17 results match your criteria: "Haid Research Institute[Affiliation]"

β-1,3-Glucans form the major carbohydrate component of fungal cell walls, playing a vital role in cell viability, stress response, virulence, and even healthy functions such as immuno-enhancement. The elongation and branching of β-1,3-glucans is a mystery. More evidence proved the β-1, 3-glucantransferases belonging to GH72 or GH17 family to branch and remodel the synthesized linear β-1, 3-glucan chain by cleaving its internal β-1, 3-linkage and transfer the cleaved fragment to the nonreducing end of another β-1, 3-glucan acceptor.

View Article and Find Full Text PDF

Advancement in the development of gene/protein-based vaccines against African swine fever virus.

Curr Res Microb Sci

March 2024

Laboratory of Molecular Virology & Immunology, Technology Innovation Center, Haid Research Institute, Guangdong Haid Group Co., Ltd, Guangzhou, 511400, China.

Article Synopsis
  • African swine fever (ASF) is a severe viral disease affecting domestic pigs, with a very high mortality rate, leading to significant economic losses, particularly in Asia.
  • There is an urgent need to create safe and effective vaccines against the African swine fever virus (ASFV), which has a complex genome and encodes around 200 proteins.
  • The article reviews vaccine candidates based on ASFV genes/proteins, focusing on structural proteins that have shown protective effects in previous studies.
View Article and Find Full Text PDF

Intestinal microbial community well explain larval growth than feed types.

Appl Microbiol Biotechnol

December 2024

Haid Research Institute, Guangdong Haid Group Co. Ltd., 5 Eighth Street, Fu Ping Road, Guangzhou, 511400, China.

Black soldier fly larvae (BSFL) are considered a sustainable ingredient in livestock feed. However, addressing issues related to feed substrate and intestinal microbiota is essential to ensure optimal larval development. The aim of this study was to assess and elucidate the contribution of substrate nutrients and intestinal microbes to protein and fat synthesis in BSFL.

View Article and Find Full Text PDF

The food safety assessment of all-female common carp (Cyprinus carpio) (cyp17a1+/-;XX genotype) generated using genome editing technology.

Food Chem Toxicol

November 2023

State Key Laboratory of Freshwater Ecology and Biotechnology, Institute of Hydrobiology, Chinese Academy of Sciences, Wuhan, 430072, China; College of Advanced Agricultural Sciences, University of Chinese Academy of Sciences, Beijing, 100101, China; Hubei Hongshan Laboratory, Huazhong Agriculture University, Wuhan, 430070, China. Electronic address:

There are several technical challenges and public issues concerning genome editing applications before they become viable in commercial aquaculture. Recently, we developed a novel strategy to generate all-female (AF) common carp, which exhibited a growth advantage over the control carp, using genetic editing through single gene-targeting manipulation. Here, we found that the body weight of the AF common carp was higher by 22.

View Article and Find Full Text PDF

Nonenveloped Avian Reoviruses Released with Small Extracellular Vesicles Are Highly Infectious.

Viruses

July 2023

Laboratory of Molecular Virology and Immunology, Technology Innovation Center, Haid Research Institute, Guangdong Haid Group Co., Ltd., Panyu, Guangzhou 511400, China.

Vesicle-encapsulated nonenveloped viruses are a recently recognized alternate form of nonenveloped viruses that can avoid immune detection and potentially increase systemic transmission. Avian orthoreoviruses (ARVs) are the leading cause of various disease conditions among birds and poultry. However, whether ARVs use cellular vesicle trafficking routes for egress and cell-to-cell transmission is still poorly understood.

View Article and Find Full Text PDF

In recent years, highly pathogenic avian influenza H5 subtype (HPAI H5) viruses have been prevalent around the world in both avian and mammalian species, causing serious economic losses to farmers. HPAI H5 infections of zoonotic origin also pose a threat to human health. Upon evaluating the global distribution of HPAI H5 viruses from 2019 to 2022, we found that the dominant strain of HPAI H5 rapidly changed from H5N8 to H5N1.

