48 results match your criteria: "Harvard Medical School (J.P.M.) - all in Boston; and Bluebird Bio[Affiliation]"
Subcutaneous and Visceral Adipose Tissue Reference Values From the Framingham Heart Study Thoracic and Abdominal CT.
Invest Radiol
July 2024
From the Division of Thoracic Imaging and Intervention, Department of Radiology, Massachusetts General Hospital, Boston, MA (J.P.M., P.E.T., A.G., F.J.F.); Harvard Medical School, Boston, MA (J.P.M., N.D.M., E.J.S., D.P.K., F.J.F.); Klinik und Poliklinik für Neurologie, Kopf- und Neurozentrum, University Medical Center Hamburg-Eppendorf, Hamburg, Germany (J.P.M.); Department of Radiology and Nuclear Medicine, University Hospital Schleswig-Holstein, Lübeck, Germany (P.E.T.); Department of Radiology, Massachusetts General Hospital, Boston, MA (N.D.M.); Center for Advanced Orthopaedic Studies, Beth Israel Deaconess Medical Center, Boston, MA (B.A., M.L.B.); Department of Orthopedic Surgery, Harvard Medical School, Boston, MA (M.L.B.); Endocrine Division, Massachusetts General Hospital, Boston, MA (M.L.B.); Hinda and Arthur Marcus Institute for Aging Research, Hebrew SeniorLife, Boston, MA (E.J.S., D.P.K.); and Department of Medicine, Beth Israel Deaconess Medical Center, Boston, MA (E.J.S., D.P.K.).
Article Synopsis
- Computed tomography (CT) measures subcutaneous and visceral adipose tissue (SAT and VAT), and this study aims to provide reference values specific to age, sex, and vertebral levels for these metrics.
- The research analyzed data from the Framingham Heart Study, including nearly 15,000 measurements from over 3700 participants, focusing on how VAT and SAT change with age and differ between genders.
- Results showed that VAT increases significantly with age, especially in males, while the ratio of VAT to SAT also increases, and the findings are available through an online tool for further reference.
Whole blood resuscitation for injured patients requiring transfusion: A systematic review, meta-analysis, and practice management guideline from the Eastern Association for the Surgery of Trauma.
J Trauma Acute Care Surg
September 2024
From the Divisions of Trauma, Surgical Critical Care, and Burns, DeWitt Daughtry Family Department of Surgery (J.P.M.), University of Miami Miller School of Medicine; Ryder Trauma Center (J.P.M.), Jackson Memorial Hospital, Miami, Florida; Department of Surgery (B.A.C.), McGovern Medical School, University of Texas Health Science Center at Houston; Red Duke Trauma Institute (B.A.C.), Memorial Hermann Hospital, Houston, Texas; Orlando Health Medical Group (R.A.L.), Orlando, Florida; Department of Surgery (L.M.K., A.M., C.A.), Yale School of Medicine, New Haven, Connecticut; Department of Surgery (J.M.L.), University of California, Davis, Sacramento; United States Air Force (J.M.L.), Travis Air Force Base, California; Burnett School of Medicine (N.R., J.J.F.), Texas Christian University, Fort Worth, Texas; Brigham and Women's Hospital (J.G.); Department of Surgery (J.G.), Harvard Medical School, Boston, Massachusetts; Louis Calder Memorial Library (J.M.R.), University of Miami Miller School of Medicine, Miami, Florida; Department of Surgery (K.L.H.), Duke University School of Medicine, Durham, North Carolina; and Inova Fairfax (G.K.), Falls Church, Virginia.
Introduction: Whole blood (WB) resuscitation has reemerged as a resuscitation strategy for injured patients. However, the effect of WB-based resuscitation on outcomes has not been established. The primary objective of this guideline was to develop evidence-based recommendations on whether WB should be considered in civilian trauma patients receiving blood transfusions.
View Article and Find Full Text PDFAcute pulmonary injury in hematology patients supported with pathogen-reduced and conventional platelet components.
Blood Adv
May 2024
Scientific Affairs, Cerus Corporation, Concord, CA.
Patients treated with antineoplastic therapy often develop thrombocytopenia requiring platelet transfusion, which has potential to exacerbate pulmonary injury. This study tested the hypothesis that amotosalen-UVA pathogen-reduced platelet components (PRPCs) do not potentiate pulmonary dysfunction compared with conventional platelet components (CPCs). A prospective, multicenter, open-label, sequential cohort study evaluated the incidence of treatment-emergent assisted mechanical ventilation initiated for pulmonary dysfunction (TEAMV-PD).
View Article and Find Full Text PDFLong-Term Outcomes of Cardiac Resynchronization Therapy in Patients With Repaired Tetralogy of Fallot: A Multicenter Study.
Circ Arrhythm Electrophysiol
March 2024
Department of Cardiology, Erasmus Medical Center, Rotterdam , The Netherlands (N.L.R.M., N.M.S.d.G.).
Background: A growing number of patients with tetralogy of Fallot develop left ventricular systolic dysfunction and heart failure, in addition to right ventricular dysfunction. Although cardiac resynchronization therapy (CRT) is an established treatment option, the effect of CRT in this population is still not well defined. This study aimed to investigate the early and late efficacy, survival, and safety of CRT in patients with tetralogy of Fallot.
View Article and Find Full Text PDFTREX1 Inactivation Unleashes Cancer Cell STING-Interferon Signaling and Promotes Antitumor Immunity.
Cancer Discov
May 2024
Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts.
Unlabelled: A substantial fraction of cancers evade immune detection by silencing Stimulator of Interferon Genes (STING)-Interferon (IFN) signaling. Therapeutic reactivation of this program via STING agonists, epigenetic, or DNA-damaging therapies can restore antitumor immunity in multiple preclinical models. Here we show that adaptive induction of three prime exonuclease 1 (TREX1) restrains STING-dependent nucleic acid sensing in cancer cells via its catalytic function in degrading cytosolic DNA.
View Article and Find Full Text PDFPost-acute sequelae of SARS-CoV-2 (PASC) is a significant public health concern. We describe Patient Reported Outcomes (PROs) on 590 participants prospectively assessed from hospital admission for COVID-19 through one year after discharge. Modeling identified 4 PRO clusters based on reported deficits (minimal, physical, mental/cognitive, and multidomain), supporting heterogenous clinical presentations in PASC, with sub-phenotypes associated with female sex and distinctive comorbidities.
View Article and Find Full Text PDFEffects of Cooking with Liquefied Petroleum Gas or Biomass on Stunting in Infants.
