Astaxanthin promotes the longevity of modulation of the intracellular redox status and PHA-4-mediated autophagy.

Astaxanthin is a xanthophyll carotenoid which has been associated with a number of health-promoting effects, including anti-aging; however, the underlying mechanisms are not fully understood. In the present study, it was found that astaxanthin promoted the longevity of wild-type (N2) (). The lifespan-extending effect of astaxanthin was associated with a significant decrease of lipofuscin accumulation and the reduction of the age-related decline in spontaneous motility.

Bright NIR-II emissive cyanine dye-loaded lipoprotein-mimicking nanoparticles for fluorescence imaging-guided and targeted NIR-II photothermal therapy of subcutaneous glioblastoma.

Cyanine dye-containing nanoparticles have widely been used in "all-in-one" NIR fluorescence imaging (FI)-guided photothermal therapy (PTT) because of their intrinsically large extinction coefficient and available physical and chemical modulation methods to tune absorption and emission wavelengths. The combination of good brightness and excellent tumor-targeting capacity is the key to realize efficient NIR-II FI-guided PTT. In this study, by covalently decorating NIR-II absorptive cyanine dyes with bulky AIE motify, we demonstrate how steric hindrance suppresses π-π stacking-induced fluorescence quenching and contributes to the good brightness of NIR-II FI of subcutaneous glioblastoma.

Can Exercise as a Complementary Technique Manage Inflammatory Markers in Women with Breast Cancer Who Are Overweight and Obese? A systematic review and meta-analysis.

Background: Inflammation can result in the development of breast cancer in women with overweight and obese, and also affects the outcome and prognosis of breast cancer patients, thereby decreasing the cure and survival rates of breast cancer patients. Exercise may benefit breast cancer patients as a supplement to conventional treatments. However, research on the effects of exercise on inflammatory markers in women with breast cancer who are overweight and obese remains incomplete.

Intensive electron transfer of a single-atom Fe-based catalytic ceramic membrane for municipal wastewater treatment: The synergistic effects of nitrogen vacancy defect and ultrathin nanostructure.

The integration of membrane separation with heterogeneous advanced oxidation processes is a prospective strategy for the elimination of contaminants during wastewater treatment. Fe-based catalysts and the green oxidant peracetic acid (PAA) are desirable candidates for the development of catalytic membranes because they are environmentally friendly. However, the construction of catalytic ceramic membranes (CMs) modified with efficient Fe-based catalysts that generate increased amounts of high-valent Fe-O species during PAA activation for the degradation of specific pollutants, especially during instantaneous membrane filtration, remains challenging.

In-situ growing carbon nanotubes reinforced highly heat dissipative three-dimensional aluminum framework composites.

The demand for lightweight heat dissipation design in highly miniaturized and portable electronic devices with high thermal density is becoming increasingly urgent. Herein, highly thermal conductive carbon nanotubes (CNTs) reinforced aluminum foam composites were prepared by catalyst chemical bath and subsequent in-situ growth approach. The dense CNTs show the intertwined structure features and construct high-speed channels near the surface of the skeletons for efficient thermal conduction, promoting the transport efficiency of heat flow.

Chlorine and UV combination sequence: Effects on antibiotic resistance control and health risks of ARGs.

The effective control of antibiotic resistance in aquatic environments is urgent. The combined chlorine and UV processes (Cl-UV, UV/Cl, and UV-Cl) are considered potential control processes for controlling antibiotic resistance. This study compared the effectiveness of these three processes in real water bodies and the potential health risks associated with antibiotic resistance genes (ARGs) after treatments.

Extracellular electron transfer-dependent bioremediation of uranium-contaminated groundwater: Advancements and challenges.

Efficient and sustainable remediation of uranium-contaminated groundwater is critical for groundwater safety and the sustainable development of nuclear energy, particularly in the context of global carbon neutrality goals. This review explores the potential of microbial reduction processes that utilize extracellular electron transfer (EET) to convert soluble uranium (U(VI)) into its insoluble form (U(IV)), presenting a promising approach to groundwater remediation. The review first outlines the key processes and factors influencing the effectiveness of dissimilatory metal-reducing bacteria (DMRB), such as Geobacter and Shewanella, during uranium bioremediation and recovery.

Succinonitrile Electrolyte Additive for Stabilizing Aqueous Zinc Metal Batteries.

The utilization of water electrolytes in zinc-ion batteries offers the advantages of enhanced safety, reduced cost, and improved environmental friendliness, rendering them an optimal choice for replacing lithium-ion batteries. Nevertheless, the conventional zinc sulfate electrolyte fails to meet stringent requirements. Therefore, developing electrolytes is crucial for addressing the low cycle life of zinc ions and suppressing the growth of zinc dendrites.

High-Quality SnSe Thin Films for Self-Powered Devices and Multilevel Information Encryption.

