5,740 results match your criteria: "Hadassah-Hebrew-University Medical Center[Affiliation]"
Age Ageing
November 2024
Nursing Research, University Hospital Schleswig-Holstein, Kiel, Germany.
Background: Delirium, an acute brain dysfunction, is proposed to be highly prevalent in clinical care and shown to significantly increase the risk of mortality and dementia.
Objectives: To report on the global prevalence of clinically documented delirium and delirium-related clinical practices in wards caring for paediatric and adult patients in healthcare facilities.
Design: A prospective, cross-sectional, 39-question survey completed on World Delirium Awareness Day, 15 March 2023.
Nat Ecol Evol
January 2025
Department of Genetics, The Alexander Silberman Institute of Life Sciences, The Hebrew University of Jerusalem, Jerusalem, Israel.
Genome-wide premortem DNA methylation patterns can be computationally reconstructed from high-coverage DNA sequences of ancient samples. Because DNA methylation is more conserved across species than across tissues, and ancient DNA is typically extracted from bones and teeth, previous works utilizing ancient DNA methylation maps focused on studying evolutionary changes in the skeletal system. Here we suggest that DNA methylation patterns in one tissue may, under certain conditions, be informative on DNA methylation patterns in other tissues of the same individual.
View Article and Find Full Text PDFRadiology
November 2024
From the Departments of Radiology (R.B., J.C.) and Digestive Diseases (Hepatology) (J.C.), Yale University School of Medicine, New Haven, Conn; Department of Radiology, Feinberg School of Medicine, Northwestern University, Chicago, Ill (R.S.); Department of Medical Oncology, Geffen School of Medicine, University of California Los Angeles, Los Angeles, Calif (R.F.); Center for Cancer Research, National Institutes of Health, Bethesda, Md (T.F.G.); Department of Radiology, Hadassah Hebrew University Medical Center, Hebrew University, Jerusalem, Israel (S.N.G.); and Department of Biomedical Engineering, Yale School of Engineering and Applied Sciences, 789 Howard Ave, Clinic Bldg 363H, New Haven, CT 06520 (J.C.).
The management of hepatocellular carcinoma (HCC) is undergoing transformational changes due to the emergence of various novel immunotherapies and their combination with image-guided locoregional therapies. In this setting, immunotherapy is expected to become one of the standards of care in both neoadjuvant and adjuvant settings across all disease stages of HCC. Currently, more than 50 ongoing prospective clinical trials are investigating various end points for the combination of immunotherapy with both percutaneous and catheter-directed therapies.
View Article and Find Full Text PDFBiomed Opt Express
November 2024
Department of Ophthalmology, Rothschild Foundation Hospital, Paris, France.
NIMO-TEMPO is a metrology device that measures all types of intraocular lenses available in the ophthalmic market. Its technology, based on interferometry, captures the wavefront of the lens to compute optical results essential to evaluate its quality and understand its characteristics. This study aims to demonstrate the reliability of this device and its associated software, TEMPO-MENTOR, in measuring intraocular lenses.
View Article and Find Full Text PDFBiomed Opt Express
November 2024
Department of Ophthalmology, Rothschild Foundation Hospital, Paris, France.
Fam Cancer
November 2024
Recanati Genetics Institute, Faculty of Medicine, Rabin Medical Center - Beilinson Hospital, Tel Aviv University, Petach Tikva, Tel Aviv, Israel.
Deciphering the spectrum and founder disease-causing variants (DCVs) in specific populations can shape and facilitate the diagnostic process of Lynch Syndrome (LS). The aim of this report was to comprehensively update on the genetic landscape of LS in the ethnically diverse Israeli-Jewish population. The cohort included 1080 carriers from 588 families; some from underrepresented, understudied Israeli ethnic groups recruited from 8 genetic institutes and high-risk clinics throughout the country.
View Article and Find Full Text PDFPediatr Pulmonol
November 2024
Pediatric Pulmonology Unit and Cystic fibrosis Center, Hadassah-Hebrew University Medical Center, Jerusalem, Israel.
Cell Prolif
November 2024
NewStem LTD, Jerusalem, Israel.
Taxanes and platinum molecules, specifically paclitaxel and carboplatin, are widely used anticancer drugs that induce cell death and serve as first-line chemotherapy for various cancer types. Despite the efficient effect of both drugs on cancer cell proliferation, many tumours have innate resistance against paclitaxel and carboplatin, which leads to inefficient treatment and poor survival rates. Haploid human embryonic stem cells (hESCs) are a novel and robust platform for genetic screening.
View Article and Find Full Text PDFJ AAPOS
December 2024
Department of Ophthalmology, Hadassah-Hebrew University Medical Center, Jerusalem, Israel.
Purpose: To investigate the clinical and biometric features of pediatric eyes with extreme hyperopia and report baseline biometric values.
Methods: In this prospective case-control study, the biometric parameters of eyes in children with extreme hyperopia were compared to those of an emmetropic cohort of similar age. Comprehensive eye examinations were conducted for new patients.
Insights Imaging
November 2024
Division of Vascular and Interventional Radiology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA.
Percutaneous image-guided ablation techniques are a consolidated therapeutic alternative for patients with high preoperative surgical risk for the management of oncological diseases in multiple body districts. Each technique has both pros and cons according to the type of energy delivered, mechanism of action, and site of application. The present article reviews the most recent literature results on ablation techniques applied in the field of genitourinary diseases (kidney, adrenal glands, prostate, and uterus), describing the advantages of the use of each technique and their technical limitations and summarizing the major recommendations from an international consensus meeting.
