Design, synthesis, and evaluation of quinolin-2(1H)-ones as PDE1 inhibitors for the treatment of inflammatory bowel disease.

Inflammatory bowel disease (IBD) is a chronic inflammatory disease that affects the entire gastrointestinal tract. The complex etiology of IBD made it difficult to cure. Phosphodiesterases (PDEs) have garnered significant attention due to their involvement in immune and inflammatory responses in IBD.

Indium-free silver thiogallate nanoflake-clusters grown on carbon nitride edges for hydrogen peroxide photosynthesis with enhanced activity and stability.

Hydrogen peroxide (HO) is a promising solar fuel and its photocatalytic production has been regarded as a green and sustainable alternative to the conventional anthraquinone method. Ternary metal sulfide photocatalysts with unique superiorities are arousing increasing attention. However, photocorrosion still exists and the extensive use of scarce indium renders a limited prospect.

Co-delivery of vitamin and amino acid within MOFs for oxidative stress-based tumor gas therapy.

As an alternative to chemotherapy, emerging gas therapy is considered a "green" treatment due to its minimal side effects. However, even typical gas molecules like nitric oxide (NO) face challenges such as a very short half-life (1.5-6 min), poor targeting, and limited therapeutic effects.

Thiazolidinedione-based structure modification of ergosterol peroxide provides thiazolidinedione-conjugated derivatives as potent agents against breast cancer cells through a PI3K/AKT/mTOR pathway.

Ergosterol peroxide (EP) is a steroidal compound isolated from the traditional Chinese medicine Ganoderma lucidum. However, EP is limited by its solubility and moderate potency in antitumor studies. In the present study, a series of novel ergosterol peroxide-3-thiazolidinedione derivatives were designed and synthesized, by changing the linker between ergosterol peroxide and thiazolidinedione, it is expected to obtain compounds with better antitumor activity.

Reconfiguring Alginate-Based Supra-amphiphiles via Redox-Responsive Pickering Emulsions for Enhancing Pesticide Droplet Retention.

In view of the micro/nanostructure tunability of colloid particles, they acted as agrichemical delivery systems. Herein, supra-amphiphilic colloids were fabricated using a host-guest interfacial recognition-architected emulsion template strategy and controlled their agricultural interfacial interactions with the superhydrophobic target surface. Interestingly, the supramolecular interfacial system possessed redox-stimulated molecular reconfigurability by regulating aggregation/disaggregation behaviors.

Phenolics-Rich Extract from Agarwood Leaf-Tea Alleviate Dextran Sulfate Sodium (DSS)-Induced Ulcerative Colitis Via Modulating Intestinal Barrier Function, Liver Inflammation, and Gut Microbiota.

Scope: At present, the incidence rate of ulcerative colitis (UC) continues to increase, causing a global burden. In addition, therapeutic drugs have great side effects. According to modern pharmacology, agarwood leaves have anti-inflammatory, antibacterial, hypoglycemic, and lipid-lowering effects.

Multi-resonance emitters with room-temperature phosphorescence in amorphous state and excited by visible light.

Unlike boron, nitrogen-containing multi-resonance emitters with thermally activated delayed fluorescence, here we report boron, sulfur (B, S)-based multi-resonance emitters with room-temperature phosphorescence (RTP) by inserting thiophene into a 5,9-dithia-13-boranaphtho[3,2,1-]anthracene skeleton that simultaneously realizes large singlet-triplet energy splitting and strong spin-orbital coupling, leading to efficient room-temperature phosphorescence in an amorphous state. Unlike most RTP emitters with ultraviolet excitation, the multi-resonance RTP emitters exhibit strong phosphorescence under daily-use blue/white LED lamps owing to their intense absorption in the visible-light region (400-486 nm). Meanwhile, such RTP behavior can be tuned by the number and fusing pattern of the thiophene moieties, with the emitters containing thiophene linked to boron atoms α-positions exhibiting bathochromatically shifted emissions and longer phosphorescence lifetimes (47.

Smartphone-based colorimetric paper chip sensor using single-atom nanozyme for the detection of carbofuran pesticide residues in vegetables.

Carbofuran (CBF), which exhibit high toxicity, persistent residues, ease of accumulation, and resistance to degradation, pose serious threats to human health and harm the ecological environment. Therefore, there is an urgent need to develop a rapid and accurate method for detecting CBF. In this work, a low-cost, portable, and easy-to-use paper chip biosensor was developed, integrating smartphones for the detection of CBF pesticide residues.

Cross-Generational Exposure to Low-Density Polyethylene Microplastics Induced Hyperactive Responses in Offsprings.

