Advances in diagnostic assays for infection in adults.

() was a gram-positive anaerobic in the gut, exhibiting clinical manifestations ranging from mild diarrhoea to fatal pseudomembranous colitis. infection (CDI) remains a serious public health problem and accounted for an estimated 360,075 cases in the United States in 2021. It has attracted the utmost attention of the world health organization (WHO).

Corrigendum to "Dietary Kaempferol exerts anti-obesity effects by inducing the browning of white adipocytes via the AMPK/SIRT1/PGC-1α signaling pathway" [Curr. Res. Food Sci. 8 (2024) 100728].

[This corrects the article DOI: 10.1016/j.crfs.

Biallelic variants in the cause mitochondrial respiratory complex assembly defects associated with Leigh syndrome in probands.

Background: Variants in have been reported to be associated with Leigh syndrome. However, further expansion of the -phenotype and variants spectrum of -related Leigh syndrome are still required.

Methods: Two patients diagnosed with Leigh syndrome were recruited, and whole-exome sequencing was performed to identify the genetic variants responsible for the abnormal gait, dystonia, and bilateral basal ganglia lesions, followed by validation using Sanger sequencing.

Psoriatic arthritis in psoriasis: optimizing the current screening system for psoriatic arthritis based on serum data from U.S. and Chinese populations.

Background: Psoriatic arthritis (PSA) is an inflammatory joint disease associated with psoriasis (PSO) that can be easily missed. Existing PSA screening tools ignore objective serologic indicators. The aim of this study was to develop a disease screening model and the Psoriatic Arthritis Inflammation Index (PSAII) based on serologic data to enhance the efficiency of PSA screening.

AMBRA1 drives gastric cancer progression through regulation of tumor plasticity.

Background: Stomach adenocarcinoma (STAD) is an aggressive malignancy characterized by high tumor plasticity and heterogeneity. This study investigates the role of Autophagy and Beclin 1 Regulator 1 (AMBRA1) in regulating tumor plasticity in STAD progression.

Methods: Combined with clinical data, the pan-cancer analysis of AMBRA1 was performed to analyze the role of AMBRA1 in STAD.

A Rare Case of Multiple Subserous Uterine Adenomyomas Misdiagnosed as an Ovarian Cyst, Diagnosed and Treated by Laparoscopy.

Objective: To report a rare case of multiple subserous uterine adenomyomas diagnosed and treated by laparoscopy.

Case Report: A premenopausal 55-year-old woman was admitted presenting with bilateral adnexal cysts. Preoperative ultrasound and magnetic resonance imaging both indicated a right ovarian cyst.

A new approach in generating stable crack propagation at twisted bilayer graphene/hBN heterostructures.

Thermodynamic theory suggests that the obvious mechanical behavior caused by temperature and interlayer angle will affect the physical properties of materials, such as mechanical properties and transportation behavior, and it is different from the behavior in three-dimensional bulk materials. We observe an abnormal physical effect of bilayer graphene/hexagonal boron nitride (G/BN)-carbon nanotube (CNT) heterostructures, with a normalized out-of-plane deformation and normalized bond angle percentage to almost several times higher those of pristine G/BN heterostructures (without CNT) at 700-800 K. Our combined finite element theory and molecular dynamics simulations confirmed that the combination of CNT and interlayer angle diverted and bridged the propagating crack and provided a stable crack propagation path and crack tip opening displacement, resulting in the stress fields to be controlled around the CNT at high temperature.

Effectiveness of written emotional disclosure interventions for eating disorders: a systematic review and meta-analysis.

Background: Eating disorders are illnesses that can seriously impair the health and wellbeing of patients. Written emotional disclosure has been recognized as a therapeutic technique that may be helpful in aiding patients' emotional and psychological adjustment. However, it is unclear what favorable effects eating disorder patients can derive from written emotional disclosure therapy.

Systemic lupus erythematosus in a patient with 22q11.2 deletion syndrome: A case report and review of the literature.