N Engl J Med
January 2024
From the Division of Pulmonary and Critical Care (W.C., S.H., K.N.W., L.N.), the Johns Hopkins Center for Global Non-Communicable Disease Research and Training (W.C., S.H., K.N.W., L.N., E.D.M.), the Eudowood Division of Pediatric Respiratory Sciences, School of Medicine (E.D.M.), and the Program in Global Disease Epidemiology and Control, Department of International Health, Bloomberg School of Public Health (W.C., L.H.M., E.D.M.), Johns Hopkins University, Baltimore, and Fogarty International Center, National Institutes of Health, Bethesda (J.R.) - both in Maryland; Nell Hodgson Woodruff School of Nursing (L.M.T.) and the Hubert Department of Global Health (S.S.S., U.R.), the Gangarosa Department of Environmental Health (K.S., T.F.C.), and the Department of Biostatistics and Bioinformatics (H.H.C., L.W., J.W., S.J., Y.C.), Rollins School of Public Health, Emory University, Atlanta, and the Departments of Epidemiology and Biostatistics (J.P.M.) and Environmental Health Science (L.P.N.), College of Public Health, University of Georgia, Athens - both in Georgia; the Faculty of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London (G.R.), and Nuffield Department of Women's and Reproductive Health, University of Oxford, Oxford (A.T.P.) - both in the United Kingdom; Eagle Research Center, Kigali, Rwanda (A.M., F.N.); the Center for Health Studies, Universidad del Valle de Guatemala, Guatemala City, Guatemala (J.P.M., A.D.-A.); the Indian Council of Medical Research Center for Advanced Research on Air Quality, Climate, and Health, Department of Environmental Health Engineering, Sri Ramachandra Institute of Higher Education and Research, Chennai, India (K.B., S.S.G., G.T., V.A.); the Latin American Center of Excellence in Climate Change and Health, Universidad Peruana Cayetano Heredia (S.M.H.), and the Biomedical Research Unit, Asociación Benéfica Prisma (M.C.) - both in Lima, Peru; the Department of Global Health and Population, Harvard T.H. Chan School of Public Health, Boston (M.A.K.); Berkeley Air Monitoring Group (M.J.) and the Division of Environmental Health Sciences, University of California at Berkeley (A.P.) - both in Berkeley; the Cardiovascular Imaging and Clinical Research Core Laboratory, Department of Medicine, Washington University in St. Louis, St. Louis (L.J.U., V.G.D.-R.); and the Department of Environmental and Radiological Health Sciences, Colorado State University, Fort Collins (J.L.P.).
Article Synopsis
- Household air pollution from biomass cooking fuels may contribute to stunted growth in infants, raising questions about whether switching to cleaner liquefied petroleum gas (LPG) can help reduce this risk.
- A randomized trial with 3200 pregnant women in low- and middle-income countries was conducted, comparing the impact of using LPG cookstoves against traditional biomass cookstoves on infant growth at 12 months old.
- Results showed that the intervention group using LPG had significantly lower exposure to fine particulate matter and a stunting rate of 27.4%, while the control group had a slightly higher stunting rate of 25.2%, indicating a potential benefit of switching to LPG.
Liquefied Petroleum Gas or Biomass Cooking and Severe Infant Pneumonia.
N Engl J Med
January 2024
From the Global Program in Pediatric Respiratory Sciences, Eudowood Division of Pediatric Respiratory Sciences (E.D.M.), the Division of Pulmonary and Critical Care (S.H., S.M.S., D.G.-P., S.M.H., K.N.W., L.N., W.C.), and the Center for Global Non-Communicable Disease Research and Training, School of Medicine (S.H., S.M.S., D.G.-P., S.M.H., K.N.W., L.N., W.C.), and the Department of International Health (E.D.M.) and the Program in Global Disease Epidemiology and Control, Department of International Health (L.H.M.), Bloomberg School of Public Health, Johns Hopkins University, Baltimore, the Division of Healthcare Delivery Research, MedStar Health Research Institute, Hyattsville (S.M.S.), and Fogarty International Center, National Institutes of Health, Bethesda (J.P.R.) - all in Maryland; the Global Health Institute, Department of Epidemiology and Biostatistics (J.P.M., L.M.G.), and the Department of Environmental Health Science, College of Public Health (L.P.N.), University of Georgia, Athens, and the Department of Biostatistics and Bioinformatics (H.H.C., L.A.W., S.J., J.W., Y.C.) and the Gangarosa Department of Environmental Health (A.E.L., K.S., T.F.C.), Rollins School of Public Health, and the Nell Hodgson Woodruff School of Nursing (L.M.T.), Emory University, Atlanta - both in Georgia; the Center for Health Studies, Universidad del Valle de Guatemala, Guatemala City (J.P.M., L.M.G., A.C., A.D.-A.); the Department of Global Health and Population, Harvard T.H. Chan School of Public Health, Boston (M.A.K.); the Division of Pulmonary and Critical Care Medicine, Georgetown University, Washington DC (S.M.S.); the Department of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London (G.R.), and Nuffield Department of Women's and Reproductive Health, University of Oxford, Oxford (A.T.P.) - both in the United Kingdom; Eagle Research Center, Kigali, Rwanda (A.M.); the Indian Council of Medical Research Center for Advanced Research on Air Quality, Climate and Health, Department of Environmental Health Engineering, Sri Ramachandra Institute for Higher Education and Research, Chennai, India (K.B., G.T., S.S.G.); the Global Health Center, Institute for Public Health and Cardiovascular Division, Department of Medicine, Washington University, St. Louis, MO (V.G.D.-R., L.J.U.); the Division of Environmental Health Sciences, School of Public Health, University of California, Berkeley (A.P., W.Y.), and Berkeley Air Monitoring Group (M.A.J.) - both in Berkeley, CA; and the Department of Environmental and Radiological Health Sciences, Colorado State University, Fort Collins (J.L.P.).
Article Synopsis
- * Conducted between May 2018 and September 2021, the trial involved 3,195 pregnant women who were randomly assigned to use either LPG stoves (intervention group) or biomass fuel (control group), and their children's exposure to air pollution was measured.
- * Results showed a slight reduction in severe pneumonia incidents among infants in the LPG group compared to the biomass group, but the difference was not statistically significant, suggesting that while LPG reduced air pollution exposure, it did not significantly lower pneumonia rates.
Time to Treat Severe Community-Acquired Pneumonia with Steroids?
N Engl J Med
May 2023
From the Department of Medicine, Massachusetts General Hospital and Harvard Medical School - both in Boston (J.P.M.); and Royal Perth Hospital and University of Western Australia - both in Perth, Australia (G.W.W.).
Probe-based bacterial single-cell RNA sequencing predicts toxin regulation.
Nat Microbiol
May 2023
IFF Health and Biosciences, Wilmington, DE, USA.
Clonal bacterial populations rely on transcriptional variation across individual cells to produce specialized states that increase fitness. Understanding all cell states requires studying isogenic bacterial populations at the single-cell level. Here we developed probe-based bacterial sequencing (ProBac-seq), a method that uses libraries of DNA probes and an existing commercial microfluidic platform to conduct bacterial single-cell RNA sequencing.
View Article and Find Full Text PDFMulti-ancestry genome-wide association analyses improve resolution of genes and pathways influencing lung function and chronic obstructive pulmonary disease risk.
Nat Genet
March 2023
Department of Population Health Sciences, University of Leicester, Leicester, UK.
Article Synopsis
- A major study involving 580,869 participants identified 1,020 genetic signals linked to lung function impairment, which is crucial in understanding chronic obstructive pulmonary disease (COPD) and predicting mortality.
- * The research found 559 genes related to lung function that were connected to 29 different biological pathways and demonstrated variations across ancestry, age, and smoking habits.
- * Findings suggest potential new targets for therapy by highlighting specific genetic variants and proteins, ultimately contributing to better understanding and treatment of COPD.
Interim Safety Profile From the Feasibility Study of the BrainGate Neural Interface System.
