7 results match your criteria: "Harvard Medical School Boston 02115[Affiliation]"
Am J Transl Res
August 2022
Department of Neurosurgery, Brigham and Women's Hospital, Harvard Medical School Boston 02115, MA, USA.
Am J Nucl Med Mol Imaging
October 2021
Department of Radiology, Hospital of The University of Pennsylvania Philadelphia 19104, PA, USA.
Alzheimer's disease (AD) is the most prevalent neurodegenerative condition. The definitive diagnosis of AD remains a post-mortem neuropathological study of the brain. Unfortunately, there are no established diagnostic criteria to achieve an accurate diagnosis of AD in a similarly objective fashion among living patients.
View Article and Find Full Text PDFAm J Transl Res
August 2019
Department of Neurosurgery, Nanjing First Hospital, Nanjing Medical University Nanjing 210006, Jiangsu, China.
Long non-coding RNAs (lncRNAs) have great value in research on tumour targeted therapy, including for glioma. In the present study, we investigated the role of the lncRNA deleted in lymphocytic leukaemia 2 (lncRNA-DLEU2) in glioma. First, we found that lncRNA-DLEU2 is highly expressed in glioma tissues and cell lines.
View Article and Find Full Text PDFAm J Transl Res
July 2018
Department of Anesthesiology, Perioperative & Pain Medicine, Brigham and Women's Hospital, Harvard Medical School Boston 02115, MA.
Sepsis is a major cause of death in intensive care units. The purpose of this study was to investigate the effect of resveratrol (RSV) on sepsis-induced acute lung injury (ALI). The underlying molecular mechanisms were deciphered by both and experiments.
View Article and Find Full Text PDFAm J Transl Res
June 2018
Department of Neurosurgery, Brigham and Women's Hospital, Harvard Medical School Boston 02115, Massachusetts, USA.
Nuclear receptor-related factor 1 (Nurr1) has a crucial role in the development and maturation of mesencephalic dopamine (DA) neurons and also plays a protective role in maintenance of DA neurons by inhibiting the activation of microglia and astrocyte. Moreover, the mutations in Nurr1 gene are associated with familial Parkinson's disease (PD), suggested that Nurr1 modulation is a potential therapeutic target for PD. This study examines the therapeutic effects of transplantation of Nurr1 gene-modified bone marrow mesenchymal stem cells (MSCs) on 6-hydroxydopamine (6-OHDA)-induced PD rat models.
View Article and Find Full Text PDFAm J Transl Res
June 2016
Department of Neurosurgery, The First Affiliated Hospital of Chongqing Medical University Chongqing 400016, China.
The aim of the present study was to investigate the effects of perfluorooctyl-bromide (PFOB) nanoparticles on hypoxia-inducible factor 1 alpha (HIF-1α) and its downstream target genes in early brain injury (EBI) after subarachnoid hemorrhage (SAH). Healthy male Sprague Dawley rats (n=100) were randomly divided into five groups: Sham, SAH, SAH + vehicle, SAH + 5 mg/kg PFOB and SAH + 10 mg/kg PFOB. A rat model of SAH was created by endovascular perforation, and PFOB treatment (5 mg/kg or 10 mg/kg injected into the caudal vein) was initiated 1 h after SAH.
View Article and Find Full Text PDFInt J Clin Exp Pathol
September 2015
Department of Urology, Shengjing Hospital of China Medical University Shenyang, Liaoning 110004, P. R. China.
Purpose: This study aimed to evaluate the expression of DNA methyltransferase (DNMT) family proteins in renal cell carcinoma (RCC) and to assess the clinical significance and prognostic value of their expression patterns.
Methods: A total of 97 renal cell carcinoma and 52 no-tumor tissues were recruited for immunohistochemical analysis of their expression.
Results: DNMT1, DNMT3A and DNMT3B proteins were highly expressed in clear cell RCC, papillary RCC and chromophobe RCC tissues than that of no-tumor tissues (all P < 0.