View Article and Find Full Text PDF

Compared to Fishmeal, Dietary Soybean Meal Improves the Reproductive Performance of Female Yellow Catfish () Broodstock.

Aquac Nutr

April 2023

State Key Laboratory of Freshwater Ecology and Biotechnology, Institute of Hydrobiology, Chinese Academy of Sciences, Wuhan 430072, China.

To investigate the effects of different dietary protein sources on the reproductive performance of female broodstock, yellow catfish () were fed with three experimental diets using fishmeal (FM), soybean meal (SBM), and rapeseed meal (RSM) as main protein sources, respectively. Females (initial weight: 64.56 ± 0.

View Article and Find Full Text PDF

Natural variant R246K in hemagglutinin increased zoonotic characteristics and renal inflammation in mice infected with H9N2 influenza virus.

Vet Microbiol

April 2023

Institute of Animal Health, Guangdong Academy of Agricultural Sciences, Guangzhou, PR China; Guangdong Laboratory for Lingnan Modern Agriculture, PR China; Key Laboratory for Prevention and Control of Avian Influenza and Other Major Poultry Diseases, Ministry of Agriculture and Rural Affairs, Guangzhou, PR China; Key Laboratory of Livestock Disease Prevention of Guangdong Province, Guangzhou, PR China. Electronic address:

Article Synopsis
  • H9N2 avian influenza viruses are spreading among poultry in Asia and North Africa, raising concerns for both poultry and human health.
  • A specific mutation (R246K) in the HA gene enhances the virus's ability to bind to human cells, leading to increased replication in lab tests and higher virus shedding in infected chickens.
  • The R246K mutation also shows greater stability and pathogenicity in mice, suggesting a heightened risk for zoonotic transmission and potential pandemic threats.
View Article and Find Full Text PDF

A quadruple protection procedure for resuming pig production in small-scale ASFV-positive farms in China.

Curr Res Microb Sci

December 2021

Laboratory of Molecular Virology and Immunology, Innovation Technology Center, Haid Research Institute, Guangdong Haid Group Co., Ltd, Guangzhou, China.

Article Synopsis
  • African swine fever (ASF) has led to significant economic losses for small-scale pig farmers in Asia since 2018, causing hesitance in pig production without effective biosafety measures.
  • A comprehensive "quadruple protection procedure" (QPP) was tested on 35 farms affected by ASF, focusing on farm construction, environmental disinfection, immunization, and feed quality to promote safe pig farming.
  • After implementing QPP, nearly all pigs on the farms were found to be healthy, demonstrating its effectiveness in protecting pigs from ASF and supporting small-scale production.
View Article and Find Full Text PDF

COVID-19 Pandemic: The Influence of Culture and Lessons for Collaborative Activities.

Adv Exp Med Biol

May 2021

Laboratory of Molecular Virology & Immunology, Technology Innovation Center, Haid Research Institute, Guangdong Haid Group Co., Ltd., Guangzhou, China.

The rapid epidemiological shift from an epidemic/outbreak in Wuhan, China, to a global pandemic of COVID-19 in less than 3 months came with lessons the world's health system should learn to prepare for the future outbreaks. Since February 20, 2020, the total number of confirmed cases of COVID-19 has been increased very slowly in the countries of East Asia, including Japan, South Korea, and China, when compared with those in the Western countries. This chapter begins with an overview of the impact of COVID-19 on healthcare workers and public health facilities, followed by immediate global actions and research in response to the newly emerged pandemic.

View Article and Find Full Text PDF

Rapid detection of SARS-CoV-2, replicating or non-replicating, using RT-PCR.

Int J Infect Dis

March 2021

Haid Research Institute, Guangdong HaidGroup Co., Ltd., Guangzhou, China. Electronic address:

To identify animals susceptible to Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) infection or to determine whether SARS-CoV-2 contaminated meat is from a SARS-CoV-2-infected animal, a convenient and safe method was developed for rapid detection of SARS-CoV-2 in a replicating or non-replicating status in samples using reverse transcriptase-polymerase chain reaction (RT-PCR). This strategy can also be applied to develop assays for the detection of other viruses, either replicating or not.

