Functional Class II Treatment Simultaneous With Selective Reduction of Talon Cusps: A Case Report.

Selective reduction of bilateral nonsyndromic talon cusps in an 11-year-old class II patient enabled successful mandibular repositioning with a twin block appliance. This approach achieved desired orthodontic outcomes without causing pain or sensitivity following reduction, highlighting a novel strategy for managing talon cusps in orthodontic treatment.

Utilizing an In-silico Approach to Pinpoint Potential Biomarkers for Enhanced Early Detection of Colorectal Cancer.

Objectives: Colorectal cancer (CRC) is a prevalent disease characterized by significant dysregulation of gene expression. Non-invasive tests that utilize microRNAs (miRNAs) have shown promise for early CRC detection. This study aims to determine the association between miRNAs and key genes in CRC.

Challenges following CRS and HIPEC surgery in cancer patients with peritoneal metastasis: a comprehensive review of clinical outcomes.

Cytoreductive Surgery (CRS) and Hyperthermic Intraperitoneal Chemotherapy (HIPEC) are a pair of relatively modern therapeutic surgical methods in advanced cancerous patients with peritoneal metastasis (PM). The goal of CRS + HIPEC is treatment or to improve survival outcomes, which are linked to high morbidity side effects and complications, even with their possible advantages. Surgical-related, chemotherapy-related, anesthetic-related, gastrointestinal, organs and systemic complications are the categories into which complications are separated according to frequency, risk factors, and effect on patient outcomes.

Comparison of the accuracy and the response time to behavioral pain scales (BPS and CPOT) during painful procedures in the intensive care unit.

Background: Pain is one of the most common symptoms in the patients hospitalized in intensive care units, and its correct and timely diagnosis is important. Identifying tools that accurately assess pain in a shorter time will help patients better manage pain. The aim of this study was to compare the accuracy and the duration of response to behavioral pain scales (BPS and CPOT) during painful procedures in the intensive care unit.

Bovine Brucellosis: First Comprehensive Evaluation from Hamedan, an Endemic Area in Iran.

Brucellosis is an infectious zoonotic disease. The disease is one of the major concerns in developing societies due to its great importance for public health and economic losses in the animal industry. The principal target of the study was to detect the prevalence of brucellosis and associated risk factors in cattle from Hamedan (western Iran) using different laboratory techniques.

Investigating the respiratory and systemic effects of exposure to BTEX among municipal solid waste workers.

Workers at municipal solid waste (MSW) facilities may be exposed to a range of volatile organic compounds (VOCs). This study aimed to evaluate the potential systemic and respiratory effects, as well as to conduct cancer and non-cancer health risk assessments, associated with exposure to an important group of VOCs-Benzene, Toluene, Ethylbenzene, and Xylenes (BTEX)-among MSW workers. For this purpose, 48 air samples were collected from an MSW facility (36 samples from the landfill and 12 samples from the transfer station) and from a green space serving as the control area (n = 6), located in Hamedan, in the west of Iran, during the spring and summer of 2019.

Optical coherence tomography (OCT) findings in patients with Parkinson's disease presenting to Farshchian Hospital (Sina) in 2019 compared to the normal population.

Objective: Parkinson's disease is the second most common disease of the central nervous system after Alzheimer's disease. Currently, no blood test or other laboratory tests are available to diagnose this condition. One of the practical methods in diagnosing and evaluating the progress of neurodegenerative diseases is the use of optical coherence tomography (OCT), with which it is possible to accurately measure the thickness of the layers of the retina, as well as the thickness and volume of the macula.

Nano-pumice derived from pumice mine waste as a low-cost electrode catalyst for microbial fuel cell treating edible vegetable oil refinery wastewater for bioenergy generation and reuse.

This study aimed to assess nano-pumice (NP) from pumice mining waste as a local, cost-effective anode catalyst in microbial fuel cells (MFCs) for treating edible vegetable oil refinery wastewater (EVORW) and generating bioenergy. Pumice mining waste was converted into nano in three stages: crushing up to ≤3 cm, reducing the size of the previous step particles to 150 μm and converting the previous step particles to <100 nm. Nano-pumice prepared was coated on the carbon cloth (CC) to increase anode surface area of MFC.

A meta-analysis of the association between adolescent pregnancy and the risk of gynecological cancers.

Objectives: Despite several investigations, the association between adolescent pregnancy and gynecological cancers has yet to be conclusively established. To further explore this association, we conducted a meta-analysis of observational studies.

Methods: We conducted a comprehensive search of databases such as PubMed, Web of Science, and Scopus to identify studies investigating the link between adolescent pregnancy and gynecologic cancers.

Improving dexamethasone drug loading and efficacy in treating rheumatoid arthritis via liposome: Focusing on inflammation and molecular mechanisms.

