5,481 results match your criteria: "Hamadan University[Affiliation]"
Novel Insights into Oxidative Stress and Antioxidant Enzymes in Acute Antibody-Mediated Rejection of Renal Allografts.
Iran J Kidney Dis
August 2024
Chronic Kidney Disease Research Center, Shahid Labbafinejad Medical Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran. AND epartment of Clinical Biochemistry, Faculty of Medicine, Hamadan University of Medical Sciences, Hamadan, Iran.
Article Synopsis
- Antibody mediated rejection (AMR) is a significant challenge in kidney transplants, negatively impacting graft survival due to oxidative stress (OS) which triggers inflammation and tissue damage.
- A study involving 22 AMR patients and 14 stable kidney recipients evaluated various OS markers and antioxidant levels, revealing heightened levels of total oxidant status and 8-isoprostane, while nitric oxide and total thiol groups were significantly lower in AMR patients.
- The findings suggest increased OS and compromised antioxidant defense in AMR patients, with nitric oxide showing promise as a potential biomarker; further research is needed to understand the mechanisms of OS in AMR and the therapeutic role of antioxidants.
Aims: The sensitivity and specificity of electrodiagnostic parameters in diagnosing carpal tunnel syndrome (CTS) have been reported differently, and this study aims to address this gap.
Methods: This case-control study was conducted on 57 cases with CTS and 58 controls without complaints, such as pain or paresthesia on the median nerve. The main assessed electrodiagnostic parameters were terminal latency index (TLI), residual latency (RL), median ulnar F-wave latency difference (FdifMU), and median sensory latency-ulnar motor latency difference (MSUMLD).
West Nile virus in adults and larvae of Culiseta longiareolata and Culex hortensis (Diptera: Culicidae) captured in Hamedan, western Iran.
Acta Trop
December 2024
Department of Medical Virology, Faculty of Medicine, Hamadan University of Medical Sciences, Hamadan, Iran; Molecular Medicine Research Center, Hamadan University of Medical Sciences, Hamadan, Iran. Electronic address:
Article Synopsis
- The study investigates the presence of West Nile virus (WNV) in mosquitoes in Hamedan, Iran, where the virus is known to circulate but its mosquito vectors are not fully understood.
- Researchers collected a total of 3,243 mosquitoes from different habitats and identified seven WNV-positive pools, mainly in the species Culiseta longiareolata and Culex hortensis, indicating that WNV is actively circulating in the area.
- The findings highlight the need for further research on local WNV transmission dynamics and vector variations across different regions in Iran, providing essential information to shape prevention strategies.
Burn injury and fear of rejection: A qualitative study.
Burns
December 2024
Department of Nursing, School of Nursing and Midwifery, Hamadan University of Medical Sciences, Hamadan, Iran. Electronic address:
Introduction: One of the most important duties of the members of the treatment team is to pay attention to the mental, psychological, and social aspects of burn patients. One of the concerns of these patients during their stay in the hospital is the fear of rejection. The objective of this research is to examine the concept of 'fear of rejection' among patients hospitalized with burn injuries.
View Article and Find Full Text PDFCytotoxic Effects of a Novel tagged Apoptin on Breast Cancer Cell Lines.
Adv Biomed Res
July 2024
Molecular Medicine Research Center, Hamadan University of Medical Sciences, Hamadan, Iran.
Article Synopsis
- Apoptin is a promising anticancer protein that selectively induces apoptosis in tumor cells, particularly in breast cancer lines, highlighting its potential for cancer therapy.
- Researchers successfully created two forms of apoptin fusion proteins (SUMO-PTD4-Apoptin and PTD4-Apoptin) and tested their effects on breast cancer cells (MDA-MB-231 and MCF-7) and normal cells (MCF-10A) using various assays.
- Results showed that SUMO-PTD4-Apoptin demonstrated a lower IC50 value in cancer cells than in normal cells, indicating higher cytotoxicity, while PTD4-Apoptin had similar effects across both cancer
Targeting Matrix Metalloproteinase-3 for Dental Caries Prevention Using Herbal Isolates: MMP3 Inhibition by Cinnamic Acids.
Int J Dent
October 2024
Research Center for Molecular Medicine, Hamadan University of Medical Sciences, Hamadan, Iran.
Article Synopsis
- Dental caries is the most common infectious disease affecting teeth, highlighting the need for effective prevention strategies.
- MMP3, an enzyme involved in the degradation of dentin, can be inhibited to help prevent dental caries, with several cinnamic acid derivatives showing potential as inhibitors.
- Among these, cynarin was identified as the strongest inhibitor, demonstrating significant stability and effectiveness through molecular simulations, suggesting its potential use in preventing dental caries.