Neurology
March 2023
From the Center for Neurotechnology and Neurorecovery (CNTR) (D.B.R., L.B., S.S.C., C.G., R.M., M.M., L.R.H.), Department of Neurology, and Department of Neurosurgery (Z.M.W.), Massachusetts General Hospital, Boston; Harvard Medical School (D.B.R., S.S.C., L.R.H.), Boston, MA; Department of Biomedical Engineering (A.B.A., R.F.K.), Case Western Reserve University, Cleveland, OH; FES Center of Excellence, Rehab. R&D Service (A.B.A., R.F.K., J.P.M., J.A.S., B.L.W.), Louis Stokes Cleveland Department of Veterans Affairs Medical Center, OH; Center for Neurorestoration and Neurotechnology (CfNN) (M.B., J.P.D., J.D.S., L.R.H.), Rehabilitation R&D Service, Department of Veterans Affairs Medical Center, Providence, RI; Legs and Walking Lab (D.C.), Shirley Ryan AbilityLab, Chicago, IL; Department of Physical Medicine and Rehabilitation (D.C.), Northwestern University Feinberg School of Medicine, Rehabilitation Institute of Chicago, IL; Department of Neuroscience (J.P.D.), Robert J. and Nancy D. Carney Institute for Brain Science (J.P.D., J.D.S., L.R.H.), School of Engineering (J.P.D., J.D.S., L.R.H.), and Department of Rehabilitation Medicine (J.A.M.), Brown University, Providence, RI; Department of Neurological Surgery (E.N.E.), Montefiore Medical Center, Albert Einstein College of Medicine, Bronx, NY; European University of Cyprus (G.F.), Nicosia, Cyprus; Department of Neurosurgery (J.M.H.), Stanford University School of Medicine, CA; Wu Tsai Neurosciences Institute (J.M.H., K.V.S.), Bio-X Institute (J.M.H., K.V.S.), and Departments of Neurobiology (K.V.S.), Electrical Engineering (K.V.S.), and Bioengineering (K.V.S.), Stanford University, CA; Department of Neurological Surgery (R.F.K., J.P.M., J.A.S.), University Hospitals Case Medical Center, Cleveland, OH; Neurology Section (S.T.M.), VA Providence Health Care System, Providence, RI; Department of Neurology (S.T.M.), Alpert Medical School of Brown University, Providence, RI; Sargent Rehabilitation Center (J.A.M.), Warwick, RI; Section of Neurosurgery (R.D.P.), Department of Surgery, University of Chicago; Department of Neurosurgery (R.D.P.), Rush University Medical Center, Chicago, IL; Department of Neurology (J.S.), Barrow Neurological Institute, Phoenix, AZ; Howard Hughes Medical Institute at Stanford University (K.V.S.); Center for Neurological Restoration (B.L.W.), Cleveland Clinic, OH; and Program in Neuroscience (Z.M.W.), Harvard-MIT Program in Health Sciences and Technology, Harvard Medical School, Boston, MA.
Background And Objectives: Brain-computer interfaces (BCIs) are being developed to restore mobility, communication, and functional independence to people with paralysis. Though supported by decades of preclinical data, the safety of chronically implanted microelectrode array BCIs in humans is unknown. We report safety results from the prospective, open-label, nonrandomized BrainGate feasibility study (NCT00912041), the largest and longest-running clinical trial of an implanted BCI.
View Article and Find Full Text PDFGlobal Impact of the COVID-19 Pandemic on Stroke Volumes and Cerebrovascular Events: A 1-Year Follow-up.
Neurology
January 2023
From the Department of Neurology (T.N.N., P.K., Anvitha Sathya, H.C.L., Andreas Charidimou, Judith Clark, S.K.F., J.R.R.), Boston Medical Center, Boston University Chobanian & Avedisian School of Medicine; Department of Radiology (T.N.N., M.M.Q., P.K., Mohamad Abdalkader, Anvitha Sathya, H.C.L., N.L.K.), Boston Medical Center, Boston University Chobanian & Avedisian School of Medicine; Department of Radiation Oncology (M.M.Q.), Boston Medical Center, Boston University Chobanian & Avedisian School of Medicine; Department of Stroke Neurology (H.Y.), National Hospital Organization, Osaka National Hospital, Japan; Department of Neurology (R.M., Petra Sedova), International Clinical Research Centre, St Anne's University Hospital and Faculty of Medicine, Masaryk University, Brno, Czech Republic; 2nd Department of Neurology (Anna Czlonkowska, M.A.K.), Institute of Psychiatry and Neurology, Warsaw, Poland; Department of Internal Medicine and Cardiology (Petra Sedova), University Hospital Brno and Faculty of Medicine, Masaryk University, Brno, Czech Republic; Department of Neurology (O.Y.M.), Alexandria University Stroke and Neurointervention Unit, Egypt; Department of Neurology (H.R.V., K.U.), Cleveland Clinic; Centre Hospitalier de l'Université de Bordeaux (E.L.), INSERM, Bordeaux Population Health Research Center, France; Second Department of Neurology (Georgios Tsivgoulis, Lina Palaiodimou), "Attikon" University Hospital, National and Kapodistrian University of Athens, Greece; Ohio Health Riverside Methodist Hospital (A.I.L.); Neurology Department (J.D., Robin Lemmens), Leuven University Hospital, Belgium; University of Tennessee Health Science Center (V.I., N.G.); Cooper Neurological Institute (J.E.S., J.W.), Cooper University Hospital, Camden, NJ; Department of Neurology (Shadi Yaghi), Rhode Island Hospital, Brown University, Providence; Stroke Center (D.A.S.), Centro Hospitalar Universitário Lisboa Central-CHULC, Portugal, CEEM; Institute of Anatomy (D.A.S.), Faculdade de Medicina, Universidade de Lisboa, Portugal; Department of Neurology (Mahmoud Mohammaden, D.C.H.), Grady Memorial Hospital, Emory University School of Medicine, Atlanta, GA; Department of Neurology (E.S.K.), Akershus University Hospital, University of Oslo, Norway and Department of General Practice, University of Oslo, Norway; Division de Neurologia Vascular (V.P.L.), Departmento de Neurologia, Institute for Neurological Research-FLENI, Buenos Aires, Argentina; Stroke Unit (S.D.S.), Ramos Mejia Hospital, Buenos Aires, Argentina; Department of Medicine and Neurology (B.C.V.C.), Melbourne Brain Centre at the Royal Melbourne Hospital, University of Melbourne, Parkville, Victoria, Australia; Royal North Shore Hospital (Alice Ma), Sydney, Australia; Department of Neurophysiology (J.O.T), Liverpool Hospital, New South Wales, Australia; Department of Neurology (M.W.P.), Liverpool Hospital, New South Wales, Australia; Departments of Neurology (Shaloo Singal) and Radiology (L.