7 results match your criteria: "Hakim Children Hospital[Affiliation]"
Complications of the Bacillus Calmette-Guerin vaccine as an early warning sign of inborn errors of immunity: a report of 197 patients.
Front Immunol
December 2024
Immunology, Asthma and Allergy Research Institute, Tehran University of Medical Sciences, Tehran, Iran.
Background: According to the WHO's recommendation for developing countries, Bacillus Calmette-Guerin (BCG) vaccination has been implemented in some countries as part of national vaccination programs at birth. Although it is generally considered safe, some complications may occur; including BCGitis (local) or BCGosis (systemic), ranging from mild like local abscesses to fatal impediments like osteomyelitis and disseminated BCG infection. This study aimed to determine the spectrum of inborn errors of immunity (IEI) in BCG-vaccinated neonates experiencing local or systemic complications.
View Article and Find Full Text PDFDifferent antithrombotic strategies to prevent cardiovascular complications in Kawasaki patients: a systematic review and meta-analysis.
BMC Pediatr
November 2024
Tehran Heart Center, Cardiovascular Diseases Research Institute, Tehran University of Medical Sciences, North Kargar Ave, Tehran, 1995614331, Iran.
Article Synopsis
- - The study focuses on the effectiveness of different antithrombotic strategies in preventing coronary artery aneurysm (CAA) complications in patients with Kawasaki disease (KD).
- - Results from the analysis of 21 studies indicated that combining warfarin with aspirin significantly reduced the risk of myocardial infarction and mortality compared to aspirin alone, though no major differences were found in overall cardiovascular events.
- - It concluded that adding high-dose aspirin to the standard IVIG treatment during the acute phase of KD does not provide additional benefits.
Triglyceride-glucose index as a predictor of cardiac adverse events in acute coronary syndrome patients undergoing percutaneous coronary intervention: role of diabetes.
BMC Cardiovasc Disord
September 2024
Health Outcomes, Policy, and Evidence Synthesis (HOPES) Group, University of Connecticut School of Pharmacy, Storrs, CT, USA.
Article Synopsis
- The Triglyceride-glucose index (TyG) serves as a marker for insulin resistance and may predict the risk of major adverse cardiac and cerebrovascular events (MACCE) in patients with acute coronary syndromes (ACS) undergoing percutaneous coronary intervention (PCI).
- A study involving 13,542 patients showed that higher TyG levels, particularly in the fourth quartile, significantly correlated with an increased risk of MACCE, such as heart attacks and strokes.
- In contrast, no significant association was found between TyG levels and MACCE in a subgroup of patients who were euglycemic, suggesting the need for further studies to confirm these findings for better clinical risk assessment.
Association between sleep duration and hypertension incidence: Systematic review and meta-analysis of cohort studies.
PLoS One
July 2024
Deep Medicine, Oxford Martin School, University of Oxford, Oxford, United Kingdom.
Article Synopsis
- - The study aimed to investigate how sleep duration impacts the risk of developing hypertension (HTN), as previous evidence has been inconsistent about this relationship.
- - A meta-analysis of 16 cohort studies (involving over 1 million participants) found that short sleep durations are linked to an increased risk of HTN, with more significant risk observed in those sleeping less than 5 hours, and females being more affected than males.
- - The findings suggest that while short sleep increases the risk of HTN, long sleep does not, indicating a need for targeted prevention strategies for those with insufficient sleep.
The association between metabolic syndrome and major adverse cardiac and cerebrovascular events in patients with acute coronary syndrome undergoing percutaneous coronary intervention.
Sci Rep
January 2024
Health Outcomes, Policy, and Evidence Synthesis (HOPES) Group, University of Connecticut School of Pharmacy, Storrs, CT, USA.
Metabolic syndrome (MetS) poses an additional risk for the development of coronary artery disease and major adverse cardiac and cerebrovascular events (MACCE). In this study, we investigated the association between MetS and its components and MACCE after percutaneous coronary intervention (PCI) in patients with acute coronary syndrome (ACS). The presence of MetS was calculated at baseline using the NCEP-ATP III criteria.
View Article and Find Full Text PDFThe Effect of Oral Protein Supplementation on the Growth of Very Low Birth Weight Preterm Infants Admitted to the Neonatal Intensive Care Unit: A Randomized Clinical Trial.
J Mother Child
June 2023
Assistant Professor of Neonatology, Tehran University of Medical Sciences, Hakim Children Hospital, Tehran, Iran.
Background: During NICU admission, extra-uterine growth retardation that can affect the neurodevelopmental outcome is a challenging problem in extremely preterm infants. This trial aimed to determine the effect of additional enteral protein supplementation on the growth velocity of the anthropometric parameters.
Method: In this randomized controlled trial, 77 preterm infants (gestational age ≤33 weeks and birth weight <1500 g) who reached full enteral feeding with either fortified breast milk or preterm formula were included.
Next-generation sequencing approach to molecular diagnosis of Iranian patients with Duchenne/Becker muscular dystrophy: Several novel variants identified.
eNeurologicalSci
March 2023
Department of Medical Genetics, National Institute of Genetic Engineering and Biotechnology (NIGEB), Tehran, Iran.
Duchenne muscular dystrophy (DMD) and Becker muscular dystrophy (BMD) constitute the second most prevalent muscular dystrophy, with large deletions or duplications accounting for 66% of cases. No effective treatment exists for DMD/BMD. At present, genetic diagnosis serves as the foundation for gene therapy treatments.
View Article and Find Full Text PDF