1,040 results match your criteria: "Hadassah School of Dental Medicine.[Affiliation]"

Intestinal bacterial communities participate in gut homeostasis and are recognized as crucial in bowel inflammation and colorectal cancer (CRC). (), a pathobiont of the oral microflora, has recently emerged as a CRC-associated microbe linked to disease progression, metastasis, and a poor clinical outcome; however, the primary cellular and/or microenvironmental targets of this agent remain elusive. We report here that directly targets putative colorectal cancer stem cells (CR-CSCs), a tumor cell subset endowed with cancer re-initiating capacity after surgery and chemotherapy.

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The FDI World Dental Federation suggests that "dentistry, as a profession, should integrate Sustainable Development Goals into daily practice and support a shift to a green economy in the pursuit of healthy lives and wellbeing for all, through all stages of life." This article reports on the recent activity of the Association for Dental Education in Europe Special Interest Group for Sustainability in Dentistry. Following on from the group's previous activities, which explored current educational practice, this work aimed to reach a pan-European consensus on a number of learning outcomes for environmental sustainability, in order to (i) support institutions in designing and delivering their curriculum, and (ii) to further harmonise the delivery of oral health professional education across Europe.

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Bladder cancer is the 4 leading cancer in men. Tumor resection followed by bladder instillation of Bacillus Calmette-Guérin (BCG) is the primary treatment for high-risk patients with Non-Muscle Invasive Bladder Cancer (NMIBC) to prevent recurrence and progression to muscle-invasive disease. This treatment, however, lacks efficiency and causes severe adverse effects.

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Athrocentesis: What, When, and Why?

Atlas Oral Maxillofac Surg Clin North Am

September 2022

Oral and Maxillofacial Surgery, Shaare Zedek Medical Center, Jerusalem, Israel.

The introduction of temporomandibular joint (TMJ) arthroscopy by Onishi in 1970 (results published in 1975 and 1980) opened a new modality for TMJ treatment. The efficiency of arthroscopic lavage and lysis led in the 1990s to its simplification: TMJ arthrocentesis. Always associated with load control, physiotherapy, and elimination of any occlusal hazards, arthrocentesis, a simple procedure, entails less expensive and more available tools and is performed under local anesthesia.

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Disclaimer: This article is based on recommendations from the 12 WALT Congress, Nice, October 3-6, 2018, and a follow-up review of the existing data and the clinical observations of an international multidisciplinary panel of clinicians and researchers with expertise in the area of supportive care in cancer and/or PBM clinical application and dosimetry. This article is informational in nature. As with all clinical materials, this paper should be used with a clear understanding that continued research and practice could result in new insights and recommendations.

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Periodontal Classification Revisited: The Classification System in the Test of Time.

Compend Contin Educ Dent

March 2022

Faculty of Dental Medicine, Department of Periodontology, The Hebrew University-Hadassah School of Dental Medicine, Jerusalem, Israel.

At the EuroPerio conference held in Amsterdam in 2018, an update to the previous classification of periodontal diseases was presented. The update was a joint effort of the American Academy of Periodontology (AAP) and the European Federation of Periodontology (EFP). On the face of it, the new classification system for diagnosing periodontal diseases and conditions is merely an update of previous definitions from 1999.

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Article Synopsis
  • Chronic orofacial pain (OFP) is associated with the endocannabinoid system, which influences pain perception but its link to salivary endocannabinoid levels was previously unexplored.
  • A study comparing 83 chronic OFP patients with 43 healthy controls revealed that OFP patients had significantly lower levels of certain endocannabinoids in their saliva, particularly those suffering from neurovascular and neuropathic pain.
  • The findings suggest that measuring salivary endocannabinoid levels can enhance the understanding of chronic OFP and could lead to new diagnostic and treatment approaches for managing this pain.
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Background: Antibacterial composite will have a significant clinical advantage in controlling caries. This study tests the antibacterial properties of a novel bulk-fill flowable composite (Infinx™, Nobio™ Ltd.) containing quaternary ammonium silica (QASi) filler particles.

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Candida albicans evades NK cell elimination via binding of Agglutinin-Like Sequence proteins to the checkpoint receptor TIGIT.

