8 results match your criteria: "Hangzhou Hospital of Chinese Medicine[Affiliation]"
Background: Antibody-drug conjugate (ADC) is an anticancer drug that links toxins to specifically targeted antibodies via linkers, offering the advantages of high target specificity and high cytotoxicity. However, complexity of its structural composition poses a greater difficulty for drug design studies.
Objectives: Pharmacokinetic/pharmacodynamic (PK/PD) based consideration of ADCs has increasingly become a hot research topic for optimal drug design in recent years, providing possible ideas for obtaining ADCs with desirable properties.
Effects of Mineralocorticoid Receptor Antagonists for Chronic Kidney Disease: A Systemic Review and Meta-Analysis.
Am J Nephrol
February 2024
Urology and Nephrology Center, Department of Nephrology, Zhejiang Provincial People's Hospital, Affiliated People's Hospital, Hangzhou Medical College, Hangzhou, China.
Background: Mineralocorticoid receptor blockade could be a potential approach for the inhibition of chronic kidney disease (CKD) progression. The benefits and harms of different mineralocorticoid receptor antagonists (MRAs) in CKD are inconsistent.
Objectives: The aim of the study was to summarize the benefits and harms of MRAs for CKD patients.
Renal Interstitial Inflammation Predicts Nephropathy Progression in IgA Nephropathy: A Two-Center Cohort Study.
Am J Nephrol
July 2022
Department of Nephrology, Hangzhou Hospital of Chinese Medicine (Guangxing Hospital), Affiliated to Zhejiang University of Chinese Medicine, Hangzhou, China.
Article Synopsis
- Renal interstitial inflammation is a key feature in immunoglobulin A nephropathy (IgAN), but its impact on the progression of kidney disease is still debated.
- A study involving 1,420 IgAN patients over about seven years assessed the severity of interstitial inflammation and its correlation with kidney function decline and severe kidney-related outcomes.
- Results indicated that higher levels of interstitial inflammation were linked to faster declines in kidney function, suggesting that inflammation severity may be an important factor in predicting patient outcomes.
Effectiveness of Chinese herbal medicine combined with Western medicine on deferring dialysis initiation for nondialysis chronic kidney disease stage 5 patients: a multicenter prospective nonrandomized controlled study.
Ann Transl Med
March 2021
Department of Nephrology, Guangdong Provincial Hospital of Chinese Medicine (The Second Affiliated Hospital of Guangzhou University of Chinese Medicine), Guangzhou, China.
Background: In clinical practice, Chinese herbal medicine (CHM) purportedly has beneficial therapeutic effects for chronic kidney disease (CKD), which include delaying disease progression and dialysis initiation. However, there is a lack of high-quality evidence-based results to support this. Therefore, this study aimed to evaluate the efficacy of CHM combined with Western medicine in the treatment of stage 5 CKD.
View Article and Find Full Text PDFThe Association of Low Hemoglobin Levels with IgA Nephropathy Progression: A Two-Center Cohort Study of 1,828 Cases.
Am J Nephrol
July 2021
Department of Nephrology, Hangzhou Hospital of Chinese Medicine (Guangxing Hospital), Affiliated to Zhejiang University of Chinese Medicine, Hangzhou, China.
Article Synopsis
- The study aimed to explore how hemoglobin levels relate to the progression of IgA nephropathy (IgAN) using a cohort of 1,828 patients with confirmed cases.
- Researchers found that lower hemoglobin levels were linked to a higher risk of both all-cause mortality and kidney failure over about 7 years of follow-up.
- Anemia significantly increased the risk for adverse outcomes in both men and women compared to those with normal hemoglobin levels, suggesting a crucial association between hemoglobin and IgAN progression.
Effect of mannose on the lung function of rats with acute pancreatitis.
J Biol Regul Homeost Agents
August 2018
Department of Critical Care Medicine, Hangzhou Hospital of Chinese Medicine Hangzhou, China.
The present study aimed to investigate the mechanisms by which mannose protects the lung injury induced in rats with acute pancreatitis (AP). An AP combined with Acute Lung Injury (ALI) model was established. A total of 90 healthy adult male Sprague-Dawley rats (300±50g weight) were randomly divided into three groups: sham operation group (SO group), severe acute pancreatitis lung injury group (SAP group), and mannose intervention group (MT group).
View Article and Find Full Text PDFExpression and clinical significance of rhubarb on serum amylase and TNF-alpha of rat model of acute pancreatitis.
J Biol Regul Homeost Agents
December 2017
Department of Critical Care Medicine, Hangzhou Hospital of Chinese Medicine Hangzhou, China
The aim of this study was to evaluate the therapeutic effect of rhubarb extract on acute pancreatitis. Ninety-six healthy Sprague Dawley rats, weighing 301±5.12 g were randomly divided into 4 groups: sham surgery (group A), acute pancreatitis model (group B), acute pancreatitis with normal saline (group C), and acute pancreatitis model with rhubarb (group D).
View Article and Find Full Text PDF[Randomized controlled clinical trials for electroacupuncture treatment of urinary incontinence in stroke patients].
Zhen Ci Yan Jiu
December 2011
Hangzhou Hospital of Chinese Medicine, Hangzhou 310007, China.
Objective: To observe clinical efficacy of electroacupuncture (EA) for post-stroke urinary incontinence in patients.
Methods: A total of 111 stroke inpatients with urinary incontinence were randomly divided into EA group (n = 56) and control group (n = 55). Patients of the control group were treated by administration of calcium ion antagon, angiotensin-converting enzyme inhibitor, angiotensin II receptor antagonist, compound thromb-clearing agent (i.