Arterialized Venous Free Flap for Hand Defect Reconstruction Due to Ischemic Steal Syndrome.

Ischemic steal syndrome (ISS) occurs in hemodialysis patients. Hence, it rarely becomes gangrene or disrupts hand function. We reported a patient with an ISS and radial atherosclerosis that presented with infected ulcer.

Clinical presentation of pediatric tuberculous spondylitis in high TB burden setting before and during the COVID-19 pandemic.

Introduction: Tuberculous spondylitis (TBS) in children can be severe, non-specific, and slowly progressive. Disruptions in tuberculosis (TB) services were observed amid the coronavirus disease (COVID-19) pandemic, prompting a closer examination of its impact on TBS patients. This study compared the presenting symptoms of TBS in children before (A) and during (B) the pandemic.

Imaging and Diagnostic Challenges in an 11-Year-Old Girl with Vaginal Agenesis: A Case Report.

BACKGROUND The prevalence of female genital tract anomalies is around 4-6.9%. Vaginal agenesis is a form of Müllerian agenesis and defined as the congenital absence of the vagina.

Standard E TB-Feron ELISA and Standard F TB-Feron FIA positivity rates and agreement with QuantiFERON-TB Gold Plus among TB high-risk population in Bandung, Indonesia.

Tuberculosis (TB) remains a global public health problem. The determination of tuberculosis infection (TBI) using interferon-gamma release assay has now been used widely. We aim to evaluate the positivity rates of Standard E TB-Feron enzyme-linked immunosorbent assay (TB-Feron ELISA) and Standard F TB-Feron fluorescent immunoassay (TB-Feron FIA) and their agreement with QuantiFERON-TB Gold Plus (QFT-Plus) among TB high-risk populations in Bandung City, Indonesia.

Bell-Tawse procedure with cortical fixation using endo-button in anterior radial head dislocation: A case report.

Introduction: Anterior radial head dislocations are rare in adults. Misdiagnosis to Monteggia fracture-dislocation can occur up to 28 %, which results in failed detection of the misaligned radiocapitellar joint. Anterior radial head dislocation is treatable using the Bell Tawse technique.

The Correlation of Calcium and Hemoglobin Level Among Pregnant Women in ≥35 Weeks with the Anthropometry of Newborn Babies.

Background: Low birth length and low birth weight can be caused by nutritional deficiencies in pregnant women, including calcium and iron deficiency anemia because it retards fetal growth during pregnancy. This study aimed to explore the correlation between calcium and hemoglobin levels in third-trimester pregnant women with anthropometry of newborn babies.

Methods: This study employed a prospective cohort design, including 120 third-trimester among pregnant women in ≥35 weeks and their newborn aterm babies, using a convenience sampling technique.

Different Immunohistochemical Expression of CTLA-4 in Diffuse Large B-Cell Lymphoma and Its Associated Prognostic Factors.

Background: Diffuse large B-cell lymphoma (DLBCL) is classified into germinal center B-cell-like (GCB) and non-GCB subtypes. This study aimed to evaluate the immunohistochemical expression of CTLA-4 in these subtypes and its association with prognostic factors.

Methods: This retrospective study analyzed 50 cases of DLBCL.

Frequency and Determinants of Flare and Persistently Active Disease in a Large Multinational Prospective Lupus Cohort.

Objective: In contrast to relapsing-remitting patterns, persistently active disease (PAD) is a disease activity pattern in patients with systemic lupus erythematosus (SLE) that is inadequately studied. We sought to identify the frequency and determinants of flare and PAD in SLE.

Methods: Flare was defined using the Safety of Estrogens in Lupus Erythematosus National Assessment version of the Systemic Lupus Erythematosus Disease Activity Index (SELENA-SLEDAI flare index), and PAD was defined as an SLEDAI-2K score of ≥4, excluding serology only, on two or more consecutive visits with a maximum six-month interval.

Determinants of Acute Otitis Media in Children: A Case-Control Study in West Java, Indonesia.

: Acute Otitis Media (AOM) is a leading cause of morbidity in children, characterized by fever, otalgia, and hearing loss. If untreated, AOM may progress to chronic complications requiring surgical management. Globally, factors such as allergies, environmental tobacco smoke, and nutritional deficiencies are well-established risk factors, but in Indonesia, particularly rural areas like Bandung Regency, limited awareness and data exacerbate the burden of disease.

