Interleukin-1 gene polymorphisms and chronic periodontitis in adult whites: a systematic review and meta-analysis.

Background: Interleukin-1 (IL-1) gene polymorphisms have been associated with increased levels of inflammatory mediators and several inflammatory diseases. Periodontitis is a bacterially induced chronic inflammatory disease that destroys the connective tissues and bone that support the teeth, affects substantial numbers of adults, and has been implicated as a contributing factor in systemic diseases. IL-1 gene polymorphisms, most prominently IL1A (-889), IL1A (+4845), and IL1B (+3954), have been associated with chronic periodontitis (CP) in whites.

BMP2 signaling in bone development and repair.

BMPs are best known for their actions as bone formation signals. Recent studies using transgenic mice in which individual osteogenic BMPs have been removed from the limb skeleton have identified BMP2 as a fundamental component of the inherent regenerative capacity of bone. This review summarizes current findings on the specific requirement for BMP2 in bone formation and repair.

Clinical results using recombinant human platelet-derived growth factor and mineralized freeze-dried bone allograft in periodontal defects.

Human studies have demonstrated the safety and effectiveness of highly purified recombinant human platelet-derived growth factor-BB (rhPDGF-BB) in combination with osteoconductive matrices for the treatment of moderate to severe periodontal intrabony defects. These study results, together with binding and release characteristics for rhPDGF-BB with different matrices, provide clear evidence that demineralized freeze-dried bone allograft and beta-tricalcium phosphate (beta-TCP) each can be combined with rhPDGF-BB to promote significant improvements in clinical, radiographic, and histologic parameters. The purpose of the current case series was to determine the clinical and radiographic regenerative potential of rhPDGF-BB-enhanced mineralized freeze-dried bone allograft (FDBA) for the treatment of severe periodontal intrabony defects.

Paracetamol is an effective drug to use for pain following oral surgery.

Data Source: Studies were identified using the Cochrane trials registers of the Oral Health Group and of the Pain, Palliative and Supportive Care Group, along with the Cochrane Central Register of Controlled Trials, Medline, Embase and the Current Controlled Trials Register. Handsearching included several dental journals as well as the bibliographies of relevant clinical trials and review articles for studies outside the journals searched by hand. Authors of the randomised controlled trials (RCT) identified and manufacturers of analgesic pharmaceuticals were contacted in an attempt to identify unpublished or ongoing RCT.

Predictors of dental implant survival.

Purpose: To summarize dental implant survival rates under a variety of clinical conditions and identify prognostic variables associated with implant survival.

Materials/methods: The articles reviewed in this paper were designed as retrospective cohort studies and composed of three subject cohorts having implants placed between 1992 and 2003. The prognostic variables were categorized as demographic/health status, anatomic, implant-specific, prosthetic, and perioperative/operative.

A study of the fate of the buccal wall of extraction sockets of teeth with prominent roots.

The objective of this investigation was to determine the fate of thin buccal bone encasing the prominent roots of maxillary anterior teeth following extraction. Resorption of the buccal plate compromises the morphology of the localized edentulous ridge and makes it challenging to place an implant in the optimal position for prosthetic restoration. In addition, the use of Bio-Oss as a bone filler to maintain the form of the edentulous ridge was evaluated.

Dyskeratosis congenita vs. chronic graft versus host disease: report of a case and a review of the literature.

Dyskeratosis congenita (DC) is a rare inherited bone marrow failure syndrome characterized by the triad of reticular pigmentation of the skin, nail dystrophy, and mucosal leukoplakia. DC is often associated with severe pancytopenia, and bone marrow failure is the principal cause of early mortality. Malignant transformation of mucosal leukoplakias may also occur.

Short-term clinical outcomes and patient compliance with temporomandibular disorder treatment recommendations.

Aims: To evaluate short-term patient compliance with 5 conservative temporomandibular disorder (TMD) treatments (jaw relaxation, jaw stretching, heat application, cold application, and occlusal splint use) and the association of compliance with changes in pain intensity, pain-related activity interference, and jaw use limitations.

Methods: Eighty-one TMD patients were given 1 to 5 treatment recommendations as part of usual care in a TMD specialty clinic. Compliance with each recommendation and pain, pain-related activity interference, and jaw use limitation measures were calculated from electronic interviews conducted 3 times daily for 2 weeks.

Oral mucosal pigmentation secondary to minocycline therapy: report of two cases and a review of the literature.

Minocycline is a semisynthetic broad-spectrum antimicrobial agent that was first introduced into clinical practice in 1967. The most common use of minocycline is for the long-term treatment of acne vulgaris. A well-recognized side effect of minocycline treatment is pigmentation, which has been reported in multiple tissues and fluids including thyroid, skin, nail beds, sclera, bone, and teeth.

Leukoplakia and intraoral malignancies: female cases increase in Greece.

Unlabelled: In the developed world, intraoral malignancies are more frequent in males than females. Recent observations from Greece suggest that the number of females is increasing.

Aim: The present study investigates gender and age statistics among subjects with cancers of the mouth or leukoplakia.

Locally aggressive solitary fibrous tumor in the infraorbital region: a case report and review of the literature.

We describe a case of a soft tissue neoplasm in the infraorbital region of a 31-year-old African-American man that met histologic and immunohistochemical criteria for solitary fibrous tumor. This uncommon spindle cell neoplasm was first described in the pleura, but it has since been reported in many other soft tissue locations. The lesion was locally aggressive and successfully treated by local excision.

Development of a clindamycin-impregnated fiber as an intracanal medication in endodontic therapy.

The effectiveness of traditional endodontic intracanal medications in reducing bacterial numbers and preventing acute flare-ups and pain continues to be questioned. In the present study, a new local delivery device was developed that releases a substantive dose of clindamycin into root canals. Clindamycin-impregnated ethylene vinyl acetate (EVA) fibers were produced, and the sensitivity of common endodontic microbes to the fibers were established.

Intragenic mutation analysis of the human epidermal growth factor receptor (EGFR) gene in malignant human oral keratinocytes.

Alteration in epidermal growth factor receptor (EGFR) expression is frequently associated with malignant transformation of epithelial tissues, including oral mucosa. This study examines the mutations in the coding region of the human EGFR gene in normal and malignant human oral keratinocytes. To examine the intragenic mutations in the human EGFR gene, a panel of normal and malignant human oral keratinocytes were examined by a nonisotopic RNase cleavage assay.

Obstructive sleep apnea: oral appliance therapy and severity of condition.

Objective: The purpose of this study was to determine whether an oral appliance can effectively treat severe obstructive sleep apnea.

Design: The study was conducted at a tertiary care military facility with an accredited sleep laboratory. Results of the treatment of the first 25 patients with obstructive sleep apnea referred for oral appliance therapy were retrospectively analyzed.

About dentinal hypersensitivity.

This article summarizes the concepts that are believed to cause dentinal hypersensitivity. It is no longer necessary and may not be feasible to obliterate dentinal tubules to obtain relief from the pain caused by dentinal hypersensitivity. In-office agents that obliterate the dentinal tubules may provide initial relief of pain, but they can impede the flow of potassium and nitrate ions toward the pulp and diminish the long-term beneficial effects seen with the routine use of potassium nitrate dentifrices.

Heat-tempered composite resin laminate veneers.

Laminate veneers have rapidly become the restoration of choice for the conservative esthetic restoration of anterior teeth. The historical development of the process for veneering teeth is presented, and the significant advancements since the introduction of the concept nearly 60 years ago are highlighted. Heat-tempered composite resin laminate veneers are evaluated, including their advantages and disadvantages relative to bonded porcelain veneers.