Impact of Climate Change on the Chemical Compositions and Antioxidant Activity of L.

A central position in Moroccan ethnobotany is held by the genus, serving as a vital reference for aromatic and medicinal plants within the Lamiaceae family. The profound importance of species in the daily lives of Moroccans is recognized, and the primary objective of this study is to assess the impact of rising temperatures and decreasing precipitation on the primary and secondary metabolites of under the following climatic conditions: sample 1, cultivated under standard temperature and precipitation conditions during the first year; sample 2, subjected to an 8 °C temperature increase and a 25% reduction in water supply; and sample 3, exposed to a 12 °C temperature rise and a 50% decrease in water availability. Phytochemical screening results reveal a progressive decline in primary metabolites from sample 1 to sample 3 due to the increase in temperature and decrease in precipitation.

A highly sensitive colorimetric DNA sensor for MicroRNA-155 detection: leveraging the peroxidase-like activity of copper nanoparticles in a double amplification strategy.

A novel and highly sensitive colorimetric DNA sensor for determination of miRNA-155 at attomolar levelsis presented that combines the peroxidase-like activity of copper nanoparticles (CuNPs) with the hybridization chain reaction (HCR) . The utilization of CuNPs offers advantages such as strong interaction with double-stranded DNA, excellent molecular recognition, and mimic catalytic activity. Herein, a capture probe DNA (P) was immobilized on carboxylated magnetic beads (MBs), allowing for amplified immobilization due to the 3D surface.

Molecular docking, drug-likeness and DFT study of some modified tetrahydrocurcumins as potential anticancer agents.

The present study utilized molecular docking and density functional theory (DFT) approaches, and ADMET (absorption, distribution, metabolism, excretion, and toxicity) properties to investigate the binding interactions, reactivity, stability, and drug-likeness of curcumin (1), tetrahydrocurcumin (2), and tetrahydrocurcumin derivatives (3-6) as potential anti-cancer agents. MGL (Molecular Graphic Laboratory) and Discovery Studio Visualizer (DSV) software employed for docking studies. Pharmacokinetic and pharmacodynamic (ADME-Tox) analyses were conducted using SwissADME and pKCSM web servers.

t(1;4) translocation in a child with acute lymphoblastic leukemia: a case report.

Background: Acute lymphoblastic leukemia is the most common childhood cancer, with an 80% frequency in children between 1 and 10 years old. The outcome and prognosis of acute lymphoblastic leukemia in children depends on various factors, such as age, clinical and biological features, and cytogenetic factors.

Case Presentation: We report the case of a pediatric patient, a 4-year-old Moroccan female who was referred to the Hematology and Oncology Department of 20 August 1953 Hospital in Casablanca and diagnosed with B-cell acute lymphoblastic leukemia associated with a rare genetic chromosomal abnormality.

Inhibition of corrosion of an aluminum alloy by rosemary and eucalyptus extracted oils in 1 M hydrochloric acid medium: an experimental and theoretical study.

In this study, we explored aluminum corrosion inhibition field of study in a 1 M HCl solution, harnessing the power of essential oils extracted from rosemary and eucalyptus plants. Our exploration gives a comprehensive analysis of the pivotal factors that shape the corrosion inhibition process. Our scientific journey was marked by a deliberate and systematic approach, encompassing the utilization of gravimetric analysis (weight loss), electrochemical potentiodynamic polarization, and the sophisticated electrochemical impedance spectrometry (EIS) techniques.

Exploring the potential of molecularly imprinted polymers and metal/metal oxide nanoparticles in sensors: recent advancements and prospects.

Metal/metal oxide nanoparticles have gained increasing attention in recent years due to their outstanding features, including optical and catalytic properties, as well as their excellent conductivity. The implementation of metal/metal oxide nanoparticles, combined with molecularly imprinted polymers (MIPs) has paved the way for a new generation of building blocks to engineer and enhance the fascinating features of advanced sensors. This review critically evaluates the impact of combining metal/metal oxide nanoparticles with MIPs in sensors.