As semiconductor technology advances toward miniaturization and portability, thin films with excellent thermoelectric performance have garnered increasing attention, particularly for applications in self-powered devices and temperature-responsive sensors. The high Seebeck coefficient of SnSe thin films makes them promising for temperature sensing, but their poor electrical conductivity limits their potential as thermoelectric generators. In this work, high-quality -axis oriented SnSe thin films were deposited on quartz substrates by using magnetron sputtering.

High-stable bimetallic AgCu nanoalloys with core-shell structures for sustainable antibacterial and biofouling mitigation in nanofiltration.

Nanofiltration (NF) is crucial for advancing water purification and wastewater reuse technologies. Incorporating biocidal nanoparticles (NPs) such as AgNPs and CuNPs is promising for developing antibacterial and antibiofouling NF membranes, while their application is limited by NPs aggregation, high cost, and severe ion release. In this study, we developed novel NF membranes by integrating bimetallic AgCu nanoalloys via an in-situ reduction and coordination method facilitated by a polydopamine/polyethyleneimine (PDA/PEI) intermediate layer.

Research on the effectiveness of multi-view slice correction strategy based on deep learning in high pitch helical CT reconstruction.

Background: Recent studies have explored layered correction strategies, employing a slice-by-slice approach to mitigate the prominent limited-view artifacts present in reconstructed images from high-pitch helical CT scans. However, challenges persist in determining the angles, quantity, and sequencing of slices.

Objective: This study aims to explore the optimal slicing method for high pitch helical scanning 3D reconstruction.

Microneedle-Based Electrochemical Array Patch for Ultra-Antifouling and Ultra-Anti-Interference Monitoring of Subcutaneous Oxygen.

Oxygen saturation is a crucial indicator in the management of various diseases and in preoperative diagnosis, and the detection of oxygen content is valuable in guiding clinical treatment. However, as the classical and dominant oxygen detection strategies, current photoelectric oximeters and electrochemical-based blood gas analyzers often suffer from significant interindividual variation and poor compliance, respectively. In recent years, wearable microneedles (MNs) for analyzing biomarkers in interstitial fluid (ISF) have received great attention and recognition mainly for the reason that the content of the substances distributed in ISF has a better correlation with that in blood circulation compared with other body fluids such as sweat and saliva.

An iodine-driven muscle-mimicking self-resetting bilayer hydrogel actuator.

Hydrogels that can swell and deswell under the influence of opposing external stimuli have frequently been reported as muscle-mimicking materials. However, the mechanism of such materials is markedly dissimilar to that of natural muscles. Natural muscles contract when fueled by ATP and spontaneously relax once ATP is completely consumed.

Guided and Space Waves Multiplexed Metasurface for Advanced Electromagnetic Functionalities in Microwave Region.

Nowadays, metasurfaces have attracted considerable attention due to their promising and advanced control of electromagnetic (EM) waves. However, it is still challenging to shape guided waves into desired free-space mode, while simultaneously manipulating spatial incident waves using a single metasurface. Herein, a class of metasurfaces capable of multiplexing guided and space waves is proposed to achieve advanced EM functionalities in microwave regions, which can find great application potentials in radar systems, wireless communications, and wireless power transfer (WPT).

GAADE: identification spatially variable genes based on adaptive graph attention network.

The rapid advancement of spatial transcriptomics (ST) sequencing technology has made it possible to capture gene expression with spatial coordinate information at the cellular level. Although many methods in ST data analysis can detect spatially variable genes (SVGs), these methods often fail to identify genes with explicit spatial expression patterns due to the lack of consideration for spatial domains. Considering spatial domains is crucial for identifying SVGs as it focuses the analysis of gene expression changes on biologically relevant regions, aiding in the more accurate identification of SVGs associated with specific cell types.

Bacterial exopolysaccharides: Characteristics and antioxidant mechanism.

Bacterial exopolysaccharides (EPS) are secondary metabolites of microorganisms which play important roles in adhesion, protection, biofilm formation, and as a source of nutrition. Compared with polysaccharides obtained from animal and plant species, bacterial polysaccharides have significant advantages in terms of production cost and large-scale production due to their abundant metabolic pathways and efficient polysaccharide production capacity. Most extracellular polysaccharides are water-soluble, and some are insoluble, such as bacterial cellulose.

A feasible regulation strategy for conjugation of antibiotic resistance genes based on different bacterial quorum sensing inhibition methods.

The dissemination of antibiotic resistance genes (ARGs) poses global environmental issues, and plasmid-mediated conjugation contributes substantially to the spread of ARGs. Quorum sensing (QS), an important cell-cell communication system that coordinates group behaviors, has potential as a feasible regulation pathway to inhibit the conjugation process. We examined the promoting effects of QS signal on conjugation, and this study is the first to report that QS inhibitors 2(3H)-benzofuranone and acylase I effectively repressed conjugation frequency of RP4 plasmid to 0.

