A Four-Component Framework Toward Patient-Centered, Integrated Mental Healthcare in Kenya.

How can we fast-track the global agenda of integrated mental healthcare in low- and middle-income countries (LMICs) such as Kenya? This is a question that has become increasingly important for individuals with lived experiences, policymakers, mental health advocates and health care providers at the local and international levels. This narrative synthesis and perspective piece encompasses an overview of mental health care competencies, best practices and capacity building needed to fast track patient responsive services. In that vein we also review key policy developments like UHC to make a case for fast-tracking our four-step framework.

BORIS promotes chromatin regulatory interactions in treatment-resistant cancer cells.

The CCCTC-binding factor (CTCF), which anchors DNA loops that organize the genome into structural domains, has a central role in gene control by facilitating or constraining interactions between genes and their regulatory elements. In cancer cells, the disruption of CTCF binding at specific loci by somatic mutation or DNA hypermethylation results in the loss of loop anchors and consequent activation of oncogenes. By contrast, the germ-cell-specific paralogue of CTCF, BORIS (brother of the regulator of imprinted sites, also known as CTCFL), is overexpressed in several cancers, but its contributions to the malignant phenotype remain unclear.

Intrinsic and instrumental perspectives to sanitation.

Public health interventions are often implemented because they are a means to an end. For example, improving population-level health outcomes is a key step towards improving social and economic outcomes, too. But what is often overlooked is the fact that a given public health intervention might be the end in itself.

Psychometric properties of the Ndetei-Othieno-Kathuku (NOK) Scale: A mental health assessment tool for an African setting.

Background: Research suggests that psychiatric conditions in children and adolescents are highly debilitating, with sparse resources for assessment and treatment in low- and middle-income countries (LMICs).

Objectives: The primary aim of this study was to evaluate the reliability, validity, and latent factor structure of an ethnographically-grounded assessment instrument for detecting common mental health complaints among rural Kenyan children and adolescents.

Methods: The Ndetei-Othieno-Kathuku Scale (NOK) was delivered to 2 282 children aged 10 to 18 years old.