Exploring the multifaceted effects of : subchronic toxicity, antioxidant capacity, immunomodulatory, and anti-inflammatory activities.

() is an annual herb that has been used in traditional medicine to treat various ailments attributed to the presence of its bioactive compounds. The purpose of this study was to identify and examine the phytochemical properties of the hydroalcoholic extract of using and models. Our findings demonstrated that the extract contained a variety of beneficial components, including phenols, flavonoids, tannins, coumarins, saponins, khellin, and visnagin.

Cytogenetic abnormalities correlate with clinico-biological characteristics in 30 Moroccan multiple myeloma patients.

Background: The nonrandom recurrence of chromosomal abnormalities in multiple myeloma (MM) raises the possibility that they play a role in the pathophysiology and development of the disease. Fluorescence in situ hybridization (FISH) can identify a high frequency of certain abnormalities without the need for the proliferative and infiltrative index of malignant plasma cells required for conventional cytogenetic analysis. In this study, we describe the association between clinico-biological characteristics and chromosomal abnormalities in 30 Moroccan patients.

Classification of common variable immunodeficiency through immunological and clinical phenotyping in Moroccan patients.

Common variable immunodeficiency (CVID) is a complex inborn error of humoral immunity with complications of both infectious and non-infectious origins. Classifications of CVID patients provide a clearer understanding of the pathogenesis, prediction, and management of non-infectious complications. This study aims to classify Moroccan CVID patients based on the European classification (EUROclass).

Association between nutritional status, body composition, and fitness level of adolescents in physical education in Casablanca, Morocco.

Aim: This study aims to analyze and compare dietary intake, as well as to examine the associations between energy intake in terms of macronutrients, body composition, and physical fitness (PF) specifically cardiorespiratory endurance (CE) among a sample of young adolescents aged 15 to 18 years, who participate in physical education and sports sessions in public schools in Casablanca, Morocco.

Materials And Methods: A total of 311 participants, including 156 girls and 154 boys, were included in the study. Each participant maintained a food diary for 3 days during the same study week.

Maxillary Sinus Ameloblastoma in Turner Syndrome: A Comprehensive Case Report and Long-Term Follow-Up.

This article was previously posted to the Research Square preprint server on 16 August 2023. Maxillary sinus ameloblastoma is an uncommon, locally aggressive odontogenic tumor. In this case report, we present a comprehensive long-term follow-up of maxillary sinus ameloblastoma occurring in a patient with Turner syndrome, managed through partial right maxillectomy followed by adjuvant operative bed radiotherapy.

Selective Sensing in Microbial Fuel Cell Biosensors: Insights from Toxicity-Adapted and Non-Adapted Biofilms for Pb(II) and Neomycin Sulfate Detection.

This study introduces the utilization of self-powered microbial fuel cell (MFC)-based biosensors for the detection of biotoxicity in wastewater. Current MFC-based biosensors lack specificity in distinguishing between different pollutants. To address this limitation, a novel approach is introduced, capitalizing on the adaptive capabilities of anodic biofilms.

Geospatial distribution and machine learning algorithms for assessing water quality in surface water bodies of Morocco.

Surface waterbodies being primary source of water for human consumption are being investigated for its quality globally. This study evaluated water quality in three rivers (River Nfifikh, Hassar and El Maleh) of Mohammedia prefecture, Morocco in terms of heavy metals occurrence during two seasons of winter and spring. The heavy metals analyzed were cadmium, iron, copper, zinc, and lead.

Li adsorption and diffusion on the surfaces of molybdenum dichalcogenides MoX (X = S, Se, Te) monolayers for lithium-ion batteries application: a DFT study.

Context: We study some of the most high performance electrode materials for lithium-ion batteries. These comprise molybdenum dichalcogenide MoX (molybdenum disulfide MoS, molybdenum diselenide MoSe, molybdenum ditelluride MoTe). The stability is studied by calculating cohesive energy and formation energy.