Rheumatoid arthritis (RA) is a chronic autoimmune disease that affects approximately 0.46% of the global population. Conventional therapeutics for RA, including disease-modifying antirheumatic drugs (DMARDs), nonsteroidal anti-inflammatory drugs (NSAIDs), and corticosteroids, frequently result in unintended adverse effects.

A 2-year longitudinal study of anxiety caused by COVID-19 and job burnout among Iranian healthcare workers.

Limited longitudinal studies can be found to describe the psychological effects of COVID-19 on healthcare workers (HCW); Therefore, the present study aimed to investigating the anxiety caused by COVID-19 (COV-anxiety) and job burnout (JB) among a sample of Iranian HCW during this pandemic longitudinally. This longitudinal study performed on 310 Iranian HCW. The data collection is done twice during 2020 and 2022.

Combining the induced pluripotent stem cell (iPSC) technology with chimeric antigen receptor (CAR)-based immunotherapy: recent advances, challenges, and future prospects.

After experiencing many ups and downs, chimeric antigen receptor (CAR)-T cell therapy has reached a milestone as an anti-cancer method, as evidenced by the increasing number of clinical trials and approved products. Nonetheless, there is a real need to optimize CAR-T cell therapy and overcome its existing limitations. The importance of cellular starting material for generating CAR-T cells is undeniable, as the current personalized manufacturing approach is the main roadblock to providing a fast, affordable, and standard treatment for patients.

Effects of Resveratrol on Nonmelanoma Skin Cancer (NMSC): A Comprehensive Review.

Nonmelanoma skin cancer (NMSC) represents the most prevalent form of skin cancer globally, with basal cell carcinoma (BCC) and squamous cell carcinoma (SCC) being the most common types. The search for effective chemopreventive and therapeutic agents has led to the exploration of natural compounds, among which resveratrol (RES), a polyphenolic phytoalexin found in grapes, berries, peanuts, and red wine, has garnered significant attention. This comprehensive review aims to elucidate the effects of RES on NMSC, focusing on its mechanisms of action, efficacy in preclinical studies, and potential as a chemopreventive and therapeutic agent.

The Impact of Vitamin E Supplementation on Oxidative Stress, Cognitive Functions, and Aging-Related Gene Expression in Aged Mice.

This study investigated the effects of different doses of vitamin E on oxidative stress, cognitive function, and gene expression in aged mice. A total of 32 male mice, aged 12 months, were divided into a control group and three treatment groups. These groups received varying daily doses of vitamin E for a period of 28 days.

Investigating the biomarker value of circRNAs in the diagnosis of colorectal cancer: a systematic review.

Circular RNAs (circRNAs) has recently been considered a class of endogenous RNAs that form a continuous closed loop with an ability to cancer development. Due to its properties, circRNAs has promising potential to be considered as non-invasive cancer biomarkers. The present review comprehensively and systematically assessed the role of circRNAs as diagnostic markers in blood or tissue samples of colorectal cancer (CRC) patients.

Impact of cooling diabetic patients' fingertips compared to vibrating stimulation on pain from the glucometer needle: A cross-over trial study.

Introduction: Blood glucose measurements using glucometers can cause discomfort due to needle insertion. Implementing effective pain management strategies is essential to alleviate this discomfort. This study aimed to evaluate the effects of cold and vibration stimulation on pain perception during glucometer needle insertion in diabetic patients.

Dynapenia-abdominal obesity and mortality risk, is independent effect obscured by age and frailty?:Birjand Longitudinal Aging Study (BLAS).

Background: Abdominal obesity and low muscle strength, known separately as risk factors for mortality, might have a synergistic effect when they co-occur. Dynapenic abdominal obesity (DAO) is a condition defined by the presence of both. However, DAO's independent and combined impact on mortality remains under investigation.

Chemical contamination in the extracted DNA affects the results of HLA typing by the PCR-SSOP method.

Background: The purity of the extracted DNA is critical for successful molecular testing. This study aimed to compare the effect of various DNA extraction methods, extraction processes, and sources of consumables, such as microtubes, on PCR results.

Methods: DNA extraction from whole blood was performed using four different approaches utilizing four types of microtubes: chloroform-based, sodium perchlorate-based, heat-assisted salting out, and solid-phase extraction.

The effects of open/closed kinetic chain exercises in water on the electrical activity of selected lumbar muscles, lumbopelvic control, ground reaction force and psychological factors in men with chronic non-specific low back pain: A study protocol for a randomized clinical trial.

Background And Aim: Research has documented chronic non-specific low back pain (CNSLBP) as one of the primary causes of absenteeism at work, often accompanied by the use of health insurance and healthcare services. Considering little research on the consequences of open/closed kinetic chain (O/CKC) exercises in water on CNSLBP improvement, the present study is to investigate the effects of such interventions on the electrical activity of selected lumbar muscles, pain, lumbopelvic control (LPC), ground reaction force (GRF), and psychological factors in men with CNSLBP.

Materials And Methods: This is a randomized controlled trial that involves individuals with CNSLBP between the ages of 40 and 60 years.