-A.S.), Monash Medical Centre, Australia; Stroke and Aging Research Group (Shaloo Singhal), School of Clinical Sciences at Monash Health, Monash University, Australia; Department of Neurology (Rodrigo Tomazini Martins), Mater Hospital, Brisbane, Australia; Department of Neurology (Chris Enzinger), Medical University of Graz, Austria; Department of Neurology and Division of Neuroradiology (T.G.), Vascular and Interventional Radiology, Medical University of Graz, Austria; Department of Neurology (Aminur Rahman), Sir Salimullah Medical College, Mitford, Dhaka, Bangladesh; Hopital Erasme (T.B., N.L.), Brussels, Belgium; Department of Neurology (S.D.R., F.V.), Universitair Ziekenhuis Brussel, Center for Neurosciences, Vrije Universiteit Brussel, Belgium; Department of Neurology (P.V.), University Hospitals Antwerp; Department of Translational Neuroscience (P.V.), University of Antwerp, Belgium; Hospital das Clínicas (A.B.C., I.L.S.), São Paulo University, Brazil; Department of Neurology and Interventional Neuroradiology (R.C.T.H.), Hospital de Base de São José do Rio Preto, São Paulo, Brazil; Department of Neurology (L.O.N., I.B.S.), Hospital São Carlos, Fortaleza, Ceará, Brazil Stroke Unit (Rodrigo Targa Martins), Neurology, Nossa Senhora da Conceição Hospital, Porto Alegre, Brazil; Moinhos de Vento Hospital (D.L.M.C.), Brazil; Hospital de Base do Distrito Federal (L.C.R.), Brasilia, Brazil; St. Anna University Hospital (T.S., Rosen Kalpachki, F.A.), Sofia, Bulgaria; Department of Neurology (Luciana Catanese), McMaster University, Hamilton, Canada; Department of Diagnostic Radiology (E.A.C.), Halifax Infirmary, Dalhousie University, Halifax, Canada; Departments of Clinical Neurosciences and Radiology (M.G., M.D.H.), Hotchkiss Brain Institute, Cummings School of Medicine, University of Calgary, Canada; Royal University Hospital (M.E.K., Lissa Peeling), Saskatoon, Saskatchewan, Canada; Department of Neurology (H.K.), Hurvitz Brain Sciences Program, Sunnybrook Health Sciences Centre, Division of Neurology, Department of Medicine, University of Toronto, Canada; Hopital Enfant Jesus (Pascale Lavoie), Centre Hospitalier de l'Université Laval, Quebec City, Canada; Toronto Western Hospital (A.P.), University of Toronto, Canada; Neuroradiology Department (R.R.), Instituto de Neurocirugía Dr. Asenjo, Santiago, Chile; Department of Neurology (H.-S.C.), General Hospital of Northern Theater Command, Shen Yang, China; Department of Neurology (Y.C., Shuiquan Yang), Foshan Sanshui District People's Hospital, China; Interventional Neuroradiology (X.H., Z.M.), Beijing Tiantian Hospital, China; Department of Neurology (M.R.B.), Sestre Milosrdnice University Hospital Center, Croatia; Department of Neurology (Marina Bralic), Clinical Hospital Center Rijeka, Croatia; Sveti Duh University Hospital - Zagreb (H.B.), Department of Neurology, Croatia; J.J. Strossmayer University of Osijek (H.B.), Faculty of Medicine, Department of Neurology and Neurosurgery, Osijek, Croatia; Department of Neurology (A.B.C.-Q.), Hospital Departamental Universitario del Quindío San Juan de Dios, Colombia; Department of Neurology (O.E.L.-S.), Clínica de la Costa, Barranquilla, Colombia; Department of Neurology (Martin Cabal), Faculty Hospital Ostrava, Czech Republic; Department of Neurology (D.T.), Blansko Hospital, Czech Republic; Oblastní Nemocnice Trutnov a.s. (Petr Fibrich), Czech Republic; Department of Neurology (R.H.), Comprehensive Stroke Center, Charles University Faculty of Medicine and University Hospital, Hradec Králové, Czech Republic; Neurology (H.H.), Hospital Příbram, Czech Republic; Uherskohradišťská Hospital (E.H.), Czech Republic; Department of Neurology (D.H.), Thomayer University Hospital Prague, Czech Republic; Neurocenter (L.J.), Regional Hospital Liberec, Czech Republic; Neurology (Jana Kadlcikova), Hospital Vyskov, Czech Republic; Regional Hospital Karlovy Vary (Igor Karpowicz), Czech Republic; Ostrava (L.K.), Czech Republic; Na Homolce Hospital (Martin Kovar), Czech Republic; Department of Neurology (D.L.), Third Faculty of Medicine, Charles University and University Hospital Kralovske Vinohrady, Czech Republic; Department of Neurology (J.N.E.S.O.), Krajská zdravotní, a.s.-Hospital Chomutov, Chomutov, Czech Republic; Karvina Mining Hospital (H.P.), Czech Republic; Neurology (Martin Reiser), České Budejovice Hospital, Czech Republic; Department of Neurology and Centre of Clinical Neuroscience (Petra Rekova), First Faculty of Medicine, Charles University and General University Hospital in Prague, Czech Republic; Department of Neurology (V.R.), University Hospital Plzen, Czech Republic; Department of Neurology (O.S.), Hospital Jihlava, Czech Republic; Department of Neurology (M.Š.), Masaryk University Faculty of Medicine, University Hospital Brno, Czech Republic; Oblastni Nemocnice Kladno (L.S.), Czech Republic; Central Military Hospital in Prague (Martin Sramek), Czech Republic; Nemocnice Třinec (Lenka Zakova), Czech Republic; Copenhagen University Hospital (H.C., N.D.), Denmark; Stroke Center (H.K.I., T.C.T.), Rigshospitalet, University of Copenhagen, Denmark; Neurovascular Center (T.W.), Zealand University Hospital, University of Copenhagen, Roskilde, Denmark; El hussein Alzahar University Hospital (Khalid Sobh), Egypt; Neurocenter (P.Y.), Turku University Hospital, Turku University, Finland; Department of Radiology (K.A.), Turku University Hospital, Finland; Department of Neurology (Daniel Strbian), Helsinki University Hospital and University of Helsinki, Finland; Bayonne Hospital Neurology (P.B.), Stroke Unit, France; Libourne Hospital Neurology (Philippe Casenave), Stroke Unit, France; Centre Hospitalier d'Arcachon-Neurologie (Maria Dan), France; Agen Hospital Neurology (J.-M.F.), Stroke Unit, France; Neuroradiologie Interventionelle (J.