Nat Commun

May 2022

The Concern Foundation Laboratories at the Lautenberg Center for Immunology and Cancer Research, Hebrew University Medical School, IMRIC, Jerusalem, 91120, Israel.

Candida albicans is the most common fungal pathogen and a prevalent cause of deadly bloodstream infections. Better understanding of the immune response against it, and the ways by which it evades immunity, are crucial for developing new therapeutics against it. Natural Killer (NK) cells are innate lymphocytes best known for their role against viruses and tumors.

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Specific inflammatory osteoclast precursors induced during chronic inflammation give rise to highly active osteoclasts associated with inflammatory bone loss.

Bone Res

April 2022

The Concern Foundation Laboratories at The Lautenberg Center for Immunology and Cancer Research, Israel-Canada Medical Research Institute, Faculty of Medicine, The Hebrew University, Jerusalem, Israel.

Article Synopsis
  • * iOCPs, although rare under normal conditions, become abundant and more active during inflammation, while hOCPs remain unchanged and produce less active OCs.
  • * The study highlights TNF-α and S100A8/A9 as crucial regulators of iOCPs in inflammation and suggests that targeting iOCPs could be a new strategy for diagnosing and treating IBL in inflammatory
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While the existence of an indigenous placental microbiota remains controversial, several pathogens are known to be involved in adverse pregnancy outcomes. Fusobacterium nucleatum is an oral bacterium that is one of several bacteria associated with preterm birth. Oral fusobacteria translocate to the placenta hematogenously; however, the mechanisms localizing them to the placenta remain unclear.

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Objective: To investigate the staining outcomes of Silver Diamine Fluoride (SDF) after its application on healthy enamel and its implications on patient's caries risk assessment.

Study Design: A review of dental and photographic records of 61 caries-free subjects under age 3, who received SDF application as part of a prevention protocol in a private pediatric dental clinic was performed. The age, gender, caries risk assessment and resulting staining were analyzed.

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Solitary Extraosseous Neurofibroma in a 5-Year-Old Child - A Case Report.

Ann Maxillofac Surg

February 2022

Department of Oral and Maxillofacial Surgery, Rambam Health Care Campus, Haifa, Israel.

Rationale: Neurofibroma (NF) is the most common benign peripheral nerve sheath tumour that most often occurs as a solitary tumour. A clinical and imaging diagnosis may be challenging since no distinctive features are unique for this lesion. Solitary NFs are treated by complete resection that may sometimes require a nerve sacrifice, ending with a neurological deficit.

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Accumulating evidence demonstrates that the oral pathobiont Fusobacterium nucleatum is involved in the progression of an increasing number of tumors types. Thus far, the mechanisms underlying tumor exacerbation by F. nucleatum include the enhancement of proliferation, establishment of a tumor-promoting immune environment, induction of chemoresistance, and the activation of immune checkpoints.

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Article Synopsis
  • Community water fluoride (CWF) was mandatory in Israel until 2014, after which treatment rates for dental issues in children aged 3-12 were evaluated through data from the "Maccabi-Dent" clinics.
  • Analysis revealed that after the termination of CWF, there was about a twofold increase in restorative dental treatments, indicating a strong link between fluoride levels in water and dental health among children.
  • These findings emphasize the need for policymakers to reconsider the addition of fluoride to drinking water to help maintain better dental health in the population.
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Early antitumor activity of oral Langerhans cells is compromised by a carcinogen.

Proc Natl Acad Sci U S A

January 2022

Institute of Biomedical and Oral Research, Faculty of Dental Medicine, Hebrew University of Jerusalem, Jerusalem 9112102, Israel;

Early diagnosis of oral squamous cell carcinoma (OSCC) remains an unmet clinical need. Therefore, elucidating the initial events of OSCC preceding tumor development could benefit OSCC prognosis. Here, we define the Langerhans cells (LCs) of the tongue and demonstrate that LCs protect the epithelium from carcinogen-induced OSCC by rapidly priming αβT cells capable of eliminating γH2AX epithelial cells, whereas γδT and natural killer cells are dispensable.

