1,121 results match your criteria: "Hantavirus Pulmonary Syndrome"
Hantavirus Pulmonary Syndrome in Northwestern Argentina: seroprevalence in rodents of Jujuy province and first seropositive record for Euryoryzomys legatus.
Acta Trop
December 2024
Laboratorio de Ecología Evolutiva y Biogeografía (LEEB) - Instituto de Ecorregiones Andinas-Consejo Nacional de Investigaciones Científicas y Técnicas(CONICET) - Universidad Nacional de Jujuy (UNJu), Gorriti 237, San Salvador de Jujuy, Jujuy, Argentina. Electronic address:
Hantavirus Pulmonary Syndrome (HPS) is a Pan-American emerging infectious disease with a high mortality rate caused by rodent-borne viruses of the genus Orthohantavirus. In Argentina, almost half of the HPS infections occur in the northwestern endemic region. In this study, we evaluated rodent composition, abundance, and antibody prevalence in wild rodents in three subtropical sites: primary forest, secondary forest, and crop fields.
View Article and Find Full Text PDFDevelopment of a seroepidemiological tool for bat-borne and shrew-borne hantaviruses and its application using samples from Zambia.
PLoS Negl Trop Dis
November 2024
Graduate School of Infectious Diseases, Hokkaido University, Sapporo, Japan.
Article Synopsis
Orthohantavirus diversity in Central-East Argentina: Insights from complete genomic sequencing on phylogenetics, Geographic patterns and transmission scenarios.
PLoS Negl Trop Dis
October 2024
Laboratorio Nacional de Referencia de Hantavirus, Instituto Nacional de Enfermedades Infecciosas, Administración Nacional de Laboratorios e Institutos de Salud "Dr. Carlos G. Malbran", Ciudad Autónoma de Buenos Aires, Argentina.
Article Synopsis
- Hantavirus Pulmonary Syndrome (HPS) is a public health threat in Argentina, particularly due to evidence of person-to-person transmission of the Andes virus and its high fatality rate.
- This study aimed to analyze the viral diversity and phylogenetic relationships of the most common orthohantaviruses associated with HPS in Central-East Argentina, utilizing complete genomic sequencing.
- Findings revealed distinct viral clades, highlighted geographic distribution patterns, and differentiated modes of transmission, suggesting a need to categorize Buenos Aires virus and Lechiguanas virus under a new species.
Hantavirus Pulmonary Syndrome Outbreak Anticipation by a Rapid Synchronous Increase in Rodent Abundance in the Northwestern Argentina Endemic Region: Towards an Early Warning System for Disease Based on Climate and Rodent Surveillance Data.
Pathogens
September 2024
National Institute of Infectious Diseases (Instituto Nacional de Enfermedades Infecciosas-INEI), National Administration of Laboratories and Health Institutes (Administración Nacional de Laboratorios e Institutos de Salud-ANLIS "Dr. C. G. Malbrán"), Buenos Aires C1282 AFF, Argentina.
Article Synopsis
- Hantavirus pulmonary syndrome (HPS) is a serious disease linked to a rodent-borne virus, with a significant number of cases occurring in northwestern Argentina.
- A study in 2022-2023 tracked rodent populations using various methods to understand their connection to human HPS infections and found a clear relationship between rising rodent numbers and HPS outbreaks.
- The research suggests that monitoring climate and rodent populations can help in planning public health campaigns, while also highlighting domestic cats as potential risk factors for increased rodent-related virus transmission.
Preclinical evaluation of a fully human, quadrivalent-hantavirus polyclonal antibody derived from a non-human source.
mBio
October 2024
Virology Division, USA Army Medical Research Institute of Infectious Diseases (USAMRIID), Fort Detrick, Maryland, USA.
Article Synopsis
- * SAB-163 is a new therapeutic treatment developed from transchromosomic bovine plasma, showing strong effectiveness against multiple hantavirus strains and extended bioavailability in animal models.
- * The treatment has demonstrated protective effects in hamsters when administered around the time of exposure and is now ready for phase 1 clinical trials after passing safety and efficacy tests.
25-Hydroxycholesterol inhibits Hantavirus infection by reprogramming cholesterol metabolism.
