A randomised controlled clinical trial comparing pure Portland cement and formocresol pulpotomies followed from 2 to 4 years.

Purpose: The purpose of the present prospective randomised clinical control trial was to evaluate the long-term clinical and radiographic success rate of pulpotomies in primary molars using pure Portland cement versus formocresol. Pure Portland cement has shown a high rate of success in pulpotomy treatments, with no side effects.

Methods: Healthy 3- to 11-year-old children were treated with pulpotomies on primary molars as part of their scheduled dental treatment.

Salivary inflammatory cytokines echo the low inflammatory burden in liver-transplanted children.

Objectives: The aims of this study were to compare the salivary cytokine profile, as a potential replacement for blood tests, in liver-transplanted children to that of a control group of healthy children, and to correlate the values of commonly tested laboratory blood tests to those of published blood values.

Methods: Liver-transplanted children, and a control group of healthy children of the same sex and age distribution, were recruited for the study. Saliva was collected at the same appointment for routine blood tests for the liver-transplanted children.

Salivary biochemical variables in liver transplanted children and young adults.

Purpose: To investigate associations between levels of blood parameters used to monitor liver-transplanted children with their salivary levels, and compare the salivary parameters of transplant recipients with those of healthy controls.

Methods: Saliva and blood samples from 30 liver transplanted recipients, mean age 11.7 years and saliva from age and sex matched 27 healthy patients were analyzed using a standard complete blood count test.

Laser Tooth Preparation for Pit and Fissure Sealing.

Various approaches are available for pit and fissure sealing, including: the use of sealants, with or without mechanical preparation; the use of etching, with or without bonding; and the use of lasers as an alternative to mechanical preparation. The objective of this study is to evaluate pit and fissure sealing by comparing the retention and microleakage of sealants, between mechanical and Er:Yag laser enamel preparation. Sixty extracted sound third molars are classified into six groups: A, bur mechanical preparation and sealant application; B, bur mechanical preparation, etching and sealant; C, bur mechanical preparation, etching, bonding and sealant; D, laser mechanical preparation and sealant; E, laser mechanical preparation, etching and sealant application; F, laser mechanical preparation, etching, bonding, and sealant.

The Dental, Oral, Medical Epidemiological (DOME) Study: Protocol and Study Methods.

Objectives: To develop and present the methods utilized for the Dental, Oral, Medical Epidemiological (DOME) study.

Methods: The DOME is an electronic record-based cross-sectional study, that was conducted to measure the dental, periodontal, and oral morbidities and their associations with systemic morbidities, among a nationally representative sample of young to middle-aged adults military personnel from the IDF (Israel Defense Forces). To that end, we developed a strict protocol including standardized terminology, data collection, and handling.

Inhalation Sedation During the COVID-19 Outbreak: An Expert Opinion.

Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), the pathogen that causes coronavirus disease-2019 (COVID-19), is thought to be transmitted via droplets and aerosols, and was detected in saliva of infected individuals. These droplets from the upper airway may infect the inhalation sedation mask and tubing. The authors determined the adequate measures needed to prevent the transmission of COVID-19 by nitrous-oxide (N2O) system during inhalation sedation in dentistry and provided evidence on mask and tubing sterilization.

Zirconia crown performance in primary maxillary anterior teeth: a retrospective photographic and radiographic cohort study.

Purpose: This retrospective cohort observational study evaluated marginal integrity, gingival health and aesthetics of zirconia crowns (ZC) placed on primary maxillary anterior teeth at 6- to over 30-month follow-up visits.

Methods: Two independent raters evaluated radiographic and photographic findings in 131 ZC placed in 36 children aged 24.8-62.

SOS Teeth: First Priority Teeth with Advanced Caries and Its Associations with Metabolic Syndrome among a National Representative Sample of Young and Middle-Aged Adults.

"SOS teeth" are defined as the first priority teeth for treatment, that have distinct cavitation reaching the pulp chamber or only root fragments are present. These are teeth with severe morbidity, that may require pulp capping, root canal treatment, or extraction, and therefore should be treated first. The study aims to explore whether or not a metabolic syndrome (MetS) is associated with SOS teeth.

Caries prevalence among 18 years old, an epidemiological survey in Israel.

Background: There is a lack of evidence on caries prevalence among 18 years old Israeli young adults with only a scarce evidence regarding this index age group. In the last few years dental care policy in Israel underwent substantial changes and a major reform in dental services was led by the Israeli Ministry of Health, including coverage of dental care for children by the state. In addition, a cessation of community water fluoridation was in a debate.

Colon Cancer-Associated May Originate From the Oral Cavity and Reach Colon Tumors via the Circulatory System.

is a common oral bacterium that is enriched in colorectal adenomas and adenocarcinomas (CRC). In humans, high fusobacterial CRC abundance is associated with chemoresistance and poor prognosis. In animal models, fusobacteria accelerate CRC progression.

Plaque Removal by a Powered Toothbrush Versus a Manual Toothbrush in Children: A Systematic Review and Meta-Analysis.

The purpose of this study was to determine the relative plaque reduction efficacy of powered versus manual toothbrushes in children. A systematic review and meta-analysis were conducted based on a literature search that included Medline, Embase, FDA publications, Cochrane Database of Systematic Reviews, Dentistry and Oral Science, and Berman Medical Library, Hebrew University. Studies were chosen that were randomized controlled trials and published between 1980 to 2019 in English that compared plaque reduction with manual and powered toothbrushes in children.

