A systematic review of viral infections associated with oral involvement in cancer patients: a spotlight on Herpesviridea.

Purpose: Our aim was to evaluate the literature for the prevalence of and interventions for oral viral infections and, based on scientific evidence, point to effective treatment protocols. Quality of life (QOL) and economic impact were assessed if available in the articles reviewed.

Methods: Our search of the English literature focused on oral viral infections in cancer patients within the timeframe of 1989-2007.

Long-term follow up of root canal treated primary molars.

Background: Root canal treatment (RCT) is commonly performed to preserve primary molars with an infected or necrotic pulp.

Aim: This study evaluates the long-term effects of RCT in primary molars on the development and eruption of their permanent successors.

Methods: This is a retrospective study of treatment of pulpectomised primary molars in a public dental clinic.

Salivary bacteria and oral health status in children with disabilities fed through gastrostomy.

Objectives: This study examined caries level, amount of calculus, and oral microbial environment in gastrostomy tube (GT)-fed children compared with healthy children and children with disabilities orally fed (PO).

Study Design: The study group consisted of 12 GT-fed children and the two control groups consisted of 16 children with disabilities orally fed and 17 healthy children. DMF-T/dmf-t index, calculus index, Mutans Streptococci (MS), Lactobacilli (LB) levels and salivary buffer capacity were examined.

The role of skin-derived dendritic cells in CD8+ T cell priming following immunization with lentivectors.

Although skin dendritic cells (DCs) have been shown to directly present Ag to CD8(+) T cells after intradermal immunization with lentivectors, the contribution of the different skin DC subsets to this process remains unclear. Using langerin-diphtheria toxin receptor transgenic mice we demonstrated that ablation of langerhans cells and langerin-expressing positive dermal DCs (Ln(+)dDCs) did not interfere with the generation of CD8(+) T cells by lentiviral vectors. Consistent with these findings, the absence of langerhans cells and Ln(+)dDCs did not hamper the presentation level of lentiviral-derived Ag by skin DCs in vitro.

Parents' attitude toward their children's appearance in the case of esthetic defects of the anterior primary teeth.

Purpose: To evaluate parents' attitude toward esthetic defects of maxillary primary incisors and the association between various demographic parameters and the treatment parents chose for their children.

Methods: The study consisted of two parts: 1) a clinical examination of the child's primary incisors, and 2) a questionnaire for the accompanying parent. 362 parents who accompanied 294 children aged 1-6 years, participated in the study.

Lip cancer: incidence, trends, histology and survival: 1970-2006.

Background: High levels of lip cancer have been reported among Israelis over the last four decades. Epidemiological descriptions and analyses for this region have not previously been presented.

Objectives: To establish the incidence, trends and histology of lip cancer and associated demographic variables in Israel over time.

Exceptional oral manifestations of amyloid light chain protein (AL) systemic amyloidosis.

Oral amyloidosis is usually presented in the tongue and is often associated with multiple myeloma. We present three patients with unusual oral manifestations of primary amyloidosis, which to the best of our knowledge have not been previously published. In two cases the oral manifestation was overt at the time of diagnosis and all cases ended in patient mortality.

Psychosocial reward of orthodontic treatment in adult patients.

The purpose of this study was to assess the short-term psychosocial impact of dental aesthetic improvement in adult subjects. Sixty-nine adult patients (61 females and 8 males, aged 21-59 years) requesting aesthetic dental improvement were prospectively and randomly recruited for the study in a private orthodontic office. A general interview included patient motivation and expectations from treatment.

Increased occurrence of dental anomalies associated with infraocclusion of deciduous molars.

Objective: To test the null hypothesis that there is no relationship between infraocclusion and the occurrence of other dental anomalies in subjects selected for clear-cut infraocclusion of one or more deciduous molars.

Materials And Methods: The experimental sample consisted of 99 orthodontic patients (43 from Boston, Mass, United States; 56 from Jerusalem, Israel) with at least one deciduous molar in infraocclusion greater than 1 mm vertical discrepancy, measured from the mesial marginal ridge of the first permanent molar. Panoramic radiographs and dental casts were used to determine the presence of other dental anomalies, including agenesis of permanent teeth, microdontia of maxillary lateral incisors, palatally displaced canines (PDC), and distal angulation of the mandibular second premolars (MnP2-DA).

Oral cancer over four decades: epidemiology, trends, histology, and survival by anatomical sites.

Background: Oral cancer is one of the few life-threatening oral diseases. The subtypes and different sites of oral cancer has different etiology epidemiology and survival rate. Prevalence of the various anatomical oral sites provided potential baseline for improvement of clinical approach.

Psychological distress and self-perception of oral health status among an immigrant population from Ethiopia.

Objectives: To examine the association between psychological distress (PD) and perception of oral health status among a group of Ethiopian immigrants compared to the 'gold standard' of clinical diagnosis.

Design: Three hundred and forty Ethiopian immigrants, aged 18 years or more, were interviewed using a version of the Self-Reporting Questionnaire (World Health Organization) for the assessment of psychological status and perceived dental and periodontal health status. Clinical data for dental and periodontal health status were used as the 'gold standard' against the self-perceived assessment scores among the PD and no psychological distress (NPD) groups.

IL-10 mediates resistance to adoptive transfer experimental autoimmune encephalomyelitis in MyD88(-/-) mice.