Structure-based virtual screening, ADMET analysis, and molecular dynamics simulation of Moroccan natural compounds as candidates for the SARS-CoV-2 inhibitors.

The lack of treatments and vaccines effective against SARS-CoV-2 has forced us to explore natural compounds that could potentially inhibit this virus. Additionally, Morocco is renowned for its rich plant diversity and traditional medicinal uses, which inspires us to leverage our cultural heritage and the abundance of natural resources in our country for therapeutic purposes. In this study, an extensive investigation was conducted to gather a collection of phytoconstituents extracted from Moroccan plants, aiming to evaluate their ability to inhibit the proliferation of the SARS-CoV-2 virus.

Computational analysis of missense variants of human MC4R and childhood obesity.

Industrialized and developing nations face severe public health problems related to childhood obesity. Previous studies revealed that the melanocortin-4 receptor gene (MC4R) is the most prevalent monogenic cause of severe early obesity. Due to its influence on food intake and energy expenditure via neuronal melanocortin-4 receptor pathways, MC4R is recognized as a regulator of energy homeostasis.

Evaluation of SARS-CoV-2 infection risks after primary vaccination with BNT162b2, BBIBP-CorV, or ChAdOx1-nCOV-19 and after homologous and heterologous booster vaccinations with these vaccines and evaluation of SARS-CoV-2 reinfection profiles.

Background: The emergence of SARS-CoV-2 variants has significantly increased the number of cases of COVID-19 among vaccinated individuals, raising concerns about the effectiveness of current vaccines. The aim of this study was to analyze the SARS-CoV-2 infection risks after primary vaccination with BNT162b2, BBIBP-CorV, or ChAdOx1-nCOV-19 and after homologues and heterologous booster vaccinations with these vaccines, as well as the profiles of reinfected patients.

Methods: We analyzed retrospectively 1082 patients vaccinated or unvaccinated with BNT162b2, BBIBP-CorV, and/or ChAdOx1nCoV-19 vaccines to determine their SARS-CoV2 infection statuses using the reverse transcription-polymerase chain reaction (RT-PCR) in addition to their clinical features.

Improving accuracy in state of health estimation for lithium batteries using gradient-based optimization: Case study in electric vehicle applications.

Significant improvements in battery performance, cost reduction, and energy density have been made since the advancements of lithium-ion batteries. These advancements have accelerated the development of electric vehicles (EVs). The safety and effectiveness of EVs depend on accurate measurement and prediction of the state of health (SOH) of lithium-ion batteries; however, this process is uncertain.

Improvement of humic acid (HA) removal using a new inorganic-organic composite coagulant: α-costic acid as a modifier of polyaluminum chloride properties.

In this work, α-costic acid (αCA), a plant sesquiterpenoid from Dittrichia viscosa, was grafted into polyaluminum chloride (PAC), forming a new eco-sustainable composite coagulant PAC-αCA with improved functionality. The α-costic acid fraction grafted into the PAC and the distribution of aluminum forms in the composite coagulant were evaluated for their effectiveness in removing bentonite and humic acid from synthetic water. The interaction mechanism between PAC and α-CA was examined by the Al-Ferron time spectrophotometric method, density functional theory (DFT), and FTIR analysis.

Molecular docking analysis of PPARγ with phytochemicals from Moroccan medicinal plants.

PPARγ agonists play a crucial role in regulating metabolic homeostasis for treating type-2 diabetes (T2D). Due to the adverse side effects associated with thiazolidinediones, a class of PPARγ agonists, there is a growing interest in identifying natural compounds from medicinal plants that have the potential to bind PPARγ. In this study, we extensively investigated Moroccan phytochemicals using computational structure-based screening with the crystal structure of the PPARγ ligand-binding domain (PDB ID: 7awc) to discover novel phytochemicals targeting PPARγ.