486 results match your criteria: "Harvard Kennedy School.[Affiliation]"

Article Synopsis
  • The introduction of immune checkpoint blockade (ICB) has greatly improved treatment outcomes for advanced melanoma, but many patients still become resistant to it due to unclear reasons.
  • Although combining different ICB therapies has been shown to enhance response rates, it also comes with increased toxicity for patients.
  • An analysis of tumor samples from ICB-naïve patients revealed that high genomic heterogeneity and low ploidy can identify those who are intrinsically resistant to aPD-1, leading to a predictive model that may help tailor treatment strategies.
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  • This study investigates how historical redlining and current racial and economic segregation affect healthcare access for people with rheumatic conditions in Massachusetts and nearby areas.
  • The research involved a cohort of 5597 patients who received care from rheumatology practices affiliated with Mass General Brigham, using data dating back to 2000 and geocoding their addresses with 1930s redlining maps.
  • Findings revealed that a significant portion of the patients lived in heavily redlined neighborhoods, highlighting the ongoing impact of structural racism on healthcare utilization and access for marginalized communities.
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During the initial year of the COVID-19 pandemic, a disproportionate share of COVID-19-related deaths occurred among nursing home residents. Initial estimates of all-cause mortality rates also spiked in early and late 2020 before falling to near or below historical rates by early 2021. During the first 3 years of the pandemic, the US nursing home resident population also decreased by 18% (239 000 fewer residents) compared with pre-pandemic levels.

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  • Carbon markets are essential for climate strategies, allowing project developers to earn carbon credits through mitigation efforts.
  • A review of 14 studies showed that only about 16% of the carbon credits from these projects represent real emission reductions, with varying effectiveness across different types of interventions.
  • The findings suggest that major reforms are necessary for carbon crediting mechanisms to effectively contribute to climate change mitigation efforts.
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COVID-19 precipitated sharp job losses, concentrated in the service sector. Prior research suggests that such shocks would negatively affect health and wellbeing. However, the nature of the pandemic crisis was distinct in ways that may have mitigated any such negative effects, and historic expansions in unemployment insurance (UI) may have buffered workers from negative health consequences.

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Engaging Low-Wage Workers in Health and Well-Being Survey Research: Strategies From 5 Occupational Studies.

Am J Public Health

February 2025

Erika L. Sabbath is with the Boston College School of Social Work, Chestnut Hill, MA. Meg Lovejoy is with the Harvard Center for Population and Development Studies, Harvard University, Cambridge, MA. Daniel K. Schneider is with the Harvard Kennedy School, Harvard University, Cambridge, MA. Yaminette Diaz-Linhart and Grace DeHorn are with the Institute for Work and Employment Research, Massachusetts Institute of Technology Sloan School of Management, Cambridge. Susan E. Peters is with the Department of Social and Behavioral Sciences, Harvard T. H. Chan School of Public Health, Boston, MA.

Article Synopsis
  • * Engaging low-wage workers in health survey research presents challenges, and the text discusses strategies identified through five case studies from 2020 to 2024 in various industries to enhance their participation.
  • * Key recommendations for researchers include building trust with workers and managers, providing support from management to allow survey participation during work hours, and employing high-touch recruitment methods to improve response rates in vulnerable populations.
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Objectives: To examine heterogeneity in physician batch ordering practices and measure the associations between a physician's tendency to batch order imaging tests on patient outcomes and resource utilization.

Study Setting And Design: In this retrospective study, we used comprehensive EMR data from patients who visited the Mayo Clinic of Arizona Emergency Department (ED) between October 6, 2018 and December 31, 2019. Primary outcomes are patient length of stay (LOS) in the ED, number of diagnostic imaging tests ordered during a patient encounter, and patients' return with admission to the ED within 72 h.

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  • A study was conducted to evaluate a joint venture (JV) in New Hampshire between a payer and multiple healthcare providers, focusing on its effects on healthcare value, spending, and member experiences from 2016 to 2020.
  • The study used a quasi-experimental method, comparing data from New Hampshire with a control group in Maine, assessing utilization, quality, and spending through claims data, and gathering perceptions from healthcare leaders through interviews.
  • Results indicated that the JV did not significantly change medical utilization, quality, or overall spending, despite an increase in pharmaceutical costs and low engagement in care management services; however, leaders believed the JV had improved costs and care quality.
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The Lancet Public Health Commission on gambling.

Lancet Public Health

October 2024

Department of Global Health and Population, Harvard TH Chan School of Public Health, Harvard University, Cambridge, MA, USA.

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Humanity's long-term welfare may lie in the hands of those who are presently living, raising the question of whether people today hold the generations of tomorrow in their moral circles. Five studies (N = 1652; Prolific) reveal present-oriented bias in the moral standing of future generations, with greater perceived moral obligation, moral concern, and prosocial intentions for proximal relative to distal future targets. Yet, present-oriented bias appears stronger for socially close compared with socially distant targets and for human targets relative to non-human animals and entities in nature.

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Clinical prediction models (CPMs) are tools that compute the risk of an outcome given a set of patient characteristics and are routinely used to inform patients, guide treatment decision-making, and resource allocation. Although much hope has been placed on CPMs to mitigate human biases, CPMs may potentially contribute to racial disparities in decision-making and resource allocation. While some policymakers, professional organizations, and scholars have called for eliminating race as a variable from CPMs, others raise concerns that excluding race may exacerbate healthcare disparities and this controversy remains unresolved.

