Characterization and phylogenetic analysis of the complete chloroplast genome sequence of (Orchidaceae).

In this study, we report the chloroplast (cp) genome of . The cp genome was 151,367 bp in length; the overall CG content of the genome was 37.46%.

Belumosudil in pediatric patients with chronic graft-versus-host disease after failed multi-line therapy: a case series.

Belumosudil is a selective small molecule inhibitor of Rho-associated coiled-coil kinase 2 (ROCK2) indicated for patients with glucocorticoid-refractory chronic graft-versus-host disease (cGVHD). Despite its approval for ages 12-18, there is limited pediatric data available. This case series presents three 12-year-old patients with severe cGVHD who had failed multiple lines of therapy.

A Magnetically Actuated MOF-Based Nanozyme for Intensified Induction of Ferroptosis and Immunogenic Cell Death Via Autophagy Blockade.

Nanozymes mimicking enzymes show great promise in anti-tumor therapy but are often limited by their low catalytic activity and lack of tumor specificity in hostile tumor microenvironments. This study develops a novel nanozyme, D/P@ZUCO, utilizing metal-organic frameworks (MOFs) with glutathione oxidase, peroxidase, and catalase-like activities. D/P@ZUCO is synthesized using ZnFeO and NH-UiO66 (Cu/Zr) through an in situ growth method, followed by loading with doxorubicin (DOX) and primaquine (PQ), and functionalization with oxidized hyaluronic acid (OHA).

Vacancy-rich NiFe-LDH/carbon paper as a novel self-supporting electrode for the electro-Fenton degradation of polyvinyl chloride microplastics.

Electrochemically upcycling polyvinyl chloride (PVC) into high-value small molecules represents a sustainable strategy for mitigating plastic pollution. Herein, a cost-effective self-supporting electrode with abundant vacancies, i.e.

Innovative microalgae technologies for mariculture wastewater treatment: Single and combined microalgae treatment mechanisms, challenges and future prospects.

The discharge of aquaculture wastewater, comprising nitrogen, phosphorus, heavy metals, and antibiotics from large-scale aquaculture, poses a significant threat to marine ecosystems and human health. Consequently, addressing the treatment of marine aquaculture wastewater is imperative. Conventional physicochemical treatment methods have various limitations, whereas microalgae-based biological treatment technologies have gained increasing attention in the field of water purification due to their ability to efficiently absorb organic matter from mariculture wastewater and convert CO₂ into biomass products.

Combined exposure effects: Multilevel impact analysis of cycloxaprid and microplastics on Penaeus vannamei.

In real environments, multiple pollutants often coexist, so studying the impact of a single pollutant does not fully reflect the actual situation. Cycloxaprid, a new neonicotinoid pesticide, poses significant ecological risks due to its unique mechanism and widespread distribution in aquatic environments. Additionally, the ecological effects of microplastics, another common environmental pollutant, cannot be overlooked.

The induction of polyamines metabolism pathway and membrane stability with silicon alleviate the vanadium toxicity in pepper plants.

The vanadium (V) toxicity predominantly is the primary limitation in restraining pepper growth. The silicon (Si) in pepper plants induced the transcript level of the polyamines metabolism pathway genes, including the arginase (CbARG), ornithine decarboxylase (CbODC), arginine decarboxylase (CbADC), N-carbamoylputrescine amidase (CbNCA), Spermidine synthase (CbSPDS), copper binding diamine oxidase (CbCuAO) to overcome the V toxicity. The polyamines, including the Spm, Spd, and Put, induced with Si about 41.

Schiff Base Mediated Food-Derived Peptide Supramolecular Self-Assembly as Curcumin Carriers.

The fusion assembly strategy of supramolecular chemistry combined with dynamic covalent chemistry has provided novel insights into the design of precision nutrition and intelligent drug delivery carriers. This work involved the development of a supramolecular self-assembly originating from entropy- and enthalpy-driven dynamic covalent bonding on Schiff bases between egg white-derived peptide Gln-Ile-Gly-Leu-Phe (QIGLF) and glutaraldehyde (GA), denoted QIGLF-GA. The assembly exhibited outstanding assembly characteristics and multiwavelength autofluorescence properties.