-C.G.), Brest University Hospital, France; Neurochirurgie (E.M.), Brest University Hospital, France; Department of Neurology (C.S.), Rothschild Foundation Hospital, Paris, France; Lariboisiere Hospital (Peggy Reiner), Paris, France; Bordeaux University Hospital Neurology (F.R.), Stroke Unit, France; Department of Neurology (F.O.B.), University Hospital, Goethe University, Frankfurt, Germany; Department of Neurology (Stefan Boskamp, Michael Rosenkranz), Albertinen Krankenhaus, Hamburg, Germany; Department of Neurology and Stroke (Joshua Mbroh, S.P.), Eberhard-Karls University, Tuebingen, Germany; Hertie Institute for Clinical Brain Research (Joshua Mbroh, S.P.), Eberhard-Karls University, Tuebingen, Germany; Department of Neurology (Simon Nagel), Klinikum Ludwigshafen, Ludwigshafen/Rhein, Germany; Department of Neurology (Simon Nagel, P.A.R.), Heidelberg University Hospital, Germany; Department of Neurology and Experimental Neurology (C.H.N.), Center for Stroke Research Berlin, Berlin Institute of Health, Charité-Universitätsmedizin Berlin, Germany; Universitätsklinikum Hamburg-Eppendorf (Götz Thomalla), Klinik und Poliklinik für Neurologie, Hamburg, Germany; Second Department of Neurology (Theodoros Karapanayiotides, Ioanna Koutroulou), AHEPA University Hospital, Aristotle University of Thessaloniki, School of Medicine, Faculty of Health Sciences, Greece; Stroke Unit (O.K.), Metropolitan Hospital, Piraeus, Greece; Hospital General San Juan de Dios (J.D.B.G.), Guatemala; Mazumdar Shaw Medical Center (V.H.), Bangalore, Karnataka, India; Department of Neurology (Bindu Menon), Apollo Specialty Hospitals Nellore, Andhra Pradesh, India; Department of Neurology (Shashank Nagendra), Grant Medical College and Sir JJ Hospital, Mumbai, India; Mazumdar Shaw Medical Center (C.P.), Bangalore, Karnataka, India; Sree Chitra Tirunal Institute for Medical Sciences and Technology (P.N.S.), Trivandrum, Kerala, India; Department of Neurology (N.A.K.P.), Faculty of Medicine Udayana University, Sanglah General Hospital Denpasar, Bali, Indonesia; Dr. Soetomo General Hospital Surabaya (A.F.S.), Universitas Airlangga, Indonesia; Stroke Research Group (A.G.), Head of Stroke Care Unit, Department of Neurology, Vali-e-Asr Hospital, School of Medicine, Zanjan University of Medical Sciences, Iran; Neurosciences Research Center (Mehdi Farhoudi, E.S.H.), Imam Reza Hospital, Tabriz University of Medical Sciences, Iran; Neurology Department (T.A.R., S.I.S.), Hillel Yaffe Medical Center, Hadera, Israel; Neurointerventional Unit (S.A.K., Levite Ronen), Shamir Medical Center, Israel; Stroke Unit (Maurizio Acampa), University of Siena, Italy; Stroke Center IRCCS Sacro Cuore Don Calabria (A.A.), Verona, Italy; Dipartimento di Neuroradiologia Diagnostica e Interventistica Policinico Universitario IRCCS San Martino (Lucio Castellan, C.R.B.), Genova, Italy; Neurology and Stroke Unit (M.L., Michele Romoli), Ospedale Bufalini, Cesena, Italy; Neuroscience Section (R.O., Simona Sacco), Department of Biotechnological and Applied Clinical Sciences, University of L'Aquila, Italy; Interventional Neurovascular Unit (Leonardo Renieri), Careggi University Hospital, Florence, Italy; Neurological Department (Andrea Salmaggi, Davide Sangalli), "Alessandro Manzoni" Hospital, ASST Lecco, Via dell'Eremo, Italy; IRCCS Istituto delle Scienze Neurologiche di Bologna (A.Z.), Neurologia e Rete Stroke Metropolitana, Italy; Department of Neurosurgery (R.D., N.K.), Iwate Prefectural Central Hospital, Japan; Department of Neurology (H.F.), Japanese Red Cross Matsue Hospital, Japan; Department of Neurosurgery (T.F.), National Hospital Organization Osaka National Hospital, Japan; Department of Endovascular Surgery (K.F.), Tokyo Medical and Dental University, Japan; Department of Neurosurgery (H.I., N.S.), Kobe City Medical Center General Hospital, Japan; NTT Medical Center Tokyo (Takuya Kanamaru), Japan; Department of Neurology (Ryuhei Kono), Kin-ikyo Chuo Hospital, Japan; Shiroyama Hospital (K.M.), Japan; Department of Neurology (Manabu Sakaguchi), Osaka General Medical Center, Japan; Department of Neurology (Kenichiro Sakai), The Jikei University School of Medicine, Japan; Department of Neurology (Kazutaka Sonoda), Saiseikai Fukuoka General Hospital, SFGH, Japan; Stroke Center (Kenichi Todo), Osaka University Hospital, Japan; Department of Neurology (Fumio Miyashita), Kagoshima City Hospital, Japan; Department of Neurology (N.T.), Japanese Red Cross Kyoto Daini Hospital, Japan; Department of Stroke and Cerebrovascular Diseases (Y.M.), University of Tsukuba Hospital, Japan; Comprehensive Strokology (S.M.), Fujita Health University School of Medicine, Toyoake, Japan; Department of Neurology (N.O.), Kobe City Medical Center General Hospital, Japan; Department of Neurology (Seigo Shindo), Japanese Red Cross Kummoto Hospital, Japan; Osaka Red Cross Hospital (Y.T.), Japan; Department of Neurology (Takeshi Yoshimoto), National Cerebral and Cardiovascular Center, Japan; Department of Cerebrovascular Medicine (Kazunori Toyoda), National Cerebral and Cardiovascular Center, Japan; Cerebrovascular Medicine (T.U.), Stroke Center, Saga Medical Centre Koseikan, Japan; Stroke Medicine (Yoshiki Yagita), Kawasaki Medical School, Japan; Department of Neurology and Stroke Treatment (Takehiro Yamada), Japanese Red Cross Kyoto Daiichi Hospital, Japan; Advanced Brain Research (N.Y.), Tokushima University, Japan; Yokohama Brain and Spine Center (R.Y.), Japan; Department of Stroke Neurology (Yukako Yazawa), Kohnan Hospital, Sendai, Japan; Toyonaka Municipal Hospital (Y.S.), Japan; Kenyatta University Teaching (P.K.W.), Referral and Research Hospital, Kenya; Department of Neurology (J.-H.B.), Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, South Korea; Department of Neurology (S.B.L.), Uijeongbu St. Mary's Hospital, College of Medicine, The Catholic University of Korea, South Korea; Department of Neurology (K.-D.S.), National Health Insurance Service Ilsan Hospital, Goyang, Korea; Department of Neurology (S.-I.S.), Keimyung University Dongsan Hospital, Keimyung University School of Medicine, Daegu, Korea; Department of Urgent Neurology (A.A.A.), University Clinic of Neurology, University Ss. Cyril and Methodius-Faculty of Medicine, Skopje, North Macedonia; Hospital Sultan Abdul Halim (Y.C.C.), Malaysia; Department of Medicine (W.A.W.Z.), National University of Malaysia; Department of Surgery (A.S.J.), National University of Malaysia; Neurovascular Unit and Neurology Department (F.G.-R., A.I.-V.), University Hospital Jose Eleuterio Gonzalez, Universidad Autonoma de Nuevo Leon, Mexico; Department of Neurology (M.M.-M.), Hospital de especialidades del Centro Médico Nacional Siglo XXI IMSS, Mexico; "Nicolae Testemitanu" State University of Medicine and Pharmacy (S.G., Pavel Leahu); Emergency Medicine Institute (L.P., S.G.), Chisinau, Republic of Moldova; Amsterdam University Medical Centers Amsterdam (J.M.C., L.A.R.), the Netherlands; Departments of Neurology (D.W.J.D.) and Neurology and Radiology (D.H.K.D.