Mothers of children with disabilities: exploring lived experiences, challenges, and divorce risk.

This qualitative study explores the psychological challenges faced by divorced Saudi mothers who are raising children with disabilities. The study highlights the impact of having a child with a disability on marital stability and family issues, and the psychological challenges experienced by single mothers. Using semi-structured in-depth interviews, data were collected from five divorced mothers recruited from a private daycare center.

Molecular detection of infection (Q fever) in livestock in Makkah Province, Saudi Arabia.

The study aims to investigate the prevalence of Q fever in livestock and ticks in Makkah Province, Saudi Arabia, by molecular methods. Using DNA obtained from (40) blood samples, (60) vaginal swabs and ticks (120) samples. Real-time PCR was used to detect the insertion sequence of in aborted animals.

Binding of the TRF2 iDDR motif to RAD50 highlights a convergent evolutionary strategy to inactivate MRN at telomeres.

Telomeres protect chromosome ends from unscheduled DNA repair, including from the MRN (MRE11, RAD50, NBS1) complex, which processes double-stranded DNA breaks (DSBs) via activation of the ATM kinase, promotes DNA end-tethering aiding the non-homologous end-joining (NHEJ) pathway, and initiates DSB resection through the MRE11 nuclease. A protein motif (MIN, for MRN inhibitor) inhibits MRN at budding yeast telomeres by binding to RAD50 and evolved at least twice, in unrelated telomeric proteins Rif2 and Taz1. We identify the iDDR motif of human shelterin protein TRF2 as a third example of convergent evolution for this telomeric mechanism for binding MRN, despite the iDDR lacking sequence homology to the MIN motif.

The feasibility of motivational interviewing on adherence to care practices, emotional intelligence, and dispositional optimism among patients with permanent pacemakers.

Aims: Motivational interviewing (MI) has been recognized as highly effective for treating chronic diseases and various conditions, with encouraging results demonstrating its effectiveness in promoting health behaviour change. The current study was proposed to evaluate the feasibility of MI on adherence to care practices, emotional intelligence (EI), and dispositional optimism among patients with permanent pacemakers.

Methods And Results: This study was a parallel arm randomized controlled trial.

Coastal Flood risk assessment using ensemble multi-criteria decision-making with machine learning approaches.

Coastal areas are at a higher risk of flooding, and novel changes in the climate are induced to raise the sea level. Flood acceleration and frequency have increased recently because of unplanned infrastructural conveniences and anthropogenic activities. Therefore, the assessment of flood susceptibility mapping is considered the most significant flood management model.

Decoding the molecular mechanism of stypoldione against breast cancer through network pharmacology and experimental validation.

Breast cancer is the primary factor contributing to female mortality worldwide. The incidence has overtaken lung cancer. It is the most difficult illness due to its heterogeneity and is made up of several subtypes, including Luminal A and B, basal-like, Her-2 overexpressed and TNBC.

Network pharmacology and experimental validation for deciphering the action mechanism of D. Don constituents in suppressing breast carcinoma.

D. Don is a well-known medicinal plant of Kashmir Himalaya. Traditionally, it has been used to treat several diseases, including cancer.

Integrons in the development of antimicrobial resistance: critical review and perspectives.

Antibiotic resistance development and pathogen cross-dissemination are both considered essential risks to human health on a worldwide scale. Antimicrobial resistance genes (AMRs) are acquired, expressed, disseminated, and traded mainly through integrons, the key players capable of transferring genes from bacterial chromosomes to plasmids and their integration by integrase to the target pathogenic host. Moreover, integrons play a central role in disseminating and assembling genes connected with antibiotic resistance in pathogenic and commensal bacterial species.

Mechanistic elucidation of Juglanthraquinone C targeting breast Cancer: A network Pharmacology-based investigation.

Breast cancer is the leading cause of death among women worldwide. Despite the recent treatment options like surgery, chemotherapy etc. the lethality of breast cancer is alarming.

Safety and efficacy of daridorexant in the treatment of insomnia: a systematic review and meta-analysis of randomized controlled trials.

Daridorexant is a novel dual orexin receptor antagonist used in treating insomnia disorder. Daridorexant improves sleep quality without impairing daytime functioning. We assess the safety and efficacy of this novel drug in the treatment of insomnia.

Protective Effect of Peel Extract-Prepared Nanoparticles on Rabbits Experimentally Infected with .

The present study used peel extract to synthesize silver nanoparticles (AgNPs). This technique is eco-friendly and can be performed in a single step; thus, it has attracted great attention for NPs biosynthesis. Herein, we biosynthesized AgNPs with peel extract and examined their anticoccidial activity in rabbit hepatic coccidiosis induced by infection.

Studies on the sensory sensilla on the tarsi and external genitalia of the Asian tiger mosquito, Aedes albopictus (Skuse).

Dengue fever is a worldwide health problem transmitted mainly by Aedes albopictus. The ability of female mosquitoes to transmit disease depends on their behavioral responses to locate their host. The presence of different types of sensory sensilla with different morphological characteristics is the most distinctive feature of Ae.

Molecular Identification of Newly Recorded Louse Columbicola tschulyschman Eichler (Phthiraptera: Philopteridae) From Saudi Arabia With a Note on Genus Columbicola spp. Phylogeny.

Chewing lice comprise a large group of ectoparasites that colonize and adversely affect several domestic and wild birds including pigeons. In Saudi Arabia, there is a lack of studies describing such ectoparasites and their infestation rates. Through this work, a new record, Columbicola, tschulyschman Eichler (C.

Histological technique to detect the physiological age of the malaria vector mosquito Anopheles pharoensis (Diptera: Culicidae).

The risk of malaria recurrence increases due to the main vector, Anopheles pharoensis. The physiological age of the mosquito population is needed to expect malaria vector dynamics. The number of completed gonotrophic cycles is of great importance in determining the physiological age of females.

A review of swarm intelligence algorithms deployment for scheduling and optimization in cloud computing environments.

Background: This review focuses on reviewing the recent publications of swarm intelligence algorithms (particle swarm optimization (PSO), ant colony optimization (ACO), artificial bee colony (ABC), and the firefly algorithm (FA)) in scheduling and optimization problems. Swarm intelligence (SI) can be described as the intelligent behavior of natural living animals, fishes, and insects. In fact, it is based on agent groups or populations in which they have a reliable connection among them and with their environment.

Fusarium sp. L-asparaginases: purification, characterization, and potential assessment as an antileukemic chemotherapeutic agent.

Asparaginases important role in the treatment of leukemia. It is part of chemotherapy in the treatment of leukemia in the last three decades. L-Asparaginase is isolated from Fusarium sp.

Psychometric properties of the Arabic version of the Basic Psychological Needs Satisfaction-Frustration Scale (BPNSFS).

Background: The aim of this study is to validate the Arabic version of the Basic Psychological Need Satisfaction and Frustration Scale (BPNSFS), and to investigate the extent of its invariance across five Arab countries and gender.

Methods: A back-translated version of the BPNSFS, the second version of the Beck Depression Inventory (BDI-II), and the Warwick-Edinburgh Mental Well-Being Scale (WEMWBS) were administered to a sample consisting of 1082 undergraduate students affiliated with universities in five Arab countries (487 males and 595 females: M = 20.04 ± 1.

Sarcocystis camelicanis increases interleukin (IL)-6 expression in one-humped camels (Camelus dromedarius) from Riyadh and Al Qassim, Saudi Arabia.

Sarcocystis spp. are intracellular protozoan parasites with an intermediate-definitive host life cycle based on a prey-predator relationship. Sarcocystis infection is common among different vertebrates including humans.