Spatial-temporal analysis of hepatitis E in Hainan Province, China (2013-2022): insights from four major hospitals.

Objective: Exploring the Incidence, Epidemic Trends, and Spatial Distribution Characteristics of Sporadic Hepatitis E in Hainan Province from 2013 to 2022 through four major tertiary hospitals in the Province.

Methods: We collected data on confirmed cases of hepatitis E in Hainan residents admitted to the four major tertiary hospitals in Haikou City from January 2013 to December 2022. We used SPSS software to analyze the correlation between incidence rate and economy, population density and geographical location, and origin software to draw a scatter chart and SAS 9.

The association of low serum uric acid with mortality in older people is modified by kidney function: National Health and Nutrition Examination Survey (NHANES) 1999-2018.

Background: In older individuals, the role of low serum uric acid (SUA) as risk factor for mortality is debated. We therefore studied whether SUA levels, particularly low SUA concentrations, are associated with all-cause and cardiovascular (CV) mortality in older population, and to clarify potential effect modification of kidney function.

Methods: We identified 14,005 older people in National Health and Nutrition Examination Survey (NHANES) data from 1999 to 2018.

Relationship between serum phosphorus and mortality in non-dialysis chronic kidney disease patients: evidence from NHANES 2001-2018.

Background: Hyperphosphatemia is common in chronic kidney disease (CKD), associated with higher mortality in dialysis patients. Its impact in non-dialysis patients, especially those with preserved kidney function, remains uncertain.

Methods: A prospective cohort study was conducted using data from the National Health and Nutrition Examination Survey (2001-2008).

Sialidosis type 1 without cherry-red spots: a case report and literature review.

Background: Sialidosis is a rare disorder caused by mutations in the NEU1 gene located on chromosome 6p21.3, constituting a group of autosomal recessive diseases. Enzyme activity analysis, electron microscopy examination and genetic testing are reliable methods for diagnosis.

Distinguishing infectivity in patients with pulmonary tuberculosis using deep learning.

Introduction: This study aimed to develop and assess a deep-learning model based on CT images for distinguishing infectivity in patients with pulmonary tuberculosis (PTB).

Methods: We labeled all 925 patients from four centers with weak and strong infectivity based on multiple sputum smears within a month for our deep-learning model named TBINet's training. We compared TBINet's performance in identifying infectious patients to that of the conventional 3D ResNet model.

Short-term effects of high-resolution (1-km) ambient PM and PM on hospital admission for pulmonary tuberculosis: a case-crossover study in Hainan, China.

Introduction: There is limited evidence regarding particulate matter (PM)'s short-term effects on pulmonary tuberculosis (PTB) hospital admission. Our study aimed to determine the short-term associations of the exposure to ambient PM with aerodynamic diameters <2.5 μm (PM) and < 10 μm (PM) with hospital admission for PTB in Hainan, a tropical province in China.

Attention-guided multi-scale learning network for automatic prostate and tumor segmentation on MRI.

Background And Objective: Image-guided clinical diagnosis can be achieved by automatically and accurately segmenting prostate and prostatic cancer in male pelvic magnetic resonance imaging (MRI) images. For accurate tumor removal, the location, number, and size of prostate cancer are crucial, especially in surgical patients. The morphological differences between the prostate and tumor regions are small, the size of the tumor is uncertain, the boundary between the tumor and surrounding tissue is blurred, and the classification that separates the normal region from the tumor is uneven.

L-shaped association of serum 25-hydroxyvitamin D with all-cause and cardiovascular mortality in older people with chronic kidney disease: results from the NHANES database prospective cohort study.

Background: This study was conducted to assess the association of serum 25-hydroxyvitamin D [25(OH)D] concentrations with all-cause and cardiovascular disease (CVD) mortality in older people with chronic kidney disease (CKD) in the United States.

Methods: We identified 3230 CKD participants aged ≥ 60 years from the National Health and Nutrition Examination Survey (2001-2018). CKD was defined as an estimated glomerular filtration rate (eGFR) < 60 ml/min/1.

Current progress on the curative effects of vasoepididymostomy for patients with obstructive azoospermia: An updated systematic review and meta-analysis of human studies.

Background: Obstructive azoospermia (OA) is an important cause of male infertility, and epididymal OA (EOA) is a common disease. Microsurgical reconstruction is a common technique used in the treatment of EOA. In the present study, we analyzed the effectiveness of microsurgical vasoepididymostomy (MVE) at different levels and compared the differences among several MVE techniques.

Automatic segmentation of prostate MRI based on 3D pyramid pooling Unet.

Purpose: Automatic segmentation of prostate magnetic resonance (MR) images is crucial for the diagnosis, evaluation, and prognosis of prostate diseases (including prostate cancer). In recent years, the mainstream segmentation method for the prostate has been converted to convolutional neural networks. However, owing to the complexity of the tissue structure in MR images and the limitations of existing methods in spatial context modeling, the segmentation performance should be improved further.

Automatic prostate and peri-prostatic fat segmentation based on pyramid mechanism fusion network for T2-weighted MRI.

Background And Objective: Automatic and accurate segmentation of prostate and peri-prostatic fat in male pelvic MRI images is a critical step in the diagnosis and prognosis of prostate cancer. The boundary of prostate tissue is not clear, which makes the task of automatic segmentation very challenging. The main issues, especially for the peri-prostatic fat, which is being offered for the first time, are hazy boundaries and a large form variation.

: a promising biomarker in clear cell renal cell carcinoma.

Background: Aurora kinase B () is an important carcinogenic factor in various tumors, while its role in clear cell renal cell carcinoma (ccRCC) still remains unclear. This study aimed to investigate its prognostic value and mechanism of action in ccRCC.

Methods: Gene expression profiles and clinical data of ccRCC patients were downloaded from The Cancer Genome Atlas database.

Decreased cytoplasmic expression of Raptor correlates with disease progression and unfavorable prognosis in hepatocellular carcinoma.

The purpose of the present study is to explore the correlation between regulatory associated protein of mTOR (Raptor) and clinicopathologic features in hepatocellular carcinoma (HCC), including patient survival. Immunohistochemistry was used to examine the expression of Raptor in 90 HCC tissues and peritumoral liver tissues. The relationship between tumor Raptor expression and clinicopathologic characteristics was analyzed.