View Article and Find Full Text PDFAm J Physiol Heart Circ Physiol
December 2024
Institute for Pathophysiology, West German Heart and Vascular Center, University of Essen Medical School, University of Duisburg-Essen, Hadassah-Hebrew University Medical Center, Essen, Germany.
Ann Clin Transl Neurol
January 2025
Faculty of Medicine, Hebrew University of Jerusalem, Jerusalem, Israel.
Objectives: Psychological stress has been suggested as a contributory factor in the onset and progression of multiple sclerosis (MS). The 7 October 2023 terrorist attacks in Israel caused significant psychological stress, providing a unique context to study its impact on MS activity. This study aims to assess the impact of war-related psychological stress on MS activity using magnetic resonance imaging (MRI) scans and clinical follow-up.
View Article and Find Full Text PDFHum Resour Health
November 2024
Nursing Administration, Soroka University Medical Center, Beersheba, Israel.
Background: Considering the global shortage of nurses, leaders in the field must understand the strengths and weaknesses of various nursing specialties in order to retain professionals within the field. Occupational prestige reflects the perceived contribution of an occupation 'to society', and measures its desirability, benefit and values. Understanding how experienced nurses view the prestige of nursing specialties may help to explain why some specialties are more desirable than others.
View Article and Find Full Text PDFChest
October 2024
Department of Physiology and Cell Biology, Faculty of Health Sciences, Ben-Gurion University, Beer-Sheva, Israel.
Background: Evaluating expiratory airway function in infants is challenging because the criterion standard, the raised-volume rapid thoracoabdominal compression technique, is technically difficult and has a high failure rate.
Research Question: Are measurements obtained during passive expiration from total lung capacity correlated with forced expiration measurements obtained by the raised-volume technique in infants?
Study Design And Methods: This observational retrospective analysis included infants born ≥ 36 weeks' gestation who underwent pulmonary function testing using the raised-volume rapid thoracoabdominal compression technique at Hadassah Medical Centre between January 2011 and December 2019. Technically acceptable forced and passive flow-volume curve measurements were included in the analysis.
Disabil Health J
October 2024
Department of Public Health, Vrije Universiteit Brussel, Belgium.
J Infect
December 2024
Head Office, Medical Division, Meuhedet Health Services, Tel Aviv, Israel; Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.
Eur Stroke J
October 2024
Department of Neurology, Charité - Universitätsmedizin Berlin, Corporate member of Freie Universität Berlin and Humboldt Universität zu Berlin, Berlin, Germany.
Background: Acute intracranial occlusion of the internal carotid artery (ICA) can be distinguished into (a) occlusion of the terminal ICA, involving the proximal segments of the middle or anterior cerebral artery (ICA-L/-T) and (b) non-terminal intracranial occlusions of the ICA with patent circle of Willis (ICA-I). While patients with ICA-L/-T occlusion were included in all randomized controlled trials on endovascular therapy (EVT) in anterior large vessel occlusion, data on EVT in ICA-I occlusion is scarce. We thus aimed to evaluate effectiveness and safety of EVT in ICA-I occlusions in comparison to ICA-L/-T occlusions.
View Article and Find Full Text PDFFront Oncol
October 2024
Oncology Institute, Shaba Medical Center, Ramat-Gan, Israel.
Cellular plasticity is enhanced by dedifferentiation processes such as epithelial-mesenchymal transition (EMT). The dynamic and transient nature of EMT-like processes challenges the investigation of cell plasticity in patient-derived breast cancer models. Here, we utilized patient-derived organoids (PDOs) as a model to study the susceptibility of primary breast cancer cells to EMT.
View Article and Find Full Text PDFPsychiatry Res
December 2024
Prof. Avraham Rivkind, Department of General Surgery, Hadassah-Hebrew University Medical Center, Jerusalem, Israel.
A preventive approach to Post-Traumatic Stress Disorder (PTSD) through an Immediate Psycho-Trauma Intervention (IPTI) may significantly reduce PTSD likelihood and provide a cost-effective way to alleviate suffering. This mixed-method study 1) compared medics who received an IPTI to those who did not after a mass medical event, 2) compared the number medics diagnosed with PTSD from the IPTI group to the minimum number in similar cases reported in the literature. The results indicated that 1.
View Article and Find Full Text PDFJ Exp Med
November 2024
The Institute of Biomedical and Oral Research, Faculty of Dental Medicine, Hebrew University, Jerusalem, Israel.
Am J Physiol Renal Physiol
December 2024
Wohl Institute for Translational Medicine, Hadassah-Hebrew University Medical Center, Jerusalem, Israel.
Clin Exp Rheumatol
October 2024
Division of Rheumatology, Department of Internal Medicine, Istanbul University, Cerrahpasa Medical Faculty, Istanbul, Turkey.
Clin Exp Rheumatol
October 2024
Rheumatology Unit, Hadassah-Hebrew University Medical Center, Jerusalem, Israel.
Plast Reconstr Surg Glob Open
October 2024
Department of Radiology, Interventional Radiology Unit, Hadassah-Hebrew University Medical Center, Jerusalem, Israel.
Clin Exp Ophthalmol
October 2024
Department of Ophthalmology, Shamir Medical Center (formerly Assaf-Harofeh), Be'er Ya'akov, Israel.