22q11.2 deletion syndrome (MIM: 192430/188400, ORPHA: 567) is the most common chromosomal microdeletion disorder, caused by a hemizygous microdeletion of 2.5 million base pairs on chromosome 22.

Single-cell profiling uncovers synovial fibroblast subpopulations associated with chondrocyte injury in osteoarthritis.

Background: Chondrocytes and synovial cells participate in the pathogenesis of osteoarthritis (OA). Nonetheless, the interactions and correlations between OA synovial cells and chondrocytes remain unclear. This study aims to elucidate the interactions and correlations between OA synovial cells and chondrocytes, so as to deepen understanding of OA pathogenesis.

STAFNet: an adaptive multi-feature learning network via spatiotemporal fusion for EEG-based emotion recognition.

Introduction: Emotion recognition using electroencephalography (EEG) is a key aspect of brain-computer interface research. Achieving precision requires effectively extracting and integrating both spatial and temporal features. However, many studies focus on a single dimension, neglecting the interplay and complementarity of multi-feature information, and the importance of fully integrating spatial and temporal dynamics to enhance performance.

Ionically conducting Li- and Na-phosphonates as organic electrode materials for rechargeable batteries.

Facilitating rapid charge transfer in electrode materials necessitates the optimization of their ionic transport properties. Currently, only a limited number of Li/Na-ion organic cathode materials have been identified, and those exhibiting intrinsic solid-phase ionic conductivity are even rarer. In this study, we present tetra-lithium and sodium salts with the generic formulae: A-Ph-CHP and A-Ph-PhP, wherein A = Li, Na; Ph-CHP = 2,5-dioxido-1,4-phenylene bis(methylphosphinate); Ph-PhP = 2,5-dioxido-1,4-phenylene bis(phenylphosphinate), as novel alkali-ion reservoir cathode materials.

Facile preparation of sulfonium peptide and protein probes for selective crosslinking of methyllysine readers.

Sulfonium is an electrophilic and biocompatible group that is widely applied in synthetic chemistry on small molecules. However, there have been few developments of peptide or protein-based sulfonium tools. We recently reported sulfonium-mediated tryptophan crosslinking and developed NleSme2 (norleucine-dimethylsulfonium) peptides as dimethyllysine mimics that crosslink site-specific methyllysine readers.

Global, regional, and national burden of HIV and tuberculosis and predictions by Bayesian age-period-cohort analysis: a systematic analysis for the global burden of disease study 2021.

Objective: To assess sex, age, regional differences, and the changing trend in human immunodeficiency virus and tuberculosis (HIV-TB) in different regions from 1990 to 2021, and project future trends.

Methods: Global Burden of Disease Study 2021 data were analyzed to assess HIV-TB incidence, death, prevalence, and DALY rates from 1990 to 2021, including different types of TB co-infections (drug-susceptible, multidrug-resistant, and extensively drug-resistant). Bayesian age-period-cohort models were used to forecast age-standardized DALY rates through 2035.

Chromatin accessibility reveals potential prognostic value of the peak set associated with smoking history in patients with lung adenocarcinoma.

Considerable differences in molecular characteristics have been defined between non-smoker and smokers in patients with lung adenocarcinoma (LUAD), yet studies on open chromatin patterns associated with LUAD progression caused by smoking are still lacking. Here, we constructed a novel network based on correlations between each ATAC-seq peak from TCGA data using our previously developed algorithm. Subsequently, principal component analysis was performed on LUAD samples with retained peaks filtered by the correlation network, and pathway analysis was conducted to identify potential pathways involved.

Corrigendum: Age effects of Moso bamboo on leaf isoprene emission characteristics.

[This corrects the article DOI: 10.3389/fpls.2023.

Role of TNFRSF12A in cell proliferation, apoptosis, and proinflammatory cytokine expression by regulating the MAPK and NF-κB pathways in thyroid cancer cells.

Tumor necrosis factor receptor superfamily member 12A (TNFRSF12A) has been reported to be upregulated in thyroid cancer (THCA). However, the role and mechanism of TNFRSF12A in THCA remain largely unknown. TNFRSF12A expression in THCA samples was analyzed using bioinformatics analysis.