-N.), Erasmus University Medical Center Rotterdam, the Netherlands; Department of Medicine (Annemarei Ranta), University of Otago-Wellington, and Department of Neurology, Wellington Hospital, New Zealand; Department of Neurology (T.Y.W.), Christchurch Hospital, New Zealand; Department of Medical Records (T.T.A.), Federal Medical Centre, Owo, Ondo State, Nigeria; Neurology Unit (A.H.B., K.W.W.), University of Ilorin, Nigeria; Neurology Unit (E.O.N.), Department of Medicine, Federal Medical Centre Owerri, Neurology Unit, Federal Medical Centre, Owerri, Nigeria; Neurology Unit, Department of Medicine, (T.A.S.) Federal Medical Center, Owo, Ondo State, Nigeria; Department of Neurology (O.M.R.), Akershus University Hospital, Norway, and Institute of Clinical Medicine, University of Oslo, Norway; Department of Neurology (E.C.S.), Oslo, Oslo, Norway and The Norwegian Air Ambulance Foundation, Norway; Central Stroke Unit (A.M.A.H.), Neuroscience Directorate, Khoula Hospital, Ministry of Health, Oman; Lahore General Hospital (S.A., U.R.), Pakistan; Departamento de Neurología (L.R.-K., M.Á.V.), Hospital Nacional Edgardo Rebagliati Martins,Essalud, Lima, Perú; St. Luke's Medical Center (P.M.Y.), Global City, Philippines; St. Luke's Medical Center (J.S.H.D., M.C.P.-F., C.O.C.), Quezon City, Philippines; Department of Neurology (W.B.), Specialist Hospital Konskie, Collegium Medicum, Jan Kochanowski University, Kielce, Poland; Clinic of Neurology (Aleksander Debiec, J.S.), Military Institute of Medicine, Warsaw, Poland; Department of Neurology (Malgorzata Dorobek), Central Clinical Hospital of the Ministry of Interior and Administration (M.D.), Warsaw, Poland; Department of Neurology (B.M.L.-R.), St. Jadwiga Provincial Specialist Hospital in Opole, Institute of Medical Sciences, University of Opole, Poland; Department of Neurology (A.L.-B.), Leszek Giec Upper Silesian Medical Centre of the Silesian Medical University in Katowice, School of Health Sciences, Medical University of Silesia in Katowice, Poland; 1st Department of Neurology (H.S.-J.), Institute of Psychiatry and Neurology, Warsaw, Poland; Department of Neurology in Sandomierz (Piotr Sobolewski), Collegium Medicum, Jan Kochanowski University in Kielce, Sandomierz, Poland; Department of Neurology (M.W.), Institute of Medical Sciences, Medical College of Rzeszow University, Rzeszow, Poland; Department of Neurology (J.Z.-T.), Central Clinical Hospital of the Ministry of Interior, Warsaw, Poland; Department of Neurology (J.Z.-T.), Central Clinical Hospital of the Ministry of Internal Affairs and Administration, Warsaw, Poland; Neuroradiology Department-Centro Hospitalar de Vila Nova de Gaia/Espinho (A.P.A.), Portugal; Neurology Department (Mariana Rocha), Centro Hospitalar Vila Nova de Gaia/Espinho; Department of Neurology (Pedro Castro), Centro Hospitalar Universitário de São João, Portugal; Stroke Unit-Hospital Pedro Hispano (V.T.C., P.V.F.), Matosinhos, Portugal; Stroke Unit (Patricia Ferreira, A.P.N.), Centro Hospitalar Universitário de Lisboa Central, Portugal; Stroke Unit (Luisa Fonseca), Medicine Department, Centro Hospitalar Universitário de São João, Portugal; Department of Neurology (J.P.M.), Hospital de Egas Moniz, Centro Hospitalar Lisboa Ocidental, Lisbon, Portugal; Hospital de Santa Maria-Centro Hospitalar Lisboa Norte (T.P.M.), Portugal; Department of Neurology (Miguel Rodrigues), Hospital Garcia de Orta, Almada, Portugal; Centro Hospitalar Universitário de São João (M.L.S.), Portugal; Bucarest University Emergency Hospital (Adela Dimitriade), Romania; Department of Neurology (C.F.-P.), County Clinic Hospital, Faculty of Medicine, Transilvania University, Brasov, Romania; Department of Neurology King Fahad Hospital of the University Imam Abdulrahman bin Faisal University Dammam (M.A.H.), Saudi Arabia; Raffles Hospital (N.V.), Singapore; Department of Neurology (G.K., Miroslav Mako), Faculty Hospital Trnava, Slovakia; Jessenius Medical Faculty (G.K., M.M.), Martin, Commenius University, Bratislava, Slovakia; Department of Neurology (G.K.), Slovak Medical University, Bratislava; Complejo Hospitalario Universitario de Albacete (O.A.-M., F.H.-F.), Albacete, Spain; Interventional Neuroradiology (J.B.), Hospital Clínic de Barcelona, Spain; Comprehensive Stroke Center (A.R.-V.), Hospital Clínic de Barcelona, Spain; Department of Neurology (Unidad de Ictus) (A.C.-C.), Hospital Universitario Ramón y Cajal, Madrid, Spain; Stroke Unit (Francisco Moniche), Neurology Department, Hospital Universitario Virgen del Rocío, Spain; Department of Neurology (Joan Montaner, S.P.-S.), Hospital Universitario Virgen Macarena & Neurovascular Research Laboratory, Instituto de Biomedicina de Sevilla-IbiS, Spain; Department of Neuroradiology (M.J.G.S.), Hospital Universitario Rey Juan Carlos, Spain; Department of Neurology (M.G.R.), Hospital Universitario Rey Juan Carlos, Spain; Institute of Neuroscience and Physiology (K.J., A.N.), Department of Clinical Neuroscience, Sahlgrenska Academy, University of Gothenburg; Department of Neurology (K.J., A.N.), Sahlgrenska University Hospital, Region Västra Götaland, Gothenburg, Sweden; Department of Neurology (M.V.M., T.T.P.M.), Karolinska University Hospital & Department of Clinical Neuroscience, Karolinska Institute, Stockholm, Sweden; Interventional Neuroradiology (G.B.), University Hospitals of Geneva, Switzerland; Department of Neurology (Morin Beyeler, U.F.), Inselspital, Bern University Hospital; Neurocenter (Manuel Bolognese), Cantonal Hospital of Lucerne, Switzerland; Department of Neurology (E.C.), University Hospitals of Geneva, Switzerland; Diagnostic and Interventional Neuroradiology (T.D.), Bern University Hospital, University of Bern, Switzerland; Radiology and Nuclear Medicine (G.M.K.), Cantonal Hospital of Lucerne, Switzerland; University Hospital (E.K.), University of Zurich, Switzerland; Department of Neurology (C.Y.H.), Tainan Sin Lau Hospital, Taiwan; Department of Radiology (Surawan Boonyakarnkul), Ramathibodi Hospital, Mahidol University, Thailand; Department of Radiology (Anchalee Churojana), Siriraj Hospital, Mahidol University, Thailand; Eskisehir Osmangazi University (O.A., M.D.O.), Turkey; Istanbul Aydın University (A.B., Songul Senadim), Florya Medicalpark Stroke Center, Turkey; Cleveland Clinic Abu Dhabi (S.I.H., S.J.), UAE; Department of Stroke Medicine (Soma Banerjee, Joseph Kwan), Imperial College Healthcare NHS Trust, Charing Cross Hospital, London, United Kingdom; Stroke (K.K.), Department of Medicine (K.K.), Nottingham University Hospitals NHS Trust, United Kingdom; Neuroradiology (Robert Lenthall), Nottingham University Hospitals NHS Trust, United Kingdom; Barking Havering and Redbridge University Hospitals (Ashok Matthews), Romford, United Kingdom; Royal London Hospital (K.W.), Barts Health NHS Trust, United Kingdom; St George's University Hospital (Liqun Zhang), London, United Kingdom; Valley Hospital Health System (D.A.), Neurosurgeons of NJ, New Jersey; Amita Health and University of Illinois-Chicago (K.S.A.); Inova Fairfax Hospital (Z.B.), Virginia; Neuroscience and Stroke Program (K.B., O.O.Z.), Bon Secours Mercy Health St Vincent Hospital, Toledo, OH; Loyola University Chicago Stritch School of Medicine (J.B.A.N.A., S.R.), Illinois; Inova Fairfax Hospital (S.A.C.), University of Virginia School of Medicine, Virginia; Rush University Medical Center (Michael Chen, Y.R.), Chicago, IL; Department of Neurology (Alex Chebl), Henry Ford Health System, Detroit, MI; Clinical Data Specialist (Jackie Cibulka), EBC Data Abstraction, University of Tennessee Health Science Center; Solution Architect II (Leon Cistrunk), Clinical Decision Support, University of Tennessee Health Science Center; Department of Radiology (Marco Colasurdo), University of Texas Medical Branch, Galveston, TX; Neurology (Alexandra Czap, S.A.S.), UTHealth McGovern Medical School, Houston, TX; Department of Neurology (A.H.), Yale University School of Medicine, New Haven; Brigham and Women's Hospital (S.D.A., A.A.D.), Boston; Baptist Health Medical Center-Little Rock (S.D., K.B.G.), Little Rock, AR; Neurointerventional Program (A.A.D.), Departments of Medical Imaging and Clinical Neurological Sciences, London Health Sciences Centre, Western University, London, ON; Neuroendovascular Program (A.A.D.), Massachusetts General Hospital & Brigham and Women's Hospital, Harvard Medical School, Boston; Department of Neurology (M.R.E., N.S.R.), Massachusetts General Hospital, Boston; Department of Interventional and Vascular Neurology (Chizoba Ezepue), Neuroscience Center, SSM Health DePaul Hospital, St. Louis, Missouri; University of Iowa (Mudassir Farooqui, S.O.G.); Santa Barbara Cottage Hospital (Lauren Fink, R.A.T.), California; Department of Neurology (U.G.), Saint Louis University School of Medicine, Missouri; Department of Neurology (A.K.G., S.L.), Wake Forest Baptist Medical Center, NC; Wayne State University (M.H.G.N.P., A.M.K.), Detroit, MI; Department of Neurosciences and Comprehensive Stroke Center (M.H., Muhib Khan), Spectrum Health and Michigan State University College of Human Medicine; Department of Neurology (D.J.), Grady Memorial Hospital, Emory University School of Medicine; Department of Neurosurgery (P.T.K.), University of Texas Medical Branch; Department of Neurology (Rakesh Khatri), Texas Tech University Health Science Center, El Paso; HSHS St. John's Hospital (N.N.K.), Southern Illinois University School of Medicine, Springfield; Virginia Hospital Center (B.S.K.); Baptist Health Medical Group (M.K.K.), Baptist Health Lexington, KY; Division of Neurointerventional Radiology (A.L.K., A.S.P.), Department of Radiology, University of Massachusetts Medical Center, Worcester, MA; Community Memorial Hospital (S.L.-H.C.A.,S.C.R.N., N.E.T.), Ventura, CA; Vascular and Neurointerventional Services (G.L.), Saint Louis University, Missouri; Miami Cardiac & Vascular Institute (I.L.), Miami Neuroscience Institute, FL; Dartmouth Hitchcock Medical Center (T.G.L., D.M.R.-S.), Lebanon, NH; Department of Neurology & Neurosurgery (S.S.M.), ECU Health Medical Center, Greenville, NC; Department of Neurology (L.M.), University of Kansas Medical Center; West Virginia University (John Mancin, Ansaar Rai); Department of Neurology (H.M., A.B.R.), SUNY Upstate, Syracuse, NY; Department of Neurology (G.A.M.), Medical University of South Carolina; Department of Neurosurgery (Andre Monteiro, A.H.S.), University at Buffalo; Department of Neurology (F.N.), Pediatrics, Emory University, Georgia; Department of Neurology (K.N.), University of Arkansas for Medical Sciences, Arkansas; Ascension St Johns Medical Center (R.H.R.), Tulsa, OK; Riverside Regional Medical Center (Pankajavalli Ramakrishnan), Newport News, VA; Department of Neurology (Aaron Rothstein), Hospital of the University of Pennsylvania, Philadelphia; University of Colorado School of Medicine (S.S.O.), Aurora, CO; Miami Neuroscience Institute (A.K.S.), Miami; UNC School of Medicine (M.J.W.), North Carolina; University of Utah (K.-H.W.); Hue Central (H.V.L., Q.V.N.), Vietnam; Da Nang Hospital (T.N.P., T.T.N.), Da Nang, Vietnam; Bach Mai Hospital (H.T.P., M.D.T.), Hanoi, Vietnam; Department of Neurology (U.F.), Basel University Hospital, University of Basel, Switzerland; Neurology Service (P.M., Davide Strambo), Department of Clinical Neurosciences, Lausanne University Hospital and University of Lausanne, Switzerland; Department of Neurology (S.O.M.), Federal University of Rio Grande do Sul, Porto Alegre; Hospital de Clínicas de Porto Alegre (S.O.M.), Brazil; and Department of Neurology (R.G.N.), University of Pittsburgh Medical Center, Pittsburgh. Ondrej Skoda is currently at the Department of Neurology, Third Faculty of Medicine, Charles University and University Hospital Kralovske Vinohrady, Prague, Czech Republic.
Background And Objectives: Declines in stroke admission, IV thrombolysis (IVT), and mechanical thrombectomy volumes were reported during the first wave of the COVID-19 pandemic. There is a paucity of data on the longer-term effect of the pandemic on stroke volumes over the course of a year and through the second wave of the pandemic. We sought to measure the effect of the COVID-19 pandemic on the volumes of stroke admissions, intracranial hemorrhage (ICH), IVT, and mechanical thrombectomy over a 1-year period at the onset of the pandemic (March 1, 2020, to February 28, 2021) compared with the immediately preceding year (March 1, 2019, to February 29, 2020).
View Article and Find Full Text PDFWhy a clinical trial is as good as its outcome measure: A framework for the selection and use of cognitive outcome measures for clinical trials of Alzheimer's disease.
Alzheimers Dement
February 2023
Alzheimer Center Amsterdam, Department of Neurology, Amsterdam UMC, location VUmc, VU University, Amsterdam, The Netherlands.
A crucial aspect of any clinical trial is using the right outcome measure to assess treatment efficacy. Compared to the rapidly evolved understanding and measurement of pathophysiology in preclinical and early symptomatic stages of Alzheimer's disease (AD), relatively less progress has been made in the evolution of clinical outcome assessments (COAs) for those stages. The current paper aims to provide a benchmark for the design and evaluation of COAs for use in early AD trials.
