Electrochemical corrosion behavior of α-titanium alloys in simulated biological environments (comparative study).

Titanium (Ti) and its alloys are widely utilized in orthopedic and dental applications due to their favorable mechanical properties and biocompatibility. Notably, titanium exhibits excellent corrosion resistance and can form a stable oxide layer, ensuring the longevity and functionality of implants in challenging physiological environments. This study investigates the corrosion behavior of α-Ti alloy in physiological saline solutions, emphasizing the role of key biomolecules found in the human body, including albumin, glycine, and glucose, as well as additional substances such as hydrogen peroxide (HO) and hydroxyapatite (Hap).

Multi-criteria Bayesian optimization of Empirical Mode Decomposition and hybrid filters fusion for enhanced ECG signal denoising and classification: Cardiac arrhythmia and myocardial infarction cases.

This paper introduces a new advanced model for denoising and classification of ECG signals, focusing on the use of a hybrid filter and Bayesian optimization. The hybrid filter synergistically combines enhanced empirical mode decomposition (EEMD), Chebyshev Type II filters, Butterworth, Daubechies Wavelet, and Savitzky-Golay filters, leveraging their respective advantages for effective noise reduction while preserving the essential features of the ECG signal. We employ a multi-criteria Bayesian optimization process, using cross-correlation and mean squared error (MSE) as key metrics, to refine the filter parameters to further improve the signal quality.

Molecular Profile of BCR-ABL1 Negative Myeloproliferative Neoplasm in a Moroccan Population.

Introduction: Myeloproliferative neoplasms (MPN) are associated with clonal hematopoiesis, genomic instability, hemostasis dysregulation, and immune response. Classic BCR-ABL1 negative myeloproliferative neoplasms (BCR-ABL1 negative MPN), including polycythemia vera (PV), essential thrombocythemia (ET), and primary myelofibrosis (PMF), are frequently associated with somatic abnormalities in JAK2, CALR, and MPL. Mutant clones induce an inflammatory immune response leading to immuno-thrombosis.

Prospective Validation of a One-Step RT-qPCR-based Test for Quantifying HER2 Gene Expression in Breast Cancer.

Objective: To Validate a one-step RT-qPCR as a reliable diagnostic tool in HER-2 positive breast cancer. Further, establishing this tool as a standard procedure to quantify HER-2 expression in Breast cancer patient.

Methods: Here we report a prospective validation study that shows the concordance of one-step RT-qPCR in assessing the HER2 levels in formalin-fixed paraffin-embedded (FFPE) tissue samples with the current paradigm of diagnosis such as Immunohistochemistry (IHC) and Fluorescence-in-situ Hybridization (FISH).

ZFYVE19 gene mutation: A novel variant of progressive familial intrahepatic cholestasis.

A recent nonsyndromic phenotype, newly linked to mutations in the ZFYVE19 gene, is characterized by the appearance of cholestasis accompanied by an increase in serum gamma-glutamyltranspeptidase (GGT) from infancy or early childhood. Affected individuals generally present with hepatosplenomegaly and may develop portal hypertension. The disease is thought to be the result of cholangiocyte-specific ciliary dysfunction, indicating a ciliopathy that appears to be limited to the liver.

Discovery of novel pyrrolo[2,3-d]pyrimidine derivatives as anticancer agents: virtual screening and molecular dynamic studies.

CDK/Cyclins are dysregulated in several human cancers. Recent studies showed inhibition of CDK4/6 was responsible for controlling cell cycle progression and cancer cell growth. In the present study, atom-based and field-based 3D-QSAR, virtual screening, molecular docking and molecular dynamics studies were done for the development of novel pyrrolo[2,3-d]pyrimidine (P2P) derivatives as anticancer agents.

Assessing Syzygium Aromaticum: From Chemical Profiling to Antioxidant, Antistaphylococcal, and Biocompatibility Attributes.

Staphylococcal infections challenge current treatments due to adverse effects and drug resistance, prompting the exploration of plant-derived compounds for their promising properties. This study aimed to analyze Syzygium aromaticum essential oil (SA-EO), aqueous (AE-SA) and ethyl acetate (EAE-SA) extracts for antioxidant and antistaphylococcal effects against sensitive and resistant clinical isolates. Erythrocytes were used as model cells for biocompatibility.

Fitness and Dietary Supplements: A Cross-Sectional Study on Food Practices and Nutrivigilance.

The use of dietary supplements (DSs) has become common among fitness enthusiasts, aiming to enhance performance, recovery, and overall well-being. : A cross-sectional study was conducted in the city of Beni Mellal from April to July 2024, assessed dietary practices, motivations for supplement use, and associated adverse effects among 420 survey participants. The majority of dietary supplement users were aged 25-64 and had higher education levels.

Integration of FTIR Spectroscopy, Volatile Compound Profiling, and Chemometric Techniques for Advanced Geographical and Varietal Analysis of Moroccan Eucalyptus Essential Oils.

Eucalyptus essential oil is widely valued for its therapeutic properties and extensive commercial applications, with its chemical composition significantly influenced by species variety, geographical origin, and environmental conditions. This study aims to develop a reliable method for identifying the geographical origin and variety of eucalyptus oil samples through the application of advanced analytical techniques combined with chemometric methods. Essential oils from Eucalyptus globulus and Eucalyptus camaldulensis were analyzed using Gas Chromatography-Flame Ionization Detection (GC-FID) and Fourier Transform Infrared (FTIR) Spectroscopy.

Exploring Moroccan Medicinal Plants for Anticancer Therapy Development Through In Silico Studies.

Background: Angiogenesis is a crucial process in the growth and proliferation of cancer, enabling tumor growth through the formation of new vasculature and the supply of nutrients and oxygen to growing malignant cells. This disease-promoting process can be targeted through the inhibition of tyrosine kinase enzymes.

