5,706 results match your criteria: "Hadassah Hebrew University Medical Center[Affiliation]"

Autosomal recessive deficiency of the IFNAR1 or IFNAR2 chain of the human type I IFN receptor abolishes cellular responses to IFN-α, -β, and -ω, underlies severe viral diseases, and is globally very rare, except for IFNAR1 and IFNAR2 deficiency in Western Polynesia and the Arctic, respectively. We report 11 human IFNAR1 alleles, the products of which impair but do not abolish responses to IFN-α and -ω without affecting responses to IFN-β. Ten of these alleles are rare in all populations studied, but the remaining allele (P335del) is common in Southern China (minor allele frequency ≈2%).

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Background And Aims: Previous observational data indicate that young adults treated with intravenous thrombolysis (IVT) for acute ischemic stroke have more favorable outcomes and less complications when compared to older adults. Given the limited data on this topic, we aimed to provide more evidence on clinical outcomes and safety in such patients, using a large international thrombolysis registry.

Methods: In this prospective multicenter study, we used data from the Thrombolysis in Ischemic Stroke Patients (TRISP) registry from 1998 to 2020.

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Tumor Suppressor miR-34a: Potential Biomarker of TACE Response in HCC.

Cardiovasc Intervent Radiol

December 2024

Department of Radiology and Nuclear Medicine, University Hospital Brno and Masaryk University Brno, Jihlavská 340/20, 625 00, Brno, Czechia.

Article Synopsis
  • The study investigates the effects of TACE treatment on microRNA levels and VEGF in HCC patients, comparing two types of particles: degradable (DSM) and nondegradable (DEB).
  • It included 52 patients, measuring biomarker concentrations at different time points before and after TACE to assess treatment responses at six and twelve months.
  • Results showed that while both particle types raised microRNA levels post-TACE, only miR-34a’s immediate increase correlated with better outcomes, suggesting it could be a useful biomarker for predicting patient prognosis.
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Background: Cystic fibrosis (CF) primarily affects Caucasian populations, with the highest prevalence in countries like Ireland, the UK, Australia, and Canada. Despite significant improvements in survival, pulmonary insufficiency remains the leading cause of death. Factors such as nutrition, chronic Pseudomonas aeruginosa (PsA) infection, genotype, pancreatic status, and cystic fibrosis-related diabetes affect pulmonary function across age groups.

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  • This study aims to examine the histopathology and outcomes in patients with retinoblastoma who underwent eye enucleation and had neovascular glaucoma (NVG).
  • The research included 1,420 total cases from five continents, revealing that 16% of patients with NVG were often at higher risk of severe histopathological findings.
  • The findings indicate that NVG is linked to more aggressive forms of the disease and a higher chance of metastasis, emphasizing the need for careful monitoring and treatment in these cases.
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  • This study evaluates the effectiveness of combining coalition resection and calcaneal lengthening osteotomy to treat symptomatic talocalcaneal coalition in children with painful flat feet.
  • An analysis of 10 pediatric patients showed significant improvements in foot deformities and pain levels, with most enjoying good postoperative outcomes after an average follow-up of 54 months.
  • The research concludes this combined surgical approach is effective, with minimal complications and no requirement for additional surgeries post-treatment.
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The docking process is a crucial step in robotic surgery, which determines the technical capability of moving the robotic arms during surgery and affects the performance of surgery. Robotic companies, therefore, provide setup guides recommending the trocar placement, arm carts, and operating table positioning for each procedure or body quadrant, to facilitate this process. This process takes time and although improves with experience, reported docking times range from 4 to 29 min.

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Prognostic Factors Associated With Increased Mortality in Pediatric Veno-Occlusive Disease Following Hematopoietic Cell Transplantation.

Clin Transplant

December 2024

Division of Pediatric Hematology Oncology and Bone Marrow Transplantation, Ruth Rappaport Children's Hospital, Rambam Medical Center, Haifa, Israel.

Background: Hepatic veno-occlusive disease (VOD) is a life-threatening complication of hematopoietic cell transplantation (HCT) and is categorized as a transplant-related, systemic endothelial disease. Severe VOD can lead to multi-organ dysfunction (MOF) and is associated with a high mortality rate.

Objective: To evaluate the incidence of VOD in children after HCT and analyze the outcomes and risk factors associated with increased mortality.

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Introduction: Universal newborn hearing screening has been successfully implemented in many places around the world, and it is recommended that cases with risk factors for hearing loss be followed-up regardless of hearing screening results. However, there is a need for clarity regarding the recommended rate of follow-up and which tests should be performed. The aim of this study was to assess the audiologic follow-up program for the group with risk factors.

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Adult Onset Foveomacular Vitelliform Dystrophy Shows Genetic Overlap With Age-Related Macular Degeneration.

Invest Ophthalmol Vis Sci

November 2024

Department of Ophthalmology, Hadassah-Hebrew University Medical Center, and the Faculty of Medicine, The Hebrew University of Jerusalem, Jerusalem, Israel.

Purpose: Adult-onset foveomacular vitelliform dystrophy (AFVD) shares phenotypic similarities with age-related macular degeneration (AMD). The genetic factors associated with AFVD are unknown in >80% of cases. This study evaluated the association of known AMD genetic risk variants with AFVD and compared systemic complement activation in these conditions.

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Tumor analysis of BRCA carriers reveals genomic similarities although separated by time.

Discov Oncol

November 2024

Department of Developmental Biology and Cancer Research, Institute for Medical Research Israel-Canada, Hebrew University Medical School, 91120, Jerusalem, Israel.

