Characterising the phenotype and progression of sporadic adult-onset foveomacular vitelliform dystrophy.

Background/aims: Adult-onset foveomacular vitelliform dystrophy (AFVD) is a relatively common macular degeneration which might lead to substantial visual loss. Our purpose was to describe the natural course of genetically evaluated patients with sporadic AFVD.

Methods: A retrospective, consecutive, cohort study included 95 eyes of 51 patients.

Association of neovascular age-related macular degeneration with specific gene expression patterns in peripheral white blood cells.

Purpose: Inflammation probably plays a major role in the pathogenesis of age-related macular degeneration (AMD). The authors evaluated whether AMD is associated with gene expression patterns in white blood cells (WBCs) and whether such a pattern may serve as a biomarker for the disease.

Methods: Microarray analysis of gene expression in peripheral WBCs was performed on patients with neovascular AMD (NVAMD; n = 16) and controls (n = 16).

The spatial distribution of monosomy 3 and network vasculogenic mimicry patterns in uveal melanoma.

Purpose: Monosomy of chromosome 3 and network vasculogenic mimicry patterns are associated with death in patients with uveal melanoma (UM). Networks are typically found in confined areas within the tumor, whereas the intratumor distribution of chromosome 3 aberrations is unknown. This study was conducted to assess the spatial correlation among chromosome 3 aberrations and networks in UM.