Objectives: The objective of this study is to evaluate the anticancer potential of various Moroccan plants from different regions.

Effective and ineffective psychological adjustment in breast cancer patients before receiving neoadjuvant chemotherapy: insights from a cohort study.

Background: The timing of a breast cancer (BC) diagnosis has a significant psychological impact on patients. However, it reported that those eligible for treatment regimens based on neoadjuvant chemotherapy may experience high levels of depression, anxiety and distress. To cope with this situation, patients deploy psychological coping strategies.

Tuning Intermediate Band Solar Cell Efficiency: The Interplay of Electric Fields, Composition, Impurities, and Confinement.

In this study, we investigated the influence of structural parameters, including active region dimensions, electric field intensity, In-composition, impurity position, and potential profiles, on the energy levels, sub-gap transitions, and photovoltaic characteristics of a p-GaN/i-(In, Ga)N/GaN-n (p-QW-n) structure. The finite element method (FEM) has been used to solve numerically the Schrödinger equation. We found that particle and sub-gap energy levels are susceptible to well width, electric field, and impurity position.

AI-Reinforced Wearable Sensors and Intelligent Point-of-Care Tests.

Artificial intelligence (AI) techniques offer great potential to advance point-of-care testing (POCT) and wearable sensors for personalized medicine applications. This review explores the recent advances and the transformative potential of the use of AI in improving wearables and POCT. The integration of AI significantly contributes to empowering these tools and enables continuous monitoring, real-time analysis, and rapid diagnostics, thus enhancing patient outcomes and healthcare efficiency.

Electrochemical study and modeling of an innovative pyrazole carboxamide derivative as an inhibitor for carbon steel corrosion in acidic environment.

The impact of N,1-dibenzyl-5-methyl-1H-pyrazol-3-carboxamide (BPC) on the carbon steel (CS) corrosion in hydrochloric acid (1 M) was studied in this work, considering concentration and temperature effects. Electrochemical investigation indicated that BPC functions as a mixed-type inhibitor. For an optimal BPC concentration of 125 ppm, the inhibition efficiency of 91.

Phenotype-genotype correlation in children with familial Mediterranean fever in Morocco.

Background: Familial Mediterranean fever (FMF) is an autosomal recessive disease caused by mutations in the MEFV gene and is characterized by recurrent febrile episodes of abdominal pain, chest pain, and joint involvement. We aim to study the clinical and genetic features of FMF in Moroccan children and to establish a phenotype-genotype correlation in this group of patients.

Methods: A total of 35 patients were included in this study.

An investigation of the adsorption of Congo red dye on two naturally occurring adsorbents Hydroxyapatite and Bentonite: An Experimental Analysis, DFT calculations, and Monte Carlo simulation.

Congo Red (CR) dye is classified as a toxic and carcinogenic substance, posing significant health and environmental risks. To address this issue, the adsorption efficiency of CR on natural bentonite and hydroxyapatite (HA) was systematically studied. The adsorbents were successfully characterized by XRD, FTIR, and SEM analysis.

Design and Optimization of Quinazoline Derivatives as Potent EGFR Inhibitors for Lung Cancer Treatment: A Comprehensive QSAR, ADMET, and Molecular Modeling Investigation.

The epidermal growth factor receptor (EGFR) is part of a protein family that controls cell growth and development. Due to its importance, EGFR has been identified as a suitable target for creating novel drugs. For this research, we conducted a 2D-QSAR analysis on a set of 31 molecules derived from quinazoline, which exhibited inhibitory activity against human lung cancer.

Active disturbance rejection control for four-wire inverters in standalone renewable resources-based microgrid - islanded microgrids ADRC-based control.

This paper presents an active disturbance rejection control (ADRC) approach for three-phase four-legs voltage source inverters (FL-VSIs) in a standalone renewable energy resources (RES)-based islanded microgrid. The key purpose of the proposed approach is to improve the control robustness against load-side disturbances, power supply parameters uncertainties, and faulty operating conditions. Indeed, a notable benefit of ADRC is its ability to operate effectively without the need for precise knowledge of disturbance characteristics or accurate modeling and FL-VSI parameters.

The link between BDNF and platelets in neurological disorders.

Platelets are considered one of the most important reservoirs not only of growth factors, but also of neurotrophic factors that could contribute to the repair of vascular lesions and the prevention of neurological deterioration. Among these factors, Brain-Derived Neurotrophic Factor (BDNF) - a protein belonging to the neurotrophin family - is widely expressed both in the hippocampus and in platelets. Platelets constitute an important reservoir of BDNF; however, little is known about the factors modulating its release into the circulation and whether anti-platelet drugs affect this secretion.

Novel food preservation strategy using sprayed PVA/chitosan-based coatings activated by macroemulsions of chamomile essential oil adsorbed on activated carbon.

Active films based on polyvinyl alcohol (PVA) and chitosan (CS) were developed by encapsulating chamomile essential oil using an emulsification process, followed by adsorption onto activated carbon (AC) to stabilize the oil droplets. Microscopic analysis showed that the average size of the micelles was between 0.1 μm and 1.

Antioxidant, Enzyme and Molecular Docking Tyrosinase Inhibitory Activities of Major Polyphenols in Boscia coriacea Graells, Grewia erythraea (Schweinf.) Chiov., Ochradenus baccatus Delile, and Orthosiphon pallidus Royle Ex Benth.

Boscia coriacea Graells (BC), Grewia erythraea (Schweinf.) Chiov. (GE), Ochradenus baccatus Delile (OB), and Orthosiphon pallidus Royle ex Benth.