Comparison of the Effects of Dill Seed, Grape Seed and Date Extracts on Postpartum Hemorrhage Rates in the Fourth Stage of Labor: A Randomized Clinical Trial.
Rev Recent Clin Trials
October 2024
Clinical Research Development Unit of Fatemieh Hospital, Hamadan University of Medical Sciences, Hamadan, Iran.
Article Synopsis
- Postpartum hemorrhage (PPH) is a major cause of maternal mortality, prompting a study to explore the effects of herbal treatments on PPH rates in women after delivery.
- The clinical trial involved 200 women who were divided into four groups, receiving either herbal extracts (dates, grape seed, dill seed) or placebo, in addition to standard care.
- Results showed significant differences in hemorrhage rates, with the dates extract group particularly effective in reducing PPH compared to placebo and other extracts.
Enhanced wound closure in rabbit oral vestibule: a comparative analysis of suturing and laser tissue soldering.
BMC Oral Health
October 2024
Health Sciences Research Center, Health Sciences & Technology Research Institute, Hamadan University of Medical Sciences, Hamadan, Iran.
Article Synopsis
- This study compares laser soldering and conventional suturing for wound closure in rabbits over a 60-day period, focusing on scar characteristics.
- Results show that the laser technique leads to better scar quality, particularly in the first few days after surgery, and a slightly quicker recovery.
- Despite early advantages, by day seven both methods resulted in similar scar conditions, indicating that while laser soldering may have short-term benefits, long-term effects are largely comparable to suturing, warranting further research.
A dose-response meta-analysis of the relationship between number of pregnancies and risk of gynecological cancers.
Arch Gynecol Obstet
December 2024
Department of Epidemiology, School of Public Health, Hamadan University of Medical Sciences, Hamadan, Iran.
Background: Despite several investigations, the association between the number of pregnancies and gynecological cancers remains inconclusive. To address this issue, we conducted a dose-response meta-analysis of observational studies.
Methods: We searched PubMed, Web of Science, and Scopus databases up to Jun 8, 2023, to identify observational studies that examined the association between the number of pregnancies and gynecologic cancers.
Correction: Toxicity and Hepatoprotective Effects of ZnO Nanoparticles on Normal and High-Fat Diet-Fed Rat Livers: Mechanism of Action.
Biol Trace Elem Res
October 2024
Faculdade de Ciências E Tecnologia, Universidade Do Algarve, Campus de Gambelas, 8005-139, Faro, MeditBio, Portugal.
Decellularization of various tissues and organs through chemical methods.
Tissue Cell
December 2024
Department of Tissue Engineering and Biomaterials, School of Advanced Medical Sciences and Technologies, Hamadan University of Medical Sciences, Hamadan, Iran. Electronic address:
Article Synopsis
- * Decellularization technology is a notable technique that removes cells from the extracellular matrix while preserving its structural and functional components.
- * This process creates a biocompatible 3D structure that reduces the risk of immune rejection and inflammatory responses, highlighting its potential in regenerative medicine and tissue engineering.
Safety and efficacy of fecal microbiota transplantation (FMT) as a modern adjuvant therapy in various diseases and disorders: a comprehensive literature review.
Front Immunol
October 2024
Department of Internal Medicine, Sina Hospital, Tehran University of Medical Sciences (TUMS), Tehran, Iran.
Article Synopsis
- * Fecal microbiota transplantation (FMT) is a promising treatment that involves transferring fecal material from healthy donors to restore microbiome balance, with a high cure rate of 80-90%.
- * While FMT generally has mild side effects, serious complications can occur, making donor screening crucial; further research is needed to confirm its safety and effectiveness for a range of diseases.
Parents' perception of challenges of caring of children with Epidermolysis bullosa: a qualitative study.
BMC Res Notes
October 2024
Department of Medical Surgical Nursing, Fasa University of Medical Sciences, Fahmideh Blv, fasa, Fasa, 81936-13119, Iran.
Article Synopsis
- The study explored the experiences of 17 parents with children affected by Epidermolysis bullosa (EB) through semi-structured interviews in Iran.
- Three main themes emerged: parents face psychological crises, a sense of living without quality of life, and the need for comprehensive support.
- The findings highlight the need for better support systems to improve parents' well-being and emphasize the importance of recognizing children's dignity in healthcare contexts.
Enhancing academic performance: a shadow curriculum approach for medical and dental student preparation in basic sciences and pre-internship comprehensive exams.
BMC Med Educ
October 2024
Ministry of Health and Medical Education, Tehran, Iran.
