β-elemene promotes the senescence of glioma cells through regulating YAP-CDK6 signaling.

Glioma is currently the most widespread and malignant primary intracranial tumor, which is characterized by high heterogeneity and high fatality rates. β-elemene, which is a bioactive compound extracted from a Chinese herb, Curcuma wenyujin, has been reported to reduce resistance of chemotherapeutic drugs and induce apoptosis in tumor cells. However, the role and mechanisms of β-elemene in glioma senescence remains unknown.

A review on the cytotoxicity of graphene quantum dots: from experiment to simulation.

Graphene quantum dots (GQDs) generate intrinsic fluorescence and improve the aqueous stability of graphene oxide (GO) while maintaining wide chemical adaptability and high adsorption capacity. Despite GO's remarkable advantages in bio-imaging, bio-sensing, and other biomedical applications, many experiments and simulations have focused on the biosafety of GQDs. Here, we review the findings on the biosafety of GQDs from experiments; then, we review the results from simulated interactions with biological membranes, DNA molecules, and proteins; finally, we examine the intersection between experiments and simulations.

Synthesis of Janus Au@BCP nanoparticles UV light-initiated RAFT polymerization-induced self-assembly.

It is a great challenge to fabricate Janus inorganic/polymeric hybrid nanoparticles with both precisely controlled nanostructures and high yields. Herein, we report a new method to synthesize Janus Au@BCPs UV light-initiated RAFT polymerization-induced self-assembly at a high solid content. This strategy provides a promising alternative for achieving asymmetric hybrid nanoparticles with a controllable size, tunable morphology and convenient operation.

Study on the interfacial properties of polymers around a nanoparticle.

The interfacial properties of polymer chains on spherical nanoparticles are investigated using off-lattice Monte Carlo simulations. Results show that the number of adsorbed monomers increases whereas the number of adsorbed polymers decreases with increasing the polymer-nanoparticle interaction strength. The interfacial layer thickness is independent of the nanoparticle size and chain length.

METTL3 plays multiple functions in biological processes.

N-methyladenosine (mA) is the most common internal modification of mRNAs in higher eukaryotic. This process is performed by methyltransferase. Methyltransferase-like 3 (METTL3) is the best known mA methyltransferase that functions in the reversible epi-transcriptome modulation of mA modification.

Iodine/water-mediated deprotective oxidation of allylic ethers to access α,β-unsaturated ketones and aldehydes.

The first iodine/water-mediated deprotective oxidation of allylic ethers to access α,β-unsaturated ketones and aldehydes was achieved. The reaction tolerates a wide range of functionalities. Furthermore, this protocol was found to be applicable to the oxidative transformation of allylic acetates.

[Breeding and variety characteristics of a new variety of Fritillaria thunbergii "Zhebei 3"].

A new variety "Zhebei 3(Zhejiao Pharmaceutical 2018002)" was selected and bred from multi seeded Fritillaria thunbergii mutants by systematic breeding method. From 2012 to 2016, the traits assessment, disease resistance appraisal, plot ratios and regional trials of the variety were continuously carried out. The results showed that "Zhebei 3" emerged early and had late seedlings.

Asp1104His polymorphism increases colorectal cancer risk especially in Asians.

Xeroderma pigmentosum group G (XPG) protein is a pivotal element of the nucleotide excision repair pathway. gene single nucleotide polymorphisms (SNPs) have been shown to confer colorectal cancer (CRC) susceptibility. In this study, we further investigated the role of Asp1104His (rs17655 G > C) in on CRC risk.

Palladium-catalyzed tandem allylic substitution/cyclization and cascade hydrosilylated reduction: the influence of reaction parameters and hydrosilanes on the stereoselectivity.

To shed light on the influence of reaction parameters on palladium-catalyzed tandem allylic alkylation in the presence of Fei-Phos (a chiral -1,2-diaminocyclohexane-derived phosphine ligand), the effect of different phosphine ligands, inorganic or organic bases, Brønsted acids, and other additives on the asymmetric palladium-catalysed alkylation of catechol with allylic diacetate was investigated. In this reaction, 2-vinyl-2,3-dihydro-benzo[1,4]dioxin products with promising enantioselectivity were achieved in good yields. In addition, a novel palladium-catalyzed three-component and one-pot allylic substitution/cyclization/reduction reaction assisted by methylphenylsilane was reported with good selectivity.

Single-subject morphological brain networks: connectivity mapping, topological characterization and test-retest reliability.

Introduction: Structural MRI has long been used to characterize local morphological features of the human brain. Coordination patterns of the local morphological features among regions, however, are not well understood. Here, we constructed individual-level morphological brain networks and systematically examined their topological organization and long-term test-retest reliability under different analytical schemes of spatial smoothing, brain parcellation, and network type.