1,828 results match your criteria: "Hassan II University[Affiliation]"

Objective: The aim of this study was to identify the molecular prevalence of high-risk HPV infection and the distribution of genotypes present in normal cytology, as well as to determine the vaccination status of our study population.

Methods: 110 cervical samples were taken from individuals, and 1 ml of each sample was added to the Xpert HPV cartridge in the sample compartment before it was placed in the Cepheid GeneXpert system. Detection was performed simultaneously via amplification of the and genes in five fluorescent channels (HPV16, HPV18/45, HPV31/33/35/52/58, HPV51/59, and HPV39/56/66/68a).

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Alpinia officinarum Hance Essential Oil as Potent Antipseudomonal Agent: Chemical Profile, Antibacterial Activity, and Computational Study.

Chem Biodivers

October 2024

Laboratory of Drugs Sciences, Biomedical Research and Biotechnology, Faculty of Medicine and Pharmacy, Hassan II University of Casablanca, B.P. 9154, Casablanca, 20250, Morocco.

Article Synopsis
  • - The study explores the antibacterial properties of the essential oil from the herb Alpinia officinarum, revealing that eucalyptol is its main component with potential antimicrobial effects.
  • - It shows that the essential oil effectively inhibits the growth of harmful bacteria like Pseudomonas aeruginosa and Escherichia coli, outperforming standard antibiotics in some tests.
  • - The research indicates that the compounds in the essential oil have good binding potential to bacterial targets and favorable pharmacokinetic and toxicity profiles, highlighting the need for alternatives to combat antibiotic resistance.
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Graves' orbitopathy (GO) is a rare autoimmune disease that affects patients in their fourth to sixth decade, resulting in retro-orbital inflammation and hypertrophy of extraocular muscles and orbital fat. It is the most common disease affecting the orbit globally, and treatment options vary depending on the severity and activity status of the affection, ranging from local measures such as lubricating eye drops and patching, glucocorticoid eye drops, mydriatics, nonsteroid anti-inflammatory medications to systemic glucocorticoids, and emergency orbital decompression surgery. Immunotherapy and orbital radiation may as well be used as a treatment option even though their efficiency remains controversial.

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Genetic variations in Interferon-Induced with Helicase C Domain 1: Impact on COVID-19 risk and severity in the Moroccan population.

Hum Immunol

November 2024

Virology Unit, Viral Hepatitis Laboratory, Institut Pasteur du Maroc, Casablanca 20360, Morocco. Electronic address:

Article Synopsis
  • The study investigates how genetic variations in the IFIH1 gene relate to COVID-19 susceptibility and severity among Moroccans, highlighting the importance of genetic factors in immune response to the virus.
  • Results showed that the TT genotype of the rs1990760 variant is linked to higher susceptibility to COVID-19, while the CT genotype appears to offer protective benefits against both infection and severe disease.
  • No significant association was found with another variant, rs3747517, indicating that not all genetic factors play a role in COVID-19 outcomes.
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Case Report of Two Independent Moroccan Families with Syndromic Epidermodysplasia Verruciformis and STK4 Deficiency.

Viruses

September 2024

Laboratory of Clinical Immunology-Inflammation and Allergy (LICIA), Faculty of Medicine and Pharmacy, Hassan II University, Casablanca 20250, Morocco.

Article Synopsis
  • Epidermodysplasia verruciformis (EV) is a rare skin condition linked to β-human papillomaviruses (HPV) in immunodeficient individuals, presenting as flat warts and pityriasis-like lesions.
  • The study details three patients from two families with syndromic EV, identified through whole exome sequencing to have new homozygous variants in the STK4 gene, resulting in a premature stop codon.
  • STK4 deficiency causes a combined immunodeficiency leading to increased susceptibility to various infections and autoimmune issues, as evidenced by immunophenotyping showing significant CD4 T cell deficiency in the patients.
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In the context of designing innovative anticancer agents, the synthesis of a series of chalcones bearing a 3,4,5-trimethoxylated A ring and a variety of B rings, including phenols and original heterocycles such as chromones, was conducted. For this end, Claisen-Schmidt condensation was performed in basic or acidic conditions between the common starting material 3,4,5-trimethoxyacetophenone and appropriate aldehydes; this allowed the recovery of fifteen chalcones in moderate-good yields. The synthesized compounds were screened for their antiproliferative activity against colorectal and prostatic cancer cells, using a colorimetric MTT assay.

