Int J Cardiol
February 2015
Department of General and Interventional Cardiology, Hamburg University Heart Center, Hamburg, Germany.
Int J Cardiol
December 2014
Hamburg University Heart Center, Department of General and Interventional Cardiology, Martinistraße 52, 20246 Hamburg, Germany. Electronic address:
Heart
November 2014
Department of Chronic Disease Prevention, National Institute for Health and Welfare, Helsinki, Finland.
Objectives: We hypothesised that soluble ST2 (sST2) levels can identify people with elevated risk of subsequent cardiovascular disease (CVD) and add to existing risk prediction algorithms.
Background: ST2 is a receptor for the inflammatory cytokine IL33. Increased sST2 levels have been associated with heart failure and death in acute myocardial infarction patients and in the general population.
Kidney Int
January 2015
Division of Vascular Medicine, Department of Cardiovascular Medicine, University Hospital of Muenster, Muenster, Germany.
Chronic kidney disease (CKD) is associated with increased cardiovascular morbidity and mortality but there are few studies available about atrial fibrillation, the most frequent arrhythmia in CKD, and the applied treatment. Based on the prospective German Competence NETwork on Atrial Fibrillation, data of 3138 patients with atrial fibrillation were analyzed and categorized by their estimated glomerular filtration rate (stages 1-3 and 4 plus 5). With advanced CKD, significantly more patients suffered from a more severe form of atrial fibrillation.
View Article and Find Full Text PDFPLoS One
February 2015
National Institute for Health and Welfare, Department of Chronic Disease Prevention, Helsinki, Finland.
Importance And Objective: Besides their role in diagnosis of acute myocardial infarction (MI), troponins may be powerful biomarkers for risk stratification in the general population. The objective of our study was to compare the performance of three troponin assays in cardiovascular disease (CVD) risk prediction in a population-based cohort without a history of CVD events.
Design, Setting And Participants: Troponin I concentrations were measured using a contemporary-sensitivity, high-sensitivity, and super-sensitivity assay in 7,899 participants of the general-population based FINRISK 1997 cohort.
Int J Cardiol
March 2014
Monash University, Melbourne, Australia. Electronic address:
Atherosclerosis
June 2013
Department of General and Interventional Cardiology, Hamburg University Heart Center, Martinistraße 52, 20246 Hamburg, Germany.
Aims And Background: Midregional proadrenomedullin (MR-proADM) is a protein, which exerts various effects on the cardiovascular system. Recent studies underscored its prognostic implications in patients with acute dyspnea and cardiovascular diseases. Therefore, we aimed to determine the distribution of MR-proADM in the general population and to reveal potential associations of MR-proADM with cardiovascular risk factors and measures of subclinical cardiovascular disease.
View Article and Find Full Text PDFPLoS One
April 2013
Department of Interventional Cardiology, Hamburg University Heart Center, University Hospital Hamburg-Eppendorf, Hamburg, Germany.
Background: The endogenous nitric oxide synthase inhibitor asymmetric dimethylarginine (ADMA) is an independent predictor of cardiovascular and overall mortality. Moreover, elevated ADMA plasma concentrations are associated with the extent of hypertension. However, data from small-sized clinical trials and experimental approaches using murine transgenic models have revealed conflicting results regarding the impact of ADMA and its metabolizing enzyme dimethylarginine dimethylaminohydrolase (DDAH) in the pathogenesis of hypertension.
View Article and Find Full Text PDFCirc Cardiovasc Interv
December 2011
Medical Care Center Prof Mathey, Prof Schofer, Hamburg University Cardiovascular Center, Hamburg University Heart Center, and Radiologische Allianz, Hamburg, Germany.
Background: Misplacement during percutaneous aortic valve implantation can be associated with severe complications. The direct flow medical (DFM) valve is repositionable and retrievable; however, the nonmetallic inflatable and conformable design of the valve results in less radial force, which may have an impact on stability and valve function over time. We, therefore, analyzed the midterm stability of the position, shape, and hemodynamic performance of the DFM percutaneous aortic valve.
View Article and Find Full Text PDFCirculation
December 2011
Department of Interventional Cardiology, Hamburg University Heart Center, Hamburg, Germany.
Background: The nitric oxide synthase inhibitor asymmetrical dimethylarginine (ADMA) and the leukocyte-derived hemoprotein myeloperoxidase (MPO) are associated with cardiovascular diseases. Activation of monocytes and polymorphonuclear neutrophils (PMNs) with concomitant release of MPO is regulated in a nitric oxide-dependent fashion. The aim of the study was to investigate a potential 2-way interaction between ADMA and MPO.
View Article and Find Full Text PDFThorac Cardiovasc Surg
February 2008
Department of Cardiology, Hamburg University Heart Center, Hamburg, Germany.
Cardiac papillary fibroelastomas (CPFs), the second most common primary cardiac tumor, are benign endocardial papillomas predominantly affecting the cardiac valves. Although CPFs are rare and benign tumors, they may result in life-threatening complications. Early diagnosis of this condition is important, since it represents a surgically correctable cause of systemic embolism, myocardial infarction, stroke, acute valve dysfunction, and sudden cardiac death.
View Article and Find Full Text PDFJ Thorac Cardiovasc Surg
February 2007
Department of Cardiology, Hamburg University Heart Center, Hamburg, Germany.
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