20 results match your criteria: "Hadassah Hebrew University of Jerusalem[Affiliation]"

Introduction: Radiation therapy plays an important role in the treatment of localized breast cancer. Hypofractionated (HF) radiation therapy has emerged as a promising alternative to conventional fractionation (CF) schedules, offering comparable efficacy with reduced treatment duration and costs. However, concerns remain regarding its safety and rate of toxicity, particularly in patients undergoing mastectomy with breast reconstruction.

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Is SNOT-22 a Reliable Tool During Periods of High Stress? A Retrospective Cohort Study.

Laryngoscope

October 2024

Department of Otolaryngology - Head and Neck Surgery, Hadassah Medical Center, Jerusalem, Israel.

Article Synopsis
  • The study aimed to analyze how the October 7, 2023 terror attack affected SNOT-22 scores, particularly in extra-rhinologic areas, by comparing data from patients before and after the event.
  • Conducted at a university hospital, the study involved 159 patients filling out the SNOT-22 questionnaire, revealing a general decline in scores, especially in the Nasal subdomain, though some subdomains showed mixed results.
  • While the study didn't find a clear connection between the attack and specific SNOT-22 subdomains, it suggested that these scores might be less reliable in high-stress situations.
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Two-year post-distraction cartilage-related structural improvement is accompanied by increased serum full-length SIRT1.

Arthritis Res Ther

May 2024

Laboratory of Cartilage Biology, Institute of Bio-Medical and Oral Research, Faculty of Dental Medicine, Hadassah-Hebrew University of Jerusalem, P. O. Box 12272, Jerusalem, 9112102, Israel.

Background: Previously, fragments from Sirtuin 1 (SIRT1) were identified in preclinical and clinical samples to display an increase in serum levels for N-terminal (NT) SIRT1 vs. C-terminal (CT) SIRT1, indicative of early signs of OA. Here we tested NT/CT SIRT1 levels as well as a novel formulated sandwich assay to simultaneously detect both domains of SIRT1 in a manner that may inform us about the levels of full-length SIRT1 in the circulation (flSIRT1) of clinical cohorts undergoing knee joint distraction (KJD).

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MSTO1 is a cytoplasmic protein that modulates mitochondrial dynamics by promoting mitochondrial fusion. Mutations in the MSTO1 gene are responsible for an extremely rare condition characterized by early-onset myopathy and cerebellar ataxia. We report here two siblings from a large Ashkenazi Jewish family, presenting with a progressive neuromuscular disease characterized by ataxia and myopathy.

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Chronic hepatitis C virus (HCV) infection, associated with severe liver disease and cancer, affects 70 million people worldwide. New treatments with direct-acting-antivirals offer cure for about 95% of affected individuals; however, treatment costs may be prohibitive in both the poorest and richest nations. Opting for cure may require sacrificing essential household assets.

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Background: Under the 'Choosing Wisely' (CW) framework, professional organisations internationally have advocated limiting imaging for asymptomatic patients following curative cancer therapy, based on limited value and high cost. F18-fluorodeoxyglucose (FDG) positron emission tomography-CT (PET/CT) was widely adopted locally for surveillance lymphoma imaging after 2004.

Objectives: Prior to ratification of a local CW recommendation to limit surveillance imaging in lymphoma, we aimed to assess: (A) performance characteristics of surveillance FDG-PET/CT; (B) rates, clinical consequences and costs of false positives (FP); and (C) patients and professionals' attitudes towards overuse.

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Background: Cytokines are known to be key players in dry eye syndrome (DES) and Sjogren's syndrome (SS) pathogenesis. In this study we compared single nucleotide polymorphism (SNP) variations in genes encoding cytokine levels among SS and DES patients in Israel.

Methods: We recruited 180 subjects, 82 with SS and 98 with DES.

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Objectives: To assess whether there are shared exposures associated with Sjogren's syndrome (SS), dry eye syndrome (DES), and B-cell non-Hodgkin lymphoma (B-NHL), in order to determine whether they are etiologically related.

Methods: In a clinic-based case-control study, 702 participants (91 SS, 120 DES, 211 (age and sex frequency-matched) controls, and 280 B-NHL cases) were recruited and interviewed regarding exposures, medical history, and family history.

Results: Female predominance was noted in SS (ratio 9.