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Novel copper complex inhibits the proteasome in skin squamous cell carcinoma induced by DMBA in mice.

J Trace Elem Med Biol

December 2024

Laboratory of Biochemistry, Environment and Agri-Food (URAC 36), Faculty of Sciences and Techniques - Mohammedia, Hassan II University, Casablanca, Morocco. Electronic address:

The proteasomal system is becoming a target for the treatment of several diseases, especially in cancer therapy. The present study aims to develop a novel copper complex that inhibits the proteasome in skin squamous cell carcinoma. New molecules based on the copper complex were synthesized for the first time to assess their potential as proteasome inhibitors, specifically targeting squamous cell carcinoma induced by 7,12-dimethylbenz(a)anthracene (DMBA) in mouse models.

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Open Anterior Subscapularis Release for Adduction and Medial Rotation Shoulder Contracture in Neonatal Brachial Plexus Palsy.

Afr J Paediatr Surg

September 2024

Department of Paediatric Orthopaedics and Traumatology, Abderrahim Harouchi Mother and Child Hospital, Ibn Rochd University Hospital, Casablanca, Morocco.

Article Synopsis
  • The study examines the effectiveness of open anterior subscapularis release surgery in children over 12 months with unresolved neonatal brachial plexus palsy, focusing on improving shoulder contracture.
  • Results showed a significant improvement in shoulder function scores and movements such as abduction and lateral rotation, with notable enhancements in activities like bringing hands to the mouth and head.
  • The findings indicate that children with more severe injuries experience greater functional recovery after surgery, although there was no significant change in medial rotation of the shoulder.
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Motorcycle Wheel Spoke Injury to the Ankle and Foot in Children: A Cross-sectional Observational Study.

Afr J Paediatr Surg

September 2024

Department of Paediatric Orthopaedics and Traumatology, Abderrahim Harouchi Mother and Child Hospital, Ibn Rochd University Hospital, Casablanca, Morocco.

Article Synopsis
  • Motorcycle accidents involving wheel spokes have become a significant cause of ankle and foot injuries in children under 16 years old in developing countries, particularly during afternoon rides as pillion passengers.
  • The study analyzed 30 cases over 11 years, revealing a notable increase in injuries after 2015, with a majority suffering severe injuries such as tendon ruptures and bone fractures.
  • Key findings indicate that larger wound sizes and loss of soft tissue are linked to the severity of injuries, highlighting the need for better prevention strategies for child passengers.
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Article Synopsis
  • * Diagnosis of osteopetrosis involves genetic testing and imaging techniques like X-rays and CT scans to confirm the condition.
  • * A case study is presented of a 13-year-old boy in Morocco whose osteopetrosis was identified through unusual symptoms and confirmed via CT imaging, highlighting challenges in accessing medical care.
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Because of its low-lying location, urbanization, and inadequate infrastructure, Jakarta (Indonesia) has experienced an increase in annual flooding events, rising from an average of five significant floods per year in the 1990s to over 20 annually (2010-2020). With climate change exacerbating extreme weather events, Jakarta encounters escalating risks of flooding. Although the recurrent flooding is exacerbated by non-point source (NPS) of pollution such as urban runoff and agricultural discharge that contribute to 40% of total pollutants leading to flood-related issues in Jakarta, none has investigated this research gap.

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Electrodeposition of CuNiSnS absorber layer on FTO substrate for solar cell applications.