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Article Synopsis
  • Scholars are concerned that deep partisan divides among the public pose a risk to American democracy.
  • A large study with over 32,000 participants tested 25 different strategies aimed at decreasing partisan animosity and support for undemocratic practices.
  • Results showed that highlighting relatable individuals with differing beliefs and emphasizing shared identities were effective at reducing animosity, while correcting misunderstandings about rival views helped lessen support for undemocratic actions.
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  • Benzodiazepines are often prescribed to older patients after an acute ischemic stroke, despite guidelines advising against this for those aged 65 and over.
  • An analysis of Medicare claims from 2013 to 2021 showed that 4.9% of stroke survivors started benzodiazepine treatment, with higher initiation rates among females and in the southeastern US.
  • Although there was a slight decline in new prescriptions over the years, many patients received overly long prescriptions, indicating a need for better prescribing policies.
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Critical Health Care Challenges for the Next U.S. President.

N Engl J Med

October 2024

From the Harvard T.H. Chan School of Public Health (R.J.B., D.B., B.D.S., M.B.R, J.F.F., J.J.K.), Harvard Medical School (J.M.M.), and Brigham and Women's Hospital (J.M.M.) - all in Boston; New York University, New York (S.G.); Vanderbilt University Medical Center, Nashville (S.B.D.); Ohio State University, Columbus (R.Y.); and the Harvard Kennedy School, Cambridge, MA (M.A.).

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The literature engaging political theory in STS often puts forward a deficit model view of STS, in which homegrown STS ideas about politics, such as co-production, are either treated as having an insufficient account of the political or not read as political theory at all. This article challenges the deficit discourse by reading co-production as a full-blown political theory in its own right, in particular by showing how it investigates normative questions of 'the good' that are central to any theorization of politics. Where political theory often concerns itself with the construction and application of universal political ideals-such as of the good citizen, legitimate procedures or smart outcomes-co-production looks at empirical sites where citizens, procedures, and outcomes articulate understandings of the good held by political actors in situ.

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Background: Effective treatment of bipolar disorder (BD) requires prompt response to mood episodes. Preliminary studies suggest that predictions based on passive sensor data from personal digital devices can accurately detect mood episodes (e.g.

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Article Synopsis
  • The study investigates the health consequences of sudden medication interruptions due to arbitrary price changes in Medicare’s drug budget for 65-year-olds, revealing significant adverse effects on mortality.
  • A decrease of $100 in monthly budget leads to a 13.9% increase in mortality risk, highlighting the vulnerability of patients who are unaware of the serious consequences of stopping medications.
  • Machine learning identifies high-risk patients who disproportionately reduce usage of critical drugs, countering standard economic predictions and demonstrating that cost-sharing strategies can be inefficient and harmful to patient health.
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Implications of the 2024 Election Outcome for U.S. Health Policy.

N Engl J Med

October 2024

From the Harvard T.H. Chan School of Public Health, Boston (R.J.B., J.M.B.), and the Harvard Kennedy School, Cambridge, MA (N.B.L.).

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Importance: Since 2019 and 2020, Medicare Advantage (MA) plans have been able to offer supplemental benefits that address long-term services and supports (LTSS) and social determinants of health (SDOH).

Objective: To examine the temporal trends and geographic variation in enrollment in MA plans offering LTSS and SDOH benefits.

Design, Setting, And Participants: This cross-sectional study used publicly available data to examine changes in beneficiary enrollment and plan offerings of LTSS and SDOH benefits from the benefits data from the second quarter of each year and other data from April of each year except 2024, for which the first quarter was the latest for benefits data and January the latest for other data at the time of analysis.

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The racial gap in infant mortality is a pressing public-health concern, and [B. N. Greenwood et al.

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Objective: Environmental hazards and heightened neighborhood social vulnerability coexist and disproportionately affect minoritized populations. We investigated associations between exposure to adverse environmental burden concentrated in areas with high social vulnerability and care fragmentation (missed appointments, emergency department visits, and hospitalizations) and social needs (eg, food and housing insecurity) among individuals with rheumatic conditions.

Methods: We identified adults receiving care in a Massachusetts multihospital system with at least two rheumatic disease codes and complete street addresses.

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Case 27-2024: A 24-Year-Old Man with Pain and Dyspnea.

N Engl J Med

September 2024

From Harvard Kennedy School of Government, Cambridge (R.P.W.), and Harvard T.H. Chan School of Public Health (R.P.W.), Harvard Business School (R.P.W.), the Departments of Medicine (M.V.B., K.M.T., D.M.D.), Radiology (J.-A.O.S.), and Pathology (D.C.S.), Massachusetts General Hospital, and the Departments of Medicine (M.V.B., K.M.T., D.M.D.), Radiology (J.-A.O.S.), and Pathology (D.C.S.), Harvard Medical School, Boston - all in Massachusetts.

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Rationale: Despite guideline warnings, older acute ischemic stroke (AIS) survivors still receive benzodiazepines (BZD) for agitation, insomnia, and anxiety despite being linked to severe adverse effects, such as excessive somnolence and respiratory depression. Due to polypharmacy, drug metabolism, comorbidities, and complications during the sub-acute post-stroke period, older adults are more susceptible to these adverse effects. We examined the impact of receiving BZDs within 30 days post-discharge on survival among older Medicare beneficiaries after an AIS.

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Since the mid-1970s, there has been a sharp rise in the prevalence of "bad jobs" in the U.S. labor market, characterized by stagnant wages, unstable work schedules, and limited fringe benefits.

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