Pharmacogenetics and Pharmacokinetics of Moxifloxacin in MDR-TB Patients in Indonesia: Analysis for and .

: Studies show that SNPs in rs2032582 and rs4149015 affect the PK profile of moxifloxacin, a key drug for MDR-TB. This study aimed to assess the genotype frequencies of rs2032582 and rs4149015; describe moxifloxacin AUC and C; and evaluate the association between genotype variations and moxifloxacin AUC and C, corrected for the effect of other determinants in MDR-TB patients in Indonesia. : The genotypes were identified using DNA sequencing.

Intronic Variants at Third to Fifth Nucleotides Cause Alport Syndrome.

Introduction: Alport syndrome (AS) is an inherited kidney disease caused by variants in the , or genes, resulting in type IV collagen abnormalities. Although autosomal dominant variants in and are increasingly being diagnosed, X-linked AS (XLAS) caused by variants predominates. Single nucleotide substitutions in introns positioned at first and second from the last nucleotide (called a consensus sequence) of exons always cause aberrant splicing.

The Effect of Neuromuscular Electrical Stimulation on Muscle Proteolysis, Muscle Mass and Strength, Cardiorespiratory Fitness, Functional Activity, and Quality of Life in Post-Cardiac Surgery Patients: A Narrative Review.

Advances in medical and surgical practices, along with enhanced cardiac ICU services, have led to a substantial increase in cardiac surgeries (CS). Consequently, CS is now more frequently performed on older patients undergoing complex procedures, which results in higher rates of postoperative complications (POC) such as muscle proteolysis, prolonged hospital stays and worsened clinical and functional outcomes. These complications can delay early mobilization (EM) programs and exercise as core components of post-CS rehabilitation even though sometimes they fail to prevent functional decline.

Potential blood biomarkers that can be used as prognosticators of spontaneous intracerebral hemorrhage: A systematic review and meta-analysis.

Background: Predicting nontraumatic spontaneous intracerebral hemorrhage (SICH) patient prognosis has been commonly practiced, particularly when providing informed consent and considering surgical treatment. Biomarkers might provide more real-time evaluation of SICH patients' condition than clinical prognostic scoring systems. This study aimed to evaluate the reliability of blood biomarkers in predicting prognosis in SICH patients by systematic review and meta-analysis.

High Rates of "Watch" and "Reserve" Class Antibiotics Used to Treat Infections in Neonates and Infants in Southeast Asia.

We evaluated antibiotic prescribing practices for neonates and infants hospitalized with infections in resource-constrained healthcare settings, where antimicrobial resistance is responsible for significant neonatal morbidity and mortality. A point prevalence survey of 667 admitted infants across 10 clinical sites in Southeast Asia revealed a total of 405 antibiotics were prescribed to 218 infants, with high use of World Health Organization-classified "Watch," "Reserve" and "Not Recommended" antibiotics.

Emerging malaria in Indonesia: An overview of infections.

Background: , the fifth malaria-causing parasite species, is currently changing the landscape of the most dominant malaria-causing species in the Southeast Asia by becoming the emerging significant cause of malaria in the region, including in Indonesia. This study aimed to provide an overview of malaria caused by in Indonesia.

Methods: This study utilized secondary data from the Indonesian National Referral Malaria Laboratory from 2011 to 2020 for the analysis.

Early rhythm control compared to rate control in atrial fibrillation - A systematic review, meta-analysis, and meta-regression.

Background: This meta-analysis aimed to compare the effectiveness of early rhythm control to rate control, and whether catheter ablation derived more benefit compared to other methods of rhythm control.

Methods: A comprehensive literature search was conducted on PubMed, SCOPUS, and EuropePMC up to July 2, 2024. The primary outcome of this study was major adverse cardio-cerebrovascular events (MACCE), defined as a composite of mortality, stroke/systemic embolism, heart failure hospitalization (HFH), and acute coronary syndrome (ACS) during the follow-up period.

Global Andrology Forum Clinical Practice Guidelines on the Management of Premature Ejaculation.

Purpose: Premature ejaculation (PE) is a commonly encountered male sexual dysfunction (MSD) with various definitions, diagnostic criteria, and treatment options, leading to significant heterogeneity and controversy in its management. This study aimed to explore the global practice patterns of the diagnosis and management of PE.

Materials And Methods: A cross-sectional, global, online survey on PE was conducted using a questionnaire developed by an international cohort of experts.