Comparative lipidomics analysis of seed oils from nine tropical fruits: Emphasizing the fatty acid and lipid molecule profiles.

While tropical fruit seeds are considered potential sources of functional or edible vegetable oils, their lipid profiles are poorly documented. Herein, the lipid profiles of nine tropical fruit seed oils were systematically evaluated and compared using lipidomics and chemometrics techniques. Cherimoya exhibited the highest total lipid content, while avocado had the lowest.

Development of a thermal stabilizer formulation optimized by response surface methodology for Senecavirus A antigen.

Numerous members of the family Picornaviridae, such as the Senecavirus A (SVA) and foot-and-mouth disease virus (FMDV), exhibit thermal instability, resulting in the dissociation of viral particles, which affects the insufficient potency of the vaccine. Based on this characteristic, this study aimed to maintain the thermal stability of SVA by supplementing it with a stabilizer. Excipients, such as sucrose, mannitol, sorbitol, polyethylene glycol (PEG), L-arginine (L-Arg), glutamic acid (Glu), polyvinyl pyrrolidone (PVP), bovine serum albumin (BSA), and potassium chloride (KCl) dissolved in Tris-HCl buffer solution, retained the infectivity of SVA in the thermostability assay.

Magnetic resonance image denoising for Rician noise using a novel hybrid transformer-CNN network (HTC-net) and self-supervised pretraining.

Background: Magnetic resonance imaging (MRI) is a crucial technique for both scientific research and clinical diagnosis. However, noise generated during MR data acquisition degrades image quality, particularly in hyperpolarized (HP) gas MRI. While deep learning (DL) methods have shown promise for MR image denoising, most of them fail to adequately utilize the long-range information which is important to improve denoising performance.

Measurement of pulmonary hematocrit using oscillation of hyperpolarized Xe MR signals in blood.

Purpose: To demonstrate the feasibility of measuring pulmonary hematocrit (Hct) in blood in vivo using oscillation of hyperpolarized Xe MR signals and its potential for disease assessment in animal models.

Methods: Hyperpolarized Xe dynamic MR spectroscopy was performed on 10 anemia model rats and 10 control rats. A concise model based on hyperpolarized Xe MR signal oscillations was built for calculating pulmonary Hct.

How do polyhydroxyalkanoates aged by aerobic compost interact with steroidal estrogens to alter their adsorption and transport characteristics? Kinetics, isotherms, and influencing factors.

Despite evidence indicating a substantial presence of microplastics (MPs) in organic fertilizers, research exploring the differences of MPs among various types of organic fertilizers remains limited. Additionally, MPs can act as carriers for organic pollutants, influencing their environmental behaviors. This study investigated the presence of MPs in organic fertilizers and their effects on the environmental behaviors of steroidal estrogens.

Rapid high-throughput isolation and purification of chicken myoblasts based on deterministic lateral displacement microfluidic chips.

Myoblasts are defined as stem cells containing skeletal muscle cell precursors. However, there are some challenges associated with the purification of myoblast samples, including long culture times and ease of bacterial contamination. In this study, we propose a microfluidic myoblast cell enrichment and purification platform based on the principle of deterministic lateral displacement (DLD).

Insights into lncRNA-mediated regulatory networks in Hevea brasiliensis under anthracnose stress.

In recent years, long non-coding RNAs (lncRNAs) and microRNAs (miRNAs) have emerged as critical regulators in plant biology, governing complex gene regulatory networks. In the context of disease resistance in Hevea brasiliensis, the rubber tree, significant progress has been made in understanding its response to anthracnose disease, a serious threat posed by fungal pathogens impacting global rubber tree cultivation and latex quality. While advances have been achieved in unraveling the genetic and molecular foundations underlying anthracnose resistance, gaps persist in comprehending the regulatory roles of lncRNAs and miRNAs under such stress conditions.