The extensive application of plastic products in daily human life has led to the accumulation of microplastics (MPs) in agricultural soil. However, little is known about the cross-generational toxicity of MPs on terrestrial invertebrates. In this study, two-generational was exposed to low-density polyethylene (LDPE, 0-5%, w/w) for 98 days to reveal the cross-generational toxicity and the underlying mechanisms.

Enhanced photoelectric desalination of CoO@NC/BiVO photoanode via in-situ construction of hole transport layer.

The solar-driven photoelectrochemical desalination (SD-PED) technology, as a new emerging desalination technique, has been developed and attracted the increasing attention. However, practical application remains hampered by several constraints, including the rapid deterioration of photocurrent, and the long-term stability of system. In this research, MOF-derived nitrogen-doped carbon@CoO/BVO (CoO@NC/BVO) heterostructured photoanode was design for efficient and durable solar driven redox desalination.

A dual-response fluorescence sensor for SO derivatives and polarity and its application in real water and food samples.

As an important gaseous pollutant, SO derivatives generally exist and significantly threaten the environment and organism health. Meanwhile, polarity is a disease-related indicator in the organism's microenvironment, where an unregulated variation may disturb the physiological metabolisms. Hence, a superior FRET-based fluorescent sensor (TLA) is presented to track polarity and sulfur dioxide derivatives by dual emission channel, an elevated red emission at 633 nm with decreasing polarity as well as a reduced red emission at 633 nm and improved blue emission at 449 nm with increasing concentration of SO derivatives.

Integrative transcriptome and metabolome analyses reveal the mechanism of melatonin in delaying postharvest senescence in cowpeas.

Rapid postharvest senescence and quality deterioration severely limit logistics of cowpeas. Melatonin (MEL) is a pivotal bioactive molecule that can modulate multiple physiological attributes in plants. In this study, physiological, transcriptomic and metabolomic analyses were conducted to explore the effects of exogenous MEL on cowpea senescence and its underlying mechanisms.

Establishment of continuous flow partial denitrification biofilm module with short hydraulic retention time.

Partial denitrification (PD) can supply essential nitrite (NO) and is supposed to promote the application of Anammox. However, PD-related research mainly involves sequencing batch reactors and activated sludge. Here, we proposed establishing PD in a continuous-flow submerged biofilm module (PD-BfM).

Coordination-Induced Magnetism Strategy for Highly Selective and Efficient Uranium Separation.

Highly efficient separation of dispersed uranium is important for the sustainable development of nuclear industry, and adsorption is the most recognized approach. However, there are many coexisting interfering metal ions that compete with uranyl ion for the chelating ligands in the adsorbents and lead to low separation selectivity and efficiency. Herein, a coordination-induced magnetism strategy is presented for the separation of uranium based on the conversion of diamagnetic cyanoferrocene (Fc-CN) nanocrystals to uranium-containing magnetic recoverable ferromagnetic aggregates.

The autotoxicity of dissolved organic matter from Microcystis may be a contributor to the decline of its bloom.

Microcystis blooms frequently occur in freshwaters worldwide, causing detrimental impacts on the ecosystems and human health. Studying the mechanisms behind the decline of Microcystis blooms can aid in mitigating their harmful effects. However, there is currently a dearth of research in this area.

Synergizing Bacillus halotolerans, Pseudomonas sihuiensis and Bacillus atrophaeus with folic acid for enhanced drought resistance in wheat by metabolites and antioxidants.

Drought stress imposes a serious challenge to cultivate wheat, restricting its growth. Drought reduces the capability of plant to uptake essential nutrients. This causes stunted growth, development and yield.

Pitaya-Inspired Metal-Organic Framework Nanozyme for Multimodal Imaging-Guided Synergistic Cuproptosis, Nanocatalytic Therapy, and Photothermal Therapy.

Nature often provides invaluable insights into technological innovation and the construction of nanomaterials. Inspired by the pitaya fruit's strategy of wrapping seeds within its pulp to enhance seed survival, a unique nanocomposite based on metal-organic framework (MOF)-encapsulated CuS nanoparticles (NPs) is developed. This design effectively addresses the challenge of short retention time afforded by CuS NPs for therapeutic and imaging purposes.

Supramolecular structure and in vitro digestive properties of plasma-treated corn starches varying in amylose content.

The effects of plasma treatment on the multi-scale structure and in vitro digestibility of maize starch with different amylose contents were systematically evaluated. The results demonstrated that all maize starches' molecular weights (MW) decreased when treated with plasma, among which the MW of waxy maize starch displayed the largest reduction. Plasma treatment led to an increase in the thickness of the semi-crystalline lamellae and double helix proportions of waxy and normal maize starches.