Temporomandibular Joint Disorders in Elderly Patients.

The management of temporomandibular disorders (TMDs) in elderly patients can present a significant challenge for dentists due to its multifactorial etiology, aging-related changes that contribute to TMD, and the fragile psychological state of these patients. Despite the growing prevalence of TMD in the elderly population, the scientific literature provides limited information about effective management strategies for this group. Therefore, it is crucial for researchers and clinicians to focus on improving our understanding of TMD in the elderly population and to develop more effective treatment approaches.

Exploring the role of leaves distillation waste as a green inhibitor for carbon steel in acidic environment: an integrated study.

In this study, the assessment of the leaves' co-product resulting from the hydrodistillation process was conducted to evaluate its anticorrosive potential for carbon steel in the hydrochloric acid medium. Phytochemical analysis of this biomass revealed its abundance in terms of polyphenols and flavonoids; hence the determination of total polyphenol content recorded a value of 75.4 mg GAE per g extract.

A comprehensive review on TiO-based heterogeneous photocatalytic technologies for emerging pollutants removal from water and wastewater: From engineering aspects to modeling approaches.

The increasing presence of emerging pollutants (EPs) in water poses significant environmental and health risks, necessitating effective treatment solutions. Originating from industrial, agricultural, and domestic sources, these contaminants threaten ecological and public health, underscoring the urgent need for innovative and efficient treatment methods. TiO-based semiconductor photocatalysts have emerged as a promising approach for the degradation of EPs, leveraging their unique band structures and heterojunction schemes.

FcRγIIA attenuates pathology of cutaneous leishmaniasis and modulates ITAMa/i balance.

Background: Leishmania is the causal parasite of leishmaniasis, a neglected tropical disease affecting millions of individuals worldwide, and its dissemination is linked to climate change. Despite the complexity and effectiveness of the immune response, the parasite has developed many strategies to evade it and take control of the host cell to replicate. These evasion strategies start at early stages of infection by hijacking immune receptors to mitigate the cellular response.

Cutaneous leishmaniasis and iron metabolism: current insights and challenges.

Leishmaniasis is a vector-borne parasitic infection induced by protozoa of the genus The disease spectrum ranges from skin lesions to visceral leishmaniasis, which is fatal if untreated. The cutaneous leishmaniasis is characterized by a clinical polymorphism of lesions with a broad range of severity ranging from a self-limited lesion to multiple disfiguring lesions stigmatizing the patient for life. Although iron is required for several process of infection including survival, growth and virulence, the number of studies on host iron metabolism during this infection remains limited.

Rare Association of Dermatitis Herpetiformis and Chronic Plaque Psoriasis.

Dermatologists should consider investigating for coexisting autoimmune conditions such as dermatitis herpetiformis and/or coeliac disease, in patients with psoriasis presenting clinical signs and symptoms, in order to ensure an accurate diagnosis and improve patients' long-term management.

Management of Deep Caries Lesions: A Study among Dentists in the Private Sector of Casablanca, Morocco.

Aim And Background: To find out which management methods are preferred by dentists in the private sector of Casablanca for a deep carious lesion or a pulp exposure during carious tissue removal in adult patients.

Materials And Methods: A questionnaire consisting of 25 questions was sent to 300 randomly sampled dentists in Casablanca. Only specialists in conservative dentistry and endodontics and general practitioners were included.

Tuberculous meningitis associated with the absence of pleocytosis in cerebrospinal fluid in an immunocompetent patient: A case report.

We report a case of tuberculous meningitis without pleocytosis of the cerebrospinal fluid (CSF) in a 27-year-old patient admitted for a meningeal syndrome with signs of basilar involvement and an infectious syndrome associated with a hacking cough with whitish sputum and night sweats, evolving for 15 days before her admission, in a context of weight loss of 2 kg, asthenia, and anorexia. Cytobacteriological and chemical analysis of the CSF revealed less than 3 cells/mm white blood cells, high protein levels of 2.54 g/l, and low glucose levels of 0.

Evaluation of modified fire hawk optimizer for new modification in double diode solar cell model.

The evaluation of photovoltaic (PV) model parameters has gained importance considering emerging new energy power systems. Because weather patterns are unpredictable, variations in PV output power are nonlinear and periodic. It is impractical to rely on a time series because traditional power forecast techniques are based on linearity.

Structure-based virtual screening to identify hypocholesterolemic phytochemicals as potent inhibitors of squalene synthase a potential target for hypercholesterolemia.

Squalene synthase (SQS) plays a crucial role in the cholesterol biosynthetic pathway. Its distinctive strategic position makes it a promising candidate for targeting and developing new anti-hypercholesterolemic agents. To uncover novel phytochemical scaffolds as potential inhibitors of SQS, we employed a structure-based virtual screening approach that involves screening 545 phytochemicals collected from Moroccan aromatic and medicinal plants and filtering them based on RMSD values and their affinity towards the target enzyme.

Electrochemical corrosion behavior of α-titanium alloys in simulated biological environments (comparative study).

Titanium (Ti) and its alloys are widely utilized in orthopedic and dental applications due to their favorable mechanical properties and biocompatibility. Notably, titanium exhibits excellent corrosion resistance and can form a stable oxide layer, ensuring the longevity and functionality of implants in challenging physiological environments. This study investigates the corrosion behavior of α-Ti alloy in physiological saline solutions, emphasizing the role of key biomolecules found in the human body, including albumin, glycine, and glucose, as well as additional substances such as hydrogen peroxide (HO) and hydroxyapatite (Hap).

Multi-criteria Bayesian optimization of Empirical Mode Decomposition and hybrid filters fusion for enhanced ECG signal denoising and classification: Cardiac arrhythmia and myocardial infarction cases.