Association of the EAT-Lancet diet, serial measures of serum proteome and gut microbiome, and cardiometabolic health: a prospective study of Chinese middle-aged and elderly adults.

Background: The EAT-Lancet diet was reported to be mutually beneficial for the human cardiometabolic system and planetary health. However, mechanistic evidence linking the EAT-Lancet diet and human cardiometabolic health is lacking.

Objectives: We aimed to investigate the role of blood proteins in the association between the EAT-Lancet diet and cardiometabolic health and explore the underlying gut microbiota-blood protein interplay.

Anti-Fatigue Cellular Graphene Aerogel Through Multiscale Joint Strengthening.

Despite fatigue free of monolayer graphene, its assemblies, like cellular graphene aerogels (CGA), are usually suffering of frequent fatigue and inherent strength degradation in repeated loading. In this work, by employing multiscale modeling, the highly intrinsic anisotropic mechanical properties of the cell wall due to the layer-by-layer stacked graphene sheets are uncovered, which easily trigger the unique skeleton joints damage during repeated loading and contribute the primary fatigue mechanism of CGA. Conversely, multiscale joint strengthening strategies are proposed by interlayer crosslinking and joint curvation, improving the interlayer interaction, and decreasing interlayer stress during compression, respectively, so as to effectively suppress joint damage to improve fatigue performance of CGA.

The development and validation of a tablet-based assessment battery of general cognitive ability.

Background: Traditional cognitive assessments, often reliant on paper-and-pencil tests and professional evaluators, suffer from subjectivity and limited result discrimination. This study introduces the Baguan Online Cognitive Assessment System (BOCAS), a tablet-based system that evaluates both general cognitive ability (GCA) and domain-specific functions across six domains: sensory-motor skills, processing speed, sustained attention, working memory, cognitive flexibility, and spatial ability.

Methods: BOCAS was validated with 151 healthy Chinese adults aged 18-40.

Expanding the phenotypic and genetic spectrum of GTPBP3 deficiency: findings from nine Chinese pedigrees.

Background: GTPBP3 catalyzes τm(s) U biosynthesis at the 34th wobble position of mitochondrial tRNAs, the hypomodification of τmU leads to mitochondrial disease. While twenty-three variants of GTPBP3 have been reported worldwide, the genetic landscape in China remains uncertain.

Methods: By using whole-exome sequencing, the candidate individuals carrying GTPBP3 variants were screened and identified.

Comparations of efficacy and safety of rituximab, calcineurin inhibitors and cyclophosphamide in primary membranous nephropathy: a single-center retrospective analysis.

Background: To compare the efficacy and safety of rituximab (RTX), calcineurin inhibitor (CNI) and cyclophosphamide (CTX) plus glucocorticoids in the treatment of primary membranous nephropathy (PMN).

Methods: Totally 478 biopsy-proven PMN patients in single center were retrospectively included. After 1:1 propensity score matching (PSM), 258 patients were included in RTX, CNI or CTX group (86 patients in each group).

Clinical characteristics and risk factors of cardiovascular disease in systemic lupus erythematosus patients.

To analyze the clinical characteristics of cardiovascular disease in systemic lupus erythematosus (SLE) patients and identify risk factors for predicting the occurrence of cardiovascular disease in SLE patients. Clinical data of 110 SLE patients were randomly selected from the Tongde Hospital of Zhejiang Province clinical medical record database, including 50 patients with cardiovascular disease and 60 patients without. Clinical data, blood biochemistry indicators, antibody detection results, and complement levels were collected.

Dynamic 3D metasurface holography via cascaded polymer dispersed liquid crystal.

Metasurface with natural static structure limits the development of dynamic metasurface holographic display with rapid response and broadband. Currently, liquid crystal (LC) was integrated onto the metasurface to convert the passive metasuface into an active one. But, majority of LC-assisted active metasurfaces often exhibit trade-offs among degree of freedom (DoF, typically less than 2), information capacity, response speed, and crosstalk.