Free Radic Biol Med
November 2024
Department of Microbiology, School of Preclinical Medicine, Air Force Medical University: Fourth Military Medical University, Xi'an, Shaanxi, 710032, China. Electronic address:
Article Synopsis
- Hantavirus causes severe diseases with high mortality rates, and current treatments are lacking; however, Type I interferon has shown promise when administered early.
- The study reveals that Hantaan virus (HTNV) increases the expression of the enzyme cholesterol 25-hydroxylase (CH25H), which then helps inhibit HTNV infection through cholesterol regulation.
- It suggests that 25-hydroxycholesterol (25HC) and cholesterol-lowering statins could be repurposed as effective antiviral treatments against hantavirus infections, highlighting the potential of targeting cholesterol metabolism in developing new therapies.
Hantavirus Cardiopulmonary syndrome: Another Reason to Avoid Mice.
J Investig Med High Impact Case Rep
August 2024
Community Hospital, Grand Junction, CO, USA.
Article Synopsis
- Hantavirus cardiopulmonary syndrome is a serious illness caused by exposure to rodent waste, which can lead to severe respiratory problems.
- A 24-year-old male presented to the emergency department with symptoms like cough, shortness of breath, and gastrointestinal issues, eventually developing acute respiratory distress syndrome (ARDS).
- Blood tests confirmed hantavirus infection, and the patient was treated with supportive care, leading to his recovery; this case underscores the need to consider hantavirus in patients showing specific critical symptoms like thrombocytopenia and ARDS.
Human disease prevalence and genotype distribution in the U.S., 2008-2020: a retrospective observational study.
Lancet Reg Health Am
September 2024
Viral Special Pathogens Branch, U.S. Centers for Disease Control and Prevention (CDC), 1600 Clifton Rd., NE Atlanta, GA, 30333, USA.
Article Synopsis
- Hantavirus pulmonary syndrome (HPS) and non-HPS hantavirus infection are tracked as nationally notifiable diseases in the U.S., with diagnostics based on symptoms and lab results between 2008 and 2020.
- A study merged epidemiological data and diagnostic lab results from the CDC to analyze the occurrence and genetic diversity of hantavirus in the U.S., revealing that the majority of cases were in western states, particularly the Four Corners region.
- Findings highlight a seasonal spike in cases between March and August and reveal discrepancies between commercial and CDC lab tests, suggesting a need for better diagnostic tests to align results.
Hantavirus Expansion Trends in Natural Host Populations in Brazil.
Viruses
July 2024
Department of Ecology, Institute of Biology, Rio de Janeiro Federal University (UFRJ), Rio de Janeiro 21941-902, Brazil.
Article Synopsis
- * This study uses a combined Kermack-McCormick SIR model and cellular automata to predict how hantavirus spreads among host populations, revealing potential new areas of infection.
- * Findings indicate that 22 previously unconfirmed municipalities may see cases in the next decade, emphasizing the need for consistent prevention efforts due to habitat fragmentation and agricultural expansion.
Innate lymphoid cells are activated in HFRS, and their function can be modulated by hantavirus-induced type I interferons.
PLoS Pathog
July 2024
Center for Infectious Medicine, Department of Medicine Huddinge, Karolinska Institutet, Stockholm, Sweden.
Hantaviruses cause the acute zoonotic diseases hemorrhagic fever with renal syndrome (HFRS) and hantavirus pulmonary syndrome (HPS). Infected patients show strong systemic inflammation and immune cell activation. NK cells are highly activated in HFRS, suggesting that also other innate lymphoid cells (ILCs) might be responding to infection.
View Article and Find Full Text PDFArticle Synopsis
- The North American Deermouse is a common mammal linked to Hantavirus Pulmonary Syndrome (HPS), posing a public health risk due to its role as a virus host.
- Recent studies reveal that the Deermouse is actually a complex of multiple species, which complicates the interpretation of longstanding hantavirus monitoring data.
- A systematic review of 46 studies from 2000 to 2022 shows that virus detection is mainly concentrated in the Western U.S. and Mexico, highlighting geographical gaps and the need to consider the new taxonomic classifications in hantavirus research.
Critical care management of hantavirus cardiopulmonary syndrome. A narrative review.