View Article and Find Full Text PDF

Effects of sources and levels of liquor distiller's grains with solubles on the growth performance, carcass characteristics, and serum parameters of Cherry Valley ducks.

Poult Sci

November 2020

Guangdong Provincial Key Laboratory of Animal Nutrition and Regulation, College of Animal Science, South China Agricultural University, Guangzhou 510000, China. Electronic address:

Liquor distiller's grains with solubles (LDGS) is high in yield and rich in crude fiber and crude protein, which suggests that LDGS might be developed and used as unconventional feedstuff for ducks. The aim of this study was to investigate the effects of sources and levels of LDGS on growth performance, carcass characteristics, serum parameters, and intestinal morphology of Cherry Valley ducks from 15 to 42 D of age. A total of 3,300 15-day-old male ducks were randomly assigned into a 1 plus 2 × 5 factorial design including 2 different sources of LDGS (unfermented LDGS [ULDGS] and fermented LDGS [FLDGS]) at 5 levels (4, 8, 12, 16, and 20%) for 4 wk.

View Article and Find Full Text PDF

Comparative review of respiratory diseases caused by coronaviruses and influenza A viruses during epidemic season.

Microbes Infect

August 2020

Laboratory of Molecular Virology & Immunology, Technology Innovation Center, Haid Research Institute, Guangdong Haid Group Co., Ltd, Guangzhou, 511400, China. Electronic address:

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) continues to sweep the world, causing infection of millions and death of hundreds of thousands. The respiratory disease that it caused, COVID-19 (stands for coronavirus disease in 2019), has similar clinical symptoms with other two CoV diseases, severe acute respiratory syndrome and Middle East respiratory syndrome (SARS and MERS), of which causative viruses are SARS-CoV and MERS-CoV, respectively. These three CoVs resulting diseases also share many clinical symptoms with other respiratory diseases caused by influenza A viruses (IAVs).

View Article and Find Full Text PDF

Lessons learned from the 2019-nCoV epidemic on prevention of future infectious diseases.

Microbes Infect

March 2020

Guangdong Haid Institute of Animal Husbandry & Veterinary, Guangdong Provincial Key Laboratory of Research on the Technology of Pig-breeding and Pig-disease Prevention, Haid Research Institute, Guangdong Haid Group Co., Ltd, Guangzhou, China. Electronic address:

Article Synopsis
  • The outbreak of pneumonia caused by 2019-nCoV rapidly escalated, infecting over forty-thousand people within a month, putting immense pressure on China's healthcare system and raising global concerns.
  • The Chinese government responded with strict traffic restrictions in Hubei province, which led to a significant decrease in the rate of new cases, indicating the effectiveness of these measures.
  • Financial support, enhanced research, and collaboration among public health experts, government officials, and the public were crucial in implementing epidemic prevention strategies, offering valuable insights for future public health emergencies.
View Article and Find Full Text PDF

Measures for diagnosing and treating infections by a novel coronavirus responsible for a pneumonia outbreak originating in Wuhan, China.

Microbes Infect

March 2020

Lindsley F. Kimball Research Institute, New York Blood Center, New York, NY, USA; Key Laboratory of Medical Molecular Virology (MOE/NHC/CAMS), School of Basic Medical Sciences, Fudan University, Shanghai, China. Electronic address:

On 10 January 2020, a new coronavirus causing a pneumonia outbreak in Wuhan City in central China was denoted as 2019-nCoV by the World Health Organization (WHO). As of 24 January 2020, there were 887 confirmed cases of 2019-nCoV infection, including 26 deaths, reported in China and other countries. Therefore, combating this new virus and stopping the epidemic is a matter of urgency.

View Article and Find Full Text PDF