5 results match your criteria: "Harvard Medical School 149[Affiliation]"

Insights into auto--fatty acylation: targets, druggability, and inhibitors.

RSC Chem Biol

December 2021

Cutaneous Biology Research Center, Massachusetts General Hospital, Harvard Medical School 149, 13th St. Charlestown MA 02129 USA

Posttranslational -fatty acylation (or -palmitoylation) modulates protein localization and functions, and has been implicated in neurological, metabolic, and infectious diseases, and cancers. Auto--fatty acylation involves reactive cysteine residues in the proteins which directly react with fatty acyl-CoA through thioester transfer reactions, and is the first step in some palmitoyl acyltransferase (PAT)-mediated catalysis reactions. In addition, many structural proteins, transcription factors and adaptor proteins might possess such "enzyme-like" activities and undergo auto--fatty acylation upon fatty acyl-CoA binding.

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Fluorescent nanodiamond - hyaluronate conjugates for target-specific molecular imaging.

RSC Adv

June 2021

Department of Materials Science and Engineering, Pohang University of Science and Technology (POSTECH) 77 Cheongam-ro, Nam-gu, Pohang Gyeongbuk KR 37673 Korea +82 54 279 2399 +82 54 279 2159.

Despite wide investigation on molecular imaging contrast agents, there are still strong unmet medical needs to enhance their signal-to background ratio, brightness, photostability, and biocompatibility with multimodal imaging capability. Here, we assessed the feasibility of fluorescent nanodiamonds (FNDs) as carbon based photostable and biocompatible materials for molecular imaging applications. Because FNDs have negatively charged nitrogen vacancy (NV) centers, they can emit bright red light.

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1H chemical shift magnetic resonance imaging probes with high sensitivity for multiplex imaging.

Contrast Media Mol Imaging

July 2012

A.A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Harvard Medical School 149, 13th Street, Suite 2301, Charlestown, MA 02129, USA.

Proton-based chemical shift imaging probes were encapsulated inside nano-carriers to increase the sensivitity of the reporters. Co-encapsulation with a relaxation agent results in improved sensitivity and suppresses background signals. Simultaneous imaging of different chemical shift reporters allows multiplexed detection.

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Presence of irritability during depressive episodes in bipolar disorder.

CNS Spectr

March 2004

Department of Psychiatry, Psychiatric Neuroscience Program and Bipolar Research Program, Harvard Medical School 149-2611, Massachusetts General Hospital Bldg. 149, 13th Street, Charlestown, MA 02129, USA.

Background: This study examined the prevalence of irritability in patients with bipolar I disorder during an episode of Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition (DSM-IV) major depression who do not meet criteria for a mixed episode.

Method: A chart review of 111 patients with bipolar I disorder treated at the Massachusetts General Hospital Bipolar Clinic between 1998 and 2000 identified 34 patients who met criteria for a DSM-IV major depressive episode in the absence of (1) mood elevation and/or (2) irritability associated with any additional above threshold DSM-IV symptoms of mania. Data gathered from the charts utilized prospective ratings made routinely at each clinic visit using the Clinical Monitoring Form (CMF), a structured assessment instrument which includes modified versions of the mood modules of the Structured Clinical Interview for DSM-IV.

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Immune reconstitution in HIV infection and its relationship to cancer.

Hematol Oncol Clin North Am

June 2003

AIDS Research Center, Massachusetts General Hospital, Harvard Medical School 149, 13th Street, Room 5212, Boston, MA 02109, USA.

HIV infection results in formidable immune dysfunction, widely affecting the immune system, but typified by T lymphopenia. This dysfunction includes a perturbed immune response to several persistent viruses that have a propensity to cause tumors. Effective control of HIV replication by highly active antiretroviral therapy (HAART) results in regeneration of the damaged immune system, and recent advances have allowed this immune reconstitution to be better defined.

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