Association between PON1 L55M polymorphism and ischemic stroke: a systematic review and meta-analysis.

Objective: The present study aims to evaluate the relation between PON1 L55M polymorphism and ischemic stroke by a meta-analysis method.

Methods: English and Chinese databases were retrieved to find qualified studies; a random or fixed effects model was used to merge the odds ratio (OR); Q test was used to assess the heterogeneity among studies, and Egger's test and funnel plot were used for the assessment of publication bias.

Results: 14 studies were included in the meta-analysis; in total populations, there was no association between PON1 gene L55M polymorphism and ischemic stroke in additive, dominant, and recessive model, respectively.