Among the dominant pathogenic genes (PG) in breast cancer are BRCA1/2. Knowing whether a patient carry one of these alterations is meaningful as it affects management. A substantial question is to what extent are the genomic profile of a tumor and its characteristics affected by the germline profile of BRCA1/2 and what is the possible contribution of other environmental factors.

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  • A phase II clinical study evaluated the effectiveness of a treatment combo (ibrutinib, bendamustine, and rituximab) in patients with relapsed or refractory aggressive B-cell non-Hodgkin lymphoma after stem cell transplants or in elderly patients.
  • The study showed a 49.1% overall response rate among patients who received at least one cycle, with better outcomes for those with relapsed disease (72.3%) versus refractory disease (37.8%).
  • Patients experiencing complete or partial responses had significantly longer median overall survival of 28.1 months, while common side effects included fatigue, diarrhea, and nausea, indicating that the treatment is both safe and effective for those needing potential transplantation.
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Introduction: During the first waves of COVID-19 in 2020, the public was confined to their homes due to closure instructions that applied to gatherings, celebrations, and restaurants, as well as voluntary self-isolation for fear of contagion. This seclusion affected, among other things, pre-hospital emergency medical services (EMS), which experienced a general decrease in their activity for trauma cases and routine medical problems. Other immediate life-saving events are cases of anaphylaxis.

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Background: Delirium, an acute brain dysfunction, is proposed to be highly prevalent in clinical care and shown to significantly increase the risk of mortality and dementia.

Objectives: To report on the global prevalence of clinically documented delirium and delirium-related clinical practices in wards caring for paediatric and adult patients in healthcare facilities.

Design: A prospective, cross-sectional, 39-question survey completed on World Delirium Awareness Day, 15 March 2023.

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Inferring DNA methylation in non-skeletal tissues of ancient specimens.

Nat Ecol Evol

November 2024

Department of Genetics, The Alexander Silberman Institute of Life Sciences, The Hebrew University of Jerusalem, Jerusalem, Israel.

Genome-wide premortem DNA methylation patterns can be computationally reconstructed from high-coverage DNA sequences of ancient samples. Because DNA methylation is more conserved across species than across tissues, and ancient DNA is typically extracted from bones and teeth, previous works utilizing ancient DNA methylation maps focused on studying evolutionary changes in the skeletal system. Here we suggest that DNA methylation patterns in one tissue may, under certain conditions, be informative on DNA methylation patterns in other tissues of the same individual.

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Interventional Oncology Meets Immuno-oncology: Combination Therapies for Hepatocellular Carcinoma.

Radiology

November 2024

From the Departments of Radiology (R.B., J.C.) and Digestive Diseases (Hepatology) (J.C.), Yale University School of Medicine, New Haven, Conn; Department of Radiology, Feinberg School of Medicine, Northwestern University, Chicago, Ill (R.S.); Department of Medical Oncology, Geffen School of Medicine, University of California Los Angeles, Los Angeles, Calif (R.F.); Center for Cancer Research, National Institutes of Health, Bethesda, Md (T.F.G.); Department of Radiology, Hadassah Hebrew University Medical Center, Hebrew University, Jerusalem, Israel (S.N.G.); and Department of Biomedical Engineering, Yale School of Engineering and Applied Sciences, 789 Howard Ave, Clinic Bldg 363H, New Haven, CT 06520 (J.C.).

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NIMO-TEMPO is a metrology device that measures all types of intraocular lenses available in the ophthalmic market. Its technology, based on interferometry, captures the wavefront of the lens to compute optical results essential to evaluate its quality and understand its characteristics. This study aims to demonstrate the reliability of this device and its associated software, TEMPO-MENTOR, in measuring intraocular lenses.

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Article Synopsis
  • The study compares the optical performance of three types of monofocal intraocular lenses (IOLs): spherical, aberration-neutral, and aberration-correcting models.
  • It uses a comprehensive approach by analyzing various corneal models and pupil sizes to account for differences in corneal spherical aberrations (SA) and pupil sizes commonly seen in both normal eyes and those post-refractive surgery.
  • Results show that pupil size and corneal SA significantly impact lens performance metrics like MTFmax (contrast at best focus), depth of focus, and refractive error tolerance, which vary based on the type of IOL used.
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The genetic landscape of Lynch syndrome in the Israeli population.

Fam Cancer

November 2024

Recanati Genetics Institute, Faculty of Medicine, Rabin Medical Center - Beilinson Hospital, Tel Aviv University, Petach Tikva, Tel Aviv, Israel.

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Advances in the restoration of CFTR in children and pwCF with "mild disease".

Pediatr Pulmonol

November 2024

Pediatric Pulmonology Unit and Cystic fibrosis Center, Hadassah-Hebrew University Medical Center, Jerusalem, Israel.

Article Synopsis
  • Cystic fibrosis (CF) is a genetic disorder that primarily affects the lungs, leading to significant health issues and shortened life expectancy.
  • Despite improvements in treatment, lung function tends to decline due to early inflammation and infections, especially from pseudomonas bacteria.
  • Current treatments aim at nutrition, airway clearance, and infection control, but CFTR modulators target the underlying genetic issue, improving lung function and potentially changing the disease's progression when started early.
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Taxanes and platinum molecules, specifically paclitaxel and carboplatin, are widely used anticancer drugs that induce cell death and serve as first-line chemotherapy for various cancer types. Despite the efficient effect of both drugs on cancer cell proliferation, many tumours have innate resistance against paclitaxel and carboplatin, which leads to inefficient treatment and poor survival rates. Haploid human embryonic stem cells (hESCs) are a novel and robust platform for genetic screening.

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