Transcatheter Tricuspid Valve-In-Valve Implantation in Patients with Tricuspid Bioprosthetic Valve Degeneration at High Surgical Risk: A Multicenter Case Series.

Background: Transcatheter tricuspid valve-in-valve implantation (TVIV) is an attractive yet under-explored alternative to redo valve surgery.

Objectives: To report the multicenter TVIV experience in Israel.

Methods: We approached multiple centers and collected data regarding seven TVIV cases.

Complications of Post-Burn Tissue Expansion Reconstruction: 9 Years Experience with 42 Pediatric and 26 Adult Patients.

Background: Burn scar reconstruction is extremely challenging, even for the most proficient reconstructive surgeon. Within the arsenal of tools at the plastic surgeon's disposal, tissue expansion provides an efficient modality for reconstruction despite the reported complication rates.

Objectives: To critically review our experience with tissue expansion for burn scar reconstruction, comparing particularly the adult and pediatric populations.

Brain neurotransmitters in an animal model with postpartum depressive-like behavior.

Post-Partum Depression (PPD) occurs in 15% of pregnancies and its patho-physiology is not known. We studied female BALB/c ("depressive") and C57BL/6 (control) mice as a model for PPD and assessed their behavior and correlates with brain neurotransmitters (NTs) - norepinephrine, dopamine, serotonin and intermediates, during the pre-pregnancy (PREP), pregnancy (PREG) and post-partum (PP) periods. Depressive-like behavior was evaluated by the Open Field (OFT), Tail Suspension (TST) and Forced Swim (FST) tests.

Osteomyelitis of the Odontoid Process in Children: Two Cases and Review of the Literature.

Objective: To report clinical, laboratory and radiologic manifestations in 2 infants with osteomyelitis of the odontoid process (dens).

Background: Vertebral osteomyelitis is uncommon, and osteomyelitis of the dens has rarely been reported in the pediatric population.

Methods: The medical records of 2 infants diagnosed with dens osteomyelitis were reviewed.

The life review experience: Qualitative and quantitative characteristics.

Background: The life-review experience (LRE) is a most intriguing mental phenomenon that fascinated humans from time immemorial. In LRE one sees vividly a succession of one's own life-events. While reports of LRE are abundant in the medical, psychological and popular literature, not much is known about LRE's cognitive and psychological basis.

Comparison of Bone Mineral Density by Dual-Energy X-Ray Absorptiometry and Bone Strength by Speed-of-Sound Ultrasonography in Adults With Gaucher Disease.

Patients with the lysosomal disorder Gaucher disease (GD) are at risk of osteoporosis and/or avascular necrosis, but to date, no adequate biomarkers are available to ascertain individual predilections. Bone mineral density by dual-energy X-ray absorptiometry (DXA) has traditionally been used to monitor trends. With the availability of a speed-of-sound (SOS) ultrasonography to assess bone strength/elasticity, we aimed to ascertain whether these modalities are complimentary or comparable so SOS, with no radiation risk, might be used more routinely as a potential biomarker.

Psychopathology of children of genocide survivors: a systematic review on the impact of genocide on their children`s psychopathology from five countries.

Background: : The health consequences of genocides on children of survivors are increasingly discussed but conclusions have been conflicting.

Methods: We systematically reviewed studies from five electronic databases (EMBASE, PILOTS, PUBMED, PsycINFO, Web of Science), which used a quantitative study design and included: (i) exposure to the genocides of Armenians in Nazi Germany, Cambodia, Rwanda and Bosnia; (ii) mental health outcomes; (iii) validated instruments; (iv) statistical tests of associations. Study quality was appraised using a quality assessment tool for genocide studies.

Erratum: Adolescent Idiopathic Scoliosis and Pregnancy: An Unsolved Paradigm.

[This corrects the article DOI: 10.1055/s-0035-1552987.].

Prisms to travel in time: Investigation of time-space association through prismatic adaptation effect on mental time travel.

Accumulating evidence suggests that humans process time and space in similar veins. Humans represent time along a spatial continuum, and perception of temporal durations can be altered through manipulations of spatial attention by prismatic adaptation (PA). Here, we investigated whether PA-induced manipulations of spatial attention can also influence more conceptual aspects of time, such as humans' ability to travel mentally back and forward in time (mental time travel, MTT).

Age-Related Effects on Future Mental Time Travel.

Mental time travel (MTT), the ability to travel mentally back and forward in time in order to reexperience past events and preexperience future events, is crucial in human cognition. As we move along life, MTT may be changed accordingly. However, the relation between re- and preexperiencing along the lifespan is still not clear.