J Crit Care
December 2024
Departamento de Medicina Intensiva, Facultad de Medicina, Pontificia Universidad Católica de Chile, Santiago, Chile. Electronic address:
Hantaviruses, members of the Bunyaviridae family, can cause two patterns of disease in humans, hantavirus hemorrhagic fever with renal syndrome (HFRS) and cardiopulmonary syndrome (HCPS), being the latter hegemonic on the American continent. Andesvirus is one of the strains that can cause HCPS and is endemic in Chile. Its transmission occurs through direct or indirect contact with infected rodents' urine, saliva, or feces and inhalation of aerosol particles containing the virus.
View Article and Find Full Text PDFEvaluating climate-dependent distribution of orthohantaviruses with monitoring wild rodents: One Health Perspective.
Braz J Microbiol
September 2024
Department of Medical Microbiology, Institute of Health Sciences, Dokuz Eylul University, Izmir, Türkiye.
Article Synopsis
- Orthohantaviruses are significant public health threats, causing various diseases like hemorrhagic fever and hantavirus pulmonary syndrome, so monitoring wild rodents for these viruses is crucial for outbreak preparedness.
- Researchers conducted a study from 2015 to 2017 in Southern Anatolia but found no evidence of orthohantavirus infections among the trapped rodents.
- The study suggests that orthohantavirus presence may be influenced by climatic conditions, particularly precipitation and temperature, and emphasizes the need for further research on rodent surveillance in different regions.
The role of health mediation in investigation of Hantavirus cases among informal settlements inhabitants of Cayenne area, French Guiana, 2022-2023.
Front Public Health
July 2024
Infectious and Tropical Diseases Unit, Centre Hospitalier de Cayenne, Cayenne, French Guiana.
Article Synopsis
- In 2022, four severe cases of Hantavirus pulmonary syndrome (HPS) were reported in informal settlements in French Guiana, prompting a study to estimate the prevalence of Hantavirus infections in the area.
- The French Red Cross trained health mediators to support the investigation, leading to increased awareness and participation from local residents, with over 90% indicating their willingness to partake in the study.
- The study found a 5.1% positivity rate of IgG anti-Hantavirus among participants, highlighting the effectiveness of the mediators' involvement in the health awareness and data collection process.
Article Synopsis
- Hantavirus pulmonary syndrome cases in northeastern Argentina are rare, but neighboring regions have higher rates, indicating possible underreporting.
- A study was conducted to check for antibodies against orthohantavirus in small rodents in Misiones province.
- Infected rodent species, Akodon affinis montensis and Oligoryzomys nigripes, were discovered in protected areas of the province.
Development and standardization of an enzyme-linked inmunosorbent for the detection of orthohantavirus infection in Argentina based on its bacterial-expressed nucleocapside protein.
Braz J Microbiol
September 2024
Instituto Nacional de Enfermedades Virales Humanas Dr. "Julio Maiztegui ", INEVH-ANLIS, Pergamino, 2700, Argentina.
Article Synopsis
Introduction: Preventive care practices are a challenge in community care. This study examined hantavirus preventive practices and their relationship with personal and social factors, lifestyle, and cultural beliefs.
Method: An explanatory sequential mixed methods design, guided by Leininger's Theory of Culture Care Diversity and Universality, was used in two phases: (a) a cross-sectional relational design ( = 109) and (b) ethnonursing research ( = 30), in an endemic community in Panama.
Article Synopsis
- A study in Austria examined 370 patients with hantavirus infections, revealing a 7.8% admission rate to the ICU.
- Among these patients, 2 cases of invasive pulmonary aspergillosis were identified, resulting in a cumulative incidence of 7%.
- One patient passed away, indicating that hantavirus infections can lead to serious complications like pulmonary aspergillosis in critically ill individuals with hemorrhagic fever and renal syndrome.
Hemorrhagic Fever with Renal Syndrome Complicated by Acute Pancreatitis, High Intraocular Pressure, and Pulmonary Involvement: a Case Report.
Infect Drug Resist
May 2024
Department of Emergency Medicine, The First Hospital of Jilin University, Changchun, Jilin, 130000, People's Republic of China.
Article Synopsis
- - Hemorrhagic fever with renal syndrome (HFRS) is a disease caused by hantaviruses, presenting symptoms like fever, hemorrhage, renal failure, and occasionally acute pancreatitis, highlighting the importance of recognizing diverse symptoms in affected patients.
