FcRγIIA response duality in leishmaniasis.

Leishmania is responsible for a neglected tropical disease affecting millions of people around the world and could potentially spread more due to climate change. This disease not only leads to significant morbidity but also imposes substantial social and economic burdens on affected populations, often exacerbating poverty and health disparities. Despite the complexity and effectiveness of the immune response, the parasite has developed various strategies to evade detection and manipulates host cells in favor of its replication.

Phytochemical characterization, antimicrobial properties and modeling perspectives of essential oil.

Medicinal plants are used widely in the treatment of various infectious diseases. One of these medical plants is Moroccan plants such as . In this study, the essential oil isolated from the leaves of (APEO) by the hydrodistillation method was analyzed using (GC/MS) analysis.

The Development and Evaluation of a New Inactivated Vaccine against subsp. .

subsp. (Mcc) and subsp. (Mccp) are pathogens that affect large and small ruminants.

Development of a novel in-situ aluminum/carbon composite from olive mill wastewater for the selective adsorption and separation of malachite green and acid yellow 61.

In this study, an aluminum/carbon composite was developed from olive mill wastewater (OMWW) and successfully applied in the removal/separation of malachite green (MG) and acid yellow 61 (AY61) and in the treatment of a real discharge from a denim dye bath. The optimized composite (0.5% Al) is microporous, has a specific surface area of 1269 m.

Therapeutic Potential of Clove Essential Oil in Diabetes: Modulation of Pro-Inflammatory Mediators, Oxidative Stress and Metabolic Enzyme Activities.

Type 1 diabetes is characterized by insulin deficiency due to the destruction of pancreatic β cells, leading to hyperglycemia, which in turn induces vascular complications. In the current study, we investigated the effect of intraperitoneal administration of clove essential oil (CEO: 20 mg/kg body weight) on certain oxidative stress and glucose metabolism enzymes, as well as the expression of proinflammatory mediators. Administration of CEO to diabetic rats showed a significant decline in blood glucose levels, total cholesterol, and xanthine oxidase, compared to the streptozotocin group.

Capparis spinosa inhibits Leishmania major growth through nitric oxide production in vitro and arginase inhibition in silico.

Cutaneous leishmaniasis is an infectious disease, considered as a major public health problem in different regions of the world. The current treatments are limited due to their toxicity and treatment failures, which have increased the search for new substances of natural origin to control this infection. Capparis spinosa is an important medicinal plant, rich in biochemical compounds with a broad range of activities including antimicrobial effects.

Olive mill wastewater from a liquid biological waste to a carbon/oxocalcium composite for selective and efficient removal of methylene blue and paracetamol from aqueous solution.

In this study, a Carbon/Oxocalcium was prepared from olive mill wastewater and successfully applied to the removal of paracetamol and methylene blue (MB) from an aqueous medium. The optimized composite (0.3 % CaO) is rich in anionic sites, porous and has a specific surface area of about 1383 m.

The Modulation of NADPH Oxidase Activity in Human Neutrophils by Moroccan Strains of and Is Not Associated with p47 Phosphorylation.

Polymorphonuclear neutrophils (PMNs) are the first phagocyte recruited and infected by . They synthetize superoxide anions (O) under the control of the NADPH oxidase complex. In Morocco, and are the main species responsible for cutaneous leishmaniasis (CL).

The pro-inflammatory cytokines in COVID-19 pathogenesis: What goes wrong?

The outbreak of coronavirus disease 2019 (COVID-19), caused by Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) infection, has emerged in China in December 2019 and rapidly spread to more than 196 countries worldwide. The physiopathology of human SARS-CoV-2 has not been completely understood, but its pathogenesis has been linked to a disproportionate response of the immune system. Just as described for SARS and MERS, an uncontrolled systemic inflammatory response, known as cytokine release syndrome (CRS) was observed in severe COVID-19 patients.

The different faces of the NLRP3 inflammasome in cutaneous Leishmaniasis: A review.

Cutaneous leishmaniasis (CL) is a vector-borne parasitic disease caused by Protozoa of the genus Leishmania. Clinical manifestations of this disease are the result of a complex interplay of diverse factors, including the genetic background and the immune status of the host. Understanding the impact of these factors on the CL pathology may provide new targets to manage the infection and improve clinical outcome.

Parameters and mechanism of membrane-oriented processes for the facilitated extraction and recovery of norfloxacin active compound.

In the present work, a polymer inclusion membrane (PIM) using an amphiphilic molecule Tween 20 (TW20) as the carrier was developed and characterized to hinder environmental contamination caused by norfloxacin (NRF), an antibiotic widely used in veterinary and human medicines. Fourier-transform infrared spectroscopy (FTIR) and scanning electron microscopy (SEM) coupled with energy X-ray dispersion spectroscopy (EDS) were used to reveal the composition, porosity, and morphology of the elaborated membrane. In order to measure the performance of the as-developed membrane, the influences of NRF initial concentration (C = 0.

Gastric IL-1β, IL-8, and IL-17A expression in Moroccan patients infected with Helicobacter pylori may be a predictive signature of severe pathological stages.

Introduction: Helicobacter pylori induces acute gastritis that can progress to serious diseases such as gastric cancer. H. pylori interacts with host cells within the gastric mucosa, resulting in activation of multiple innate immune signalling pathways, leading to pro-inflammatory cytokines production and immune cells recruitment.

Moroccan strains of Leishmania major and Leishmania tropica differentially impact on nitric oxide production by macrophages.

Background: Cutaneous leishmaniasis (CL) is a vector-borne parasitic disease caused by protozoa of the genus Leishmania. In Morocco, CL is a public health problem mainly caused by Leishmania major and Leishmania tropica, which are responsible for zoonotic and anthroponotic CL, respectively. Macrophages are the primary cells infected by Leishmania parasites and their capacity to produce nitric oxide (NO) is of critical importance for parasite elimination.