View Article and Find Full Text PDFCardiorenal Outcomes With Ertugliflozin by Baseline Metformin Use: Post Hoc Analyses of the VERTIS CV Trial.
Circulation
August 2022
Pfizer Inc., New York, NY (N.B.C.).
Phenotypes of disease severity in a cohort of hospitalized COVID-19 patients: Results from the IMPACC study.
EBioMedicine
September 2022
Emory University, Atlanta, GA, United States. Electronic address:
Background: Better understanding of the association between characteristics of patients hospitalized with coronavirus disease 2019 (COVID-19) and outcome is needed to further improve upon patient management.
Methods: Immunophenotyping Assessment in a COVID-19 Cohort (IMPACC) is a prospective, observational study of 1164 patients from 20 hospitals across the United States. Disease severity was assessed using a 7-point ordinal scale based on degree of respiratory illness.
Ertugliflozin and incident obstructive sleep apnea: an analysis from the VERTIS CV trial.
Sleep Breath
May 2023
Section of Pulmonary, Critical Care and Sleep Medicine, Yale School of Medicine, New Haven, CT, USA.
Purpose: The sodium-glucose transporter 2 inhibitor (SGLT2i) empagliflozin may reduce the incidence of obstructive sleep apnea (OSA) in patients with type 2 diabetes (T2D) and cardiovascular (CV) disease. This analysis of VERTIS CV, the CV outcome trial for the SGLT2i ertugliflozin conducted in a similar group of patients, explored the effects of ertugliflozin on reported incident OSA.
Methods: In VERTIS CV, patients ≥ 40 years with T2D and atherosclerotic CV disease (ASCVD) were randomized to ertugliflozin 5 or 15 mg or placebo.
Therapeutic efficacy of an Ad26/MVA vaccine with SIV gp140 protein and vesatolimod in ART-suppressed rhesus macaques.
NPJ Vaccines
May 2022
Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, 02215, USA.
Developing an intervention that results in virologic control following discontinuation of antiretroviral therapy (ART) is a major objective of HIV-1 cure research. In this study, we investigated the therapeutic efficacy of a vaccine consisting of adenovirus serotype 26 (Ad26) and modified vaccinia Ankara (MVA) with or without an SIV Envelope (Env) gp140 protein with alum adjuvant in combination with the TLR7 agonist vesatolimod (GS-9620) in 36 ART-suppressed, SIVmac251-infected rhesus macaques. Ad26/MVA therapeutic vaccination led to robust humoral and cellular immune responses, and the Env protein boost increased antibody responses.
View Article and Find Full Text PDFClathrin-nanoparticles deliver BDNF to hippocampus and enhance neurogenesis, synaptogenesis and cognition in HIV/neuroAIDS mouse model.
Commun Biol
March 2022
ExQor Technologies Inc, Boston, MA, 02114, USA.
Brain derived neurotrophic factor (BDNF) promotes the growth, differentiation, maintenance and survival of neurons. These attributes make BDNF a potentially powerful therapeutic agent. However, its charge, instability in blood, and poor blood brain barrier (BBB) penetrability have impeded its development.
View Article and Find Full Text PDFCardiorenal outcomes with ertugliflozin assessed according to baseline glucose-lowering agent: An analysis from VERTIS CV.
Diabetes Obes Metab
July 2022
AdventHealth Translational Research Institute, Orlando, Florida, USA.
Aim: To assess selected cardiorenal outcomes with ertugliflozin according to use of baseline glucose-lowering agent.
Materials And Methods: VERTIS CV was a cardiovascular (CV) outcome trial for ertugliflozin versus placebo, conducted in patients with type 2 diabetes and established atherosclerotic CV disease. The primary outcome was time to the first event of CV death, myocardial infarction or stroke (major adverse CV events [MACE]), with other CV outcomes also assessed.
Tumor fraction-guided cell-free DNA profiling in metastatic solid tumor patients.
Genome Med
May 2021
Marie-Josée and Henry R. Kravis Center for Molecular Oncology, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY, 10065, USA.
Background: Cell-free DNA (cfDNA) profiling is increasingly used to guide cancer care, yet mutations are not always identified. The ability to detect somatic mutations in plasma depends on both assay sensitivity and the fraction of circulating DNA in plasma that is tumor-derived (i.e.
View Article and Find Full Text PDFSARS-CoV-2 and Stroke Characteristics: A Report From the Multinational COVID-19 Stroke Study Group.
Stroke
May 2021
Neurology Department, Neuroscience Institute, Geisinger Health System, PA (S. Shahjouei, A. Mowla, D.C., C.J.G., R.Z.).
[Figure: see text].
View Article and Find Full Text PDFAd26.COV2.S protects Syrian hamsters against G614 spike variant SARS-CoV-2 and does not enhance respiratory disease.
NPJ Vaccines
March 2021
Janssen Vaccines & Prevention B.V., Leiden, The Netherlands.
Previously we have shown that a single dose of recombinant adenovirus serotype 26 (Ad26) vaccine expressing a prefusion stabilized SARS-CoV-2 spike antigen (Ad26.COV2.S) is immunogenic and provides protection in Syrian hamster and non-human primate SARS-CoV-2 infection models.
View Article and Find Full Text PDFClinical Decision Making During the COVID-19 Pandemic.
Ann Intern Med
May 2021
Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts (J.P.M., K.A.A.).
The authors apply principles for translating imprecision in diagnostic and therapeutic information into clinical decisions to address 3 ongoing areas of uncertainty related to diagnosis, treatment, and prevention of COVID-19. They briefly review the current state of knowledge, highlight the level of uncertainty, and then suggest a pathway forward for clinical decision making during the pandemic.
View Article and Find Full Text PDFPost-Transcriptional Genetic Silencing of to Treat Sickle Cell Disease.
N Engl J Med
January 2021
From the Dana-Farber/Boston Children's Cancer and Blood Disorders Center, Harvard Medical School (E.B.E., L.E.L., A.B., C.B., M.F.C., B.M., K.B., S.-Y.P., W.B.L., C.D., M.M.H., D.A.W.), the Harvard Stem Cell Institute, Harvard Medical School (A.B., C.B.), the Gene Therapy Program, Dana-Farber/Boston Children's Cancer and Blood Disorders Center (A.B., M.F.C., B.M., E.M., A.F., S.-Y.P., C.D., D.A.W.), the Division of Hematology, Brigham and Women's Hospital, Harvard Medical School (M. Achebe), the Connell and O'Reilly Families Cell Manipulation Core Facility, Dana-Farber Cancer Institute (H.D., R.K., K.S., H.N., S.N., J.R.), the TransLab, Boston Children's Hospital (D.A., M. Armant), and the Department of Laboratory Medicine, Boston Children's Hospital, Harvard Medical School (J.P.M.) - all in Boston; and Bluebird Bio, Cambridge, MA (O.N.).
Background: Sickle cell disease is characterized by hemolytic anemia, pain, and progressive organ damage. A high level of erythrocyte fetal hemoglobin (HbF) comprising α- and γ-globins may ameliorate these manifestations by mitigating sickle hemoglobin polymerization and erythrocyte sickling. is a repressor of γ-globin expression and HbF production in adult erythrocytes.
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