Intensity-based masking: A tool to improve functional connectivity results of resting-state fMRI.

Seed-based functional connectivity (FC) of resting-state functional MRI data is a widely used methodology, enabling the identification of functional brain networks in health and disease. Based on signal correlations across the brain, FC measures are highly sensitive to noise. A somewhat neglected source of noise is the fMRI signal attenuation found in cortical regions in close vicinity to sinuses and air cavities, mainly in the orbitofrontal, anterior frontal and inferior temporal cortices.

Reduced Sirtuin1 expression at the femoral neck in women who sustained an osteoporotic hip fracture.

Unlabelled: To investigate the role of Sirtuin1 in osteoporosis, Sirtuin1 was determined at the femoral neck in female patients undergoing hip operation for fractured hip or osteoarthritis. Reduced Sirtuin1 was found in osteoporotic patients. Pharmacologic activation of Sirtuin1 reduced sclerostin, an inhibitor of bone formation.

Brain system for mental orientation in space, time, and person.

Orientation is a fundamental mental function that processes the relations between the behaving self to space (places), time (events), and person (people). Behavioral and neuroimaging studies have hinted at interrelations between processing of these three domains. To unravel the neurocognitive basis of orientation, we used high-resolution 7T functional MRI as 16 subjects compared their subjective distance to different places, events, or people.

Ultrasound diagnosis of Clostridium difficile-associated diarrhea.

Clostridium difficile colitis is diagnosed using an immunoassay or polymerase chain reaction (PCR) assay for toxins A/B. Since ultrasound is frequently used as a screening test for hospitalized patients suffering from different abdominal morbidities, we searched for sonographic indicators of C. difficile infection (CDI).

Adolescent Idiopathic Scoliosis and Pregnancy: An Unsolved Paradigm.

Study Design Retrospective cohort study with a cross-sectional comparison. Objective To compare the rates of anesthesia prescription and satisfaction with surgery, prevalence and severity of low back pain, prevalence of depression, and sexual dysfunction among pregnant and nonpregnant patients with AIS undergoing correction surgery with pedicle-based systems and healthy woman with a history of pregnancy. Methods Women between the ages of 18 and 40 years who underwent correction surgery for AIS with a pedicle screw system were interviewed regarding pregnancies, child delivery, method of pain control during delivery, and any long-term outcome after delivery.

Valproic acid hypersensitivity and desensitization.

Rash, a hypersensitivity reaction, is a common cause of withdrawal from an effective antiepileptic drug (AED) in patients with epilepsy. We present a case of successful desensitization to valproic acid in a 12-year-old male with childhood absence epilepsy and a hypersensitivity reaction, whose epilepsy did not respond to other AEDs. Desensitization is a practical therapeutic solution for patients who develop a non-life-threatening hypersensitivity reaction to an AED for which there may be no substitute.

The science of neuropsychiatry: past, present, and future.

The field of neuropsychiatry aims to overcome the separation of neurology and psychiatry, which is reflected in a gap between the neurologist, searching for the underlying neuroanatomical basis of a disorder, and the psychiatrist, dipping into its phenomenology and underlying genetics. This gap becomes slighter in our day, as recent research in clinical neurosciences enables us to better investigate the neural basis of neuropsychiatric disorders. This article reviews the history and development of neuropsychiatry in the occidental world, suggesting that the science of neuropsychiatry could optimize for the diagnosis, monitoring, and treatment of behavioral, cognitive, and so-called mental disorders.

Orientation and disorientation: lessons from patients with epilepsy.

Orientation in time, space, and person is a fundamental cognitive faculty and the bedrock of neurological and psychiatric mental status examination. Nevertheless, research in orientation and disorientation is neglected in both cognitive science and neuropsychiatry. Specifically, it is still unclear whether disorientations in time, space, and person represent a failure of the same system or merely share a common nomenclature and whether these three domains of orientation depend on different psychological and neural systems.

α-Synuclein rs356219 polymorphisms in patients with Gaucher disease and Parkinson disease.

Mutations in β-glucocerebrosidase, the genetic defect in Gaucher disease (GD), are an important susceptibility factor for Parkinson disease (PD). A PD effector is α-synuclein (SNCA) hypothesized to selectively interact with β-glucocerebrosidase under lysosomal conditions. SNCA polymorphism rs356219 may be associated with early-age-onset PD, common among patients with GD+PD.