Restoration of Sestrin 3 Expression Mitigates Cardiac Oxidative Damage in Ischemia-Reperfusion Injury Model.

Cardiac ischemia-reperfusion injury (IRI) occurs when blood flow is restored to the myocardium after a period of ischemia, leading to oxidative stress and subsequent myocardial cell damage, primarily due to the accumulation of reactive oxygen species (ROS). In our previous research, we identified that miR-25 is significantly overexpressed in pressure overload-induced heart failure, and its inhibition improves cardiac function by restoring the expression of SERCA2a, a key protein involved in calcium regulation. In this study, we aimed to investigate the role of miR-25 in the context of ischemia-reperfusion injury.

Lipid core-chitosan shell hybrid nanoparticles for enhanced oral bioavailability of sorafenib.

Limited aqueous solubility is a major hurdle resulting in poor and variable oral bioavailability, high doses, side effects, and the suboptimal therapeutic efficacy of sorafenib (SRF). In this study, we developed SRF-loaded solid lipid nanoparticles (SRF-SLNs) and lipid core-chitosan shell hybrid nanoparticles (CS-SRF-SLNs) to improve the oral absorption of SRF. SRF-SLNs were prepared using a stearyl alcohol core stabilized with a surfactant mixture, followed by surface decoration with chitosan to form CS-SRF-SLNs.

Cadmium-induced iron dysregulation contributes to functional impairment in brain endothelial cells via the ferroptosis pathway.

Cadmium (Cd) is a heavy metal that is a major hazardous environmental contaminant, ubiquitously present in the environment. Cd exposure has been closely associated with an increased prevalence and severity of neurological and cardiovascular diseases (CVD). The blood-brain barrier (BBB) plays a crucial role in protecting the brain from external environmental factors.

Mechanistic Insights into the Eco-Friendly Conifer Cone Extract's Corrosion Inhibition on Steel Rebar and Cement Mortar: An Experimental and Simulation Approach.

This study investigates the corrosion inhibition effects of eco-friendly conifer cone extract (CCE) on steel rebars embedded in cement mortar exposed to 3.5% NaCl under alternate wet/dry cycles. CCE concentrations of 0, 0.

Effect of Light Regime on Puniceispirillum marinum IMCC1322 in Nutrient-Replete Conditions.

Previous studies showed no improvement in bacterial biomass for Puniceispirillum marinum IMCC1322 under light regimes. Nevertheless, in nutrient-replete cultures with higher inoculating cell densities, strain IMCC1322 exhibited proteorhodopsin photoheterotrophy. Increasing both inoculum size and the amino acid pool can eliminate quorum sensing and starvation responses in strain IMCC1322.

Ring-Opening Polymerization of Surface Ligands Enables Versatile Optical Patterning and Form Factor Flexibility in Quantum Dot Assemblies.

The evolution of display technologies is rapidly transitioning from traditional screens to advanced augmented reality (AR)/virtual reality (VR) and wearable devices, where quantum dots (QDs) serve as crucial pure-color emitters. While solution processing efficiently forms QD solids, challenges emerge in subsequent stages, such as layer deposition, etching, and solvent immersion. These issues become especially pronounced when developing diverse form factors, necessitating innovative patterning methods that are both reversible and sustainable.

Development of an Equivalent Analysis Model of PVB Laminated Glass for TRAM Crash Safety Analysis.

This study focuses on an equivalent model of Polyvinyl Butyral (PVB) laminated glass to simulate the Head Injury Criterion (HIC) when a pedestrian collides with a TRAM. To simulate the collision behavior that occurs when a pedestrian's head collides with PVB laminated glass, a comparison was made between the results of the widely used PLC model for PVB laminated glass modeling and an actual dynamic head impact test. The material properties of the tempered glass and PVB film used in the PLC and equivalent models were obtained via four-point bending tests and tensile tests, respectively.

Secure privacy-preserving record linkage system from re-identification attack.