- - A 30-year-old male with HFRS experienced fever, nausea, abdominal pain, petechiae, and elevated intraocular pressure, leading to a diagnosis that included acute pancreatitis confirmed by CT scans and a positive hantavirus antibody test.
- - The patient underwent treatment for both renal failure and respiratory complications, eventually recovering normal functions; this case emphasizes the necessity for thorough assessments and monitoring of HFRS patients, especially regarding intraocular pressure.
Hantavirus infection in central Sri Lanka - an unusual clinical presentation: a case report.
Access Microbiol
April 2024
National Hospital Kandy, Kandy, Sri Lanka.
Article Synopsis
- Hantavirus infections are emerging diseases transmitted from animals to humans, primarily seen in Asia as haemorrhagic fever with renal syndrome (HFRS), characterized by fever and kidney issues.
- Some rare cases present atypical symptoms, including cardiopulmonary problems, as observed in Asia, like Sri Lanka.
- The report focuses on a specific case of hantavirus infection that showed unusual cardiopulmonary symptoms, confirmed by serological evidence of the Puumala/Puumala-like virus.
Epidemiological and clinical characteristics of death from hemorrhagic fever with renal syndrome: a meta-analysis.
Front Microbiol
April 2024
College of Chinese Medicine, Beijing University of Chinese Medicine, Beijing, China.
Article Synopsis
- Hemorrhagic fever with renal syndrome (HFRS) is a serious infectious disease with five distinct stages and a mortality rate between 1-15%, characterized by increased vascular permeability and renal injury.
- A comprehensive study analyzed data from 37 articles involving over 140,000 HFRS patients to identify clinical features associated with fatalities, revealing that deceased patients were generally older and had higher incidences of smoking, hypertension, and diabetes.
- Patients who did not survive exhibited significant differences in various health complications and laboratory results, such as elevated leukocyte counts and altered liver function tests, indicating more severe organ dysfunction and the need for intensive care like continuous renal therapy.
Hybrid capture-based next-generation sequencing of new and old world Orthohantavirus strains and wild-type Puumala isolates from humans and bank voles.
J Clin Virol
June 2024
Department of Clinical Microbiology, Umeå University, SE-90185, Umeå, Sweden. Electronic address:
Article Synopsis
- Orthohantaviruses, primarily transmitted by rodents, cause serious illnesses such as hemorrhagic fever with renal syndrome in Eurasia and hantavirus pulmonary syndrome in the Americas, with no effective treatments or vaccines currently available.
- The study focused on the Puumala virus (PUUV), carried by bank voles, which causes a milder form of HFRS; researchers developed a hybrid-capture method for complete genomic sequencing of PUUV isolates, revealing valuable information about nucleotide diversity and lineage.
- The findings offer crucial insights into PUUV evolution and epidemiology in Northern Sweden, highlighting the panel's diagnostic potential that could improve understanding of Orthohantavirus transmission routes.
Hantavirus Pulmonary Syndrome in an Adolescent from North Dakota.
Pediatr Infect Dis J
June 2024
From the Division of Infectious Diseases, Cincinnati Children's Hospital Medical Center.
Article Synopsis
- Hantavirus pulmonary syndrome is a rare but serious viral disease affecting mainly children and adolescents, leading to severe respiratory issues and potential death.
- Medical professionals need to be aware of the disease's risk factors, symptoms, and diagnostic imaging to effectively manage it.
- A case study is discussed involving a 14-year-old girl from North Dakota who successfully recovered from hantavirus pulmonary syndrome without lasting effects.
Production and Purification of Hantavirus Glycoproteins in Drosophila melanogaster S2 Cells.
Methods Mol Biol
February 2024
G5 Structural Biology of Infectious Diseases, Institut Pasteur, Université Paris Cité, Paris, France.
Article Synopsis
- * The viral particles have a protein coating made of two specific glycoproteins (Gn and Gc) that help them attach to and fuse with host cells, which are important for developing neutralizing antibodies.
- * The study describes a method for producing soluble recombinant glycoproteins in various forms, including a stable Gn/Gc complex, using genetically modified Drosophila S2 cells.