MyD88 is an adaptor molecule that functions in the innate signaling induced by proinflammatory adjuvants that interact with TLRs. Mice lacking MyD88, for example, resist active experimental autoimmune encephalomyelitis (EAE) induced by immunization with an encephalitogenic myelin oligodendrocyte glycoprotein (MOG) peptide in CFA. We reasoned that MyD88(-/-) mice, nevertheless, should be susceptible to EAE mediated by adoptive transfer of activated encephalitogenic T cell lines, which do not require adjuvant signaling for their effector functions.

Endoscopic root canal treatment.

Objective: To describe an innovative endoscopic technique for root canal treatment.

Materials And Methods: Root canal treatment was performed on 12 patients (15 teeth), using a newly developed endoscope (Sialotechnology), which combines an endoscope, irrigation, and a surgical microinstrument channel.

Results: Endoscopic root canal treatment of all 15 teeth was successful with complete resolution of all symptoms (6-month follow-up).

Saliva enables the antimicrobial activity of LL-37 in the presence of proteases of Porphyromonas gingivalis.

Proteolysis is a common microbial virulence mechanism that enables the destruction of host tissue and evasion from host defense mechanisms. Antimicrobial peptides, also known as host defense peptides, are effector molecules of the innate immunity that demonstrate a broad range of antimicrobial and immunoregulatory activities. Deficiency of the human LL-37 antimicrobial peptide was previously correlated with severe periodontal disease.

The influence of handheld mobile phones on human parotid gland secretion.

Background: Handheld mobile phones (MPHs) have become a 'cultural' accessory device, no less so than a wrist watch. Nevertheless, the use of MPHs has given rise to great concern because of possible adverse health effects from exposure to the radiofrequency radiation (RFR) emitted by the device. Previous studies suggested correlation between MPH and salivary gland tumors.

Validation of the National Institutes of Health (NIH) scale for oral chronic graft-versus-host disease (cGVHD).

The aim of this study was to validate the 2005-2006 National Institutes of Health (NIH) scale for patient's self-reporting and clinical manifestations of oral chronic graft-versus-host disease (cGVHD). Numerical parameters of the NIH scale were analyzed for their construct validity (correlation of the NIH scale with numerical rating scale [NRS] for pain) and internal consistency reliability (correlation between different parameters of the same scale). Categoric parameters were analyzed by comparison between severity subgroups defined by the oral manifestation (lichenoid/erythema/ulceration).

Mandibular reconstruction using stereolithographic 3-dimensional printing modeling technology.

Mandibular reconstruction can be challenging for the surgeon wishing to restore its unique geometry. Reconstruction can be achieved with titanium bone plates followed by autogenous bone grafting. Incorporation of the bone graft into the mandible provides continuity and strength required for proper esthetics and function and permitting dental implant rehabilitation at a later stage.

Trends of oral and pharyngeal cancer in Israel, by gender, age, ethnic group, and country of origin: 1970-2006.

Background: Oral and pharyngeal cancer is one of the few life-threatening oral diseases. Israel is recognized as a developed country, characterized by a heterogeneous population, a high level of sun exposure, and a large proportion of faired skinned inhabitants. The purpose of this study was to describe trends in incidence and survival rates of oral and pharyngeal cancer between 1970 and 2006.

Buccal ectopia of maxillary canines with no crowding.

Introduction: Buccally displaced canines (BDC) are usually found in crowded dentitions. Nevertheless, a small but significant number of patients with BDC have no crowding. In this study, we compared BDC dentitions with no crowding (BDC-nc), BDC dentitions with crowding (BDC-c), and uncrowded dentitions with normally erupted canines (C).

Bisphosphonate-related osteonecrosis of the jaw: clinical correlations with computerized tomography presentation.

The aim of this study was to correlate clinical and computerized tomography (CT) features of bisphosphonate-related osteonecrosis of the jaws (BRONJ). All ONJ patients for whom there was complete CT scan imaging were eligible. Selected clinical parameters retrieved from their medical records were analyzed for correlation with CT parameters.

Comparison of a dentifrice containing 0.243% sodium fluoride, 0.3% triclosan, and 2.0% copolymer in a silica base, and a dentifrice containing 0.243% sodium fluoride in a silica base: a three-year clinical trial of root caries and dental crowns among adults.

Objective: Colgate Total toothpaste has been demonstrated to be highly effective in plaque and gingivitis control. The effect of triclosan on root caries and on the survival of dental crowns (fixed dental prosthetic treatment) has not been evaluated. In order to examine these important variables, a randomized controlled clinical trial was conducted comparing Colgate Total toothpaste with triclosan, and an identical fluoride toothpaste without triclosan.

Does granisetron eliminate the gag reflex? A crossover, double-blind, placebo-controlled pilot study.

Although gagging is a frequent problem that, when severe, can jeopardize the dental procedure, no single protocol is used to alleviate this phenomenon. Selective 5-HT3 antagonists, such as granisetron, may attenuate gagging. In this study, granisetron and placebo were administered intravenously, in a crossover, double-blind manner, to 25 healthy volunteers in 2 different sessions.

A matter of timing: unsynchronized antigen expression and antigen presentation diminish secondary T cell responses.

Despite the low and short expression of secondary Ag, prime-boost immunizations using homologous or heterologous vectors are capable of amplifying memory CD8(+) T cells. This is mainly attributed to the rapid presentation of Ag by APCs and the high proliferative capacity of memory CD8(+) T cells. Nevertheless, certain viruses and vectors often require prolonged Ag presentation for optimal T cell priming, and the influence of such a prolonged presentation during secondary immune induction is not clear.