RSC Adv

September 2024

Laboratory of Physical Chemistry and Biotechnology of Biomolecules and Materials, Faculty of Sciences and Technology, Hassan II University of Casablanca Mohammedia 20650 Morocco

Potentiostatic and electrochemical impedance spectroscopy (EIS) measurements were recorded to study the nucleation and growth mechanisms of electrodeposited CuNiSnS (CNTS) thin films from aqueous solution at different applied potentials. The electrodeposition process of Cu-Ni-Sn-S precursors were studied using cyclic voltammetry and chronoamperometry techniques. The nucleation and growth mechanism of these films was found to follow a three-dimensional progressive nucleation limited by diffusion-controlled growth.

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A rare case of Erdheim Chester disease.

Radiol Case Rep

December 2024

Central Unit of Radiology, University Hospital Center Ibn Rochd, School of Medicine and Pharmacy of Casablanca, Hassan II University, Casablanca, Morocco.

Article Synopsis
  • Erdheim-Chester disease (ECD) is a rare condition classified as non-Langerhans cell histiocytosis, with limited cases documented in literature.
  • A 53-year-old patient exhibited symptoms including xanthelasma (skin lesions), extreme fatigue, loss of appetite, and chronic breathing difficulties over five years.
  • Imaging scans revealed significant signs of ECD, and a biopsy solidified the diagnosis, emphasizing the need for radiologists to recognize ECD signs to prevent misdiagnosis.
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Background: Faced with a deemed mediocre quality of life (QoL) in people with multiple sclerosis (pwMS), the effectiveness of therapeutic education (TPE) programs is called into question. This systematic review is conducted to examine the impact of the TPE programs on the QoL of pwMS.

Methods: A search was performed in three databases (PubMed, Web of Science and Scopus) to identify relevant studies published between 2007 and 2022.

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Psychological distress and coping strategies in breast cancer patients under neoadjuvant therapy: A systematic review.

Womens Health (Lond)

September 2024

Laboratory of Epidemiology and Research in Health Sciences, Faculty of Medicine, Pharmacy and Dental Medicine, Sidi Mohamed Ben Abdallah University, Fez, Morocco.

Article Synopsis
  • - The study explores psychological distress (PD) and coping strategies in patients undergoing neoadjuvant therapy (NAT) for locally advanced breast cancer (LABC), finding a significant prevalence of depression and anxiety both before and after treatment.
  • - Results indicate that PD can decrease during NAT, and factors such as social support and living conditions play a role in patients' mental health; also, the effectiveness of coping strategies shifted, with "resigned coping" decreasing while "social support" increased post-treatment.
  • - Interventions like mobile health apps, diet changes, and relaxation techniques showed promise in reducing PD, emphasizing the need for psychological support throughout the treatment process for LABC patients.
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Hydatid cyst of the gluteal muscle: a case report and literature review.

Tunis Med

September 2024

Sidi Mohammed Ben Abdellah University, Faculty of Medicine, Pharmacy, and Dental Medicine, 30000, Hassan II University Hospital Center, Parasitology-Mycology Department, Fez, Morocco.

Introduction: Echinococcosis is a relatively widespread anthropozoonosis in endemic regions, preferentially affecting the liver and lungs. Although rare, it can sometimes be localized in the muscles. The clinical symptoms are insidious and not very indicative, often leading to a delayed diagnosis.

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Insights into the genetic theory of infectious diseases.

Tunis Med

September 2024

Laboratory of Clinical Immunology, Inflammation and Allergies LICIA, Faculty of Medicine and Pharmacy, Hassan II University, Casablanca, Morocco.

Article Synopsis
  • Classical microbiology and immunology have made significant strides in controlling infectious diseases, but recent pandemics like SARS-COV-2 expose limitations in these traditional methods.
  • Human genetics plays a crucial role in determining an individual's susceptibility or resistance to infections, influencing how different people react to the same pathogens.
  • Integrating genetic insights with microbiology can enhance our understanding of infections and help develop better prevention and treatment strategies.
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Assessing PV inverter efficiency degradation under semi-arid conditions: A case study in Morocco.