Article Synopsis
- The shadow curriculum is a new concept in education that encompasses informal programs and activities aimed at helping students improve their academic performance outside of traditional classes.
- A study was conducted to create and assess an online course based on this shadow curriculum for medical and dental students in Iran, utilizing the ADDIE design model and the Kirkpatrick evaluation method.
- Findings showed that students had a positive response to the course, with significant improvements in test scores and success rates in comprehensive exams for basic medical sciences and dentistry after participating.
Psychometrics assessment of clinical reasoning competency scale in nurses of critical care units.
BMC Nurs
October 2024
Department of Cardiology, School of Medicine, Farshchian Cardiovascular Subspecialty Medical Center, Hamadan University of Medical Sciences, Hamadan, Iran.
Article Synopsis
- - The study focused on translating and assessing the Persian version of the Clinical Reasoning Competence Scale (CRCS) for nurses in critical care settings in Iran to evaluate their clinical reasoning skills effectively.
- - A total of 630 nurses participated, and the scale's psychometric properties were rigorously analyzed, showing high validity and reliability, with validity indices exceeding 0.82 and a Cronbach's alpha of 0.91.
- - Results identified three key dimensions of clinical reasoning—"plan setting," "intervention strategy regulation," and "self-instruction"—which together explained over 74% of the variance, confirming the scale's usefulness for nursing managers to enhance clinical reasoning education.
Investigating the Role of Serotonin Levels in Cognitive Impairments Associated with Long COVID-19.
Chonnam Med J
September 2024
Laboratory Sciences Research Center, Golestan University of Medical Sciences, Golestan, Iran.
Article Synopsis
- - The study investigates how the immune response to SARS-CoV-2 triggers inflammation and affects serotonin levels in those suffering from long COVID-19.
- - Patients with long COVID-19 showed lower serotonin and tryptophan levels compared to those who fully recovered, suggesting a link between the infection and neurotransmitter regulation.
- - The research highlights potential treatments, like dietary tryptophan supplementation or SSRIs, that could help improve mood and cognitive issues in long COVID-19 patients.
Development of silibinin-loaded nanostructured lipid carriers for Alzheimer's disease induced by amyloid beta in Wistar rats.
J Mater Chem B
November 2024
Department of Pharmacology & Toxicology, School of Pharmacy, Hamadan University of Medical Sciences, Hamadan, Iran.
Article Synopsis
- This study focused on creating and testing silibinin-loaded nanostructured lipid carriers (SB-NLCs) as a potential oral treatment for Alzheimer's disease in rats.
- The SB-NLCs were characterized using various methods, and results showed optimal particle size and stability, alongside effective drug release.
- Behavioral and histological tests indicated that SB-NLCs significantly improved cognitive performance compared to other groups, suggesting their potential as a treatment for Alzheimer's.
A review of the importance of top-down processing assessment in auditory processing disorder.
Int J Pediatr Otorhinolaryngol
November 2024
Department of Audiology, School of Rehabilitation, Hamadan University of Medical Science, Hamadan, Iran.
Introduction: Auditory perception process is a transient phenomenon, which enables the person to make the relationship between events and auditory factor by working memory and obtain the sequence of auditory features and be able differentiate the auditory sources by using these component. In auditory processing, the basis formed by bottom - up process (data - driven). This pathway is dependent on the central auditory integration and also on acoustic signal input and interpreting auditory information is involved top-down process (concept - driven), which this pathway is dependent on central higher resource such as perception, attention, working memory and its span.
View Article and Find Full Text PDFMalignant Transformation of Normal Oral Tissue to Dysplasia and Early Oral Squamous Cell Carcinoma: An Transcriptomics Approach.
Anal Cell Pathol (Amst)
October 2024
Research Center for Molecular Medicine, Hamadan University of Medical Sciences, Hamadan, Iran.
Article Synopsis
- Oral squamous cell carcinoma (OSCC) is a serious type of head and neck cancer often found at advanced stages, making it important to understand how normal oral tissue transforms into cancerous lesions for better early diagnosis and treatment.
- Researchers identified differentially expressed genes (DEGs) from datasets by comparing normal tissue to pre-invasive lesions and OSCC, discovering 34 hub genes with significant roles in the cancer process and associated with patient prognosis.
- Key findings included pathways related to skin development and keratinization, with some genes linked to poor outcomes, while others indicated better prognosis, ultimately highlighting potential targets for therapy and diagnosis improvements.
Development, Statistical Optimization, and Characterization of Resveratrol-Containing Solid Lipid Nanoparticles (SLNs) and Determination of the Efficacy in Reducing Neurodegenerative Symptoms Related to Alzheimer's Disease: In Vitro and In Vivo Study.
