6 results match your criteria: "Hangzhou Institute of Medicine (HIM) Chinese Academy of Sciences[Affiliation]"
Article Synopsis
- Advances in spatial transcriptomics (ST) are revolutionizing translational oncology by enhancing experimental design and bioinformatics approaches to research.
- A systematic review presents the evolution of ST techniques, focusing on bioinformatic tools and proposing a workflow for ST data exploration, especially in the context of tumor microenvironments.
- The review summarizes current ST-based studies in cancer research, highlighting their roles in mechanistic understanding and biomarker profiling, while offering guidance on using high-resolution ST tools for clinically significant biological insights.
The CRISPR gene editing tool holds great potential for curing genetic disorders. However, the safe, efficient, and specific delivery of the CRISPR/Cas9 components into cells and tissues remains a challenge. While many currently available delivery methods achieve high levels of gene editing effects in vivo, they often result in genotoxicity and immunogenicity.
View Article and Find Full Text PDFEffects of interrupting residues on DNA dumbbell structures formed by CCTG tetranucleotide repeats associated with myotonic dystrophy type 2.
FEBS Lett
October 2024
Zhejiang Cancer Hospital, Hangzhou Institute of Medicine (HIM) Chinese Academy of Sciences, China.
Article Synopsis
- Myotonic dystrophy type 2 (DM2) is linked to expansions of CCTG tetranucleotide repeats in the CNBP gene, leading to genetic instability.
- Interrupting motifs like NCTG within CCTG repeats may help maintain genomic stability, though their effects on DNA structure were not fully understood.
- Research indicates that CCTG repeats with certain interrupting residues form more stable structures, while others can create chaotic forms, possibly increasing the risk of genetic errors and repeat expansions in DM2.
A red blood cell-derived bionic microrobot capable of hierarchically adapting to five critical stages in systemic drug delivery.
Exploration (Beijing)
April 2024
The tumour-targeting efficiency of systemically delivered chemodrugs largely dictates the therapeutic outcome of anticancer treatment. Major challenges lie in the complexity of diverse biological barriers that drug delivery systems must hierarchically overcome to reach their cellular/subcellular targets. Herein, an "all-in-one" red blood cell (RBC)-derived microrobot that can hierarchically adapt to five critical stages during systemic drug delivery, that is, circulation, accumulation, release, extravasation, and penetration, is developed.
View Article and Find Full Text PDFMicroRNAs (miRNAs) are relatively stable in blood, emerging as one of the most promising biomarkers in tumor liquid biopsy. Both total and extracellular vesicles (EVs) encapsulated miRNA have been studied for prognostic potential in a variety of cancers. Here, we systematically compared and verified the total and vesicle-derived miRNA expression profiles from plasma samples in healthy controls and patients with esophageal squamous cell carcinoma (ESCC).
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