Heliyon

September 2024

Laboratory of Complex Cyber Physical Systems (LCCPS), The National Higher School of Arts and Crafts (ENSAM), Hassan II University, 20000, Casablanca, Morocco.

The worldwide shift towards renewable energy sources, including solar and wind, is progressing rapidly. This change is driven by decreasing prices and technical advancements that are becoming more centralized. The objective is to develop a cutting-edge approach and technology that seamlessly incorporates photovoltaic (PV) energy sources into a power network while ensuring grid stability.

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Quality of life and its determinants in patients with chronic respiratory diseases in the Fes-Meknes region, Morocco.

Monaldi Arch Chest Dis

September 2024

Laboratory of Epidemiology, Clinical Research and Community Health, Faculty of Medicine, Pharmacy and Dentistry, Sidi Mohammed Ben Abdellah University, Fez; Laboratory of Epidemiology and Health Sciences Research (ERESS), Sidi Mohammed Ben Abdellah University, Fez; Hospital of Specialties, Hassan II University Hospital, Fez.

Chronic respiratory diseases (CRDs) pose a serious public health issue, affecting social functioning and psychological well-being and leading to a deterioration in the quality of life. The aim of this study was to assess the quality of life of patients with CRDs and determine the factors associated with their impairment in Morocco. A cross-sectional study was conducted in the Pulmonology Department of the Hassan II University Hospital in Fez in 2021.

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IgG4-related autoimmune pancreatitis (AIP) is a chronic inflammatory disease of the pancreas with a distinct histological feature. Its diagnosis remains challenging as some features overlap with pancreatic cancer. We present a case of IgG4-related AIP mimicking pancreatic cancer.

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Article Synopsis
  • - The gene associated with alpha-thalassemia mental retardation X-linked is a chromatin remodeler linked to severe conditions like intellectual disability and facial anomalies, among others.
  • - A report highlights a 7-year-old Moroccan boy with significant intellectual challenges, autistic traits, specific facial features, and other physical issues, linked to a newly discovered variant in this gene.
  • - The identified variant (c.745G>A) shows strong predictions of being harmful and impacts a highly conserved protein domain, indicating further research is necessary to confirm its significance for proper genetic counseling.
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Introduction: Aspergillus fumigatus, a significant fungal pathogen, poses a threat to human health, especially in immunocompromised individuals. Addressing the need for novel antifungal strategies, this study employs virtual screening to identify potential inhibitors of Fructosamine oxidase, also known as Amadoriase II, a crucial enzyme in A. fumigatus (PDB ID: 3DJE).

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Article Synopsis
  • Aframomum melegueta, or grains of paradise, is a medicinal plant known for its beneficial phytochemicals and healing properties, which were evaluated for antioxidant and cytotoxic effects using both in vitro and in vivo methods.
  • Key compounds found in the extracts included gallic acid, caffeic acid, and quercetin, and the extracts showed significant antioxidant activity while being safe for animal health based on chronic toxicity tests.
  • The study indicates the extracts' potential in preventing oxidative stress-related diseases by protecting cells from damage and improving overall health.
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Article Synopsis
  • Extracellular vesicles (EVs) have gained attention in recent years for their involvement in cancer and other diseases, shifting the perception from being waste disposal mechanisms for cells to active players in cellular communication.
  • The review focuses on glioblastoma, a highly aggressive brain tumor, emphasizing how EVs contribute to communication within its heterogeneous tumor environment and their role in evading immune responses.
  • It highlights the influence of EVs from glioblastoma, immune cells, and the microbiome on local tumor dynamics and immune interactions, suggesting their potential in affecting treatment outcomes, particularly with immunotherapies.
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The complement system is a set of over 50 proteins that constitutes an essential part of the innate immune system. Complement system activation involves an organized proteolytic cascade. Overactivation of complement system activation is the main pathogenic mechanism of several diseases and contributes to the manifestations of many other conditions.

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