Hydrophilic/hydrophobic heterojunctions for enhanced photocatalytic hydrogen evolution via gas release dynamics.

Covalent-organic frameworks (COFs), characterized by their exceptional light absorption and ordered architecture, have emerged as potential candidates for photocatalytic hydrogen production. In this work, we discovered that the incorporation of fluorine into the sub-nanocavity of azine-linked COF (TF-COF) not only augments its hydrophobicity but also strengthens the interaction between Pt cocatalysts and COFs. In an effort to enhance photocatalytic water splitting efficiency, we integrated the hydrophobic TF-COF with the hydrophilic carbon nitride (CN) to construct a hydrophilic/hydrophobic heterojunction (CTF-x heterojunction).

Orientation-Related Giant Photothermoelectric Energy Conversion in Quasi-One-Dimensional van der Waals TaSe Crystals.

Featuring the capabilities of self-power, low dark current, and broadband response, photothermoelectric (PTE) detection demonstrates great potential for application in the military and civilian fields. The development of materials with an intrinsically high efficiency for PTE energy conversion and the in-depth study of its thermoelectric properties on the device performance are of great significance. Here, we reported a quasi-one-dimensional (quasi-1D) van der Waals (vdW) TaSe crystal as a promising material candidate for PTE detection.

Improved T-shaped quartz tuning fork with isosceles-trapezoidal grooves optimized for quartz-enhanced photoacoustic spectroscopy.

The quartz tuning fork (QTF) being the acoustic-electrical conversion element for quartz-enhanced photoacoustic spectroscopy (QEPAS) system directly affects the detection sensitivity. However, the low electromechanical conversion efficiency characteristic of standard QTF limits the further enhancement of the system. Therefore, the optimized design for QTF is becoming an important approach to improve the performance of QEPAS.

Synergistic SDT/cuproptosis therapy for liver hepatocellular carcinoma: enhanced antitumor efficacy and specific mechanisms.

The efficacy of sonodynamic therapy (SDT), an emerging approach for tumor treatment, is hindered by the high levels of the antioxidant glutathione (GSH) in the tumor microenvironment (TME). In this study, we constructed nanobubbles loaded with the sonosensitizer HMME and the tumor-targeting peptide RGD (HMME-RGD@CF NBs) for synergistic SDT/cuproptosis therapy of liver hepatocellular carcinoma (LIHC) in combination with Elesclomol-Cu as cuproptosis inducers. Endogenous GSH is consumed by Cu to modulate the complex TME, thereby amplifying oxidative stress and further improving SDT performance.

What influences the community well-being of Chinese living in metropolitan areas? A scale validation and invariance test across gender, age, and hukou.

Background: Rapid socioeconomic development has congregated urban dwellers in various communities, and it remains unclear whether raising income has brought greater happiness or well-being in China. The study aims to validate the Multi-dimensional Community Well-being Scale (MCWS) in the context of Chinese metropolitan areas.

Methods: Multistage stratified sampling from North, East, and West China yielded a total of 4786 community-dwelling adults (mean age = 54.

Scalable production of ultraflat and ultraflexible diamond membrane.

Diamond is an exceptional material with great potential across various fields owing to its interesting properties. However, despite extensive efforts over the past decades, producing large quantities of desired ultrathin diamond membranes for widespread use remains challenging. Here we demonstrate that edge-exposed exfoliation using sticky tape is a simple, scalable and reliable method for producing ultrathin and transferable polycrystalline diamond membranes.

Synergistic modification of ovalbumin by pH-driven and metal-phenolic networks: Development of dysphagia friendly high internal phase Pickering emulsions.

Dysphagia is a common functional disorder that limits the variety of available foods. This study explored the coordination assembly of tannic acid (TA) with Fe to form a metal-phenolic network (MPN) and developed ovalbumin (OVA)/MPN via a pH-driven method as a novel emulsifier to stabilize high internal phase Pickering emulsions (HIPPEs). Results indicated that, following pH-driven treatment, the OVA/MPN composite particles exhibited smaller sizes, enhanced electrostatic repulsion, and improved stability.

Bioactive Milk-Derived Nutrient MFG-E8 Ameliorates Skeletal Muscle Atrophy Induced by Mitochondria Damage in Aging Rat via Activating MAPK/ERK Signaling Pathway.

Sarcopenia is an age-related muscle loss, fiber number and decreased regenerative capacity with increased abundance of ROS levels and electron transport chain (ETC) abnormalities. The aim of the study is to investigate the anti-sarcopenia effect of MFG-E8 in alleviating skeletal muscle dysfunction induced by D-gal, reveal the mechanism on promoting myoblast cell proliferation and mediating cell cycle. In vivo experiment showed that MFG-E8 can improve the anti-oxidant status and increase soleus muscle mass (35.