Privacy-preserving record linkage (PPRL) technology, crucial for linking records across datasets while maintaining privacy, is susceptible to graph-based re-identification attacks. These attacks compromise privacy and pose significant risks, such as identity theft and financial fraud. This study proposes a zero-relationship encoding scheme that minimizes the linkage between source and encoded records to enhance PPRL systems' resistance to re-identification attacks.

Unsymmetric Triazine-Based Triglucoside Detergents for Membrane Protein Stability.

Membrane proteins play a crucial role in a variety of biological processes and are key targets for pharmaceutical development. Structural studies of membrane proteins provide molecular insights into the mechanisms of these processes and are essential for effective drug discovery. Historically, these studies have relied on solubilization of the target protein using detergents, but conventional detergents often fail to maintain the stability of challenging membrane proteins.

Experimental Study on the Flexural Performance of Composite Beams with Lipped Channels.

This study conducted experiments to investigate the flexural behavior of steel-concrete composite beams with U-shaped sections, utilizing cold-formed lipped channels as web components. To enhance both flexural and shear performance, trapezoidal plates were added to the lower sides of the composite beams. A total of ten specimens were fabricated, with variables defined according to the following criteria: presence of bottom tension reinforcement and bottom studs, thickness of the trapezoidal side plates (6 mm and 8 mm), and the welding method.

Causal Relationship Between Physical Activity and Thymic Tumors Mediated by Circulating Cytokines: A Mendelian Randomization Mediation Analysis.

Physical activity reduces chronic disease risk and enhances immune function, but its causal relationship with thymic tumors-rare neoplasms of the anterior mediastinum-remains unclear. This study investigated whether physical activity reduces thymic tumor risk and whether circulating cytokines mediate this effect. We performed a two-sample Mendelian randomization (MR) analysis using genetic variants as instrumental variables for physical activity and cytokines.

Advanced spectroscopic evidence for the sequestration of heavy metals via repetitive in situ synthesis of Fe oxide.

The in situ synthesis of Fe oxide is an established method for stabilizing metals and metalloids (Me) in contaminated soils. Nevertheless, the potential for enhanced Me sequestration through repeated Fe oxide application and the fundamental mechanisms of this process yet to be systemically investigated. In this study, the means by which repetitive Fe oxide synthesis enhances the immobilization of Cd, Zn, and As was investigated using batch experiments.

Tetragonal Tungsten Oxide for Supercapacitor Electrodes: Study of Phase-Driven Charge Storage Mechanism and Work Function Control.

The crystal phase of pseudocapacitive materials significantly influences charge storage kinetics and capacitance; yet, the underlying mechanisms remain poorly understood. This study focuses on tungsten oxide (WO), a material exhibiting multiple crystal phases with potential for energy storage. Despite extensive research on WO, the impact of different crystal structures on charge storage properties remains largely unexplored.

Functional Group Effects on the Interfacial Adsorption of Arylquinoline-3-Carbonitriles on Iron: A DFT-D3 Investigation of Surface Interaction Mechanisms.

Reliable corrosion inhibition systems are crucial for extending the lifespan of industrial metal structures. Quinolines, with their high adsorption capacity and protective efficiency, are promising next-generation inhibitors. However, the impact of substitutions on their coordination with iron surfaces requires deeper understanding.

Inhibition of the mitochondrial permeability transition pore as a promising target for protecting auditory function in cisplatin-induced hearing loss.

mPTP is a multi-protein complex that opens in mitochondria during cell death. Cisplatin-induced hearing loss is also known to be caused by mPTP opening. Thus, our study evaluated the protective effect of a novel mPTP inhibitor named DBP-iPT against cisplatin-induced hearing loss.

A meta-analytic study of complex exercise interventions for cognitive performance in older adults.

Purpose: To analyze the effect of complex exercise on cognitive ability of the elderly.