This paper introduces a new advanced model for denoising and classification of ECG signals, focusing on the use of a hybrid filter and Bayesian optimization. The hybrid filter synergistically combines enhanced empirical mode decomposition (EEMD), Chebyshev Type II filters, Butterworth, Daubechies Wavelet, and Savitzky-Golay filters, leveraging their respective advantages for effective noise reduction while preserving the essential features of the ECG signal. We employ a multi-criteria Bayesian optimization process, using cross-correlation and mean squared error (MSE) as key metrics, to refine the filter parameters to further improve the signal quality.

Molecular Profile of BCR-ABL1 Negative Myeloproliferative Neoplasm in a Moroccan Population.

Introduction: Myeloproliferative neoplasms (MPN) are associated with clonal hematopoiesis, genomic instability, hemostasis dysregulation, and immune response. Classic BCR-ABL1 negative myeloproliferative neoplasms (BCR-ABL1 negative MPN), including polycythemia vera (PV), essential thrombocythemia (ET), and primary myelofibrosis (PMF), are frequently associated with somatic abnormalities in JAK2, CALR, and MPL. Mutant clones induce an inflammatory immune response leading to immuno-thrombosis.

Prospective Validation of a One-Step RT-qPCR-based Test for Quantifying HER2 Gene Expression in Breast Cancer.

Objective: To Validate a one-step RT-qPCR as a reliable diagnostic tool in HER-2 positive breast cancer. Further, establishing this tool as a standard procedure to quantify HER-2 expression in Breast cancer patient.

Methods: Here we report a prospective validation study that shows the concordance of one-step RT-qPCR in assessing the HER2 levels in formalin-fixed paraffin-embedded (FFPE) tissue samples with the current paradigm of diagnosis such as Immunohistochemistry (IHC) and Fluorescence-in-situ Hybridization (FISH).

ZFYVE19 gene mutation: A novel variant of progressive familial intrahepatic cholestasis.

A recent nonsyndromic phenotype, newly linked to mutations in the ZFYVE19 gene, is characterized by the appearance of cholestasis accompanied by an increase in serum gamma-glutamyltranspeptidase (GGT) from infancy or early childhood. Affected individuals generally present with hepatosplenomegaly and may develop portal hypertension. The disease is thought to be the result of cholangiocyte-specific ciliary dysfunction, indicating a ciliopathy that appears to be limited to the liver.

Discovery of novel pyrrolo[2,3-d]pyrimidine derivatives as anticancer agents: virtual screening and molecular dynamic studies.

CDK/Cyclins are dysregulated in several human cancers. Recent studies showed inhibition of CDK4/6 was responsible for controlling cell cycle progression and cancer cell growth. In the present study, atom-based and field-based 3D-QSAR, virtual screening, molecular docking and molecular dynamics studies were done for the development of novel pyrrolo[2,3-d]pyrimidine (P2P) derivatives as anticancer agents.

Integration of FTIR Spectroscopy, Volatile Compound Profiling, and Chemometric Techniques for Advanced Geographical and Varietal Analysis of Moroccan Eucalyptus Essential Oils.

Eucalyptus essential oil is widely valued for its therapeutic properties and extensive commercial applications, with its chemical composition significantly influenced by species variety, geographical origin, and environmental conditions. This study aims to develop a reliable method for identifying the geographical origin and variety of eucalyptus oil samples through the application of advanced analytical techniques combined with chemometric methods. Essential oils from Eucalyptus globulus and Eucalyptus camaldulensis were analyzed using Gas Chromatography-Flame Ionization Detection (GC-FID) and Fourier Transform Infrared (FTIR) Spectroscopy.

Exploring Moroccan Medicinal Plants for Anticancer Therapy Development Through In Silico Studies.

Background: Angiogenesis is a crucial process in the growth and proliferation of cancer, enabling tumor growth through the formation of new vasculature and the supply of nutrients and oxygen to growing malignant cells. This disease-promoting process can be targeted through the inhibition of tyrosine kinase enzymes.

Objectives: The objective of this study is to evaluate the anticancer potential of various Moroccan plants from different regions.

AI-Reinforced Wearable Sensors and Intelligent Point-of-Care Tests.

Artificial intelligence (AI) techniques offer great potential to advance point-of-care testing (POCT) and wearable sensors for personalized medicine applications. This review explores the recent advances and the transformative potential of the use of AI in improving wearables and POCT. The integration of AI significantly contributes to empowering these tools and enables continuous monitoring, real-time analysis, and rapid diagnostics, thus enhancing patient outcomes and healthcare efficiency.

An investigation of the adsorption of Congo red dye on two naturally occurring adsorbents Hydroxyapatite and Bentonite: An Experimental Analysis, DFT calculations, and Monte Carlo simulation.

Congo Red (CR) dye is classified as a toxic and carcinogenic substance, posing significant health and environmental risks. To address this issue, the adsorption efficiency of CR on natural bentonite and hydroxyapatite (HA) was systematically studied. The adsorbents were successfully characterized by XRD, FTIR, and SEM analysis.

Design and Optimization of Quinazoline Derivatives as Potent EGFR Inhibitors for Lung Cancer Treatment: A Comprehensive QSAR, ADMET, and Molecular Modeling Investigation.

The epidermal growth factor receptor (EGFR) is part of a protein family that controls cell growth and development. Due to its importance, EGFR has been identified as a suitable target for creating novel drugs. For this research, we conducted a 2D-QSAR analysis on a set of 31 molecules derived from quinazoline, which exhibited inhibitory activity against human lung cancer.