1 results match your criteria: "Haematopoietic Stem Cell Lab The Francis Crick Institute London UK.[Affiliation]"
Article Synopsis
- Immunodeficient mouse models are commonly used to study human stem cells, but issues with reproducibility and variation in engraftment remain unresolved.
- This research investigates how the sex of both human donor cells and recipient mice affects the engraftment of healthy and leukemic cells, discovering significant differences based on their genders.
- Notably, human female donor cells show increased engraftment and sensitivity to the gender of recipient mice, highlighting the need to consider donor-recipient characteristics in future pre-clinical studies.