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Objectives: Part 1 of this two-part study aims to investigate systemic antibiotics (SA) prescribing practices for various endodontic diagnoses and clinical scenarios by general practitioners, post-graduate students and endodontists in Israel and the former Soviet Union (FSU) states.

Materials And Methods: A total of 7500 dentists from Israel and FSU states were invited to fill in an online questionnaire. The questionnaire consisted the SA prescribing for endodontic diagnoses and clinical scenarios (post operative pain, post apical surgery and post avulsion).

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Oral mucositis (OM) is a common, highly symptomatic complication of cancer therapy that affects patients' function, quality of life, and ability to tolerate treatment. In certain patients with cancer, OM is associated with increased mortality. Research on the management of OM is ongoing.

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Background: Gum infection, known as gingivitis, is a global issue. Gingivitis does not cause pain; however, if left untreated, it can worsen, leading to bad breath, bleeding gums, and even tooth loss, as the problem spreads to the underlying structures anchoring the teeth in the jaws. The asymptomatic nature of gingivitis leads people to postpone dental appointments until clinical signs are obvious or pain is evident.

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Titanium plats are the gold-standard for fracture fixation. Titanium is considered biocompatible, corrosion resistant with an elasticity-modulus closest to bone. Nonetheless, titanium plates are not always as inherent as hoped.

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Zinc Oxide Zinc Sulfate versus Zinc Oxide Eugenol as Pulp Chamber Filling Materials in Primary Molar Pulpotomies.

Children (Basel)

September 2021

Department of Pediatric Dentistry, Hadassah School of Dental Medicine, Hebrew University, Jerusalem 9112102, Israel.

The long-term effect of Zinc oxide zinc sulfate (Coltosol) dressing material on pulpotomy success and tooth survival has not yet been studied. This study compared the success rates of Zinc oxide zinc sulfate and zinc oxide eugenol as coronal dressing materials post radicular pulp amputation in primary teeth pulpotomies. This study included healthy two- to ten-year-old children who had pulpotomies on primary molars between 2012 and 2018 at the Pediatric Dentistry Clinic of the School of Dental Medicine.

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Background: Gingivitis is a nonpainful, inflammatory condition that can be managed at home. Left untreated, gingivitis can lead to tooth loss. Periodic dental examinations are important for early diagnosis and treatment of gum diseases.

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Recent studies on the oral, anaerobic, gram-negative bacterium revealed its presence and involvement in colorectal, esophageal and breast cancer. We previously demonstrated that binds and activates the human inhibitory receptors TIGIT and CEACAM1 leading to inhibition of T and NK cell anti-tumor immunity. CEACAM1 was found to be bound and activated by the fusobacterial trimeric autotransporter adhesin CbpF.

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CbpF Mediates Inhibition of T Cell Function Through CEACAM1 Activation.

Front Cell Infect Microbiol

August 2021

The Concern Foundation Laboratories at the Lautenberg Center for General and Tumor Immunology, Department of Immunology and Cancer Research, Institute for Medical Research Israel Canada (IMRIC), Faculty of Medicine, The Hebrew University Medical School, Jerusalem, Israel.

is an anaerobic bacterium that is associated with several tumor entities and promotes tumorigenesis. Recent evidence suggests that binds the inhibitory receptor carcinoembryonic antigen cell adhesion molecule 1 (CEACAM1) the trimeric autotransporter adhesin CbpF. However, whether this binding is functional or whether other fusobacterial trimeric autotransporter adhesins are involved in CEACAM1 activation is unknown.

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The inhibitory receptor CD300a is essential for neutrophil-mediated clearance of urinary tract infection in mice.

Eur J Immunol

September 2021

The Concern Foundation Laboratories at the Lautenberg Center for Immunology and Cancer Research, IMRIC, The Hebrew University Medical School, Jerusalem, Israel.

Neutrophils play a crucial role in immune defense against and clearance of uropathogenic Escherichia coli (UPEC)-mediated urinary tract infection, the most common bacterial infection in healthy humans. CD300a is an inhibitory receptor that binds phosphatidylserine and phosphatidylethanolamine, presented on the membranes of apoptotic cells. CD300a binding to phosphatidylserine and phosphatidylethanolamine, also known as the "eat me" signal, mediates immune tolerance to dying cells.

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