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Article Synopsis
  • By 2020, it's expected that lifestyle choices will contribute to two-thirds of global diseases, highlighting a gap in physician education on healthy behaviors.
  • Hebrew University created a 58-hour Lifestyle Medicine curriculum between 2010 and 2014 to address this gap, covering nutrition, exercise, smoking cessation, and health coaching practices.
  • A survey showed high acceptance of the curriculum among students, who felt empowered as coaches and expressed a willingness to improve their own health behaviors.
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Purpose: This study aimed to investigate the effect of OM-101 on the fibrotic response occurring in proliferative vitreoretinopathy (PVR) in an animal model.

Methods: Antifibrotic effect of OM-101 was investigated . As control, eight weeks old c57black mice underwent intravitreal injection with Hepes (group A) or dispase (0.

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Empiric antibiotic protocols for cancer patients with neutropenia: a single-center study of treatment efficacy and mortality in patients with bacteremia.

Int J Antimicrob Agents

January 2018

Department of Clinical Microbiology and Infectious Diseases, Hadassah-Hebrew University Medical Center, Jerusalem, Israel; IBM T.J Watson Research Center, Yorktown Heights, New York, USA.

Background: There are several empiric antibiotic treatment options for febrile neutropenia, yet there is no universally-accepted initial protocol. We aimed to assess the performance of a protocol (piperacillin, gentamicin and cefazolin) introduced over 40 years ago and compare its coverage against bacteria isolated from blood of neutropenic patients with that of various commonly used antibiotic treatment protocols.

Methods: Adults with neutropenia admitted between 2003 and 2012 to the hemato-oncologic departments and in whom blood cultures were taken on admission were included.

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Fresh water scarcity has led to increased use of reclaimed wastewater as an alternative and reliable source for crop irrigation. Beyond microbiological safety, concerns have been raised regarding contamination of reclaimed wastewater by xenobiotics including pharmaceuticals. This study focuses on carbamazepine, an anticonvulsant drug which is ubiquitously detected in reclaimed wastewater, highly persistent in soil, and taken up by crops.

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Autophagy is an evolutionarily conserved mechanism for degrading long-lived or malfunctioning proteins and organelles, such as those resulting from oxidative stress. Several publications have demonstrated the importance of the autophagy process in the pathophysiology of dry age-related macular degeneration (AMD). Still, the mechanism underlying this process and its involvement in dry AMD are not fully characterized.

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The Labile Side of Iron Supplementation in CKD.

J Am Soc Nephrol

November 2015

Department of Biological Chemistry, Alexander Silberman Institute of Life Sciences, The Hebrew University of Jerusalem, Jerusalem, Israel.

The practice of intravenous iron supplementation has grown as nephrologists have gradually moved away from the liberal use of erythropoiesis-stimulating agents as the main treatment for the anemia of CKD. This approach, together with the introduction of large-dose iron preparations, raises the future specter of inadvertent iatrogenic iron toxicity. Concerns have been raised in original studies and reviews about cardiac complications and severe infections that result from long-term intravenous iron supplementation.

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Background And Aim: Proliferative vitreoretinopathy (PVR) is an active process that develops as a complication upon retinal detachment (RD), accompanied by formation of fibrotic tissue. The main cells involved in the development of fibrotic tissue during PVR are the retinal pigment epithelial (RPE) cells. The RPE cells undergo epithelial-mesenchymal transition (EMT) which leads to complex retinal detachment and loss of vision.

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Purpose: Oxidative stress and cellular senescence are known to contribute to the development of AMD; however, the mechanism is not fully understood. This study investigated the role of TGF-β-activated kinase 1 (TAK1) in the senescence of RPE cells as a model for the development of dry AMD.

Methods: Cultured human RPE cells were treated with the TAK1 inhibitor 5Z-7-oxozeaenol for 1 hour, and then treated with 200 μM hydrogen peroxide for 1 hour.

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A study of 190 mothers of firstborn, 6 month-old infants showed that different mechanisms affect onset and duration of breast feeding. Maternal education is related both to onset and duration of breast feeding; more highly educated women begin breast feeding and they breast feed for a longer period. Type of delivery is significantly associated with onset of breast feeding, even when controlling for educational level: cesarean delivered women are less likely to begin breast feeding than mothers delivered vaginally, although once breast feeding has begun, type of delivery no longer plays any role.

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