4 results match your criteria: "Harbin Medial University[Affiliation]"
Identification of an Amino Acid Metabolism Reprogramming Signature for Predicting Prognosis, Immunotherapy Efficacy, and Drug Candidates in Colon Cancer.
Appl Biochem Biotechnol
September 2024
Department of Colorectal Surgery, Harbin Medical University Cancer Hospital, Harbin Medial University, Harbin, Heilongjiang Province, People's Republic of China.
Article Synopsis
- Colon cancer is the third most common cancer globally, and amino acid metabolism plays a significant role in its development.
- Researchers identified six key amino acid metabolism genes (AMGs) as prognostic markers and created an amino acid metabolism scoring model (AMS) that categorizes patients into low and high AMS groups.
- The study found that patients in the low AMS group had better overall survival rates and responded more favorably to immunotherapy compared to those in the high AMS group, indicating the AMS model's potential for predicting prognosis and therapeutic responses in colon cancer.
A Novel Quantification System Combining iTRAQ Technology and Multi-Omics Assessment to Predict Prognosis and Immunotherapy Efficacy in Colon Cancer.
Front Bioeng Biotechnol
April 2022
Department of Colorectal Surgery, Harbin Medical University Cancer Hospital, Harbin Medial University, Harbin, China.
Colon cancer is one of the most common cancer types, although it has certain unique genetic features. This study aimed to develop a unique score for assessing prognosis and immunotherapy efficacy using integrated multi-omics analysis. Isobaric tagging for relative and absolute quantification (iTRAQ) based proteomic analysis was used to screen differentially expressed proteins (DEP) between tumor and normal samples.
View Article and Find Full Text PDFIdentification of proteins responsible for adriamycin resistance in breast cancer cells using proteomics analysis.
Sci Rep
March 2015
Department of Medical Oncology, The Third Affiliated Hospital of Harbin Medical University, Haping Road 150 of Nangang District, Harbin 150081, Heilongjiang Province, China.
Chemoresistance is a poor prognostic factor in breast cancer and is a major obstacle to the successful treatment of patients receiving chemotherapy. However, the precise mechanism of resistance remains unclear. In this study, a pair of breast cancer cell lines, MCF-7 and its adriamycin-resistant counterpart MCF-7/ADR was used to examine resistance-dependent cellular responses and to identify potential therapeutic targets.
View Article and Find Full Text PDF[Treatment of capsular contracture through areolar incision after augmentation mammaplasty].
Zhonghua Zheng Xing Wai Ke Za Zhi
May 2002
Department of Plastic Surgery, First Clinic Hospital, Harbin Medial University, Harbin 150001, China.
Objective: To explore the treatment of breast sclerosis caused by capsular contracture after augmentation mammaplasty, and preventive measures after the treatment to avoid the recurrence.
Methods: With the incision through periareola, a part of the fibrous capsule and fibrillate tissue which is between the base of the capsula and the wall of the capsula were resected in the shape of wedge. At the same time, the wall of the capsular cavity was incised in radiant shape to relax it.