Study Design: By means of literature screening and quality assessment, high-quality studies were extracted to comprehensively analyze the effects of complex exercise on cognitive ability of the elderly.

Method: By searching databases such as Web of Science and CNKI, we integrated experimental studies on the effects of complex exercise on cognitive ability in the elderly, conducted literature quality assessment according to Cochrane bias risk assessment tool, and conducted meta-analysis using Review Manager 5.

Deeply Implantable, Shape-Morphing, 3D MicroLEDs for Pancreatic Cancer Therapy.

Controlled photooxidation-mediated disruption of collagens in the tumor microenvironment can reduce desmoplasia and enhance immune responsiveness. However, achieving effective light delivery to solid tumors, particularly those with dynamic volumetric changes like pancreatic ductal adenocarcinoma (PDAC), remains challenging and limits the repeated and sustained photoactivation of drugs. Here, 3D, shape-morphing, implantable photonic devices (IPDs) are introduced that enable tumor-specific and continuous light irradiation for effective metronomic photodynamic therapy (mPDT).

Riding safety Evaluation of food delivery motor scooters based on Associating Sensor-based riding behavior and road traffic characteristics.

The safety of motor scooters used to deliver food has come under scrutiny due to the growing popularity of food delivery services in Republic of Korea. Policymakers have been tasked with investigating and identifying the factors associated with scooter safety to prevent accidents and develop mitigating strategies. A comprehensive analysis of the components of road traffic influencing the safety of motor scooters has received little attention to date.

cGAS/STING pathway modulation in polyhexamethyleneguanidine phosphate-induced immune dysregulation and pulmonary fibrosis using human monocytic cells (THP-1) and male C57BL/6 mice.

Polyhexamethyleneguanidine phosphate (PHMG), a widely used antimicrobial agent, has been implicated in humidifier disinfectant-associated lung injuries (HDLI). PHMG exposure suppressed interferon regulatory factor 3 (IRF3) activation and interferon-β (IFN-β) expression induced by a cGAS agonist or a STING agonist in human monocytic cells (THP-1), which are known to transition to alveolar macrophages during pulmonary fibrosis development. However, the mechanisms underlying PHMG-induced pulmonary toxicity in lung remain unclear.

Synergistic Configuration of Binary Rhodium Single Atoms in Carbon Nanofibers for High-Performance Alkaline Water Electrolyzer.

Electrochemical alkaline water electrolysis offers significant economic advantages; however, these benefits are hindered by the high kinetic energy barrier of the water dissociation step and the sluggish kinetics of the hydrogen evolution reaction (HER) in alkaline media. Herein, the ensemble effect of binary types of Rh single atoms (Rh-N and Rh-O) on TiO-embedded carbon nanofiber (Rh-TiO/CNF) is reported, which serves as potent active sites for high-performance HER in anion exchange membrane water electrolyzer (AEMWE). Density functional theory (DFT) analyses support the experimental observations, highlighting the critical role of binary types of Rh single atoms facilitated by the TiO sites.

Development and validation of e-scooter riding behavior questionnaire (ERBQ) among Korean riders.

The main objective of this research was to develop a questionnaire that demonstrates elevated levels of reliability to assess the behaviour of e-scooter users. The researchers designed an E-scooter Riding Behaviour Questionnaire (ERBQ) with 27 items. This questionnaire aimed to assess the self-reported frequency of various e-scooter riding behaviours, including errors, violations and behaviours.

First principle calculations of Janus 2D-TiSSe as an anodic electrode in batteries of lithium, sodium, and magnesium ions.

Context: In recent years, rechargeable batteries have received considerable attention as a way to improve energy storage efficiency. Anodic (negative) electrodes based on Janus two-dimensional (2D) monolayers are among the most promising candidates. In this effort, the adsorption and diffusion of these Li, Na, and Mg ions on and through Janus 2D-TiSSe as anodic material was investigated by means of periodic DFT-D calculations.