1 results match your criteria: "Harvard T.H. Chan School of Public Health (K.J.[Affiliation]"
Trial of the MIND Diet for Prevention of Cognitive Decline in Older Persons.
N Engl J Med
August 2023
From Rush Alzheimer's Disease Center (L.L.B., P.A., S.Z., F.G., N.T.A., K.A.), the Department of Neurology (L.L.B., N.T.A.), Rush Institute for Healthy Aging (K.D., X.L., C.S.H., T.M.H.), and the Departments of Internal Medicine (K.D., X.L., C.S.H., P.A., F.G., T.M.H., M.C.M.), Clinical Nutrition (J.V., P.A., C.C.T.), Preventive Medicine (J.V., C.C.T.), and Diagnostic Radiology and Nuclear Medicine (K.A.), Rush University Medical Center, and the Department of Biomedical Engineering, Illinois Institute of Technology (K.A.) - all in Chicago; and Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital (V.J.C., N.L., B.J.S., X.R.), Harvard Medical School (V.J.C., N.L., B.J.S., X.R.), and the Department of Nutrition, Harvard T.H. Chan School of Public Health (K.J., L.B., F.M.S.) - all in Boston.
Background: Findings from observational studies suggest that dietary patterns may offer protective benefits against cognitive decline, but data from clinical trials are limited. The Mediterranean-DASH Intervention for Neurodegenerative Delay, known as the MIND diet, is a hybrid of the Mediterranean diet and the DASH (Dietary Approaches to Stop Hypertension) diet, with modifications to include foods that have been putatively associated with a decreased risk of dementia.
Methods: We performed a two-site, randomized, controlled trial involving older adults without cognitive impairment but with a family history of dementia, a body-mass index (the weight in kilograms divided by the square of the height in meters) greater than 25, and a suboptimal diet, as determined by means of a 14-item questionnaire, to test the cognitive effects of the MIND diet with mild caloric restriction as compared with a control diet with mild caloric restriction.