Expression of stem cell markers in stroma of odontogenic cysts and tumors.

Background: The stroma of odontogenic cysts/tumors may confer them differential biological behavior. We aimed to investigate the immunoexpression of stem cell markers (Nanog, SOX2, Oct4, and CD34) in the stroma of odontogenic cysts and tumors. CD34 was investigated exclusively as a marker for stromal fibroblast/fibrocyte cells (CD34 + SFCs).

Salivary Cytokines in Children with Nephrotic Syndrome versus Healthy Children: A Comparative Study.

Background: The aims of this study were to compare salivary cytokines and total protein between children with nephrotic syndrome (NS) and healthy children, and to examine whether saliva parameters can differentiate between steroid sensitivity and resistance and between disease remission and relapse.

Methods: Twenty-seven children with nephrotic syndrome were classified according to steroid sensitivity and resistance, and disease remission and relapse. Twenty healthy children served as controls.

Oral verruciform xanthoma in chronic graft-versus-host disease patients.

Background: Verruciform xanthoma (VX) is an uncommon benign epithelial lesion which mainly appears in inflamed oral epithelium. In this study, our aim was to present new cases of oral VX (OVX) in chronic graft-versus-host disease (cGVHD) and review the literature.

Methods: We conducted a retrospective chart review of cGVHD patients (2012-2019) to reveal cases of OVX.

Developing a Mobile App (iGAM) to Promote Gingival Health by Professional Monitoring of Dental Selfies: User-Centered Design Approach.

Background: Dental visits are unpleasant; sometimes, patients only seek treatment when they are in intolerable pain. Recently, the novel coronavirus (COVID-19) pandemic has highlighted the need for remote communication when patients and dentists cannot meet in person. Gingivitis is very common and characterized by red, swollen, bleeding gums.

An artificial intelligence system using machine-learning for automatic detection and classification of dental restorations in panoramic radiography.

Objectives: The aim of this study was to develop a computer vision algorithm based on artificial intelligence, designed to automatically detect and classify various dental restorations on panoramic radiographs.

Study Design: A total of 738 dental restorations in 83 anonymized panoramic images were analyzed. Images were automatically cropped to obtain the region of interest containing maxillary and mandibular alveolar ridges.

SOS Teeth: Age and Sex Differences in the Prevalence of First Priority Teeth among a National Representative Sample of Young and Middle-Aged Adults.

Background: "SOS teeth" are defined as the first priority teeth for treatment, that have distinct cavitation reaching the pulp chamber or only root fragments are present.

Objectives: To assess the prevalence and distribution of SOS teeth with regard to age and sex difference among young to middle-aged adults.

Methods: This is a cross-sectional records-based study of a nationally representative sample, consisting of young to middle-aged military personnel, who attended the military dental clinics of the Israel Defense Forces (IDF) for one year.

Severe chronic nonlichenoid oral mucositis in pembrolizumab-treated patients: new cases and a review of the literature.

To report of severe chronic oral mucositis (OM) in two pembrolizumab-treated cancer patients. A retrospective chart review was performed. Inclusion/exclusion criteria detected patients that developed OM during pembrolizumab immunotherapy.

Breast cancer colonization by Fusobacterium nucleatum accelerates tumor growth and metastatic progression.

Fusobacterium nucleatum is an oral anaerobe recently found to be prevalent in human colorectal cancer (CRC) where it is associated with poor treatment outcome. In mice, hematogenous F. nucleatum can colonize CRC tissue using its lectin Fap2, which attaches to tumor-displayed Gal-GalNAc.

The effect of Ekman-Westborg and Julin trait (generalized megadontia) and localized megadontia on tooth components size and ion content.

Aims: The objective of this study is to compare size, enamel thickness and ion relative concentration in generalized megadontia (Ekman- Westborg and Julin trait) and a localized megadont upper third molar to normal teeth.

Materials And Methods: The MD dimensions of permanent teeth were compared to controls. Tooth components of molars were measured from X-rays and compared to controls.

An efficient and eco-friendly workflow for dual fingermark processing and STR profiling.

Since its discovery in 1997, DNA retrieved from touched or handled items (touch DNA) has been increasingly used in criminal casework. Depending on the nature of the substrate examined, numerous techniques are being used for fingermark (FM) collection and development, however, it has been shown that FM processing may impede or even prevent the dual analysis of FMs and DNA. In search for a possible solution, we have recently established a novel workflow for a non-destructive collection and eco-friendly visualization of latent FMs using white BVDA gel-lifters and black Wetwop® solution.

Regeneration of grade 3 ankle sprain, using the recombinant human amelogenin protein (rHAM ) in a rat model.

Lateral ligament tears, also known as high-grade ankle sprains, are common, debilitating, and usually heal slowly. Ten to thirty percent of patients continue to suffer from chronic pain and ankle instability even after 3 to 9 months. Previously, we showed that the recombinant human amelogenin (rHAM ) induced regeneration of fully transected rat medial collateral ligament, a common proof-of-concept model.

Atypical Developmental Defects of Enamel in Primary Incisors Versus Preeruptive Intracoronal Resorption (PEIR): Case Reports.

Developmental defects of enamel (DDE) in children range from moderate to severe and may predispose to dental fractures and early childhood caries. The prevalence of DDE in the primary dentition range from 24 to 75 percent, and the right time to diagnose DDE should be as soon as the teeth erupt. However, early detection of DDE in primary incisors is difficult because parents seldom visit the dentist at this age and, later on, caries lesions mask the original alteration.