Pregnancies in women after peri-partum cardiomyopathy: the global European Society of Cardiology EuroObservational Research Programme Peri-Partum Cardiomyopathy Registry.

Background And Aims: The risk of heart failure progression or mortality in patients with peri-partum cardiomyopathy (PPCM) during subsequent pregnancies (SSPs) is a significant concern for patients, their families, and healthcare providers. However, there is limited contemporary, prospective data on SSP outcomes in PPCM patients from diverse ethnic and sociodemographic groups. This study aimed to assess maternal and neonatal outcomes in PPCM patients undergoing SSPs.

Anemia, Hyperglycemia, and Reduced Left Ventricular Ejection Fraction Improve the GRACE Score's Predictability for In-hospital Mortality in Acute Coronary Syndrome; Single-Centre Cross-Sectional Study.

Purpose: This study investigates the predictive value of incorporating anemia, hyperglycemia, and left ventricular ejection fraction (LVEF) into the Global Registry of Acute Coronary Events (GRACE) score for in-hospital mortality in Acute Coronary Syndrome (ACS).

Patients And Methods: We conducted a single-center, cross-sectional study involving 634 ACS patients admitted to Dr. Hasan Sadikin General Hospital between 2021 and 2023.

Comparison of Platelet Indices, Lymphocyte, and Systemic Inflammation Indices on Days 1 and 8 in Surviving and Non-Surviving COVID-19 Patients at Hasan Sadikin General Hospital, Bandung, Indonesia.

Purpose: This study aimed to compare platelet count, platelet indices, lymphocyte, and systemic inflammation indices between surviving and non-surviving COVID-19 patients, measured at admission and on the eighth day of hospitalization.

Patients And Methods: A retrospective cohort study was conducted on COVID-19 patients hospitalized at Hasan Sadikin General Hospital, Bandung, from March to December 2020. Patient characteristics and laboratory data were sourced from medical records and the Clinical Pathology Laboratory.

Anterior urethral hamartoma in a female infant with anorectal malformation: A rare case report and literature review.

Introduction And Importance: Urethral hamartoma is highly unusual, as documented in the literature with only one case that ever reported. Here, we report a case of female infant with urethral hamartoma and anorectal malformation.

Case Presentation: An 8 months old female infant was previously diagnosed with anorectal malformation (ARM) with rectovestibular fistula that had underwent colostomy.

Correlation of ferritin and glutathione peroxidase 4 (GPX4) level as a marker of ferroptosis process in endometrioma.

Endometriosis is a chronic inflammatory disease characterized by the presence of endometrial-like tissues (glands and stroma) located outside the uterine cavity. The pathophysiology of this condition remains incompletely understood. Local bleeding and inflammation within endometriosis lesions, which occur in an environment rich in iron, reactive oxygen species (ROS), and free radicals, can disturb the balance of iron within the peritoneal cavity.

Chondroblastoma with secondary aneurysmal bone cyst of the diaphyseal ulna: A rare case report.

Chondroblastomas are rare benign cartilaginous neoplasms that primarily affect young patients. Aneurysmal bone cysts (ABCs) are also rare, accounting for 1-2% of all bone tumors, and can arise either idiopathically or as secondary lesions associated with other tumors, such as giant cell tumors or chondroblastomas. Here, we present a rare case of a secondary aneurysmal bone cyst arising in conjunction with a chondroblastoma located in the left diaphysis of the ulna.

Assessing the validity and reliability of the Indonesian version of Patient-Reported Outcomes Measurement Information System (PROMIS) Global Health Scale v1.2.

Background: The assessment of Health-Related Quality of Life (HRQoL) is essential in clinical outcomes, focusing on the subjective perception of individuals regarding the physical, mental, and social aspects of health status. However, conducting a large-scale HRQoL assessment poses various challenges that necessitate the development of a non-burdensome instrument. One promising solution is adapting Patient-Reported Outcomes Measurement Information System (PROMIS) Global Health Scale v1.

Chronic moderate‑intensity exercise can induce physiological hypertrophy in aged cardiomyocytes through autophagy, with minimal Yap/Taz involvement.

Aging is known to cause increased comorbidities associated with cardiovascular decline. Physical exercises were known to be an effective intervention for the age-associated decline in cardiac function. Exercise caused physiological hypertrophy influenced by Yap/Taz, autophagy and myosin heavy chain (MHC) dynamics.