulation.

Originating in Wuhan, the COVID-19 pandemic wave has had a profound impact on the global healthcare system. In this study, we used a 2D QSAR technique, ADMET analysis, molecular docking, and dynamic simulations to sort and evaluate the performance of thirty-nine bioactive analogues of 9,10-dihydrophenanthrene. The primary goal of the study is to use computational approaches to create a greater variety of structural references for the creation of more potent SARS-CoV-2 3Clpro inhibitors.

A Solitary Abscessed Hydatid Cyst of the Buttock: A Rare Case.

The hydatid cyst is a cosmopolitan parasitic infection caused by tapeworms of the genus and is a major public health problem in developing countries. Solitary hydatid cysts located in the buttocks are very rare, and the unusual location of the cyst can aid in the differential diagnosis of subcutaneous masses in this area, particularly in endemic areas. In this report, we present the case of a 39-year-old man who was admitted to the emergency department with a painful, abscessed cyst in the buttock region.

Development of a novel in-situ aluminum/carbon composite from olive mill wastewater for the selective adsorption and separation of malachite green and acid yellow 61.

In this study, an aluminum/carbon composite was developed from olive mill wastewater (OMWW) and successfully applied in the removal/separation of malachite green (MG) and acid yellow 61 (AY61) and in the treatment of a real discharge from a denim dye bath. The optimized composite (0.5% Al) is microporous, has a specific surface area of 1269 m.

Modulation of Gut Microbiome in Ecstasy/MDMA-Induced Behavioral and Biochemical Impairment in Rats and Potential of Post-Treatment with L. Aqueous Extract to Mitigate Adverse Effects.

The use of illicit substances continues to pose a substantial threat to global health, affecting millions of individuals annually. Evidence suggests the existence of a 'brain-gut axis' as the involving connection between the central nervous system and gut microbiome (GM). Dysbiosis of the GM has been associated with the pathogenesis of various chronic diseases, including metabolic, malignant, and inflammatory conditions.

and POM analysis for potential antimicrobial agents of thymidine analogs by using molecular docking, molecular dynamics and ADMET profiling.

Nucleoside analogs are an important, well-established class of clinically useful medicinal agents that exhibit potent antimicrobial activity. Thus, we designed to explore the synthesis and spectral characterization of 5'-(myristoyl)thymidine esters (2-6) for antimicrobial, molecular docking, molecular dynamics, SAR, and POM analyses. An unimolar myristoylation of thymidine under controlled conditions furnished the 5'-(myristoyl)thymidine and it was further converted into four 3'--(acyl)-5'--(myristoyl)thymidine analogs.

Internationalization of the Moroccan Journal of Chemistry: A bibliometric study.

In this research paper, we analyzed the bibliographic data of the research publications issued by the Moroccan Journal of Chemistry between 2013 and 2021. As an open-access country-based research journal with a narrow area of interest and international online exposure, it will be interesting to see how it affects the local chemical research community through the comparison of the characteristics of the research outputs of the journal as retrieved from the (DOAJ) with the features of Moroccan chemical research from 2014 to 2021 in the (WoS). In this context, we generated scientometric networks using , a tool for large-scale data visualization, to reveal the patterns of the publications in the Moroccan Journal of Chemistry.