Biomed Res Int
October 2024
Department of Pharmaceutics School of Pharmacy Hamadan University of Medical Sciences, Hamadan, Iran.
Article Synopsis
- Resveratrol (RSV) is being researched for its potential in treating neurodegenerative diseases, but its effectiveness is limited due to low oral bioavailability, which this study aimed to improve by encapsulating it in solid lipid nanoparticles (SLNs).
- The RSV-SLNs were created using a solvent emulsification-evaporation technique and analyzed for their size, efficiency, and drug loading characteristics, displaying favorable properties for potential therapeutic use.
- In behavioral and biochemical tests on rats, RSV-SLNs showed greater neuroprotective effects compared to free RSV, evidenced by reduced escape latency in the Morris water maze, decreased lipid peroxidation, increased glutathione levels, and improved neural cell morphology in histological examinations.
Immunomodulatory Biomaterials: Tailoring Surface Properties to Mitigate Foreign Body Reaction and Enhance Tissue Regeneration.
Adv Healthc Mater
November 2024
Department of Oral and Craniofacial Sciences, School of Dental Medicine, University of Pittsburgh, Pittsburgh, PA, 15261, USA.
Article Synopsis
- * Modifying the surface properties of biomaterials can influence immune cell behavior, affecting their adhesion, proliferation, and how they interact during tissue healing or injury responses.
- * The review explores the relationship between immune cells and biomaterials, highlighting surface modification techniques aimed at minimizing foreign body reactions while promoting effective tissue repair and regeneration, and discusses future challenges and advancements in this field.
Antibiotics-free compounds for managing carbapenem-resistant bacteria; a narrative review.
Front Pharmacol
September 2024
Infectious Disease Research Center, Hamadan University of Medical Sciences, Hamadan, Iran.
Article Synopsis
- Carbapenem-resistant (CR) Gram-negative bacteria have emerged as a major public health issue, with their prevalence growing over the past decade due to various resistance mechanisms.
- Genetic changes and factors like biofilms contribute to this resistance, prompting scientists to explore new strategies to combat these bacteria.
- Promising alternatives include using bacteriophages, natural products, and nanoparticles, which can not only inhibit CR bacteria but also enhance the effectiveness of traditional antibiotics while reducing side effects.
TGF-β/Smad signaling pathway in fatty liver disease: a case-control study.
Mol Biol Rep
October 2024
Department of Clinical Biochemistry, Faculty of Medicine, Hamadan University of Medical Sciences, Shahid Fahmideh Street, Hamadan, Iran.
Article Synopsis
- Fatty liver disease is divided into two types: metabolic dysfunction-associated fatty liver disease (MAFLD) and non-MAFLD, with the TGF-β signaling pathway playing a crucial role in its development.
- In a study comparing 41 patients with fatty liver (22 with MAFLD, 19 with non-MAFLD) to 22 healthy controls, significant changes were observed in gene and protein expressions related to the TGF-β pathway.
- Results indicated decreased expressions of TGF-β1 and TGF-β3 and an increase in CTGF, with notable differences in Smad2/3 protein levels between the two patient groups, suggesting metabolic factors primarily influence TGF-β1
The impact of Trifolium pratense extract on apoptosis and autophagy in NALM-6 cells: implications for B-ALL intervention.
Med Oncol
October 2024
Division of Hematology and Blood Bank, Department of Laboratory Science, School of Paramedical Science, Shiraz University of Medical Sciences, Shiraz, Iran.
B-cell acute lymphoblastic leukemia (B-ALL), a prevalent malignancy predominantly affecting children, poses challenges such as drug resistance and cytotoxicity despite available treatment methods. The persistence of these challenges underscores the necessity for innovative therapeutic approaches to enhance efficacy. Natural compounds derived from plants, recognized for their potential to inhibit cancer cell growth, have drawn attention.
View Article and Find Full Text PDFSynthesis and biological assessment of novel 4H-chromene-3-carbonitrile derivatives as tyrosinase inhibitors.
BMC Chem
September 2024
Department of Persian Medicine, School of Medicine, Research Center for Traditional Medicine and History of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran.
Article Synopsis
- Excessive tyrosinase activity leads to hyperpigmentation, necessitating the development of effective inhibitors to treat this skin condition.
- In this study, novel 4H-chromene-3-carbonitrile compounds were synthesized and compound 6f showed the highest tyrosinase inhibition, performing better than the known inhibitor, kojic acid.
- Molecular studies revealed that the R-enantiomer of compound 6f has greater binding stability and competitive inhibition, highlighting its potential as a strong candidate for treating hyperpigmentation.